AU551523B2 - Quaternary piperidinium halides - Google Patents
Quaternary piperidinium halidesInfo
- Publication number
- AU551523B2 AU551523B2 AU81485/82A AU8148582A AU551523B2 AU 551523 B2 AU551523 B2 AU 551523B2 AU 81485/82 A AU81485/82 A AU 81485/82A AU 8148582 A AU8148582 A AU 8148582A AU 551523 B2 AU551523 B2 AU 551523B2
- Authority
- AU
- Australia
- Prior art keywords
- compound
- encainide
- methoxybenzoyl
- phenyl
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- -1 piperidinium halides Chemical class 0.000 title description 7
- 150000001875 compounds Chemical class 0.000 claims description 11
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 3
- 229910052794 bromium Inorganic materials 0.000 claims description 3
- 239000000460 chlorine Substances 0.000 claims description 3
- 229910052801 chlorine Inorganic materials 0.000 claims description 3
- VOGFBLDDNZRUDZ-UHFFFAOYSA-N n-[2-[2-(1,1-dimethylpiperidin-1-ium-2-yl)ethyl]phenyl]-4-methoxybenzamide;iodide Chemical compound [I-].C1=CC(OC)=CC=C1C(=O)NC1=CC=CC=C1CCC1[N+](C)(C)CCCC1 VOGFBLDDNZRUDZ-UHFFFAOYSA-N 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- PARNNBHKHKKNQF-UHFFFAOYSA-N n-[2-[2-(1-benzyl-1-methylpiperidin-1-ium-2-yl)ethyl]phenyl]-4-methoxybenzamide;bromide Chemical compound [Br-].C1=CC(OC)=CC=C1C(=O)NC1=CC=CC=C1CCC1[N+](CC=2C=CC=CC=2)(C)CCCC1 PARNNBHKHKKNQF-UHFFFAOYSA-N 0.000 claims 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 15
- PJWPNDMDCLXCOM-UHFFFAOYSA-N encainide Chemical compound C1=CC(OC)=CC=C1C(=O)NC1=CC=CC=C1CCC1N(C)CCCC1 PJWPNDMDCLXCOM-UHFFFAOYSA-N 0.000 description 11
- 229960001142 encainide Drugs 0.000 description 11
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 6
- 238000005481 NMR spectroscopy Methods 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 239000003416 antiarrhythmic agent Substances 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 230000003288 anthiarrhythmic effect Effects 0.000 description 3
- 150000004820 halides Chemical class 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical group C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
- 206010003119 arrhythmia Diseases 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000011630 iodine Substances 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- LOUPRKONTZGTKE-LHHVKLHASA-N quinidine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-LHHVKLHASA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 1
- 125000001999 4-Methoxybenzoyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C(*)=O 0.000 description 1
- 208000008457 Neurologic Manifestations Diseases 0.000 description 1
- 241000906446 Theraps Species 0.000 description 1
- 206010047281 Ventricular arrhythmia Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- AGEZXYOZHKGVCM-UHFFFAOYSA-N benzyl bromide Chemical compound BrCC1=CC=CC=C1 AGEZXYOZHKGVCM-UHFFFAOYSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 1
- 231100001231 less toxic Toxicity 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- XICNVRJHHCHOGI-UHFFFAOYSA-N n-[2-[2-(1-benzyl-1-methylpiperidin-1-ium-2-yl)ethyl]phenyl]-4-methoxybenzamide;bromide;hydrate Chemical compound O.[Br-].C1=CC(OC)=CC=C1C(=O)NC1=CC=CC=C1CCC1[N+](CC=2C=CC=CC=2)(C)CCCC1 XICNVRJHHCHOGI-UHFFFAOYSA-N 0.000 description 1
- 230000007971 neurological deficit Effects 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000003386 piperidinyl group Chemical group 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 229960001404 quinidine Drugs 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/229,244 US4321386A (en) | 1981-01-28 | 1981-01-28 | Quaternary piperidinium halides |
| US229244 | 1994-04-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU8148582A AU8148582A (en) | 1982-08-16 |
| AU551523B2 true AU551523B2 (en) | 1986-05-01 |
Family
ID=22860396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU81485/82A Ceased AU551523B2 (en) | 1981-01-28 | 1982-01-27 | Quaternary piperidinium halides |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4321386A (enExample) |
| JP (1) | JPH0348904B2 (enExample) |
| AR (1) | AR230266A1 (enExample) |
| AT (1) | AT378183B (enExample) |
| AU (1) | AU551523B2 (enExample) |
| BE (1) | BE891938A (enExample) |
| CA (1) | CA1184917A (enExample) |
| CH (1) | CH651021A5 (enExample) |
| DE (1) | DE3223499T1 (enExample) |
| DK (1) | DK156649C (enExample) |
| FI (1) | FI65239C (enExample) |
| GB (1) | GB2100736B (enExample) |
| GR (1) | GR74720B (enExample) |
| IE (1) | IE52420B1 (enExample) |
| IT (1) | IT1147809B (enExample) |
| NL (1) | NL8220049A (enExample) |
| SE (1) | SE435057B (enExample) |
| WO (1) | WO1982002551A1 (enExample) |
| YU (1) | YU43063B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI1007624A2 (pt) * | 2009-04-09 | 2016-07-26 | Cognition Therapeutics Inc | composto, método para preparar uma composição, composto ou sal farmaceuticamente aceitável deste e uso de um composto ou um sal farmaceuticamente aceitável deste |
| SG10201506978UA (en) | 2009-07-31 | 2015-10-29 | Cognition Therapeutics Inc | Inhibitors Of Cognitive Decline |
| WO2012106426A1 (en) | 2011-02-02 | 2012-08-09 | Cognition Therapeutics, Inc. | Isolated compounds from turmeric oil and methods of use |
| EP3099296B1 (en) | 2014-01-31 | 2019-01-30 | Cognition Therapeutics, Inc. | Isoindoline derivative, compositions and methods for treating neurodegenerative disease |
| US11214540B2 (en) | 2017-05-15 | 2022-01-04 | Cognition Therapeutics, Inc. | Compositions for treating neurodegenerative diseases |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3037910A (en) * | 1958-04-18 | 1962-06-05 | Burroughs Wellcome Co | Process for treatment of hypertension |
| US3931195A (en) * | 1971-03-03 | 1976-01-06 | Mead Johnson & Company | Substituted piperidines |
| US3917679A (en) * | 1974-04-12 | 1975-11-04 | Lilly Co Eli | Quaternary ammonium salts of N-dialkylaminoalkyl-N-(2-indanyl)anilines |
-
1981
- 1981-01-28 US US06/229,244 patent/US4321386A/en not_active Expired - Lifetime
-
1982
- 1982-01-27 CH CH5828/82A patent/CH651021A5/de not_active IP Right Cessation
- 1982-01-27 WO PCT/US1982/000108 patent/WO1982002551A1/en not_active Ceased
- 1982-01-27 JP JP57500784A patent/JPH0348904B2/ja not_active Expired - Lifetime
- 1982-01-27 AT AT0900782A patent/AT378183B/de active
- 1982-01-27 DE DE823223499T patent/DE3223499T1/de active Granted
- 1982-01-27 AU AU81485/82A patent/AU551523B2/en not_active Ceased
- 1982-01-27 GB GB08220076A patent/GB2100736B/en not_active Expired
- 1982-01-28 BE BE0/207171A patent/BE891938A/fr not_active IP Right Cessation
- 1982-01-28 YU YU197/82A patent/YU43063B/xx unknown
- 1982-01-28 IE IE191/82A patent/IE52420B1/en unknown
- 1982-01-28 NL NL8220049A patent/NL8220049A/nl unknown
- 1982-01-28 CA CA000395068A patent/CA1184917A/en not_active Expired
- 1982-01-28 AR AR288281A patent/AR230266A1/es active
- 1982-01-28 GR GR67146A patent/GR74720B/el unknown
- 1982-01-28 IT IT47667/82A patent/IT1147809B/it active
- 1982-07-08 FI FI822443A patent/FI65239C/fi not_active IP Right Cessation
- 1982-09-27 DK DK429382A patent/DK156649C/da not_active IP Right Cessation
- 1982-09-28 SE SE8205535A patent/SE435057B/sv not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AR230266A1 (es) | 1984-03-01 |
| AT378183B (de) | 1985-06-25 |
| IT1147809B (it) | 1986-11-26 |
| SE435057B (sv) | 1984-09-03 |
| US4321386A (en) | 1982-03-23 |
| AU8148582A (en) | 1982-08-16 |
| IT8247667A0 (it) | 1982-01-28 |
| GB2100736A (en) | 1983-01-06 |
| DK156649C (da) | 1990-02-05 |
| GR74720B (enExample) | 1984-07-10 |
| JPS57502216A (enExample) | 1982-12-16 |
| ATA900782A (de) | 1984-11-15 |
| DE3223499C2 (enExample) | 1989-11-23 |
| SE8205535L (sv) | 1982-09-28 |
| FI822443A0 (fi) | 1982-07-08 |
| GB2100736B (en) | 1985-01-30 |
| NL8220049A (nl) | 1982-11-01 |
| FI65239B (fi) | 1983-12-30 |
| YU19782A (en) | 1985-04-30 |
| DK156649B (da) | 1989-09-18 |
| YU43063B (en) | 1989-02-28 |
| FI65239C (fi) | 1984-04-10 |
| IE52420B1 (en) | 1987-10-28 |
| FI822443L (fi) | 1982-07-08 |
| BE891938A (fr) | 1982-07-28 |
| CA1184917A (en) | 1985-04-02 |
| IE820191L (en) | 1982-07-28 |
| DE3223499T1 (de) | 1983-01-13 |
| SE8205535D0 (sv) | 1982-09-28 |
| DK429382A (da) | 1982-09-27 |
| CH651021A5 (de) | 1985-08-30 |
| JPH0348904B2 (enExample) | 1991-07-25 |
| WO1982002551A1 (en) | 1982-08-05 |
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