AU618756B2 - Inductive collagen-based bone repair preparations - Google Patents

Inductive collagen-based bone repair preparations Download PDF

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Publication number
AU618756B2
AU618756B2 AU22751/88A AU2275188A AU618756B2 AU 618756 B2 AU618756 B2 AU 618756B2 AU 22751/88 A AU22751/88 A AU 22751/88A AU 2275188 A AU2275188 A AU 2275188A AU 618756 B2 AU618756 B2 AU 618756B2
Authority
AU
Australia
Prior art keywords
collagen
composition
mineral
suspension
drying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU22751/88A
Other languages
English (en)
Other versions
AU2275188A (en
Inventor
George Chu
Ranga Nathan
Saeid Seyedin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Collagen Aesthetics Inc
Original Assignee
Collagen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Collagen Corp filed Critical Collagen Corp
Publication of AU2275188A publication Critical patent/AU2275188A/en
Application granted granted Critical
Publication of AU618756B2 publication Critical patent/AU618756B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/365—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/92—Method or apparatus for preparing or treating prosthetic
    • Y10S623/923—Bone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU22751/88A 1987-09-25 1988-09-23 Inductive collagen-based bone repair preparations Ceased AU618756B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US100990 1987-09-25
US07/100,990 US4888366A (en) 1984-10-24 1987-09-25 Inductive collagen-based bone repair preparations

Publications (2)

Publication Number Publication Date
AU2275188A AU2275188A (en) 1989-04-06
AU618756B2 true AU618756B2 (en) 1992-01-09

Family

ID=22282569

Family Applications (1)

Application Number Title Priority Date Filing Date
AU22751/88A Ceased AU618756B2 (en) 1987-09-25 1988-09-23 Inductive collagen-based bone repair preparations

Country Status (8)

Country Link
US (1) US4888366A (de)
EP (1) EP0309241B1 (de)
JP (1) JPH01158964A (de)
AT (1) ATE98879T1 (de)
AU (1) AU618756B2 (de)
CA (1) CA1335177C (de)
DE (1) DE3886493T2 (de)
ES (1) ES2060656T3 (de)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5246457A (en) * 1985-03-28 1993-09-21 Collagen Corporation Xenogeneic collagen/mineral preparations in bone repair
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US6919308B2 (en) 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US5162114A (en) * 1989-02-23 1992-11-10 Stryker Corporation Bone collagen matrix for xenogenic implants
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5447966A (en) * 1988-07-19 1995-09-05 United States Surgical Corporation Treating bioabsorbable surgical articles by coating with glycerine, polalkyleneoxide block copolymer and gelatin
US5573771A (en) * 1988-08-19 1996-11-12 Osteomedical Limited Medicinal bone mineral products
US5108436A (en) * 1988-09-29 1992-04-28 Collagen Corporation Implant fixation
US5258029A (en) * 1988-09-29 1993-11-02 Collagen Corporation Method for improving implant fixation
US5207710A (en) * 1988-09-29 1993-05-04 Collagen Corporation Method for improving implant fixation
US5264214A (en) * 1988-11-21 1993-11-23 Collagen Corporation Composition for bone repair
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5819748A (en) * 1988-11-30 1998-10-13 Ed Geistlich Sohne Ag Fur Chemische Industrie Implant for use in bone surgery
WO1991001720A1 (en) * 1989-08-07 1991-02-21 Herman Wade Schlameus Composition and method of promoting hard tissue healing
DK0448704T3 (da) * 1989-10-17 1999-04-06 Stryker Corp Osteogene anordninger
US5236456A (en) * 1989-11-09 1993-08-17 Osteotech, Inc. Osteogenic composition and implant containing same
US5425769A (en) * 1990-04-23 1995-06-20 Snyders, Jr.; Robert V. Composition of material for osseous repair
US5645591A (en) 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
CA2363965C (en) * 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
NZ241979A (en) * 1991-03-20 1996-01-26 Merck & Co Inc Treatment of benign prostatic hyperplasia using 5alpha-reductase inhibitor and an alpha1-adrenergic recepter blocker
US5290763A (en) * 1991-04-22 1994-03-01 Intermedics Orthopedics/Denver, Inc. Osteoinductive protein mixtures and purification processes
US5563124A (en) * 1991-04-22 1996-10-08 Intermedics Orthopedics/ Denver, Inc. Osteogenic product and process
US5693615A (en) * 1991-06-05 1997-12-02 The Procter & Gamble Company Therapeutic compositions for osteoinduction
US5356629A (en) * 1991-07-12 1994-10-18 United States Surgical Corporation Composition for effecting bone repair
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5320844A (en) * 1992-03-12 1994-06-14 Liu Sung Tsuen Composite materials for hard tissue replacement
US5531791A (en) * 1993-07-23 1996-07-02 Bioscience Consultants Composition for repair of defects in osseous tissues, method of making, and prosthesis
DE4425776C2 (de) * 1994-07-13 2002-08-29 Britta Hofmann Verfahren zur Herstellung eines verbesserten Kollagentransplantats mit aufgelockerter Struktur
US5782919A (en) * 1995-03-27 1998-07-21 Sdgi Holdings, Inc. Interbody fusion device and method for restoration of normal spinal anatomy
US5674292A (en) 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
US6902584B2 (en) 1995-10-16 2005-06-07 Depuy Spine, Inc. Bone grafting matrix
US5776193A (en) 1995-10-16 1998-07-07 Orquest, Inc. Bone grafting matrix
US6083522A (en) * 1997-01-09 2000-07-04 Neucoll, Inc. Devices for tissue repair and methods for preparation and use thereof
US6679918B1 (en) 1997-02-13 2004-01-20 Centerpulse Biologics Inc. Implantable putty material
US20030032586A1 (en) * 1997-05-15 2003-02-13 David C. Rueger Compositions for morphogen-induced osteogenesis
US5972368A (en) * 1997-06-11 1999-10-26 Sdgi Holdings, Inc. Bone graft composites and spacers
DE69714035T2 (de) 1997-08-14 2003-03-06 Sulzer Innotec Ag, Winterthur Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren
US20040081704A1 (en) * 1998-02-13 2004-04-29 Centerpulse Biologics Inc. Implantable putty material
US6383519B1 (en) * 1999-01-26 2002-05-07 Vita Special Purpose Corporation Inorganic shaped bodies and methods for their production and use
AU770196B2 (en) * 1999-02-04 2004-02-12 Warsaw Orthopedic, Inc. Osteogenic paste compositions and uses thereof
DE60006356T2 (de) * 1999-02-04 2004-09-09 SDGI Holding, Inc., Wilmington Hochmineralisierte osteogene schwammzusammensetzungen und ihre verwendung
US6458162B1 (en) * 1999-08-13 2002-10-01 Vita Special Purpose Corporation Composite shaped bodies and methods for their production and use
US20030228288A1 (en) 1999-10-15 2003-12-11 Scarborough Nelson L. Volume maintaining osteoinductive/osteoconductive compositions
US9387094B2 (en) 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
US7323193B2 (en) 2001-12-14 2008-01-29 Osteotech, Inc. Method of making demineralized bone particles
US20020114795A1 (en) * 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US20020115742A1 (en) * 2001-02-22 2002-08-22 Trieu Hai H. Bioactive nanocomposites and methods for their use
KR20040047746A (ko) 2001-10-12 2004-06-05 오스테오테크, 인코포레이티드 향상된 골 이식물
US6752938B2 (en) * 2001-10-13 2004-06-22 Invigor Biotechnology Co., Ltd. Method of preparing microsphere composite of collagen and bioceramic powder
TW200400062A (en) 2002-04-03 2004-01-01 Mathys Medizinaltechnik Ag Kneadable, pliable bone replacement material
US7166133B2 (en) * 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
AU2004247143B2 (en) 2003-06-11 2010-09-23 Warsaw Orthopedic, Inc. Osteoimplants and methods for their manufacture
US8734525B2 (en) 2003-12-31 2014-05-27 Warsaw Orthopedic, Inc. Osteoinductive demineralized cancellous bone
US8328876B2 (en) 2003-12-31 2012-12-11 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
US7189263B2 (en) 2004-02-03 2007-03-13 Vita Special Purpose Corporation Biocompatible bone graft material
KR100974733B1 (ko) 2004-04-28 2010-08-06 안지오디바이스 인터내셔널 게엠베하 가교된 생합성물질을 형성하기 위한 조성물 및 시스템, 및이와 관련된 제조 및 사용 방법
US7348802B2 (en) * 2004-06-15 2008-03-25 Stmicroelectronics Pvt. Ltd. Differential receiver
US9220595B2 (en) 2004-06-23 2015-12-29 Orthovita, Inc. Shapeable bone graft substitute and instruments for delivery thereof
US7722895B1 (en) 2004-09-20 2010-05-25 Warsaw Orthopedic, Inc. Osteogenic implants with combined implant materials, and materials and methods for same
DE102005016443A1 (de) * 2004-11-23 2006-05-24 Ossacur Ag Bioresorbierbares und mineralisiertes Material zur Füllung von Knochendefekten
US7857853B2 (en) * 2005-04-29 2010-12-28 Sdgi Holdings, Inc Synthetic loadbearing collagen-mineral composites useful for spinal implants, and methods of manufacture
US8506646B2 (en) * 2005-04-29 2013-08-13 Warsaw Orthopedic, Inc. Multi-purpose medical implant devices
ES2393756T3 (es) * 2005-11-01 2012-12-27 Warsaw Orthopedic, Inc. Métodos para producir composiciones de matriz ósea
WO2007056671A1 (en) 2005-11-02 2007-05-18 Osteotech, Inc. Hemostatic bone graft
AU2007265379B9 (en) 2006-06-29 2014-05-29 Orthovita, Inc. Bioactive bone graft substitute
US20080177330A1 (en) * 2006-10-24 2008-07-24 Ralph James D Self-locking screws for medical implants
US7544212B2 (en) * 2006-12-08 2009-06-09 Collagen Matrix, Inc. Bone implant composite
US7381224B1 (en) * 2006-12-08 2008-06-03 Collagen Matrix, Inc. Bone implant composite
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
WO2008157495A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Bone matrix compositions and methods
WO2008157497A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Method of treating tissue
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
WO2009009684A1 (en) 2007-07-10 2009-01-15 Osteotech, Inc. Delivery system
WO2009052492A2 (en) 2007-10-19 2009-04-23 Osteotech, Inc. Demineralized bone matrix compositions and methods
US9149563B2 (en) * 2007-11-06 2015-10-06 The University Of Connecticut Calcium phosphate/structural protein composites and method of preparation thereof
CA2704652A1 (en) * 2007-11-06 2009-05-14 Mei Wei Ceramic/structural protein composites and method of preparation thereof
US20090131886A1 (en) 2007-11-16 2009-05-21 Liu Y King Steerable vertebroplasty system
US20090131867A1 (en) 2007-11-16 2009-05-21 Liu Y King Steerable vertebroplasty system with cavity creation element
US9510885B2 (en) 2007-11-16 2016-12-06 Osseon Llc Steerable and curvable cavity creation system
KR20110086045A (ko) 2008-10-24 2011-07-27 오스테오테크, 인코포레이티드 뼈 형성 촉진용 조성물 및 뼈 형성 촉진방법
WO2010093955A1 (en) 2009-02-12 2010-08-19 Osteotech,Inc. Segmented delivery system
US20100226959A1 (en) * 2009-03-04 2010-09-09 Warsaw Orthopedic, Inc. Matrix that prolongs growth factor release
US20100298832A1 (en) 2009-05-20 2010-11-25 Osseon Therapeutics, Inc. Steerable curvable vertebroplasty drill
US9125671B2 (en) 2010-04-29 2015-09-08 Dfine, Inc. System for use in treatment of vertebral fractures
AU2011329054B2 (en) 2010-11-15 2015-05-28 Zimmer Orthobiologics, Inc. Bone void fillers
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
EP2529764A1 (de) 2011-05-31 2012-12-05 Curasan AG Biologisch degradierbares kompositmaterial
US9078832B2 (en) 2012-03-22 2015-07-14 The University Of Connecticut Biomimetic scaffold for bone regeneration
US20130345826A1 (en) 2012-06-22 2013-12-26 Collagen Matrix, Inc. Implants for Bone and Cartilage Repair
US9539363B2 (en) 2014-04-24 2017-01-10 Warsaw Orthopedic, Inc. Collagen matrix
JP5900692B1 (ja) * 2015-09-08 2016-04-06 東洋紡株式会社 多孔質複合体および骨再生材料
EP3348286A4 (de) 2015-09-08 2018-08-22 Toyobo Co., Ltd. Poröser komplex und knochenregenerationsmaterial
JP5900691B1 (ja) * 2015-09-08 2016-04-06 東洋紡株式会社 多孔質複合体および骨再生材料
US10478241B2 (en) 2016-10-27 2019-11-19 Merit Medical Systems, Inc. Articulating osteotome with cement delivery channel
CA3041114A1 (en) 2016-11-28 2018-05-31 Dfine, Inc. Tumor ablation devices and related methods
WO2018107036A1 (en) 2016-12-09 2018-06-14 Dfine, Inc. Medical devices for treating hard tissues and related methods
EP3565486B1 (de) 2017-01-06 2021-11-10 Dfine, Inc. Osteotom mit distalem abschnitt zum gleichzeitigen vorschieben und artikulieren
US11510723B2 (en) 2018-11-08 2022-11-29 Dfine, Inc. Tumor ablation device and related systems and methods
EP4031040A4 (de) 2019-09-18 2023-11-15 Merit Medical Systems, Inc. Osteotom mit aufblasbarem teil und mehrdrahtgelenk
US11883302B2 (en) 2021-11-22 2024-01-30 Warsaw Orthopedic, Inc. Spinal implant having a compressible insert

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294753A (en) * 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process
US4394370A (en) * 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
US4434094A (en) * 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US717072A (en) 1901-05-08 1902-12-30 John Burry Magnetotherapeutic apparatus.
US816268A (en) 1905-03-30 1906-03-27 Otto W Steindorf Tripod for cameras.
US848443A (en) 1906-07-12 1907-03-26 Frederick Conrath Lamp-jack.
US4097935A (en) 1976-07-21 1978-07-04 Sterling Drug Inc. Hydroxylapatite ceramic
US4455256A (en) 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4314380A (en) 1980-09-26 1982-02-09 Koken Co., Ltd. Artificial bone
US4430760A (en) 1981-12-18 1984-02-14 Collagen Corporation Nonstress-bearing implantable bone prosthesis
US4440750A (en) * 1982-02-12 1984-04-03 Collagen Corporation Osteogenic composition and method
US4485097A (en) 1982-05-26 1984-11-27 Massachusetts Institute Of Technology Bone-equivalent and method for preparation thereof
JPS60126217A (ja) * 1983-12-14 1985-07-05 Sumitomo Chem Co Ltd 長期徐放性製剤
US4596574A (en) * 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
JPS60253455A (ja) * 1984-05-28 1985-12-14 京セラ株式会社 骨形成因子を含有する生体材料とその製造方法
US4627982A (en) 1984-07-16 1986-12-09 Collagen Corporation Partially purified bone-inducing factor
US4563350A (en) 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
CA1260391A (en) * 1985-03-28 1989-09-26 Karl A. Piez Xenogeneic collagen/mineral preparations in bone repair
JPH0662679B2 (ja) * 1985-06-21 1994-08-17 新田ゼラチン株式会社 組織親和性コラ−ゲンとその製法
JPH0759522B2 (ja) * 1985-12-27 1995-06-28 住友製薬株式会社 徐放性製剤の製造法
CA1294876C (en) * 1986-04-22 1992-01-28 Karl A. Piez Marrow/collagen/mineral matrix for bone defect repair
US4865602A (en) * 1986-11-06 1989-09-12 Collagen Corporation Gamma irradiation of collagen/mineral mixtures

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294753A (en) * 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process
US4394370A (en) * 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
US4434094A (en) * 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone

Also Published As

Publication number Publication date
DE3886493D1 (de) 1994-02-03
EP0309241B1 (de) 1993-12-22
ES2060656T3 (es) 1994-12-01
EP0309241A2 (de) 1989-03-29
CA1335177C (en) 1995-04-11
AU2275188A (en) 1989-04-06
ATE98879T1 (de) 1994-01-15
JPH0553139B2 (de) 1993-08-09
US4888366A (en) 1989-12-19
EP0309241A3 (en) 1989-09-06
JPH01158964A (ja) 1989-06-22
DE3886493T2 (de) 1994-04-14

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