AU602891B2 - 4H-1-benzopyran-4-one derivatives, a process for their preparation and their use as medicaments - Google Patents

4H-1-benzopyran-4-one derivatives, a process for their preparation and their use as medicaments

Info

Publication number
AU602891B2
AU602891B2 AU71397/87A AU7139787A AU602891B2 AU 602891 B2 AU602891 B2 AU 602891B2 AU 71397/87 A AU71397/87 A AU 71397/87A AU 7139787 A AU7139787 A AU 7139787A AU 602891 B2 AU602891 B2 AU 602891B2
Authority
AU
Australia
Prior art keywords
alkyl
aryl
cycloalkyl
represents hydrogen
integer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU71397/87A
Other languages
English (en)
Other versions
AU7139787A (en
Inventor
Alihussein Nomanbhai Dohadwalla
Samba Laxminarayan Kattige
Aftab Dawoodbhai Lakdawalla
Ramchandra Ganapati Naik
Richard Helmut Rupp
Noel John De Souza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU7139787A publication Critical patent/AU7139787A/en
Application granted granted Critical
Publication of AU602891B2 publication Critical patent/AU602891B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU71397/87A 1986-04-11 1987-04-10 4H-1-benzopyran-4-one derivatives, a process for their preparation and their use as medicaments Expired AU602891B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863612337 DE3612337A1 (de) 1986-04-11 1986-04-11 4h-1-benzopyran-4-on-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3612337 1986-04-11

Publications (2)

Publication Number Publication Date
AU7139787A AU7139787A (en) 1987-10-15
AU602891B2 true AU602891B2 (en) 1990-11-01

Family

ID=6298535

Family Applications (1)

Application Number Title Priority Date Filing Date
AU71397/87A Expired AU602891B2 (en) 1986-04-11 1987-04-10 4H-1-benzopyran-4-one derivatives, a process for their preparation and their use as medicaments

Country Status (15)

Country Link
US (1) US4900727A (en:Method)
EP (1) EP0241003B1 (en:Method)
JP (1) JPH0686446B2 (en:Method)
KR (1) KR950009861B1 (en:Method)
AT (2) ATE95519T1 (en:Method)
AU (1) AU602891B2 (en:Method)
CA (1) CA1332238C (en:Method)
DE (2) DE3612337A1 (en:Method)
DK (1) DK169760B1 (en:Method)
ES (1) ES2060582T3 (en:Method)
IE (1) IE62244B1 (en:Method)
IL (1) IL82149A (en:Method)
IN (1) IN164232B (en:Method)
PT (1) PT84654B (en:Method)
ZA (1) ZA872555B (en:Method)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU628409B2 (en) * 1988-10-28 1992-09-17 Hoechst Aktiengesellschaft The use of 4h-1-benzopyran-4-one derivatives, novel 4h-1- benzopyran-4-one derivatives, and pharmaceuticals containing them
AU653800B2 (en) * 1991-04-10 1994-10-13 Hoechst Aktiengesellschaft 5,7-dihydroxy-2-methyl-8-{4-(3-hydroxy-1-(1-propyl) piperidinyl}-4H-1-benzophyran-4-one, its preparation and its use

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US5284856A (en) * 1988-10-28 1994-02-08 Hoechst Aktiengesellschaft Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives
US5278174A (en) * 1990-06-04 1994-01-11 Scios Nova, Inc. Sigma binding site agents
US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
US6011024A (en) 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
GB9604709D0 (en) * 1996-03-05 1996-05-01 Imperial College A compound
US6903084B2 (en) * 1991-08-28 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
SK280617B6 (sk) * 1992-01-16 2000-05-16 Hoechst Aktiengesellschaft Arylcykloalkylové deriváty, spôsob ich prípravy, f
US5733920A (en) * 1995-10-31 1998-03-31 Mitotix, Inc. Inhibitors of cyclin dependent kinases
US6506792B1 (en) 1997-03-04 2003-01-14 Sterix Limited Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using
US20060241173A1 (en) * 1996-02-16 2006-10-26 Sterix Ltd. Compound
US6087366A (en) * 1996-03-07 2000-07-11 The Trustees Of Columbia University In The City Of New York Use of flavopiridol or a pharmaceutically acceptable salt thereof for inhibiting cell damage or cell death
US5849733A (en) * 1996-05-10 1998-12-15 Bristol-Myers Squibb Co. 2-thio or 2-oxo flavopiridol analogs
US5908934A (en) * 1996-09-26 1999-06-01 Bristol-Myers Squibb Company Process for the preparation of chiral ketone intermediates useful for the preparation of flavopiridol and analogs
DE19802449A1 (de) * 1998-01-23 1999-07-29 Hoechst Marion Roussel De Gmbh Verfahren zur Herstellung von (-)cis-3-Hydroxy-1-methyl-4-(2,4,6-trimethoxypyhenyl)-piperidin
GB9807779D0 (en) * 1998-04-09 1998-06-10 Ciba Geigy Ag Organic compounds
US6399633B1 (en) * 1999-02-01 2002-06-04 Aventis Pharmaceuticals Inc. Use of 4-H-1-benzopryan-4-one derivatives as inhibitors of smooth muscle cell proliferation
DE19959546A1 (de) * 1999-12-09 2001-06-21 Rhone Poulenc Rorer Gmbh Pharmazeutische Zubereitung zur Behandlung von Tumorerkrankungen
US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition
EA005247B1 (ru) * 2000-01-18 2004-12-30 Авентис Фармасьютикалз Инк. Псевдополиморф (-)-цис-2-(2-хлорфенил)-5,7-дигидрокси-8[4r-(3s-гидрокси-1-метил)пиперидинил]-4h-1-бензопиран-4-она
US6576647B2 (en) 2000-01-18 2003-06-10 Aventis Pharmaceuticals Inc. Pseudopolymorph of (—)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy -1-methyl)piperidinyl]-4H-1-benzopyran-4-one
JP2003520798A (ja) * 2000-01-18 2003-07-08 アベンテイス・フアーマシユーチカルズ・インコーポレーテツド （−）−シス−２−（２−クロロフェニル）−５，７−ジヒドロキシ−８［４ｒ−（３ｓ−ヒドロキシ−１−メチル）ピペリジニル］−４ｈ−１−ベンゾピラン−４−オンのエタノール溶媒化合物
US6821990B2 (en) * 2000-01-18 2004-11-23 Aventis Pharma Deutschland Gmbh Ethanol solvate of (-)-cis-2-(2-chlorophenyl)-5, 7-dihydroxy-8 [4R-(3S-hydroxy-1-M ethyl) piperidinyl]-4H-1-benzopyran-4-one
FR2805538B1 (fr) * 2000-02-29 2006-08-04 Hoechst Marion Roussel Inc Nouveaux derives de flavones, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
KR100423899B1 (ko) 2000-05-10 2004-03-24 주식회사 엘지생명과학 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸
DE60333094D1 (de) 2002-04-17 2010-08-05 Cytokinetics Inc Verbindungen, zusammensetzungen und verfahren
US7884127B2 (en) * 2002-07-08 2011-02-08 Pirimal Life Sciences Ltd. Inhibitors of cyclin dependent kinases and their use
US7271193B2 (en) * 2002-07-08 2007-09-18 Nicholas Piramal India, Ltd. Inhibitors of cyclin-dependent kinases and their use
US7915301B2 (en) * 2002-07-08 2011-03-29 Piramal Life Science Limited Inhibitors of cyclin dependent kinases and their use
EP1539727B1 (en) * 2002-07-17 2009-02-18 Cytokinetics, Inc. Compounds, compositions, and methods for treating cellular proliferative diseases
JP2005539062A (ja) * 2002-09-13 2005-12-22 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
EP1670456A2 (en) * 2003-10-06 2006-06-21 Cytokinetics, Inc. Compounds, compositions and methods
TR200808208T1 (tr) * 2003-12-09 2008-12-22 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bir immün tepkinin bastırılması veya proliferatif bir hastalığın tedavisi
JP2007513967A (ja) * 2003-12-11 2007-05-31 セラヴァンス， インコーポレーテッド 変異レセプターチロシンキナーゼが駆動する細胞増殖性疾患の処置において使用するための組成物
CA2594477C (en) 2005-01-21 2016-07-12 Astex Therapeutics Limited Pharmaceutical compounds
ES2491140T3 (es) 2006-06-21 2014-09-05 Piramal Enterprises Limited Derivados de flavona enantioméricamente puros para el tratamiento de trastornos proliferativos y procesos para su preparación
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
TWI461194B (zh) 2009-05-05 2014-11-21 Piramal Entpr Ltd 吡咯啶取代黃酮作為輻射致敏劑
KR20130027476A (ko) 2010-02-26 2013-03-15 피라말 엔터프라이지즈 리미티드 염증 질환을 치료하기 위한 피롤리딘으로 치환된 플라본
EP3399026B1 (en) 2010-06-14 2024-06-26 The Scripps Research Institute Reprogramming of cells to a new fate
TW201300105A (zh) 2011-05-31 2013-01-01 Piramal Life Sciences Ltd 治療頭頸鱗狀細胞癌之相乘藥物組合物
WO2014167580A1 (en) 2013-04-10 2014-10-16 Council Of Scientific & Industrial Research Novel chromone alkaloid dysoline for the treatment of cancer and inflammatory disorders
EP2986605B1 (en) 2013-04-17 2017-11-15 Council of Scientific and Industrial Research Rohitukine analogs as cyclin-dependent kinase inhibitors and a process for the preparation thereof
DK3019166T3 (da) 2013-07-12 2019-07-29 Piramal Entpr Ltd A Pharmaceutical Combination for the Treatment of Melanoma
US20170306046A1 (en) 2014-11-12 2017-10-26 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
EP3611506B1 (en) 2015-04-20 2021-11-17 Sumitomo Dainippon Pharma Oncology, Inc. Predicting response to alvocidib by mitochondrial profiling
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Citations (3)

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Publication number Priority date Publication date Assignee Title
AU2591484A (en) * 1983-03-25 1984-09-27 Bayer Aktiengesellschaft Chromone- and thiochromone- substituted 1,4-dihydropyridine derivatives
EP0137193A2 (de) * 1983-08-12 1985-04-17 Hoechst Aktiengesellschaft Chromonalkaloid, Verfahren zu seiner Isolierung aus Dysoxylum Binectariferum, und seine Verwendung als Arzneimittel
AU5107085A (en) * 1984-12-15 1986-06-19 Bayer Aktiengesellschaft 1,4-dihydropyridine carboxamide derivatives

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GB1223690A (en) * 1967-10-17 1971-03-03 Fisons Pharmaceuticals Ltd Substituted chromon-2-carboxylic acids
DE2731566A1 (de) * 1977-07-13 1979-02-01 Bayer Ag Verfahren zur herstellung von neuen chromon-derivaten, sowie ihre verwendung als pflanzenschutzmittel
GB2101115A (en) * 1980-10-23 1983-01-12 Pfizer Ltd Thromboxane synthetase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2591484A (en) * 1983-03-25 1984-09-27 Bayer Aktiengesellschaft Chromone- and thiochromone- substituted 1,4-dihydropyridine derivatives
EP0137193A2 (de) * 1983-08-12 1985-04-17 Hoechst Aktiengesellschaft Chromonalkaloid, Verfahren zu seiner Isolierung aus Dysoxylum Binectariferum, und seine Verwendung als Arzneimittel
AU5107085A (en) * 1984-12-15 1986-06-19 Bayer Aktiengesellschaft 1,4-dihydropyridine carboxamide derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU628409B2 (en) * 1988-10-28 1992-09-17 Hoechst Aktiengesellschaft The use of 4h-1-benzopyran-4-one derivatives, novel 4h-1- benzopyran-4-one derivatives, and pharmaceuticals containing them
AU653800B2 (en) * 1991-04-10 1994-10-13 Hoechst Aktiengesellschaft 5,7-dihydroxy-2-methyl-8-{4-(3-hydroxy-1-(1-propyl) piperidinyl}-4H-1-benzophyran-4-one, its preparation and its use

Also Published As

Publication number Publication date
HK1006021A1 (en) 1999-02-05
EP0241003B1 (de) 1993-10-06
KR870010045A (ko) 1987-11-30
KR950009861B1 (en) 1995-08-29
IN164232B (en:Method) 1989-02-04
ATE95519T1 (de) 1993-10-15
PT84654B (pt) 1989-12-29
EP0241003A3 (en) 1988-10-12
DE3612337A1 (de) 1987-10-15
AU7139787A (en) 1987-10-15
ATA260587A (de) 1989-07-15
DE3787661D1 (de) 1993-11-11
AT389875B (de) 1990-02-12
ES2060582T3 (es) 1994-12-01
IL82149A (en) 1994-01-25
EP0241003A2 (de) 1987-10-14
IL82149A0 (en) 1987-10-30
JPS62242680A (ja) 1987-10-23
ZA872555B (en) 1987-11-25
DK169760B1 (da) 1995-02-20
JPH0686446B2 (ja) 1994-11-02
PT84654A (de) 1987-05-01
DK185287A (da) 1987-10-12
IE62244B1 (en) 1995-01-11
IE870941L (en) 1987-10-11
US4900727A (en) 1990-02-13
CA1332238C (en) 1994-10-04
DK185287D0 (da) 1987-04-10

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