AU600248B2 - N- (butenyl-substituted) azaheterocyclic carboxylic acids - Google Patents

N- (butenyl-substituted) azaheterocyclic carboxylic acids Download PDF

Info

Publication number
AU600248B2
AU600248B2 AU67193/87A AU6719387A AU600248B2 AU 600248 B2 AU600248 B2 AU 600248B2 AU 67193/87 A AU67193/87 A AU 67193/87A AU 6719387 A AU6719387 A AU 6719387A AU 600248 B2 AU600248 B2 AU 600248B2
Authority
AU
Australia
Prior art keywords
derivatives
substituted
group
lower alkyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU67193/87A
Other languages
English (en)
Other versions
AU6719387A (en
Inventor
Ursula Sonnewald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Industri AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK5186A external-priority patent/DK5186D0/da
Priority claimed from DK95686A external-priority patent/DK95686D0/da
Application filed by Novo Industri AS filed Critical Novo Industri AS
Publication of AU6719387A publication Critical patent/AU6719387A/en
Application granted granted Critical
Publication of AU600248B2 publication Critical patent/AU600248B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU67193/87A 1986-01-07 1987-01-07 N- (butenyl-substituted) azaheterocyclic carboxylic acids Ceased AU600248B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK51/86 1986-01-07
DK5186A DK5186D0 (da) 1986-01-07 1986-01-07 Aminosyrer
DK956/86 1986-03-03
DK95686A DK95686D0 (enExample) 1986-03-03 1986-03-03

Publications (2)

Publication Number Publication Date
AU6719387A AU6719387A (en) 1987-07-09
AU600248B2 true AU600248B2 (en) 1990-08-09

Family

ID=26063196

Family Applications (1)

Application Number Title Priority Date Filing Date
AU67193/87A Ceased AU600248B2 (en) 1986-01-07 1987-01-07 N- (butenyl-substituted) azaheterocyclic carboxylic acids

Country Status (12)

Country Link
US (1) US4931450A (enExample)
EP (1) EP0231996B1 (enExample)
JP (1) JPH0791289B2 (enExample)
AU (1) AU600248B2 (enExample)
CA (1) CA1297105C (enExample)
DE (1) DE3787657T2 (enExample)
DK (1) DK165692C (enExample)
ES (1) ES2059360T3 (enExample)
FI (1) FI89481C (enExample)
IL (1) IL81179A (enExample)
NO (1) NO170976C (enExample)
PT (1) PT84064B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK704488D0 (da) * 1988-12-19 1988-12-19 Novo Industri As Nye n-substituerede azaheterocykliske carboxylsyrer
DK288385D0 (da) * 1985-06-26 1985-06-26 Novo Industri As Aminosyrederivater
DK270488D0 (da) * 1988-05-18 1988-05-18 Novo Industri As Hidtil ukendte o-substituerede ketoximer
DK588189D0 (da) * 1989-11-22 1989-11-22 Novo Nordisk As Nye heterocykliske carboxylsyrer
US5112980A (en) * 1989-12-27 1992-05-12 Monsanto Company Process of preparing substituted pyridine compounds
US5962449A (en) 1995-04-07 1999-10-05 Novo Nordisk A/S Tricyclic compounds in treating hyperalgesic conditions and NIDDM
US6191165B1 (en) 1996-05-31 2001-02-20 Allelix Neuroscience Inc. Pharmaceutical for treatment of neurological and neuropsychiatric disorders
AU3104097A (en) * 1996-06-27 1998-01-14 Ciaran Regan Use of nipecotic acid or guvacine derivatives for the manufacture of a medicament for the treatment of postischemic neurodegenerative disorders
US6288083B1 (en) 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6503926B2 (en) 1998-09-04 2003-01-07 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
DE19840611A1 (de) * 1998-09-05 2000-03-09 Klaus Wanner GABA-uptake-Inhibitoren mit Pyrrolidinstruktur
JP2004523548A (ja) 2001-02-16 2004-08-05 アレリックス ニューロサイエンス インコーポレーテッド ＧｌｙＴ−１阻害剤
US7355042B2 (en) * 2001-10-16 2008-04-08 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators
WO2003032912A2 (en) * 2001-10-16 2003-04-24 Hypnion, Inc. Treatment of cns disorders using cns target modulators
US7189757B2 (en) * 2001-10-16 2007-03-13 Hypnion, Inc. Treatment of sleep disorders using CNS target modulators
CN1382441A (zh) * 2002-05-21 2002-12-04 中国科学院上海生命科学研究院 γ－氨基丁酸转运蛋白抑制剂在制备镇痛药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4383999A (en) * 1981-05-26 1983-05-17 Smithkline Beckman Corporation Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU552050B2 (en) * 1981-05-26 1986-05-22 Smithkline Beckman Corporation N-substituted azeheterocyclic carboxylic acids and their esters
US4681884A (en) * 1983-09-01 1987-07-21 Boehringer Ingelheim Pharmaceuticals, Inc. Diazine-ethenylphenyl oxamic acids and esters and salts thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4383999A (en) * 1981-05-26 1983-05-17 Smithkline Beckman Corporation Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters

Also Published As

Publication number Publication date
JPS62228073A (ja) 1987-10-06
DK3887D0 (enExample) 1987-01-06
FI89481B (fi) 1993-06-30
DE3787657T2 (de) 1994-02-03
PT84064B (pt) 1989-07-31
CA1297105C (en) 1992-03-10
ES2059360T3 (es) 1994-11-16
FI89481C (fi) 1993-10-11
JPH0791289B2 (ja) 1995-10-04
AU6719387A (en) 1987-07-09
EP0231996B1 (en) 1993-10-06
NO170976C (no) 1993-01-06
DE3787657D1 (de) 1993-11-11
IL81179A0 (en) 1987-08-31
NO170976B (no) 1992-09-28
US4931450A (en) 1990-06-05
IL81179A (en) 1992-02-16
DK165692B (da) 1993-01-04
NO870049D0 (no) 1987-01-06
DK3887A (enExample) 1987-09-17
NO870049L (no) 1987-07-08
FI870059A0 (fi) 1987-01-07
EP0231996A3 (en) 1988-10-19
FI870059L (fi) 1987-07-08
EP0231996A2 (en) 1987-08-12
PT84064A (en) 1987-02-01
DK165692C (da) 1993-11-08

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