AU648789B2 - Bicyclic 1-aza-cycloalkanes - Google Patents
Bicyclic 1-aza-cycloalkanes Download PDFInfo
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- AU648789B2 AU648789B2 AU77130/91A AU7713091A AU648789B2 AU 648789 B2 AU648789 B2 AU 648789B2 AU 77130/91 A AU77130/91 A AU 77130/91A AU 7713091 A AU7713091 A AU 7713091A AU 648789 B2 AU648789 B2 AU 648789B2
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- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4016212 | 1990-05-19 | ||
| DE4016212 | 1990-05-19 | ||
| DE4018886 | 1990-06-13 | ||
| DE4018886 | 1990-06-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU7713091A AU7713091A (en) | 1991-11-21 |
| AU648789B2 true AU648789B2 (en) | 1994-05-05 |
Family
ID=25893382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU77130/91A Ceased AU648789B2 (en) | 1990-05-19 | 1991-05-20 | Bicyclic 1-aza-cycloalkanes |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0458214A1 (cs) |
| JP (1) | JP2853837B2 (cs) |
| KR (1) | KR910020009A (cs) |
| AU (1) | AU648789B2 (cs) |
| CA (1) | CA2042860A1 (cs) |
| CZ (1) | CZ281837B6 (cs) |
| FI (1) | FI912409A7 (cs) |
| HU (1) | HUT58091A (cs) |
| IE (1) | IE911688A1 (cs) |
| IL (1) | IL98176A0 (cs) |
| NO (1) | NO911934L (cs) |
| PT (1) | PT97703A (cs) |
| SK (1) | SK279168B6 (cs) |
| YU (1) | YU84791A (cs) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE65997B1 (en) * | 1990-05-11 | 1995-11-29 | Sankyo Co | Piperidyloxy- and quinuclidinyloxy- isoxazole derivatives their preparation and their therapeutic use |
| GB9122988D0 (en) * | 1991-10-30 | 1991-12-18 | Ici Plc | Heterocyclic compounds |
| GB9127279D0 (en) * | 1991-12-23 | 1992-02-19 | Ici Plc | Heterocyclic derivatives |
| AU3901393A (en) * | 1992-04-10 | 1993-11-18 | Zeneca Limited | Biphenylylquinuclidine derivatives as squalene synthase inhibitors |
| GB9211796D0 (en) * | 1992-06-04 | 1992-07-15 | Ici Plc | Heterocyclic derivatives |
| IT1255179B (it) * | 1992-06-26 | 1995-10-20 | Enzo Cereda | Azaciclo e azabiciclo alchiliden idrossilamine |
| GB9216721D0 (en) * | 1992-08-06 | 1992-09-23 | Ici Plc | Therapeutic heterocyclic derivatives |
| GB9218334D0 (en) * | 1992-08-28 | 1992-10-14 | Ici Plc | Heterocyclic compounds |
| IL107184A (en) * | 1992-10-09 | 1997-08-14 | Abbott Lab | Heterocyclic ether compounds that enhance cognitive function |
| DE4236331A1 (de) * | 1992-10-28 | 1994-05-05 | Boehringer Ingelheim Kg | Synergistische Kombination |
| GB9226573D0 (en) * | 1992-12-21 | 1993-02-17 | Ici Plc | Heterocyclic compounds |
| IL109451A0 (en) * | 1993-04-29 | 1994-07-31 | Zeneca Ltd | Heterocyclic derivatives |
| US5998404A (en) | 1994-10-24 | 1999-12-07 | Eli Lilly And Company | Heterocyclic compounds and their use |
| US5512574A (en) * | 1994-12-21 | 1996-04-30 | American Home Products Corporation | Quinuclidine and azabicyclo 2.2.1! heptane pyrazinyl ethers as muscarinic agonists |
| EP0809494A1 (en) * | 1995-02-17 | 1997-12-03 | Novo Nordisk A/S | The use of heterocyclic compounds |
| US6040442A (en) * | 1995-06-01 | 2000-03-21 | Eli Lilly And Company | Process for preparing 1,2,5-thiadiazole containing ethers |
| CA2239301A1 (en) * | 1995-12-06 | 1997-06-12 | Charles Howard Mitch | Composition for treating pain |
| AU2738397A (en) * | 1996-04-23 | 1997-11-12 | Eli Lilly And Company | Heterocyclic compounds |
| EP1905771A3 (en) * | 2002-08-14 | 2008-11-26 | NeuroSearch A/S | Quinuclidine derivatives and their use |
| GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
| EP1656375B1 (en) | 2003-08-13 | 2011-01-19 | NeuroSearch A/S | Novel quinuclidine derivatives and their pharmaceutical use |
| US7160876B2 (en) | 2003-12-22 | 2007-01-09 | Abbott Laboratories | Fused bicycloheterocycle substituted quinuclidine derivatives |
| US7655657B2 (en) | 2003-12-22 | 2010-02-02 | Abbott Laboratories | Fused bicycloheterocycle substituted quinuclidine derivatives |
| US20050137203A1 (en) * | 2003-12-22 | 2005-06-23 | Jianguo Ji | 3-quinuclidinyl amino-substituted biaryl derivatives |
| AR049401A1 (es) * | 2004-06-18 | 2006-07-26 | Novartis Ag | Aza-biciclononanos |
| GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
| JP2008523058A (ja) * | 2004-12-10 | 2008-07-03 | アボット・ラボラトリーズ | 縮合ビシクロ複素環置換キヌクリジン誘導体 |
| GB0521508D0 (en) | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
| GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| TWI775313B (zh) | 2020-02-18 | 2022-08-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TWI883391B (zh) | 2020-02-18 | 2025-05-11 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| US12030903B2 (en) | 2020-02-18 | 2024-07-09 | Gilead Sciences, Inc. | Antiviral compounds |
| JP7688152B2 (ja) | 2021-04-16 | 2025-06-03 | ギリアード サイエンシーズ， インコーポレイテッド | アミドを使用してカルバヌクレオシドを調製する方法 |
| WO2023023527A1 (en) | 2021-08-18 | 2023-02-23 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7469487A (en) * | 1986-06-27 | 1988-01-07 | Beecham Group Plc | Substituted 1-azabicycloheptane to decane derivatives |
| AU1455788A (en) * | 1987-04-15 | 1988-10-27 | Beecham Group Plc | 1-azabicyclic compounds |
| AU4540389A (en) * | 1988-11-22 | 1990-05-31 | Boehringer Ingelheim International Gmbh | Quinuclidines, their use as medicaments and processes for their preparation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE321933B (cs) * | 1967-10-05 | 1970-03-23 | Astra Ab | |
| FR2014831A1 (en) * | 1968-08-01 | 1970-04-24 | Sogeras | Quinuclidinyl and quinuclidinylalkyl ethers with cholino - lytic, antihistaminic and neurosedative activity |
| CA1307790C (en) * | 1987-08-04 | 1992-09-22 | Ian Anthony Cliffe | Ethers |
| GB8718445D0 (en) * | 1987-08-04 | 1987-09-09 | Wyeth John & Brother Ltd | Pyridyl-ethers |
-
1991
- 1991-05-15 YU YU84791A patent/YU84791A/sh unknown
- 1991-05-16 CZ CS911448A patent/CZ281837B6/cs not_active IP Right Cessation
- 1991-05-16 SK SK1448-91A patent/SK279168B6/sk unknown
- 1991-05-16 NO NO91911934A patent/NO911934L/no unknown
- 1991-05-17 IE IE168891A patent/IE911688A1/en unknown
- 1991-05-17 FI FI912409A patent/FI912409A7/fi not_active Application Discontinuation
- 1991-05-17 IL IL98176A patent/IL98176A0/xx unknown
- 1991-05-17 PT PT97703A patent/PT97703A/pt not_active Application Discontinuation
- 1991-05-17 HU HU911663A patent/HUT58091A/hu unknown
- 1991-05-17 EP EP91108054A patent/EP0458214A1/de not_active Ceased
- 1991-05-17 JP JP3113418A patent/JP2853837B2/ja not_active Expired - Lifetime
- 1991-05-17 CA CA002042860A patent/CA2042860A1/en not_active Abandoned
- 1991-05-18 KR KR1019910008106A patent/KR910020009A/ko not_active Withdrawn
- 1991-05-20 AU AU77130/91A patent/AU648789B2/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7469487A (en) * | 1986-06-27 | 1988-01-07 | Beecham Group Plc | Substituted 1-azabicycloheptane to decane derivatives |
| AU1455788A (en) * | 1987-04-15 | 1988-10-27 | Beecham Group Plc | 1-azabicyclic compounds |
| AU4540389A (en) * | 1988-11-22 | 1990-05-31 | Boehringer Ingelheim International Gmbh | Quinuclidines, their use as medicaments and processes for their preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH04226981A (ja) | 1992-08-17 |
| NO911934D0 (no) | 1991-05-16 |
| NO911934L (no) | 1991-11-20 |
| YU84791A (sh) | 1994-06-10 |
| KR910020009A (ko) | 1991-12-19 |
| FI912409L (fi) | 1991-11-20 |
| IE911688A1 (en) | 1991-11-20 |
| HUT58091A (en) | 1992-01-28 |
| FI912409A0 (fi) | 1991-05-17 |
| PT97703A (pt) | 1992-02-28 |
| CZ281837B6 (cs) | 1997-02-12 |
| HU911663D0 (en) | 1991-11-28 |
| IL98176A0 (en) | 1992-06-21 |
| FI912409A7 (fi) | 1991-11-20 |
| CS144891A3 (en) | 1992-05-13 |
| SK279168B6 (sk) | 1998-07-08 |
| JP2853837B2 (ja) | 1999-02-03 |
| CA2042860A1 (en) | 1991-11-20 |
| EP0458214A1 (de) | 1991-11-27 |
| AU7713091A (en) | 1991-11-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |