AU580295B2 - New polypeptides with an anticoagulant action, a process to prepare or obtain them, their use and agents containing them - Google Patents

New polypeptides with an anticoagulant action, a process to prepare or obtain them, their use and agents containing them

Info

Publication number
AU580295B2
AU580295B2 AU41364/85A AU4136485A AU580295B2 AU 580295 B2 AU580295 B2 AU 580295B2 AU 41364/85 A AU41364/85 A AU 41364/85A AU 4136485 A AU4136485 A AU 4136485A AU 580295 B2 AU580295 B2 AU 580295B2
Authority
AU
Australia
Prior art keywords
prepare
agents containing
new polypeptides
anticoagulant action
anticoagulant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU41364/85A
Other languages
English (en)
Other versions
AU4136485A (en
Inventor
Dominique Tripier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU4136485A publication Critical patent/AU4136485A/en
Application granted granted Critical
Publication of AU580295B2 publication Critical patent/AU580295B2/en
Assigned to SCHERING AKTIENGESELLSCHAFT reassignment SCHERING AKTIENGESELLSCHAFT Alteration of Name(s) in Register under S187 Assignors: HOECHST AKTIENGESELLSCHAFT
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU41364/85A 1984-04-18 1985-04-17 New polypeptides with an anticoagulant action, a process to prepare or obtain them, their use and agents containing them Expired AU580295B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3414593 1984-04-18
DE3414593 1984-04-18
DE3438296 1984-10-19
DE19843438296 DE3438296A1 (de) 1984-04-18 1984-10-19 Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel

Publications (2)

Publication Number Publication Date
AU4136485A AU4136485A (en) 1985-10-24
AU580295B2 true AU580295B2 (en) 1989-01-12

Family

ID=25820510

Family Applications (1)

Application Number Title Priority Date Filing Date
AU41364/85A Expired AU580295B2 (en) 1984-04-18 1985-04-17 New polypeptides with an anticoagulant action, a process to prepare or obtain them, their use and agents containing them

Country Status (18)

Country Link
US (1) US4668662A (forum.php)
EP (1) EP0158986B1 (forum.php)
JP (1) JP2552263B2 (forum.php)
KR (1) KR930000054B1 (forum.php)
AR (1) AR242800A1 (forum.php)
AU (1) AU580295B2 (forum.php)
CA (1) CA1271298A (forum.php)
DE (2) DE3438296A1 (forum.php)
DK (1) DK171824B1 (forum.php)
ES (3) ES8605770A1 (forum.php)
FI (1) FI851521A7 (forum.php)
GR (1) GR850942B (forum.php)
HU (1) HU198085B (forum.php)
IE (1) IE60581B1 (forum.php)
IL (1) IL74948A (forum.php)
NO (1) NO851535L (forum.php)
PT (1) PT80301B (forum.php)
ZA (1) ZA852854B (forum.php)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3342139A1 (de) * 1983-11-22 1985-05-30 Ciba-Geigy Ag, Basel Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
DE3583361D1 (de) * 1984-06-14 1991-08-08 Ucp Gen Pharma Ag Verfahren zur herstellung von thrombin-inhibitoren.
DE3506992A1 (de) * 1985-02-27 1986-08-28 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
DE3738541A1 (de) * 1987-11-13 1989-05-24 Hoechst Ag Verfahren zur isolierung und reinigung von hirudin
FI96956C (fi) * 1985-04-11 1996-09-25 Hoechst Ag Menetelmä terapeuttisesti käyttökelpoisen hirudiinijohdannaisen valmistamiseksi
EP0209061B1 (de) * 1985-07-17 1994-01-12 Hoechst Aktiengesellschaft Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel
GB8530631D0 (en) 1985-12-12 1986-01-22 Ciba Geigy Ag Thrombin inhibitors
US6005071A (en) * 1987-01-23 1999-12-21 Merrell Pharmaceuticals Inc. Anticoagulant peptides
US5789540A (en) * 1987-01-23 1998-08-04 Merrell Pharmaceuticals Inc. Anticoagulant peptides
PT87083B (pt) * 1987-03-28 1992-07-31 Boehringer Ingelheim Int Processo para a preparacao de uma proteina anticoagulante vascular, de adn que codifica para esta proteina e de composicoes farmaceuticas que a contem
US5236898A (en) * 1987-05-21 1993-08-17 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
US5192745A (en) * 1987-05-21 1993-03-09 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
US5256559A (en) * 1988-03-04 1993-10-26 Biogen, Inc. Methods and compositions for inhibiting platelet aggregation
NZ228995A (en) * 1988-05-10 1992-03-26 Merrell Dow Pharma Hirudin peptide derivatives and pharmaceutical compositions
US4971953A (en) * 1988-05-10 1990-11-20 Merrell Dow Pharmaceuticals Anticoagulant peptide alcohols
US5114921A (en) * 1988-05-27 1992-05-19 The Children's Hospital Of Philadelphia Amphiphilic peptides and use thereof
AU626890B2 (en) * 1988-05-27 1992-08-13 Children's Hospital Of Philadelphia, The Amphiphilic peptides and use thereof
DE3819079A1 (de) * 1988-06-04 1989-12-07 Hoechst Ag Hirudin-derivate mit verzoegerter wirkung
DE3819078A1 (de) * 1988-06-04 1989-12-07 Hoechst Ag Amblyommin, ein neuer wirkstoff fuer die antikoagulationstherapie
US5268296A (en) * 1988-06-11 1993-12-07 Ciba-Geigy Corporation DNA vector and recombinant host cell for production of hirullin P6 and P18
DE58907266T2 (de) * 1988-06-11 1994-09-29 Ciba Geigy Ag Polypeptide mit einer die Koagulierung hemmenden Wirkung.
US5167960A (en) * 1988-08-03 1992-12-01 New England Deaconess Hospital Corporation Hirudin-coated biocompatible substance
US5112615A (en) * 1988-08-03 1992-05-12 New England Deaconess Hospital Corporation Soluble hirudin conjugates
DE3835815A1 (de) * 1988-10-21 1990-04-26 Hoechst Ag Neue isohirudine
US4861865A (en) * 1989-01-23 1989-08-29 Washington University Novel antithrombin peptide
US5254535A (en) * 1989-04-17 1993-10-19 The Children's Hospital Of Pennsylvania Composition and treatment with biologically active peptides and antibiotic
US5179196A (en) * 1989-05-04 1993-01-12 Sri International Purification of proteins employing ctap-iii fusions
US5192747A (en) * 1989-10-03 1993-03-09 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
DE3939801A1 (de) * 1989-12-01 1991-06-06 Basf Ag Neue proteine und ihre herstellung
JPH07504152A (ja) * 1990-02-08 1995-05-11 マゲイニン　ファーマスーティカルズ，　インコーポレーテッド 生物活性ペプチドおよび標的細胞、ウイルス、あるいはウイルス感染細胞の成長を抑制する方法
US5459237A (en) * 1990-02-08 1995-10-17 Magainin Pharmaceuticals Inc. Peptide compositions and uses therefor
US5792831A (en) * 1990-02-08 1998-08-11 Magainin Pharmaceuticals Inc. Analogues of magainin peptides containing D-amino acids
CA2035917C (en) * 1990-02-13 2001-10-02 John L. Krstenansky Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
DE4009268A1 (de) * 1990-03-22 1991-09-26 Consortium Elektrochem Ind Sekretion von hirudinderivaten
EP0533795A4 (en) * 1990-05-14 1993-10-20 Magainin Sciences, Inc. Composition of and treatment with biologically active peptides having d-amino acid residues
CA2045073A1 (en) * 1990-06-27 1991-12-28 Barry Berkowitz Composition and treatment with biologically active peptides and antibiotics which inhibit dna gyrase
US5208220A (en) * 1990-06-27 1993-05-04 Magainin Pharmaceuticals, Inc. Composition and treatment with biologically active peptides and antibiotics which inhibit DNA gyrase
ES2094228T3 (es) * 1990-07-24 1997-01-16 Merrell Pharma Inc Peptidos anticoagulantes.
US5574012A (en) * 1990-07-24 1996-11-12 Merrell Pharmaceuticals Inc. Analogs of hirudin having anti-platelet activity
US5118790A (en) * 1990-07-24 1992-06-02 Sri International Analogs of hirudin
US6514730B1 (en) * 1991-03-21 2003-02-04 Consortium für elektrochemische Industrie GmbH Secretion of hirudin derivatives
AU2901692A (en) * 1991-10-16 1993-05-21 Children's Hospital Of Philadelphia, The Composition and treatment with biologically active peptides and antibiotic
DE4140381A1 (de) * 1991-12-07 1993-06-09 Hoechst Ag, 6230 Frankfurt, De Neue synthetische isohirudine mit verbesserter stabilitaet
HUT73187A (en) * 1993-06-11 1996-06-28 Merrell Pharma Inc Trifunctional antithrombin and antiplatelet peptides
NZ270194A (en) * 1994-01-07 1996-05-28 Ciba Geigy Ag Hirustasin, a serine protease inhibitor from hirudo medicinalis
GB9401447D0 (en) 1994-01-26 1994-03-23 Ciba Geigy Ag Pharmaceutical compositions
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung
DE19529997C1 (de) 1995-08-16 1997-04-10 Hoechst Ag Verfahren zur Inaktivierung von Carboxypeptidase Y in hirudinhaltigen Kulturbrühen
DE19543737A1 (de) 1995-11-24 1997-05-28 Hoechst Ag Verfahren zur Ultrafiltration von Peptide oder Proteine enthaltender biologischer Matrices
DE19544233A1 (de) 1995-11-28 1997-06-05 Hoechst Ag Verfahren zur Nutzung des Hefe-ADH II-Promotorsystems zur biotechnologischen Produktion heterologer Proteine in hohen Ausbeuten
EP0787569B1 (en) 1996-01-31 2002-10-02 Sumitomo Bakelite Company Limited Method of producing epoxy resin-encapsulated semiconductor device
DE19607239A1 (de) 1996-02-27 1997-08-28 Behringwerke Ag Pharmazeutische Zusammensetzung, enthaltend Hirudin und Verfahren zu deren Herstellung
US7795205B2 (en) 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
CN101095697A (zh) * 2006-06-28 2008-01-02 李振国 水蛭和/或地龙分子量5800道尔顿以下的提取物
US9056118B2 (en) * 2007-06-26 2015-06-16 Mudanjiang Youbo Pharmaceutical Co., Ltd. Extract for preventing of treating thrombotic diseases
CA2744145A1 (en) * 2008-11-19 2010-05-27 Avantor Performance Materials, Inc. New chromatographic media based on phenoxy alkyl and alkoxy-or phenoxy-phenyl alkyl ligands

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3342139A1 (de) * 1983-11-22 1985-05-30 Ciba-Geigy Ag, Basel Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
EP0158564B1 (fr) * 1984-03-27 1992-07-15 Transgene S.A. Vecteurs d'expression de l'hirudine, cellules transformées et procédé de préparation de l'hirudine
DE3429430A1 (de) * 1984-08-10 1986-02-20 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens

Also Published As

Publication number Publication date
DK171824B1 (da) 1997-06-23
IL74948A0 (en) 1985-08-30
FI851521A0 (fi) 1985-04-16
IE850983L (en) 1985-10-18
IL74948A (en) 1989-09-10
DK173985A (da) 1985-10-19
ZA852854B (en) 1985-11-27
CA1271298A (en) 1990-07-03
EP0158986A3 (en) 1988-09-21
AU4136485A (en) 1985-10-24
ES8605772A1 (es) 1985-12-16
GR850942B (forum.php) 1985-11-25
EP0158986A2 (de) 1985-10-23
ES542311A0 (es) 1985-12-16
ES8605771A1 (es) 1985-12-16
NO851535L (no) 1985-10-21
KR850007801A (ko) 1985-12-09
FI851521L (fi) 1985-10-19
HUT37806A (en) 1986-02-28
HU198085B (en) 1989-07-28
FI851521A7 (fi) 1985-10-19
US4668662A (en) 1987-05-26
ES542309A0 (es) 1985-12-16
DE3587576D1 (de) 1993-10-21
DE3438296A1 (de) 1985-11-07
PT80301B (de) 1987-02-10
JPS60233098A (ja) 1985-11-19
ES542310A0 (es) 1985-12-16
IE60581B1 (en) 1994-07-27
AR242800A1 (es) 1993-05-31
DK173985D0 (da) 1985-04-17
JP2552263B2 (ja) 1996-11-06
EP0158986B1 (de) 1993-09-15
KR930000054B1 (ko) 1993-01-06
PT80301A (de) 1985-05-01
ES8605770A1 (es) 1985-12-16

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Legal Events

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PC Assignment registered

Owner name: SCHERING AKTIENGESELLSCHAFT

Free format text: FORMER OWNER WAS: HOECHST AKTIENGESELLSCHAFT