AU598469B2 - Process and intermediates for preparing 1alpha-hydroxyvitamin d compounds - Google Patents

Process and intermediates for preparing 1alpha-hydroxyvitamin d compounds Download PDF

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Publication number
AU598469B2
AU598469B2 AU59511/86A AU5951186A AU598469B2 AU 598469 B2 AU598469 B2 AU 598469B2 AU 59511/86 A AU59511/86 A AU 59511/86A AU 5951186 A AU5951186 A AU 5951186A AU 598469 B2 AU598469 B2 AU 598469B2
Authority
AU
Australia
Prior art keywords
document
hydroxy
hydroxyvitamin
compound according
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU59511/86A
Other languages
English (en)
Other versions
AU5951186A (en
Inventor
Hector F. Deluca
Seok Ho Lee
Heinrich K. Schnoes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of AU5951186A publication Critical patent/AU5951186A/en
Application granted granted Critical
Publication of AU598469B2 publication Critical patent/AU598469B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/296—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with lead derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/32—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/26—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C47/267—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing hydroxy groups containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU59511/86A 1985-06-10 1986-05-20 Process and intermediates for preparing 1alpha-hydroxyvitamin d compounds Expired AU598469B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/743,129 US4755329A (en) 1985-06-10 1985-06-10 Process and intermediates for preparing 1α-hydroxyvitamin D compounds
US743129 1985-06-10

Publications (2)

Publication Number Publication Date
AU5951186A AU5951186A (en) 1987-01-07
AU598469B2 true AU598469B2 (en) 1990-06-28

Family

ID=24987631

Family Applications (1)

Application Number Title Priority Date Filing Date
AU59511/86A Expired AU598469B2 (en) 1985-06-10 1986-05-20 Process and intermediates for preparing 1alpha-hydroxyvitamin d compounds

Country Status (9)

Country Link
US (1) US4755329A (OSRAM)
EP (1) EP0225915A4 (OSRAM)
JP (3) JPS63500033A (OSRAM)
AU (1) AU598469B2 (OSRAM)
CA (1) CA1304389C (OSRAM)
DK (1) DK54787A (OSRAM)
GB (1) GB2178424B (OSRAM)
IE (1) IE58441B1 (OSRAM)
WO (1) WO1986007364A1 (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2564841B2 (ja) * 1987-08-19 1996-12-18 日産化学工業株式会社 光学活性な液晶化合物
JPH0667896B2 (ja) * 1988-03-09 1994-08-31 大同ほくさん株式会社 １β，７，８―トリヒドロキシビタミンＤ２若しくはＤ３またはそれらの誘導体、およびそれらの製造方法
US5283345A (en) * 1988-03-09 1994-02-01 Hoxan Corporation 1β,7,8-trihydroxy vitamin D2, 1∘,7,8-trihydroxy vitamin D3 and their derivatives and method of manufacturing these chemicals
US5789397A (en) * 1991-01-08 1998-08-04 Bone Care International, Inc. Methods for preparation and use of 1A,24(S)-dihydroxy vitamin D2
US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
ES2093180T3 (es) * 1991-07-05 1996-12-16 Duphar Int Res Compuesto de vitamina d, metodo de preparar este compuesto y producto intermedio de dicho metodo.
US5300705A (en) * 1993-03-18 1994-04-05 Hoffmann-La Roche Inc. Process for the preparation of 1α,25,26-trihydroxy-22-ene-cholecalciferol
AU2010208323B2 (en) 2009-01-27 2016-03-10 Berg Llc Vitamin D3 and analogs thereof for alleviating side effects associated with chemotherapy
EP2464357B1 (en) 2009-08-14 2019-05-22 Berg LLC Vitamin d3 and analogs thereof for treating alopecia
SG10201709894RA (en) 2013-05-29 2018-01-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4225596A (en) * 1978-10-13 1980-09-30 Wisconsin Alumni Research Foundation Method for treating calcium imbalance and improving calcium absorption in mammals
US4594432A (en) * 1983-01-28 1986-06-10 Hoffman-La Roche Inc. Process for the synthesis of 1α,23(S),25-trihydroxycholecalciferol and 1α,23(R),25-trihydroxycholecalciferol
US4448726A (en) * 1983-05-11 1984-05-15 Wisconsin Alumni Research Foundation Ring A- and triene-modified vitamin D compounds
US4594340A (en) * 1984-11-29 1986-06-10 Hoffmann-La Roche Inc. 25,26-dehydro-1α,24R-dihydroxycholecalciferol and 25,26-dehydro-1α,24S-dihydroxycholecalciferol and the epimeric mixture

Also Published As

Publication number Publication date
US4755329A (en) 1988-07-05
DK54787D0 (da) 1987-02-03
JP2741497B2 (ja) 1998-04-15
JPH0523251B2 (OSRAM) 1993-04-02
DK54787A (da) 1987-02-03
CA1304389C (en) 1992-06-30
GB2178424A (en) 1987-02-11
GB2178424B (en) 1989-07-26
EP0225915A4 (en) 1987-08-12
GB8613945D0 (en) 1986-07-16
JPH05271182A (ja) 1993-10-19
JPH08259479A (ja) 1996-10-08
IE861526L (en) 1986-12-10
EP0225915A1 (en) 1987-06-24
AU5951186A (en) 1987-01-07
JPH0662558B2 (ja) 1994-08-17
WO1986007364A1 (en) 1986-12-18
IE58441B1 (en) 1993-09-22
JPS63500033A (ja) 1988-01-07

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