AU564876B2 - Stable plurilamellar vesicles - Google Patents
Stable plurilamellar vesiclesInfo
- Publication number
- AU564876B2 AU564876B2 AU15196/83A AU1519683A AU564876B2 AU 564876 B2 AU564876 B2 AU 564876B2 AU 15196/83 A AU15196/83 A AU 15196/83A AU 1519683 A AU1519683 A AU 1519683A AU 564876 B2 AU564876 B2 AU 564876B2
- Authority
- AU
- Australia
- Prior art keywords
- splvs
- vesicles
- entrapped
- infection
- stable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36299482A | 1982-03-29 | 1982-03-29 | |
| US36299582A | 1982-03-29 | 1982-03-29 | |
| US362994 | 1982-03-29 | ||
| US41146682A | 1982-08-25 | 1982-08-25 | |
| US411466 | 1982-08-25 | ||
| US44724782A | 1982-12-06 | 1982-12-06 | |
| US447247 | 1982-12-06 | ||
| US46390083A | 1983-02-04 | 1983-02-04 | |
| US463900 | 1983-02-04 | ||
| US06/476,496 US4522803A (en) | 1983-02-04 | 1983-03-24 | Stable plurilamellar vesicles, their preparation and use |
| US362995 | 1994-12-23 | ||
| US476496 | 1999-12-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU1519683A AU1519683A (en) | 1983-10-24 |
| AU564876B2 true AU564876B2 (en) | 1987-08-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU15196/83A Expired AU564876B2 (en) | 1982-03-29 | 1983-03-24 | Stable plurilamellar vesicles |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0092453B1 (Sortimente) |
| AU (1) | AU564876B2 (Sortimente) |
| DD (1) | DD210217A5 (Sortimente) |
| DE (1) | DE3373273D1 (Sortimente) |
| DK (1) | DK163105C (Sortimente) |
| FI (1) | FI83161C (Sortimente) |
| GR (1) | GR78163B (Sortimente) |
| HK (1) | HK96190A (Sortimente) |
| IE (1) | IE54706B1 (Sortimente) |
| IL (1) | IL68250A (Sortimente) |
| NZ (1) | NZ203746A (Sortimente) |
| PT (1) | PT76476B (Sortimente) |
| SG (1) | SG13489G (Sortimente) |
| WO (1) | WO1983003383A1 (Sortimente) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5030453A (en) * | 1983-03-24 | 1991-07-09 | The Liposome Company, Inc. | Stable plurilamellar vesicles |
| ATE159858T1 (de) * | 1983-09-26 | 1997-11-15 | Ehrenfeld Udo | Mittel und erzeugnis für die diagnose und therapie von tumoren sowie zur behandlung von schwächen der zelligen und humoralen immunabwehr |
| DE3336583A1 (de) * | 1983-09-26 | 1985-04-25 | Udo Dr. 8400 Regensburg Ehrenfeld | Erzeugnis zur diagnose und therapie von malignen tumoren |
| DE3585967D1 (de) * | 1984-03-08 | 1992-06-11 | Phares Pharma Holland | Liposombildende zusammensetzung. |
| FR2562421B1 (fr) * | 1984-04-09 | 1989-02-17 | Sandoz Sa | Perfectionnements a la therapie par l'interleukine |
| AU591466B2 (en) * | 1984-10-22 | 1989-12-07 | Vestar, Inc. | Method of delivering micellular particles encapsulating imaging and chemotherapeutic agents to tumors in a body |
| EP0179660A3 (en) * | 1984-10-26 | 1987-08-12 | The Liposome Company, Inc. | Multilayered vesicles prepared by reverse-phase evaporation |
| BE902199A (fr) * | 1984-10-29 | 1985-07-31 | Vira Tek Inc | Procede de traitement medical de maladies virales utilisant le 1-beta-d-ribofurannosyl-1, 2,4-triazole-3-carboxamide. |
| US5409704A (en) * | 1985-06-26 | 1995-04-25 | The Liposome Company, Inc. | Liposomes comprising aminoglycoside phosphates and methods of production and use |
| JP2579625B2 (ja) * | 1985-07-05 | 1997-02-05 | ザ リポソ−ム カンパニ−，インコ−ポレイテツド | 改良された取り込み効率を有するマルチラメラリポソ−ム |
| IL79114A (en) * | 1985-08-07 | 1990-09-17 | Allergan Pharma | Method and composition for making liposomes |
| US4983397A (en) * | 1985-08-19 | 1991-01-08 | Board Of Regents, University Of Texas System | Pharmaceutical compositions consisting of acylated phospholipids |
| US5068198A (en) * | 1986-03-26 | 1991-11-26 | Syntex (U.S.A.) Inc. | Liquid single reagent for assays involving confining gels |
| NZ219745A (en) * | 1986-03-26 | 1990-06-26 | Syntex Inc | Single liquid reagent for analyte binding type assays |
| JPH0751496B2 (ja) * | 1986-04-02 | 1995-06-05 | 武田薬品工業株式会社 | リポソ−ムの製造法 |
| CA1320130C (en) * | 1986-06-12 | 1993-07-13 | Alan L. Weiner | Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs |
| PT85537B (pt) * | 1986-08-18 | 1990-06-29 | Univ Texas | Processo para a preparacao de um sistema de administracao farmaceutica contendo peptidos apresentando quimiotaxia |
| MX9203808A (es) * | 1987-03-05 | 1992-07-01 | Liposome Co Inc | Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos. |
| US4914088A (en) * | 1987-04-02 | 1990-04-03 | Thomas Glonek | Dry eye treatment solution and method |
| FR2648462B1 (fr) * | 1989-06-15 | 1994-01-28 | Oreal | Procede pour ameliorer l'efficacite therapeutique de corticosteroides liposolubles et composition pour la mise en oeuvre de ce procede |
| JP4524071B2 (ja) | 2000-11-09 | 2010-08-11 | ネオファーム、インコーポレイティッド | Ｓｎ−３８脂質複合体及び使用方法 |
| WO2003030864A1 (en) | 2001-05-29 | 2003-04-17 | Neopharm, Inc. | Liposomal formulation of irinotecan |
| DE102008005673A1 (de) * | 2008-01-23 | 2009-08-20 | Universität Augsburg | Bläschen, sowie Verfahren zur Herstellung und Manipulation von Bläschen |
| US10307491B2 (en) | 2015-01-30 | 2019-06-04 | The Regents Of The University Of Michigan | Liposomal particles comprising biological molecules and uses thereof |
| CA2979712C (en) | 2015-03-25 | 2024-01-23 | The Regents Of The University Of Michigan | Nanoparticle compositions for delivery of biomacromolecules |
| US20210093565A1 (en) * | 2016-01-19 | 2021-04-01 | The Regents Of The University Of Michigan | Vesicle-encapsulated socs |
| CA3028721A1 (en) | 2016-06-20 | 2017-12-28 | The Regents Of The University Of Michigan | Compositions and methods for delivery of biomacromolecule agents |
| US11278493B2 (en) | 2018-12-10 | 2022-03-22 | EternaTear, Inc. | Ophthalmic formulations providing durable ocular lubrication |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4115544A (en) * | 1976-08-18 | 1978-09-19 | Alza Corporation | Ocular system made of bioerodible esters having linear ether |
| CH624011A5 (Sortimente) * | 1977-08-05 | 1981-07-15 | Battelle Memorial Institute | |
| US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
-
1983
- 1983-03-24 WO PCT/US1983/000419 patent/WO1983003383A1/en not_active Ceased
- 1983-03-24 AU AU15196/83A patent/AU564876B2/en not_active Expired
- 1983-03-28 GR GR70918A patent/GR78163B/el unknown
- 1983-03-28 IE IE690/83A patent/IE54706B1/en not_active IP Right Cessation
- 1983-03-28 IL IL68250A patent/IL68250A/xx not_active IP Right Cessation
- 1983-03-29 EP EP83400652A patent/EP0092453B1/en not_active Expired
- 1983-03-29 NZ NZ203746A patent/NZ203746A/en unknown
- 1983-03-29 DE DE8383400652T patent/DE3373273D1/de not_active Expired
- 1983-03-29 PT PT76476A patent/PT76476B/pt unknown
- 1983-03-29 DD DD83249304A patent/DD210217A5/de unknown
- 1983-11-28 DK DK544883A patent/DK163105C/da not_active IP Right Cessation
- 1983-11-29 FI FI834364A patent/FI83161C/fi not_active IP Right Cessation
-
1989
- 1989-02-28 SG SG134/89A patent/SG13489G/en unknown
-
1990
- 1990-11-22 HK HK961/90A patent/HK96190A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK163105C (da) | 1992-06-15 |
| PT76476A (en) | 1983-04-01 |
| DK163105B (da) | 1992-01-20 |
| EP0092453B1 (en) | 1987-09-02 |
| SG13489G (en) | 1989-07-07 |
| IL68250A0 (en) | 1983-06-15 |
| HK96190A (en) | 1990-11-30 |
| DD210217A5 (de) | 1984-06-06 |
| NZ203746A (en) | 1987-03-06 |
| DE3373273D1 (de) | 1987-10-08 |
| FI834364A7 (fi) | 1983-11-29 |
| FI83161C (fi) | 1991-06-10 |
| DK544883D0 (da) | 1983-11-28 |
| IE54706B1 (en) | 1990-01-17 |
| IL68250A (en) | 1990-02-09 |
| WO1983003383A1 (en) | 1983-10-13 |
| FI834364A0 (fi) | 1983-11-29 |
| EP0092453A3 (en) | 1983-12-07 |
| PT76476B (en) | 1985-12-10 |
| IE830690L (en) | 1983-09-29 |
| EP0092453A2 (en) | 1983-10-26 |
| AU1519683A (en) | 1983-10-24 |
| FI83161B (fi) | 1991-02-28 |
| DK544883A (da) | 1983-11-28 |
| GR78163B (Sortimente) | 1984-09-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |