AU666772B2 - Quinolone carboxylic acids - Google Patents

Quinolone carboxylic acids Download PDF

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Publication number
AU666772B2
AU666772B2 AU48644/93A AU4864493A AU666772B2 AU 666772 B2 AU666772 B2 AU 666772B2 AU 48644/93 A AU48644/93 A AU 48644/93A AU 4864493 A AU4864493 A AU 4864493A AU 666772 B2 AU666772 B2 AU 666772B2
Authority
AU
Australia
Prior art keywords
diazabicyclo
cyclopropyl
acid
methyl
nonane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU48644/93A
Other languages
English (en)
Other versions
AU4864493A (en
Inventor
Klaus-Dieter Bremm
Andreas Drebs
Rainer Endermann
Klaus Grohe
Dieter Habisch
Karl-Georg Metzger
Uwe Petersen
Thomas Dr. Philipps
Thomas Schenke
Wilfred Schrock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of AU4864493A publication Critical patent/AU4864493A/en
Application granted granted Critical
Publication of AU666772B2 publication Critical patent/AU666772B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU48644/93A 1992-10-09 1993-09-27 Quinolone carboxylic acids Ceased AU666772B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4234078 1992-10-09
DE4234078A DE4234078A1 (de) 1992-10-09 1992-10-09 Chinoloncarbonsäuren

Publications (2)

Publication Number Publication Date
AU4864493A AU4864493A (en) 1994-04-21
AU666772B2 true AU666772B2 (en) 1996-02-22

Family

ID=6470084

Family Applications (1)

Application Number Title Priority Date Filing Date
AU48644/93A Ceased AU666772B2 (en) 1992-10-09 1993-09-27 Quinolone carboxylic acids

Country Status (19)

Country Link
US (1) US5480879A (esLanguage)
EP (1) EP0591808A1 (esLanguage)
JP (1) JPH0820587A (esLanguage)
KR (1) KR940009193A (esLanguage)
CN (1) CN1090285A (esLanguage)
AU (1) AU666772B2 (esLanguage)
CA (1) CA2107812A1 (esLanguage)
CZ (1) CZ9302001A3 (esLanguage)
DE (1) DE4234078A1 (esLanguage)
FI (1) FI934411A7 (esLanguage)
HU (1) HUT66376A (esLanguage)
IL (1) IL107188A0 (esLanguage)
MX (1) MX9306023A (esLanguage)
NO (1) NO933393L (esLanguage)
NZ (1) NZ248871A (esLanguage)
PL (1) PL300628A1 (esLanguage)
SK (1) SK109293A3 (esLanguage)
TW (1) TW288018B (esLanguage)
ZA (1) ZA937474B (esLanguage)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7706394A (en) * 1994-02-25 1995-09-11 Arrieta Munguia, Judith Marcia Quinolonylcarboxamidocephalosporin derivatives and pharmaceutical compositions containing them
AU718806B2 (en) * 1995-02-17 2000-04-20 Daiichi Asubio Pharma Co., Ltd. Penem derivatives and antimicrobial agent containing the same
DE19546249A1 (de) 1995-12-12 1997-06-19 Bayer Ag Neue Kristallmodifikation des 1-Cyclopropyl-7-([S,S]-2,8-diazabicyclo[4,3,0]non-8-yl)-6-fluor-1,4-dihydro-8-methoxy-4-oxo-3-chinolincarbonsäure Hydrochlorid (CDCH), Verfahren zu dessen Herstellung und diese enthaltende pharmazeutische Zubereitungen
RU2193558C2 (ru) * 1997-09-15 2002-11-27 Дзе Проктер Энд Гэмбл Компани Производные хинолона и фармацевтическая композиция на их основе
DE19751948A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verfahren zur Herstellung von 8-Methoxy-Chinoloncarbonsäuren
DE19821039A1 (de) 1998-05-11 1999-11-18 Bayer Ag Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan
US6509327B1 (en) 1998-09-30 2003-01-21 Alcon Manufacturing, Ltd. Compositions and methods for treating otic, ophthalmic and nasal infections
US6395746B1 (en) 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
US6716830B2 (en) * 1998-09-30 2004-04-06 Alcon, Inc. Ophthalmic antibiotic compositions containing moxifloxacin
DE19927412A1 (de) * 1999-06-16 2000-12-21 Bayer Ag Verfahren zur Enantiomerenanreicherung von cis-8-Benzyl-7,9-dioxo-2,8-diazabicyclo [4.3.0]nonan
DE19931115A1 (de) * 1999-07-06 2001-01-11 Bayer Ag Racemisierung von R, S-Dioxo-Benzylpyrrolopiperidin
AU2001261748A1 (en) * 2000-05-19 2001-12-03 Alcon Laboratories Inc. Antibiotic compositions for treatment of the eye, ear and nose
EP2495245A3 (en) * 2004-06-10 2012-12-19 FOB Synthesis, Inc. Gram-positive carbapenem antibacterials and processes for their preparation
CN1325494C (zh) * 2005-08-18 2007-07-11 中国药科大学 3－位取代的萘啶酮类化合物及其制备方法和在制药中的应用
WO2007110835A2 (en) 2006-03-28 2007-10-04 The Procter & Gamble Company A coupling process for preparing quinolone intermediates
MY148393A (en) 2006-03-28 2013-04-15 Taigen Biotechnology Co Ltd Malate salts, and polymorphs of (3s, 5s)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
US7692015B2 (en) * 2007-01-05 2010-04-06 Zheqing Wang Economical process for preparing (S, S)-2, 8-diazabicyclo[4.3.0]nonane and its enantiomer
FR2928150A1 (fr) * 2008-02-29 2009-09-04 Vetoquinol Sa Sa Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens
EP2145891A1 (en) * 2008-07-09 2010-01-20 Vetoquinol S.A. 9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials
EP2154137A1 (en) 2008-08-04 2010-02-17 Chemo Ibérica, S.A. Crystalline form of moxifloxacin base
IT1393337B1 (it) 2009-03-06 2012-04-20 Italiana Sint Spa Sintesi di (4as, 7as)-ottaidro-1h-pirrolo[3,4-b]piridina
MX2011012134A (es) 2009-05-15 2012-02-08 Redx Pharma Ltd Derivados de farmaco de oxido-reduccion.
CA2802529C (en) 2010-06-18 2019-10-29 Woo-Baeg Choi Carbapenem antibacterials with gram-negative activity
CN102952130B (zh) * 2011-08-24 2016-03-23 重庆华邦胜凯制药有限公司 手性合成(s,s)-2,8-二氮杂双环壬烷的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT49889A (en) * 1988-03-31 1989-11-28 Hoffmann La Roche Process for producing acyl derivatives
CS273349B2 (en) * 1988-03-31 1991-03-12 Hoffmann La Roche Method of cephalosporin's new derivatives production
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
EP0997466A1 (en) * 1988-10-24 2000-05-03 PROCTER & GAMBLE PHARMACEUTICALS, INC. Novel antimicrobial lactam-quinolones
DE3910663A1 (de) * 1989-04-03 1990-10-04 Bayer Ag 5-alkylchinoloncarbonsaeuren
JPH03188080A (ja) * 1989-12-15 1991-08-16 Banyu Pharmaceut Co Ltd ピリドンカルボン酸誘導体
ZA912279B (en) * 1990-04-09 1992-02-26 Hoffmann La Roche Carbapenem compounds
EP0492277A3 (en) * 1990-12-20 1992-10-14 F. Hoffmann-La Roche Ag Cephalosporin derivatives

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
43683/89 C07D 519/00 *
74205/91 C07D 519/00 *
89947/91 C07D 519/00 *

Also Published As

Publication number Publication date
NO933393L (no) 1994-04-11
NZ248871A (en) 1995-12-21
KR940009193A (ko) 1994-05-20
MX9306023A (es) 1994-05-31
FI934411L (fi) 1994-04-10
IL107188A0 (en) 1994-01-25
PL300628A1 (en) 1994-05-16
NO933393D0 (no) 1993-09-23
FI934411A7 (fi) 1994-04-10
US5480879A (en) 1996-01-02
ZA937474B (en) 1994-04-26
DE4234078A1 (de) 1994-04-14
SK109293A3 (en) 1994-09-07
TW288018B (esLanguage) 1996-10-11
HUT66376A (en) 1994-11-28
FI934411A0 (fi) 1993-10-07
CN1090285A (zh) 1994-08-03
CZ9302001A3 (en) 1994-04-13
CA2107812A1 (en) 1994-04-10
EP0591808A1 (de) 1994-04-13
HU9302843D0 (en) 1993-12-28
JPH0820587A (ja) 1996-01-23
AU4864493A (en) 1994-04-21

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