AU595948B2 - Transdermal flux enhancing compositions - Google Patents

Transdermal flux enhancing compositions Download PDF

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Publication number
AU595948B2
AU595948B2 AU80542/87A AU8054287A AU595948B2 AU 595948 B2 AU595948 B2 AU 595948B2 AU 80542/87 A AU80542/87 A AU 80542/87A AU 8054287 A AU8054287 A AU 8054287A AU 595948 B2 AU595948 B2 AU 595948B2
Authority
AU
Australia
Prior art keywords
ethanol
composition
acid
cis
piroxicam
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU80542/87A
Other languages
English (en)
Other versions
AU8054287A (en
Inventor
Michael Lee Francoeur
Russell Owen Potts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of AU8054287A publication Critical patent/AU8054287A/en
Application granted granted Critical
Publication of AU595948B2 publication Critical patent/AU595948B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
AU80542/87A 1986-10-31 1987-10-30 Transdermal flux enhancing compositions Ceased AU595948B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92564186A 1986-10-31 1986-10-31
US925641 1986-10-31

Publications (2)

Publication Number Publication Date
AU8054287A AU8054287A (en) 1988-05-05
AU595948B2 true AU595948B2 (en) 1990-04-12

Family

ID=25452022

Family Applications (1)

Application Number Title Priority Date Filing Date
AU80542/87A Ceased AU595948B2 (en) 1986-10-31 1987-10-30 Transdermal flux enhancing compositions

Country Status (24)

Country Link
EP (1) EP0271983B1 (el)
JP (1) JPH0757725B2 (el)
KR (1) KR900003697B1 (el)
CN (1) CN87107548A (el)
AT (1) ATE64306T1 (el)
AU (1) AU595948B2 (el)
CA (1) CA1338008C (el)
DE (1) DE3770786D1 (el)
DK (1) DK568187A (el)
EG (1) EG18324A (el)
ES (1) ES2031518T3 (el)
GR (1) GR3002137T3 (el)
HU (1) HU197993B (el)
IE (1) IE60379B1 (el)
IL (1) IL84269A (el)
MX (1) MX171058B (el)
MY (1) MY102980A (el)
NO (1) NO175617C (el)
NZ (1) NZ222346A (el)
PH (1) PH25498A (el)
PT (1) PT86023B (el)
RU (2) RU1836078C (el)
YU (1) YU46755B (el)
ZA (1) ZA878161B (el)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196416A (en) * 1987-08-28 1993-03-23 Eli Lilly And Company Transdermal flux-enhancing pharmaceutical compositions comprising azone, ethanol and water
DE3871464D1 (de) * 1987-08-28 1992-07-02 Lilly Co Eli Die permeation verbessernde zusammensetzung.
PT89837B (pt) * 1988-02-29 1994-01-31 Pfizer Processo para a preparacao de composicoes para aumentar o fluxo transdermico contendo uma 1-alquilazaciclo-heptan-2-ona ou uma cis-olefina
CH679119A5 (el) * 1988-05-13 1991-12-31 Sandoz Ag
US5024843A (en) * 1989-09-05 1991-06-18 Alza Corporation Oral hypoglycemic glipizide granulation
US5023085A (en) * 1989-11-29 1991-06-11 Pfizer Inc. Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals
US5149719A (en) * 1990-04-27 1992-09-22 Minnesota Mining And Manufacturing Company Composition for transdermal penetration of medicaments
WO1992017185A1 (en) * 1991-03-29 1992-10-15 University Of Florida Targeted drug delivery via mixed phosphate derivatives
EP0676962B9 (en) * 1992-12-31 2002-04-03 Sunkyong Industries Co., Ltd. Enhanced pharmaceutical compositions for skin penetration for piroxicam
DE4341572C1 (de) * 1993-12-07 1995-06-22 Univ Dresden Tech Zahnriemengetriebe
TW304167B (el) * 1995-01-30 1997-05-01 Lilly Co Eli
GB2306885B (en) * 1995-11-08 1999-07-14 Reckitt & Colmann Prod Ltd Supersaturated Pharmaceutical Compositions
EP0849265A1 (de) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Neue polymorphe Form von Doxazosin-Mesylat (Form II)
JP2000143540A (ja) * 1998-11-06 2000-05-23 Bristol Myers Squibb Co 非ステロイド系消炎鎮痛薬含有外用剤
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
JP4626202B2 (ja) * 2003-07-16 2011-02-02 大正製薬株式会社 ピロキシカム含有外用消炎鎮痛剤組成物
JP5619337B2 (ja) 2003-10-10 2014-11-05 フェリング ビー．ブイ． 皮膚残渣を最小限に抑えるための経皮的医薬製剤
WO2006125642A1 (en) 2005-05-27 2006-11-30 Antares Pharma Ipl Ag Methods and apparatus for transdermal or transmucosal application of testosterone
US20080319092A1 (en) * 2005-08-05 2008-12-25 Nuvo Research Inc. Transdermal Drug Delivery Formulation
PT1937276E (pt) 2005-10-12 2013-02-21 Besins Healthcare Luxembourg Gel de testosterona melhorado e método para a sua utilização
CA2646667C (en) 2006-04-21 2014-03-11 Antares Pharma Ipl Ag Methods of treating hot flashes with formulations for transdermal or transmucosal application
WO2010070705A1 (ja) * 2008-12-17 2010-06-24 株式会社メドレックス アムロジピンの安定な含水経口製剤
WO2012158405A2 (en) * 2011-05-16 2012-11-22 Pearlman Dale L Compositions and methods for the treatment of skin diseases
US8580286B2 (en) 2012-03-16 2013-11-12 Dale L. Pearlman Compositions and methods for the treatment of skin diseases
EP4054549A4 (en) 2019-11-06 2023-12-06 Smartech Topical, Inc. TOPICAL FORMULATIONS OF CYCLO-OXYGENASE INHIBITORS AND THEIR USE

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0129285A2 (en) * 1983-06-21 1984-12-27 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl)pyrrolidone
AU560908B2 (en) * 1983-06-21 1987-04-16 Procter & Gamble Company, The Topical pharmaceutical composition with penetration enhencing properties
AU568590B2 (en) * 1982-05-20 1988-01-07 Whitby Research, Inc. Penetration enhancers for transdermal drug delivery of systemic agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1538903A (en) * 1975-04-11 1979-01-24 Nelson Res & Dev Carrier for a topically applied physiologically active agent or cosmetic agent
US4316893A (en) * 1975-06-19 1982-02-23 Nelson Research & Development Co. Vehicle composition containing 1-substituted azacycloalkan-2-ones
BE843140A (fr) * 1975-06-19 1976-10-18 Aazacycloalcan-2-ones 1-substituees et compositions pharmaceutiques contenant ces composes a titre d'excipients
EP0127426A1 (en) * 1983-05-23 1984-12-05 Takeda Chemical Industries, Ltd. Percutaneous pharmaceutical compositions for external use
DK243084A (da) * 1983-05-26 1984-11-27 Takeda Chemical Industries Ltd Perkutane farmaceutiske praeparater til udvortes brug

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU568590B2 (en) * 1982-05-20 1988-01-07 Whitby Research, Inc. Penetration enhancers for transdermal drug delivery of systemic agents
EP0129285A2 (en) * 1983-06-21 1984-12-27 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl)pyrrolidone
AU560908B2 (en) * 1983-06-21 1987-04-16 Procter & Gamble Company, The Topical pharmaceutical composition with penetration enhencing properties

Also Published As

Publication number Publication date
EP0271983B1 (en) 1991-06-12
PH25498A (en) 1991-07-24
AU8054287A (en) 1988-05-05
NO874531D0 (no) 1987-10-30
RU1836078C (ru) 1993-08-23
CN87107548A (zh) 1988-05-11
NO874531L (no) 1988-05-02
IE60379B1 (en) 1994-07-13
ES2031518T3 (es) 1992-12-16
JPS63122631A (ja) 1988-05-26
YU46755B (sh) 1994-05-10
ATE64306T1 (de) 1991-06-15
MX171058B (es) 1993-09-27
NZ222346A (en) 1990-08-28
CA1338008C (en) 1996-01-30
YU196487A (sh) 1993-05-28
EG18324A (en) 1992-09-30
GR3002137T3 (en) 1992-12-30
IE872896L (en) 1988-04-30
EP0271983A1 (en) 1988-06-22
KR880004823A (ko) 1988-06-27
DK568187D0 (da) 1987-10-30
ZA878161B (en) 1989-06-28
PT86023A (en) 1987-11-01
MY102980A (en) 1993-03-31
DK568187A (da) 1988-05-01
HUT45403A (en) 1988-07-28
RU2107515C1 (ru) 1998-03-27
JPH0757725B2 (ja) 1995-06-21
NO175617C (no) 1994-11-09
KR900003697B1 (ko) 1990-05-30
NO175617B (el) 1994-08-01
HU197993B (en) 1989-07-28
PT86023B (pt) 1990-07-31
IL84269A0 (en) 1988-03-31
DE3770786D1 (de) 1991-07-18
IL84269A (en) 1991-08-16

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