AU605036B2 - Expression of hepatitis B2 pres protein in methylothrophic yeasts - Google Patents

Expression of hepatitis B2 pres protein in methylothrophic yeasts Download PDF

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Publication number
AU605036B2
AU605036B2 AU33282/89A AU3328289A AU605036B2 AU 605036 B2 AU605036 B2 AU 605036B2 AU 33282/89 A AU33282/89 A AU 33282/89A AU 3328289 A AU3328289 A AU 3328289A AU 605036 B2 AU605036 B2 AU 605036B2
Authority
AU
Australia
Prior art keywords
gene
pichia pastoris
isolated
pres
vector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU33282/89A
Other languages
English (en)
Other versions
AU3328289A (en
Inventor
Gregory Patrick Thill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phillips Petroleum Co
Original Assignee
Phillips Petroleum Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phillips Petroleum Co filed Critical Phillips Petroleum Co
Publication of AU3328289A publication Critical patent/AU3328289A/en
Application granted granted Critical
Publication of AU605036B2 publication Critical patent/AU605036B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
AU33282/89A 1988-04-25 1989-04-21 Expression of hepatitis B2 pres protein in methylothrophic yeasts Ceased AU605036B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18642188A 1988-04-25 1988-04-25
US186421 1988-04-25

Publications (2)

Publication Number Publication Date
AU3328289A AU3328289A (en) 1989-11-02
AU605036B2 true AU605036B2 (en) 1991-01-03

Family

ID=22684891

Family Applications (1)

Application Number Title Priority Date Filing Date
AU33282/89A Ceased AU605036B2 (en) 1988-04-25 1989-04-21 Expression of hepatitis B2 pres protein in methylothrophic yeasts

Country Status (17)

Country Link
EP (1) EP0339567A1 (enEXAMPLES)
JP (1) JPH0284176A (enEXAMPLES)
KR (1) KR890016175A (enEXAMPLES)
CN (1) CN1040053A (enEXAMPLES)
AU (1) AU605036B2 (enEXAMPLES)
DD (1) DD283836A5 (enEXAMPLES)
DK (1) DK196689A (enEXAMPLES)
FI (1) FI891941L (enEXAMPLES)
HU (1) HUT52556A (enEXAMPLES)
IL (1) IL89991A0 (enEXAMPLES)
IN (1) IN171656B (enEXAMPLES)
NO (1) NO891687L (enEXAMPLES)
NZ (1) NZ228774A (enEXAMPLES)
PL (1) PL279105A1 (enEXAMPLES)
PT (1) PT90359A (enEXAMPLES)
YU (1) YU85589A (enEXAMPLES)
ZA (1) ZA892886B (enEXAMPLES)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL86832A (en) 1987-06-22 2002-09-12 Medeva Holdings Bv A recombinant DNA molecule containing a nucleotide sequence of part of the region encoding HBV pre-1s, an immunogenic particle containing multiple peptide monomers containing a pre-s1 epitope and pharmaceutical preparations containing it
IL90161A0 (en) * 1988-05-13 1989-12-15 Phillips Petroleum Co Expression of hepatitis b s and pres2 proteins in methylotrophic yeasts
US6197548B1 (en) * 1990-04-02 2001-03-06 Medeva Pharma Limited Transformed Pichia expressing the pertactin antigen
CU22290A1 (es) * 1990-10-08 1995-01-31 Cigb Procedimiento para la obtencion de antigeno de superficie del virus de la hepatitis b de superior capacidad inmunoganica y su uso en un preparado vacunal
WO1992013951A1 (en) * 1991-02-04 1992-08-20 The Salk Institute Biotechnology/Industrial Associates, Inc. Production of human serum albumin in methylotrophic yeast cells
LT3988B (en) 1992-02-17 1996-06-25 Fermentas Biotech Inst Recombinant plasmides pfs19, pfps2-48 and pjlfds1 codingsynthesis of human hepatite b of surfice virus antigenes, methods fof producing thereof
JP2011115042A (ja) * 2008-03-13 2011-06-16 Hamamatsu Univ School Of Medicine ＨＢｓペプチド融合体

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU583683B2 (en) * 1985-11-26 1989-05-04 Research Corporation Technologies, Inc. Yeast production of hepatitis B surface antigen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879231A (en) * 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
US4855231A (en) * 1984-10-30 1989-08-08 Phillips Petroleum Company Regulatory region for heterologous gene expression in yeast
US4882279A (en) * 1985-10-25 1989-11-21 Phillips Petroleum Company Site selective genomic modification of yeast of the genus pichia
US4816564A (en) * 1986-01-31 1989-03-28 Merck & Co., Inc. Method for producing hepatitis B virus proteins in yeast
ZA88488B (en) * 1987-01-30 1988-10-26 Smith Kline Rit Hepatitis b virus surface antigens and hybrid antigens containing them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU583683B2 (en) * 1985-11-26 1989-05-04 Research Corporation Technologies, Inc. Yeast production of hepatitis B surface antigen

Also Published As

Publication number Publication date
CN1040053A (zh) 1990-02-28
KR890016175A (ko) 1989-11-28
PL279105A1 (en) 1989-12-27
ZA892886B (en) 1989-12-27
JPH0284176A (ja) 1990-03-26
NO891687D0 (no) 1989-04-24
AU3328289A (en) 1989-11-02
EP0339567A1 (en) 1989-11-02
FI891941A0 (fi) 1989-04-24
HUT52556A (en) 1990-07-28
FI891941A7 (fi) 1989-10-26
FI891941L (fi) 1989-10-26
DK196689D0 (da) 1989-04-24
YU85589A (sh) 1992-07-20
IN171656B (enEXAMPLES) 1992-12-05
DD283836A5 (de) 1990-10-24
PT90359A (pt) 1989-11-10
IL89991A0 (en) 1989-12-15
NZ228774A (en) 1991-05-28
NO891687L (no) 1989-10-26
DK196689A (da) 1989-10-26

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