AU596508B2 - Skin substitute - Google Patents

Skin substitute Download PDF

Info

Publication number
AU596508B2
AU596508B2 AU13742/88A AU1374288A AU596508B2 AU 596508 B2 AU596508 B2 AU 596508B2 AU 13742/88 A AU13742/88 A AU 13742/88A AU 1374288 A AU1374288 A AU 1374288A AU 596508 B2 AU596508 B2 AU 596508B2
Authority
AU
Australia
Prior art keywords
substitute
cells
skin
dermis
equivalent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU13742/88A
Other languages
English (en)
Other versions
AU1374288A (en
Inventor
Daniel Asselineau
Bruno Bernard
Yves-Michel Darmon
Marie-Cecile Lenoir
Braham Shroot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galderma Research and Development SNC
Original Assignee
Centre International de Recherches Dermatologiques Galderma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26225869&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU596508(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR878704205A external-priority patent/FR2612938B1/fr
Application filed by Centre International de Recherches Dermatologiques Galderma filed Critical Centre International de Recherches Dermatologiques Galderma
Publication of AU1374288A publication Critical patent/AU1374288A/en
Application granted granted Critical
Publication of AU596508B2 publication Critical patent/AU596508B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698—Skin equivalents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/10—Hair or skin implants
    • A61F2/105—Skin implants, e.g. artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/40—Nucleotides, nucleosides, bases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/395—Thyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/80—Neurotransmitters; Neurohormones
    • C12N2501/81—Adrenaline
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/092—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells hair cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Treatment And Processing Of Natural Fur Or Leather (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
AU13742/88A 1987-03-26 1988-03-25 Skin substitute Expired AU596508B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR8704205 1987-03-26
FR878704205A FR2612938B1 (fr) 1987-03-26 1987-03-26 Procede d'obtention d'un equivalent de peau et equivalent de peau correspondant
FR8708604 1987-06-19
FR878708604A FR2612939B1 (fr) 1987-03-26 1987-06-19 Equivalent de peau

Publications (2)

Publication Number Publication Date
AU1374288A AU1374288A (en) 1988-09-29
AU596508B2 true AU596508B2 (en) 1990-05-03

Family

ID=26225869

Family Applications (1)

Application Number Title Priority Date Filing Date
AU13742/88A Expired AU596508B2 (en) 1987-03-26 1988-03-25 Skin substitute

Country Status (13)

Country Link
US (1) US5667961A (no)
EP (1) EP0285474B1 (no)
JP (1) JP2655269B2 (no)
AU (1) AU596508B2 (no)
CA (1) CA1296259C (no)
CH (1) CH694497A5 (no)
DE (2) DE285474T1 (no)
DK (1) DK164688A (no)
ES (1) ES2004844T3 (no)
FR (1) FR2612939B1 (no)
NO (1) NO881348L (no)
NZ (1) NZ223827A (no)
PT (1) PT87085B (no)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2612938B1 (fr) * 1987-03-26 1989-06-23 Cird Procede d'obtention d'un equivalent de peau et equivalent de peau correspondant
IL94611A (en) * 1989-06-05 1994-12-29 Organogenesis Inc Medium for cell cultures containing insulin or growth factor similar to insulin, transferrin or iron ion, triiodothyronine or thyroxine and method of use
US5106949A (en) * 1989-09-15 1992-04-21 Organogenesis, Inc. Collagen compositions and methods for preparation thereof
IL95429A (en) * 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
GB8928634D0 (en) * 1989-12-19 1990-02-21 Unilever Plc Method of testing
WO1991016010A1 (en) * 1990-04-24 1991-10-31 Mark Eisenberg Composite living skin equivalents
US5256418A (en) * 1990-04-06 1993-10-26 Organogenesis, Inc. Collagen constructs
FR2667246A1 (fr) * 1990-10-02 1992-04-03 Imedex Biomateriau a base de collagene et des applications.
EP0655910A4 (en) * 1992-07-29 1996-02-28 Univ Washington USE OF A POCKET FOR THE IMPLANTATION OF LIVING CELLS.
DE69310339T2 (de) * 1993-02-19 1997-08-21 Philippe Djian Präparate, die Corneozyt Proteine enthalten
US5616500A (en) * 1993-04-30 1997-04-01 The United States Of America As Represented By The Department Of Health & Human Services Trichohyalin and transglutaminase-3 and methods of using same
US6334872B1 (en) 1994-02-18 2002-01-01 Organogenesis Inc. Method for treating diseased or damaged organs
FR2745088B1 (fr) * 1996-02-15 1998-04-10 Oreal Procede pour tester une substance eventuellement active dans le domaine capillaire
EP1054998A1 (en) 1998-01-20 2000-11-29 Pericor Science, Inc. Transglutaminase linkage of agents to tissue
EP1082057B1 (en) 1998-06-05 2009-02-25 Organogenesis Inc. Bioengineered tubular graft prostheses
AU754838B2 (en) * 1998-06-05 2002-11-28 Organogenesis Inc. Bioengineered flat sheet graft prostheses
AU753773B2 (en) * 1998-06-05 2002-10-31 Organogenesis Inc. Bioengineered vascular graft prostheses
AU763724B2 (en) * 1998-06-05 2003-07-31 Duke University School Of Medicine Bioengineered vascular graft support prostheses
BR9915476A (pt) * 1998-11-19 2002-01-02 Organogenesis Inc Construtos de tecidos feitos por bioengenharia e métodos para a sua produção e utilização
FR2786092B1 (fr) 1998-11-20 2002-11-29 Oreal Composition de teinture d'oxydation des fibres keratiniques et procede de teinture mettant en oeuvre cette composition
US6454787B1 (en) 1998-12-11 2002-09-24 C. R. Bard, Inc. Collagen hemostatic foam
US6361551B1 (en) 1998-12-11 2002-03-26 C. R. Bard, Inc. Collagen hemostatic fibers
US6884427B1 (en) * 1999-02-08 2005-04-26 Aderans Research Institute, Inc. Filamentary means for introducing agents into tissue of a living host
WO2000047129A2 (en) * 1999-02-11 2000-08-17 The General Hospital Corporation Microfabricated membranes and matrices
US6746485B1 (en) * 1999-02-18 2004-06-08 St. Francis Medical Technologies, Inc. Hair used as a biologic disk, replacement, and/or structure and method
EP1290145B1 (de) 2000-05-31 2005-11-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Dreidimensionales hautmodell
AU7920901A (en) * 2000-08-08 2002-03-04 Bioamide Inc Scaffolds for tissue engineered hair
EP1320390A2 (en) * 2000-09-18 2003-06-25 Organogenesis Inc. Bioengineered flat sheet graft prosthesis and its use
US20040068284A1 (en) * 2002-01-29 2004-04-08 Barrows Thomas H. Method for stimulating hair growth and kit for carrying out said method
US7597885B2 (en) * 2004-03-26 2009-10-06 Aderans Research Institute, Inc. Tissue engineered biomimetic hair follicle graft
AR050212A1 (es) * 2004-08-13 2006-10-04 Aderans Res Inst Inc Organogenesis a partir de celulas disociadas
FR2889808B1 (fr) 2005-08-17 2011-07-22 Oreal Utilisation de l'acide 8-hexadecene-1,16-dicarboxylique comme agent de soin destine a favoriser la cohesion de la couche cornee
US20070148138A1 (en) * 2005-11-22 2007-06-28 Aderans Research Institute, Inc. Hair follicle graft from tissue engineered skin
AR057628A1 (es) * 2005-11-22 2007-12-05 Aderans Res Inst Inc Injertos capilares derivados de cabello extirpado
FR2903702B1 (fr) 2006-07-13 2012-10-19 Oreal Equivalent d'epiderme capable de se pigmenter obtenu a partir de cellules de la matrice, procede de preparation et utilisation
US8105380B2 (en) * 2006-10-23 2012-01-31 Stemedica Cell Technologies, Inc. Cellular scaffold
US8709081B2 (en) 2006-10-23 2014-04-29 Stemedica Cell Technologies, Inc. Cellular scaffold
US7985537B2 (en) * 2007-06-12 2011-07-26 Aderans Research Institute, Inc. Methods for determining the hair follicle inductive properties of a composition
FR2967163A1 (fr) 2010-11-05 2012-05-11 Centre Nat Rech Scient Procede in vitro ou ex vivo pour la maintenance en survie et la generation ou reconstruction d'un epiderme
US8691951B2 (en) 2011-02-14 2014-04-08 Japan Institute Of Leather Research Type I-type IV collagen hybrid gel
EP2489375B1 (en) * 2011-02-16 2015-04-08 Japan Institute of Leather Research Type I-type IV collagen hybrid gel
JP2012205516A (ja) 2011-03-29 2012-10-25 Osaka Univ 人工皮膚モデルの製造方法、及び人工皮膚モデル
FR2976001B1 (fr) 2011-05-30 2014-10-31 Oreal Modele de cuir chevelu reconstruit et procede de screening de molecules actives
US9644177B2 (en) * 2012-07-12 2017-05-09 Board Of Regents, The University Of Texas System Extracellular matrix films and methods of making and using same
WO2014038599A1 (ja) * 2012-09-04 2014-03-13 国立大学法人大阪大学 人工皮膚組織、人工皮膚モデル及びそれらの製造方法
US9545302B2 (en) 2013-11-20 2017-01-17 Dermagenesis Llc Skin printing and auto-grafting
FR3033697B1 (fr) * 2015-03-17 2020-03-27 Universite Pierre Et Marie Curie (Paris 6) Suspensions de collagene injectables, leur procede de preparation et leurs utilisations, notamment pour la formation de matrices denses de collagene
FR3041974B1 (fr) * 2015-10-02 2017-12-22 Isp Investments Inc Equivalent de derme comprenant des cellules de type skp, son procede de preparation et ses utilisations
FR3054449B1 (fr) 2016-07-29 2018-08-31 L'oreal Equivalent de peau a compartiments dermiques juxtaposes distincts
FR3071512B1 (fr) 2017-09-28 2022-02-25 Oreal Signatures moleculaires de trois sous-populations de fibroblastes dermiques et equivalent de derme comprenant une de ces sous-populations
FR3111904B1 (fr) 2020-06-30 2022-10-21 Oreal Bioencre pour bioimpression d’un modèle de jonction dermo-épidermique invaginée
EP4159250A1 (en) * 2021-09-30 2023-04-05 Korea University Research and Business Foundation Method of enhancing structural integrity of epidermis in culture of reconstructed human skin
LU502391B1 (en) 2022-06-28 2024-01-09 Univerza V Mariboru A complex in vitro model of human skin, a process for preparation and use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458678A (en) * 1981-10-26 1984-07-10 Massachusetts Institute Of Technology Cell-seeding procedures involving fibrous lattices
EP0243132A2 (en) * 1986-04-19 1987-10-28 Koken Co. Ltd. Artificial skin and its production
AU1374388A (en) * 1987-03-26 1988-09-29 Centre International De Recherches Dermatologiques C.I.R.D. Process for creating a skin substitute and the resulting skin substitute

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4539716A (en) * 1981-03-19 1985-09-10 Massachusetts Institute Of Technology Fabrication of living blood vessels and glandular tissues
US4485096A (en) * 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
US4485097A (en) * 1982-05-26 1984-11-27 Massachusetts Institute Of Technology Bone-equivalent and method for preparation thereof
US4604346A (en) * 1984-10-09 1986-08-05 Massachusetts Institute Of Technology Skin-equivalent prepared by the use of punch biopsy

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458678A (en) * 1981-10-26 1984-07-10 Massachusetts Institute Of Technology Cell-seeding procedures involving fibrous lattices
EP0243132A2 (en) * 1986-04-19 1987-10-28 Koken Co. Ltd. Artificial skin and its production
AU1374388A (en) * 1987-03-26 1988-09-29 Centre International De Recherches Dermatologiques C.I.R.D. Process for creating a skin substitute and the resulting skin substitute

Also Published As

Publication number Publication date
ES2004844A4 (es) 1989-02-16
EP0285474B1 (fr) 1992-12-09
CH694497A5 (fr) 2005-02-28
EP0285474A1 (fr) 1988-10-05
DK164688D0 (da) 1988-03-25
DK164688A (da) 1988-09-27
FR2612939B1 (fr) 1989-06-23
CA1296259C (fr) 1992-02-25
PT87085A (pt) 1988-04-01
ES2004844T3 (es) 1993-05-16
JP2655269B2 (ja) 1997-09-17
NO881348L (no) 1988-09-27
DE3876469T2 (de) 1993-04-15
NO881348D0 (no) 1988-03-25
JPS6415041A (en) 1989-01-19
FR2612939A1 (fr) 1988-09-30
NZ223827A (en) 1989-10-27
PT87085B (pt) 1992-07-31
DE3876469D1 (de) 1993-01-21
AU1374288A (en) 1988-09-29
DE285474T1 (de) 1990-03-01
US5667961A (en) 1997-09-16

Similar Documents

Publication Publication Date Title
AU596508B2 (en) Skin substitute
US5639654A (en) Process for creating a skin substitute and the resulting skin substitute
DE LUCA et al. Evidence that human oral epithelium reconstituted in vitro and transplanted onto patients with defects in the oral mucosa retains properties of the original donor site1
Compton et al. Organized skin structure is regenerated in vivo from collagen-GAG matrices seeded with autologous keratinocytes
DE69927600T2 (de) Biotechnisch konstruiertes gewebe und verfahren zu dessen produktion und benutzung
US8222031B2 (en) Three-dimensional skin model
JP3387891B2 (ja) 加齢した皮膚等価物、それらの調製方法及びそれらの用途
JP6549213B2 (ja) 真皮層及び表皮層を含む三次元培養皮膚モデルを製造する方法及びそれにより製造された三次元培養皮膚モデル
JPH05506169A (ja) 合成生体皮膚等価物
Kinikoglu et al. Reconstruction of a full-thickness collagen-based human oral mucosal equivalent
RU2498808C9 (ru) Способ лечения состояния ротовой полости больного (варианты)
Lauer et al. Cultured gingival epithelium: a possible suitable material for pre-prosthetic surgery
Ophof et al. Oral keratinocytes cultured on dermal matrices form a mucosa-like tissue
EP1709160B1 (en) Preparation of fibroblast-populated connective tissue substitute
Kremer et al. Organotypical engineering of differentiated composite-skin equivalents of human keratinocytes in a collagen-GAG matrix (INTEGRA Artificial Skin) in a perfusion culture system
KR20010072553A (ko) 살아있는 키메릭 피부 대체물
Zhang et al. Tissue-engineered skin regenerative units for epidermal keratinocytes expansion and wound healing
Aihara Ultrastructural study of grafted autologous cultured human epithelium
CN103764816B (zh) 重建头皮模型和筛选活性分子的方法
Sugimura et al. Transplantation of cultured mucosal epithelium: an experimental study
JPS59501298A (ja) 骨同等物およびその製造法
US20100040665A1 (en) Method for obtaining three-dimensional structures for tissue engineering
Kınıkoğlu The Influence of The Biopsy Procedure on The Quality of a Three-Dimensional Reconstructed Artificial Tissue
IE80689B1 (en) Composite living skin equivalents
MXPA01005098A (en) Bioengineered tissue constructs and methods for producing and using them