AU649696B2 - Preparation process of sustained release compositions and the compositions thus obtained - Google Patents

Preparation process of sustained release compositions and the compositions thus obtained Download PDF

Info

Publication number
AU649696B2
AU649696B2 AU81466/91A AU8146691A AU649696B2 AU 649696 B2 AU649696 B2 AU 649696B2 AU 81466/91 A AU81466/91 A AU 81466/91A AU 8146691 A AU8146691 A AU 8146691A AU 649696 B2 AU649696 B2 AU 649696B2
Authority
AU
Australia
Prior art keywords
gel
mixture
temperature
microballs
percent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU81466/91A
Other languages
English (en)
Other versions
AU8146691A (en
Inventor
Jean-Marc Ruiz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Publication of AU8146691A publication Critical patent/AU8146691A/en
Application granted granted Critical
Publication of AU649696B2 publication Critical patent/AU649696B2/en
Assigned to IPSEN PHARMA S.A.S reassignment IPSEN PHARMA S.A.S Request to Amend Deed and Register Assignors: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Glanulating (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU81466/91A 1990-08-01 1991-07-31 Preparation process of sustained release compositions and the compositions thus obtained Ceased AU649696B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9016885 1990-08-01
GB909016885A GB9016885D0 (en) 1990-08-01 1990-08-01 Sustained release pharmaceutical compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU59393/94A Division AU666808B2 (en) 1990-08-01 1994-04-11 Sustained release compositions

Publications (2)

Publication Number Publication Date
AU8146691A AU8146691A (en) 1992-02-06
AU649696B2 true AU649696B2 (en) 1994-06-02

Family

ID=10679993

Family Applications (2)

Application Number Title Priority Date Filing Date
AU81466/91A Ceased AU649696B2 (en) 1990-08-01 1991-07-31 Preparation process of sustained release compositions and the compositions thus obtained
AU59393/94A Ceased AU666808B2 (en) 1990-08-01 1994-04-11 Sustained release compositions

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU59393/94A Ceased AU666808B2 (en) 1990-08-01 1994-04-11 Sustained release compositions

Country Status (30)

Country Link
US (1) US5213812A (ref)
JP (1) JP2818704B2 (ref)
KR (1) KR920003962A (ref)
AT (1) AT396425B (ref)
AU (2) AU649696B2 (ref)
BE (1) BE1004772A3 (ref)
CA (1) CA2048270C (ref)
CH (1) CH682715A5 (ref)
DE (1) DE4125542A1 (ref)
DK (1) DK175756B1 (ref)
ES (1) ES2046083B1 (ref)
FI (1) FI104149B (ref)
FR (1) FR2665360B1 (ref)
GB (1) GB9016885D0 (ref)
GR (1) GR1001512B (ref)
HK (1) HK33294A (ref)
IE (1) IE65124B1 (ref)
IN (1) IN178446B (ref)
IT (1) IT1251788B (ref)
LU (1) LU87982A1 (ref)
MA (1) MA22245A1 (ref)
MY (1) MY107500A (ref)
NL (1) NL194637C (ref)
NO (1) NO300158B1 (ref)
NZ (1) NZ238981A (ref)
OA (1) OA09387A (ref)
PT (1) PT98497B (ref)
SE (1) SE505734C2 (ref)
TN (1) TNSN91067A1 (ref)
ZA (1) ZA915565B (ref)

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GB9310030D0 (en) * 1993-05-15 1993-06-30 Scras Dry processed particles and process for the preparation of the same
US5569467A (en) * 1993-05-15 1996-10-29 Societe De Conseils De Recherches Et D'applications (S.C.R.A.S.) Process for the preparation of microballs and microballs thus obtained
HUT75469A (en) * 1994-02-28 1997-05-28 Medinova Med Consulting Gmbh Drug targeting system, method for preparing same and its use
US5980945A (en) * 1996-01-16 1999-11-09 Societe De Conseils De Recherches Et D'applications Scientifique S.A. Sustained release drug formulations
DE19604744A1 (de) 1996-02-09 1997-08-14 Henkel Kgaa Technische Di-/Triglyceridgemische
DE19617137C1 (de) * 1996-04-29 1997-02-27 Henkel Kgaa Verwendung von Copolymerestern für die Herstellung von Mikrosphären
WO1998015263A2 (en) * 1996-10-09 1998-04-16 Takeda Chemical Industries, Ltd. A method for producing a microparticle
AR012448A1 (es) * 1997-04-18 2000-10-18 Ipsen Pharma Biotech Composicion en forma de microcapsulas o de implantes que comprende un excipiente biodegradable, polimero o co-polimero, o una mezcla de talesexcipientes, y una sustancia activa o una mezcla de sustancias activas, procedimiento para la preparacion de una sustancia soluble en agua de elevada
AU3555599A (en) 1998-04-13 1999-11-01 Luminex Corporation Liquid labeling with fluorescent microparticles
IL143761A0 (en) * 1998-12-16 2002-04-21 Aventis Pharma Inc Biodegradable polymer encapsulated serotonin receptor antagonist and method for preparing the same
AU5644400A (en) * 1999-09-24 2001-03-29 Rohm And Haas Company Pellet compositions
US6458387B1 (en) * 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
WO2002043580A2 (en) 2000-10-27 2002-06-06 Epic Therapeutics, Inc. Production of microspheres
EP1418890B1 (en) * 2001-08-16 2008-05-14 Baxter International Inc. Propellant-based microparticle formulations
US20080026068A1 (en) * 2001-08-16 2008-01-31 Baxter Healthcare S.A. Pulmonary delivery of spherical insulin microparticles
US20040166077A1 (en) * 2002-12-04 2004-08-26 L'oreal Process for treating keratin materials with aromatic active principles
FR2848113B1 (fr) * 2002-12-04 2005-02-25 Oreal Stabilisation de principes actifs aromatiques par des polymeres aromatiques
WO2005035088A2 (en) * 2003-07-18 2005-04-21 Baxter International, Inc. Method for preparing small spherical by controlled phase separation
US20070092452A1 (en) * 2003-07-18 2007-04-26 Julia Rashba-Step Methods for fabrication, uses, compositions of inhalable spherical particles
US20050142205A1 (en) * 2003-07-18 2005-06-30 Julia Rashba-Step Methods for encapsulating small spherical particles prepared by controlled phase separation
JP2007508240A (ja) * 2003-07-22 2007-04-05 バクスター・インターナショナル・インコーポレイテッド 低分子量有機分子の小球状粒子ならびにその調製方法および使用方法
US20060135277A1 (en) * 2003-09-10 2006-06-22 Marnocha Bendict F Golf club and practice arrangement
FR2865938B1 (fr) * 2004-02-05 2006-06-02 Sod Conseils Rech Applic Formulation retard solide comprenant de l'acetate de triptoreline
US8728525B2 (en) * 2004-05-12 2014-05-20 Baxter International Inc. Protein microspheres retaining pharmacokinetic and pharmacodynamic properties
CA2566079A1 (en) 2004-05-12 2005-12-01 Terrence L. Scott Nucleic acid microspheres, production and delivery thereof
WO2005112885A2 (en) * 2004-05-12 2005-12-01 Baxter International Inc. Oligonucleotide-containing microspheres, their use for the manufacture of a medicament for treating diabetes type 1
EP1753404A1 (en) * 2004-05-12 2007-02-21 Baxter International Inc. Microspheres comprising protein and showing injectability at high concentrations of said agent
WO2006017337A1 (en) * 2004-07-13 2006-02-16 Altairnano, Inc. Ceramic structures for controlled release of drugs
AU2005271781A1 (en) * 2004-07-13 2006-02-16 Altairnano, Inc. Ceramic structures for prevention of drug diversion
CA2585634A1 (en) * 2004-10-29 2006-05-11 Adhesives Research, Inc. Microscopic tagging system for security identification
MX2007013356A (es) * 2005-04-27 2008-03-26 Baxter Int Microparticulas modificadas en la superficie y metodos de formacion y uso de las mismas.
AU2006283170A1 (en) * 2005-08-23 2007-03-01 Altairnano, Inc. Highly photocatalytic phosphorus-doped anatase-TiO2 composition and related manufacturing methods
US20080020175A1 (en) * 2006-03-02 2008-01-24 Fred Ratel Nanostructured Indium-Doped Iron Oxide
US20080038482A1 (en) * 2006-03-02 2008-02-14 Fred Ratel Method for Low Temperature Production of Nano-Structured Iron Oxide Coatings
US20080008843A1 (en) * 2006-03-02 2008-01-10 Fred Ratel Method for Production of Metal Oxide Coatings
US20070281031A1 (en) * 2006-06-01 2007-12-06 Guohan Yang Microparticles and methods for production thereof
EP2647712A3 (en) * 2006-08-04 2013-11-20 Baxter International Inc Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes
WO2008060786A2 (en) * 2006-10-06 2008-05-22 Baxter International Inc. Microencapsules containing surface-modified microparticles and methods of forming and using the same
CA2702340C (en) 2006-10-12 2014-12-16 The University Of Queensland Compositions and methods for modulating immune responses
US20090169628A1 (en) 2006-10-17 2009-07-02 Armark Authentication Technologies, Llc Article and method for focused delivery of therapeutic and/or diagnostic materials
US20080254258A1 (en) * 2007-04-12 2008-10-16 Altairnano, Inc. Teflon® replacements and related production methods
CA2682135A1 (en) * 2007-04-17 2008-10-30 Baxter International Inc. Nucleic acid microparticles for pulmonary delivery
US9782300B2 (en) 2008-02-01 2017-10-10 Kci Licensing, Inc. Fiber-microsphere bioresorbable composite scaffold for wound healing
DK2281042T3 (en) 2008-04-18 2015-11-09 Baxter Int Microsphere-based composition for preventing and / or deletion of starting autoimmune diabetes
US8367427B2 (en) * 2008-08-20 2013-02-05 Baxter International Inc. Methods of processing compositions containing microparticles
US20100047292A1 (en) * 2008-08-20 2010-02-25 Baxter International Inc. Methods of processing microparticles and compositions produced thereby
US8323615B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing multi-phasic dispersions
US8323685B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing compositions containing microparticles
US20100078848A1 (en) * 2008-09-29 2010-04-01 Armark Authentication Technologies, Llc Spinneret and method of spinning fiber
US20100291214A1 (en) * 2008-12-23 2010-11-18 Armark Authentication Technologies, Llc Three-dimensional microfiber extrudate structure and process for forming three-dimensional microfiber extrudate structure
WO2010132763A1 (en) * 2009-05-15 2010-11-18 Armark Authentication Technologies, Llc Fiber having non-uniform composition and method for making same
WO2010138192A2 (en) 2009-05-27 2010-12-02 Selecta Biosciences, Inc. Nanocarriers possessing components with different rates of release
WO2011038053A1 (en) * 2009-09-25 2011-03-31 Armark Authentication Technologies, Llc Tissue fiber scaffold and method for making
CN102905728B (zh) 2010-05-26 2015-11-25 西莱克塔生物科技公司 具有不偶合的佐剂的纳米载体组合物
EP2399931A1 (fr) * 2010-06-22 2011-12-28 Ipsen Pharma S.A.S. Nouveaux composés octapeptidiques et leur utilisation thérapeutique
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Also Published As

Publication number Publication date
NL9101306A (nl) 1992-03-02
JPH05178740A (ja) 1993-07-20
US5213812A (en) 1993-05-25
JP2818704B2 (ja) 1998-10-30
AU8146691A (en) 1992-02-06
AT396425B (de) 1993-09-27
IE912700A1 (en) 1992-02-12
ZA915565B (en) 1992-04-29
DK141891A (da) 1992-02-02
CH682715A5 (fr) 1993-11-15
PT98497B (pt) 1997-10-31
FI913646A0 (fi) 1991-07-31
FI104149B1 (fi) 1999-11-30
MY107500A (en) 1995-12-30
AU666808B2 (en) 1996-02-22
GR910100330A (en) 1992-08-31
OA09387A (fr) 1992-09-15
BE1004772A3 (fr) 1993-01-26
CA2048270C (en) 1997-02-25
MA22245A1 (fr) 1992-04-01
SE9102249D0 (sv) 1991-07-26
NO300158B1 (no) 1997-04-21
NL194637B (nl) 2002-06-03
NO912986L (no) 1992-02-03
FR2665360B1 (fr) 1995-02-10
KR920003962A (ko) 1992-03-27
NZ238981A (en) 1992-11-25
FR2665360A1 (fr) 1992-02-07
DK141891D0 (da) 1991-07-31
FI104149B (fi) 1999-11-30
ES2046083B1 (es) 1994-08-01
NO912986D0 (no) 1991-07-31
AU5939394A (en) 1994-06-02
NL194637C (nl) 2002-10-04
IE65124B1 (en) 1995-10-04
HK33294A (en) 1994-04-22
CA2048270A1 (en) 1992-02-02
ES2046083A1 (es) 1994-01-16
IN178446B (ref) 1997-05-03
SE505734C2 (sv) 1997-10-06
ATA152591A (de) 1993-01-15
TNSN91067A1 (fr) 1992-10-25
FI913646L (fi) 1992-02-02
DK175756B1 (da) 2005-02-14
SE9102249L (sv) 1992-02-02
GB9016885D0 (en) 1990-09-12
LU87982A1 (fr) 1992-04-15
DE4125542A1 (de) 1992-02-06
GR1001512B (el) 1994-02-28
ITMI911953A1 (it) 1993-01-15
IT1251788B (it) 1995-05-26
ITMI911953A0 (it) 1991-07-15
PT98497A (pt) 1992-06-30

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