AU559451B2 - Haloallylate of levallorphan - Google Patents
Haloallylate of levallorphanInfo
- Publication number
- AU559451B2 AU559451B2 AU88922/82A AU8892282A AU559451B2 AU 559451 B2 AU559451 B2 AU 559451B2 AU 88922/82 A AU88922/82 A AU 88922/82A AU 8892282 A AU8892282 A AU 8892282A AU 559451 B2 AU559451 B2 AU 559451B2
- Authority
- AU
- Australia
- Prior art keywords
- haloallylate
- levallorphan
- opiates
- bromine
- iodine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- OZYUPQUCAUTOBP-QXAKKESOSA-N Levallorphan Chemical compound C([C@H]12)CCC[C@@]11CCN(CC=C)[C@@H]2CC2=CC=C(O)C=C21 OZYUPQUCAUTOBP-QXAKKESOSA-N 0.000 title abstract 2
- 229960000263 levallorphan Drugs 0.000 title abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 229940127240 opiate Drugs 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229940124531 pharmaceutical excipient Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8119607 | 1981-10-19 | ||
| FR8119607A FR2514644A1 (fr) | 1981-10-19 | 1981-10-19 | Composition pharmaceutique a action antagoniste peripherique des opiaces |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU8892282A AU8892282A (en) | 1983-04-28 |
| AU559451B2 true AU559451B2 (en) | 1987-03-12 |
Family
ID=9263165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU88922/82A Expired - Fee Related AU559451B2 (en) | 1981-10-19 | 1982-09-30 | Haloallylate of levallorphan |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4489079A (enExample) |
| EP (1) | EP0077723B1 (enExample) |
| JP (1) | JPS5874608A (enExample) |
| AT (1) | ATE17942T1 (enExample) |
| AU (1) | AU559451B2 (enExample) |
| DE (1) | DE3269082D1 (enExample) |
| FR (1) | FR2514644A1 (enExample) |
| IL (1) | IL66853A (enExample) |
| NZ (1) | NZ202210A (enExample) |
| ZA (1) | ZA827063B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2547820B1 (fr) * | 1983-06-24 | 1986-04-18 | Midy Spa | Antagonistes peripheriques des opiaces |
| US5624958A (en) * | 1987-12-31 | 1997-04-29 | Isaacs; Charles E. | Disinfecting contact lenses |
| US5552406A (en) * | 1994-06-17 | 1996-09-03 | The Mclean Hospital Corporation | Method for treating pain and brain perfusion abnormalities using mixed opioid agonist-antagonists |
| DE19752080A1 (de) * | 1997-11-25 | 1999-07-29 | Karlsruhe Forschzent | Verfahren zur Herstellung eines mehrkomponentigen, oxidischen Keramikpulvers |
| US6469030B2 (en) * | 1999-11-29 | 2002-10-22 | Adolor Corporation | Methods for the treatment and prevention of ileus |
| EP1244448B1 (en) * | 1999-11-29 | 2009-05-27 | Adolor Corporation | Novel methods for the treatment and prevention of ileus |
| DK2939696T3 (en) * | 2001-10-18 | 2016-05-23 | Nektar Therapeutics | Polymer Conjugates of Opioid Antagonists |
| US20050191340A1 (en) * | 2002-08-09 | 2005-09-01 | Gruenenthal Gmbh | Opioid-receptor antagonists in transdermal systems having buprenorphine |
| DK1694363T3 (en) * | 2003-12-16 | 2014-03-24 | Nektar Therapeutics | Monodisperse PEGylated Naloxole Compositions |
| EP2190819B1 (en) | 2007-08-09 | 2016-05-25 | Rensselaer Polytechnic Institute | Quaternary opioid carboxamides |
| NZ600379A (en) | 2009-12-04 | 2014-05-30 | Alkermes Pharma Ireland Ltd | Morphinan derivatives for the treatment of drug overdose |
| US8436175B2 (en) * | 2010-03-22 | 2013-05-07 | Rensselaer Polytechnic Institute | Carboxamide bioisosteres of opiates |
| SI3446565T1 (sl) | 2010-08-23 | 2024-03-29 | Alkermes Pharma Ireland Limited | Metode zdravljenja povečanja teže, povzročene z antipsihotiki |
| RS56181B1 (sr) | 2011-06-29 | 2017-11-30 | Alkermes Inc | Periferno delujuća opioidna jedinjenja |
| US9211293B2 (en) | 2011-12-15 | 2015-12-15 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
| US9656961B2 (en) | 2013-05-24 | 2017-05-23 | Alkermes Pharma Ireland Limited | Methods for treating depressive symptoms |
| JP2016519161A (ja) | 2013-05-24 | 2016-06-30 | アルカームス ファーマ アイルランド リミテッド | モルファン及びモルフィナン類似物及び使用の方法 |
| EP4243768A1 (en) | 2020-11-12 | 2023-09-20 | Alkermes Pharma Ireland Limited | Immediate release multilayer tablet |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4176186A (en) * | 1978-07-28 | 1979-11-27 | Boehringer Ingelheim Gmbh | Quaternary derivatives of noroxymorphone which relieve intestinal immobility |
-
1981
- 1981-10-19 FR FR8119607A patent/FR2514644A1/fr active Granted
-
1982
- 1982-09-22 IL IL66853A patent/IL66853A/xx unknown
- 1982-09-24 US US06/422,568 patent/US4489079A/en not_active Expired - Fee Related
- 1982-09-27 ZA ZA827063A patent/ZA827063B/xx unknown
- 1982-09-30 AU AU88922/82A patent/AU559451B2/en not_active Expired - Fee Related
- 1982-10-12 JP JP57177719A patent/JPS5874608A/ja active Pending
- 1982-10-13 DE DE8282401876T patent/DE3269082D1/de not_active Expired
- 1982-10-13 AT AT82401876T patent/ATE17942T1/de not_active IP Right Cessation
- 1982-10-13 EP EP82401876A patent/EP0077723B1/fr not_active Expired
- 1982-10-18 NZ NZ202210A patent/NZ202210A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL66853A0 (en) | 1982-12-31 |
| ZA827063B (en) | 1983-07-27 |
| US4489079A (en) | 1984-12-18 |
| EP0077723B1 (fr) | 1986-02-12 |
| FR2514644B1 (enExample) | 1984-04-20 |
| IL66853A (en) | 1985-08-30 |
| DE3269082D1 (en) | 1986-03-27 |
| AU8892282A (en) | 1983-04-28 |
| NZ202210A (en) | 1985-03-20 |
| JPS5874608A (ja) | 1983-05-06 |
| FR2514644A1 (fr) | 1983-04-22 |
| ATE17942T1 (de) | 1986-02-15 |
| EP0077723A1 (fr) | 1983-04-27 |
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