AU607434B2 - Ethanal fill formulation of softgels containing vitamins dietary supplements and the like - Google Patents
Ethanal fill formulation of softgels containing vitamins dietary supplements and the like Download PDFInfo
- Publication number
- AU607434B2 AU607434B2 AU77655/87A AU7765587A AU607434B2 AU 607434 B2 AU607434 B2 AU 607434B2 AU 77655/87 A AU77655/87 A AU 77655/87A AU 7765587 A AU7765587 A AU 7765587A AU 607434 B2 AU607434 B2 AU 607434B2
- Authority
- AU
- Australia
- Prior art keywords
- weight
- ethanol
- fatty acids
- capsule
- partial glycerides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 235000015872 dietary supplement Nutrition 0.000 title claims description 5
- 239000000203 mixture Substances 0.000 title abstract description 18
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 title description 4
- 239000011782 vitamin Substances 0.000 title description 4
- 229940088594 vitamin Drugs 0.000 title description 4
- 229930003231 vitamin Natural products 0.000 title description 4
- 235000013343 vitamin Nutrition 0.000 title description 4
- 238000009472 formulation Methods 0.000 title description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 80
- 239000002775 capsule Substances 0.000 claims abstract description 43
- 239000007903 gelatin capsule Substances 0.000 claims abstract description 30
- 125000005456 glyceride group Chemical group 0.000 claims abstract description 22
- 239000013543 active substance Substances 0.000 claims abstract description 20
- 108010010803 Gelatin Proteins 0.000 claims abstract description 19
- 239000008273 gelatin Substances 0.000 claims abstract description 19
- 229920000159 gelatin Polymers 0.000 claims abstract description 19
- 235000019322 gelatine Nutrition 0.000 claims abstract description 19
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 19
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 17
- 229930195729 fatty acid Natural products 0.000 claims abstract description 17
- 239000000194 fatty acid Substances 0.000 claims abstract description 17
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 17
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 8
- 235000005911 diet Nutrition 0.000 claims abstract description 5
- 230000000378 dietary effect Effects 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 14
- 239000002904 solvent Substances 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 2
- WBHHMMIMDMUBKC-QJWNTBNXSA-M ricinoleate Chemical compound CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O WBHHMMIMDMUBKC-QJWNTBNXSA-M 0.000 claims 2
- 229940066675 ricinoleate Drugs 0.000 claims 2
- 239000011877 solvent mixture Substances 0.000 abstract description 10
- 239000004014 plasticizer Substances 0.000 abstract description 4
- 239000003795 chemical substances by application Substances 0.000 abstract description 3
- 239000004480 active ingredient Substances 0.000 abstract description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 32
- 235000011187 glycerol Nutrition 0.000 description 11
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 description 9
- 229920001223 polyethylene glycol Polymers 0.000 description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 5
- 239000007788 liquid Substances 0.000 description 4
- CWRVKFFCRWGWCS-UHFFFAOYSA-N Pentrazole Chemical compound C1CCCCC2=NN=NN21 CWRVKFFCRWGWCS-UHFFFAOYSA-N 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- -1 ethoxyl groups Chemical group 0.000 description 3
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 3
- 229960002695 phenobarbital Drugs 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 239000011149 active material Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 229940057917 medium chain triglycerides Drugs 0.000 description 2
- 229960005152 pentetrazol Drugs 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- WBHHMMIMDMUBKC-XLNAKTSKSA-N ricinelaidic acid Chemical compound CCCCCC[C@@H](O)C\C=C\CCCCCCCC(O)=O WBHHMMIMDMUBKC-XLNAKTSKSA-N 0.000 description 2
- 229960003656 ricinoleic acid Drugs 0.000 description 2
- FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
- 108010036949 Cyclosporine Proteins 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical class OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- HDIFHQMREAYYJW-XGXNLDPDSA-N Glyceryl Ricinoleate Chemical compound CCCCCC[C@@H](O)C\C=C/CCCCCCCC(=O)OCC(O)CO HDIFHQMREAYYJW-XGXNLDPDSA-N 0.000 description 1
- 241000238367 Mya arenaria Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
- 229960001265 ciclosporin Drugs 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000009918 complex formation Effects 0.000 description 1
- 229930182912 cyclosporin Natural products 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 150000005527 organic iodine compounds Chemical class 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- VJZLQIPZNBPASX-OJJGEMKLSA-L prednisolone sodium phosphate Chemical compound [Na+].[Na+].O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)COP([O-])([O-])=O)[C@@H]4[C@@H]3CCC2=C1 VJZLQIPZNBPASX-OJJGEMKLSA-L 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000009192 sprinting Effects 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- General Preparation And Processing Of Foods (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3629386 | 1986-08-29 | ||
| DE19863629386 DE3629386A1 (de) | 1986-08-29 | 1986-08-29 | Gelatinekapseln und verfahren zu ihrer herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU7765587A AU7765587A (en) | 1988-03-03 |
| AU607434B2 true AU607434B2 (en) | 1991-03-07 |
Family
ID=6308451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU77655/87A Expired AU607434B2 (en) | 1986-08-29 | 1987-08-28 | Ethanal fill formulation of softgels containing vitamins dietary supplements and the like |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4888239A (OSRAM) |
| EP (1) | EP0257386B1 (OSRAM) |
| JP (1) | JPH0830006B2 (OSRAM) |
| KR (1) | KR930008955B1 (OSRAM) |
| AT (1) | ATE68967T1 (OSRAM) |
| AU (1) | AU607434B2 (OSRAM) |
| CA (1) | CA1296628C (OSRAM) |
| DE (2) | DE3629386A1 (OSRAM) |
| ES (1) | ES2025601T3 (OSRAM) |
| GR (1) | GR3003036T3 (OSRAM) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0148748B1 (ko) * | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
| US6007840A (en) * | 1988-09-16 | 1999-12-28 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
| GB8904182D0 (en) * | 1989-02-23 | 1989-04-05 | Glaxo Canada | Pharmaceutical compositions |
| DE4025912A1 (de) * | 1990-08-16 | 1992-02-20 | Werner Ratjen | Mittel zur oralen einnahme |
| US5141961A (en) * | 1991-06-27 | 1992-08-25 | Richrdson-Vicks Inc. | Process for solubilizing difficulty soluble pharmaceutical actives |
| US6262022B1 (en) | 1992-06-25 | 2001-07-17 | Novartis Ag | Pharmaceutical compositions containing cyclosporin as the active agent |
| JP3121080B2 (ja) * | 1991-12-19 | 2000-12-25 | アール・ピー・シーラー コーポレイション | カプセル封入用溶液 |
| EP0642332B1 (en) | 1992-05-13 | 1997-01-15 | Sandoz Ltd. | Ophthalmic compositions containing a cyclosporin |
| ES2168271T3 (es) | 1992-09-25 | 2002-06-16 | Novartis Ag | Composiciones farmaceuticas que contienen ciclosporinas. |
| US5376688A (en) * | 1992-12-18 | 1994-12-27 | R. P. Scherer Corporation | Enhanced solubility pharmaceutical solutions |
| US5431916A (en) * | 1993-04-29 | 1995-07-11 | The Procter & Gamble Company | Pharmaceutical compositions and process of manufacture thereof |
| US20020099067A1 (en) * | 1993-07-08 | 2002-07-25 | Ulrich Posanski | Pharmaceutical compositions for sparingly soluble therapeutic agents |
| EP0649651B1 (en) | 1993-09-28 | 2000-12-13 | R.P. Scherer GmbH | Soft gelatin capsule manufacture |
| US5484606A (en) * | 1994-01-24 | 1996-01-16 | The Procter & Gamble Company | Process for reducing the precipitation of difficulty soluble pharmaceutical actives |
| EP0789580B1 (de) | 1994-11-03 | 2002-06-05 | Novartis AG | Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung |
| DE19544507B4 (de) | 1995-11-29 | 2007-11-15 | Novartis Ag | Cyclosporin enthaltende Präparate |
| US5858401A (en) | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
| KR20000069900A (ko) * | 1997-01-30 | 2000-11-25 | 한스 루돌프 하우스, 헨리테 브룬너, 베아트리체 귄터 | 오일을 함유하지 않은 사이클로스포린 ａ 함유 제약 조성물 |
| SI0999826T1 (en) * | 1997-07-29 | 2004-12-31 | Pharmacia & Upjohn Company | Self-emulsifying formulation for lipophilic compounds |
| DE69804624T2 (de) * | 1997-07-29 | 2002-09-19 | PHARMACIA & UPJOHN CO., KALAMAZOO | Selbstemulgierende formulierung enthaltend lipophile verbindungen |
| US6063401A (en) * | 1998-05-06 | 2000-05-16 | M.E. Cody Products, Inc. | Plantago major and hypericum perforatum compound for use in treating a tobacco or nicotine habit |
| US6045825A (en) | 1998-06-17 | 2000-04-04 | M. E. Cody Products, Inc. | Plantago major and Piper methysticum compound for use in treating a tobacco or nicotine habit |
| US6346231B1 (en) * | 1999-10-06 | 2002-02-12 | Joar Opheim | Flavored gelatin capsule and method of manufacture |
| US20030124225A1 (en) * | 1999-11-01 | 2003-07-03 | Paul West | Encapsulated alcoholic beverage |
| US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| KR100393920B1 (ko) * | 2000-11-28 | 2003-08-06 | 주식회사 서흥캅셀 | 정전기 발생을 억제하고 피막의 윤활성을 증대시킨 젤라틴경질 캅셀 |
| ITMI20011401A1 (it) * | 2001-07-02 | 2003-01-02 | Altergon Sa | Formulazioni farmaceutiche per ormoni tiroidei |
| JP4156234B2 (ja) * | 2001-12-27 | 2008-09-24 | 日本メナード化粧品株式会社 | 軟カプセル |
| ATE387191T1 (de) * | 2002-04-25 | 2008-03-15 | Banner Pharmacaps Inc | Kaubare weichkapsel |
| EP1885342B8 (en) * | 2005-03-21 | 2016-06-22 | Teva Czech Industries s.r.o. | Crystallization inhibitor and its use in gelatin capsules |
| US20150118365A1 (en) * | 2013-10-31 | 2015-04-30 | Steven J. Hollenkamp | Alcohol containing beads and method for making same |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4062799A (en) * | 1973-01-30 | 1977-12-13 | Fuji Photo Film Co., Ltd. | Method of forming microcapsule films having low porosity |
| US4029758A (en) * | 1975-12-15 | 1977-06-14 | Hoffmann-La Roche Inc. | Preparation of pharmaceutical unit dosage forms |
| BE861612A (fr) * | 1977-12-07 | 1978-06-07 | Kali Chemie Pharma Gmbh | Preparations fortement resorbables par voie enterale de medicaments peu resorbables de nature et procede pour la preparation de celles-ci |
| US4627850A (en) * | 1983-11-02 | 1986-12-09 | Alza Corporation | Osmotic capsule |
| US4717566A (en) * | 1984-03-19 | 1988-01-05 | Alza Corporation | Dosage system and method of using same |
| NZ211078A (en) * | 1984-03-19 | 1987-08-31 | Bristol Myers Co | Oral dosage form of etoposide |
| DE3500103C2 (de) * | 1985-01-04 | 1987-01-22 | R.P. Scherer GmbH, 6930 Eberbach | Pharmazeutische Zubereitung mit einem in Wasser und Verdauungssäften schwer löslichen Wirkstoff |
| US4717568A (en) * | 1985-08-09 | 1988-01-05 | Alza Corporation | Laminar arrangement for increasing delivery of beneficial agent from dispenser |
-
1986
- 1986-08-29 DE DE19863629386 patent/DE3629386A1/de active Granted
-
1987
- 1987-08-05 ES ES198787111310T patent/ES2025601T3/es not_active Expired - Lifetime
- 1987-08-05 EP EP87111310A patent/EP0257386B1/de not_active Expired - Lifetime
- 1987-08-05 DE DE8787111310T patent/DE3774210D1/de not_active Expired - Lifetime
- 1987-08-05 AT AT87111310T patent/ATE68967T1/de not_active IP Right Cessation
- 1987-08-25 US US07/089,065 patent/US4888239A/en not_active Expired - Lifetime
- 1987-08-28 AU AU77655/87A patent/AU607434B2/en not_active Expired
- 1987-08-28 CA CA000545611A patent/CA1296628C/en not_active Expired - Lifetime
- 1987-08-29 JP JP62216277A patent/JPH0830006B2/ja not_active Expired - Lifetime
- 1987-08-29 KR KR1019870009524A patent/KR930008955B1/ko not_active Expired - Lifetime
-
1991
- 1991-10-31 GR GR91401480T patent/GR3003036T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU7765587A (en) | 1988-03-03 |
| JPH0830006B2 (ja) | 1996-03-27 |
| CA1296628C (en) | 1992-03-03 |
| US4888239A (en) | 1989-12-19 |
| ATE68967T1 (de) | 1991-11-15 |
| EP0257386A2 (de) | 1988-03-02 |
| GR3003036T3 (en) | 1993-02-17 |
| EP0257386A3 (en) | 1989-05-03 |
| JPS63132826A (ja) | 1988-06-04 |
| DE3629386A1 (de) | 1988-03-03 |
| EP0257386B1 (de) | 1991-10-30 |
| DE3774210D1 (de) | 1991-12-05 |
| KR880002512A (ko) | 1988-05-09 |
| KR930008955B1 (ko) | 1993-09-17 |
| ES2025601T3 (es) | 1992-04-01 |
| DE3629386C2 (OSRAM) | 1988-06-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU607434B2 (en) | Ethanal fill formulation of softgels containing vitamins dietary supplements and the like | |
| US4727109A (en) | Pharmaceutical preparation with an active substance of low solubility in water and gastric juices | |
| FI111130B (fi) | Menetelmä syklosporiinijohdannaista sisältävän farmaseuttisen koostumuksen valmistamiseksi | |
| KR100386533B1 (ko) | 난용성활성제용약학적조성물 | |
| US4869900A (en) | Pharamaceutical composition containing ubidecarenone | |
| JPS63500597A (ja) | ゼラチンカプセル及びその製造法 | |
| US5028432A (en) | Pharmaceutical capsules containing panetidine | |
| JP2006206615A (ja) | 経口投与用シクロスポリン含有新規製剤 | |
| US4397835A (en) | Enterosoluble hard-capsulated medicaments | |
| HU210565B (en) | Process for production of enhanced bioavailability pharmaceutical coposition containing probucol | |
| US20230310328A1 (en) | Softgel capsules having a fill composition comprising magnesium oxide | |
| EP0431659B1 (en) | Pharmaceutical compositions of tebufelone | |
| JPH07267875A (ja) | オーレオバシジン類の高濃度溶液製剤 | |
| JPS6062960A (ja) | ビタミンａ及びｅを含有するゼラチン軟カプセル | |
| HK1034444A (en) | Cyclosporin-containing microemulsion preconcentrate composition |