AU535320B2 - 2-(2-(1,4-benzodioxanyl))-2-imidazoling derivatives - Google Patents

2-(2-(1,4-benzodioxanyl))-2-imidazoling derivatives

Info

Publication number
AU535320B2
AU535320B2 AU66758/81A AU6675881A AU535320B2 AU 535320 B2 AU535320 B2 AU 535320B2 AU 66758/81 A AU66758/81 A AU 66758/81A AU 6675881 A AU6675881 A AU 6675881A AU 535320 B2 AU535320 B2 AU 535320B2
Authority
AU
Australia
Prior art keywords
compound
salt
presynaptic
ethyl
toxic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU66758/81A
Other languages
English (en)
Other versions
AU6675881A (en
Inventor
Christopher Bourne Chapleo
Peter Leslie Myers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Reckitt and Colman Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt and Colman Products Ltd filed Critical Reckitt and Colman Products Ltd
Publication of AU6675881A publication Critical patent/AU6675881A/en
Application granted granted Critical
Publication of AU535320B2 publication Critical patent/AU535320B2/en
Assigned to PIERRE FABRE MEDICAMENT SA reassignment PIERRE FABRE MEDICAMENT SA Alteration of Name(s) in Register under S187 Assignors: RECKITT & COLMAN PRODUCTS LIMITED
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU66758/81A 1980-02-04 1981-01-30 2-(2-(1,4-benzodioxanyl))-2-imidazoling derivatives Ceased AU535320B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8003636 1980-02-04
GB8003636 1980-02-04

Publications (2)

Publication Number Publication Date
AU6675881A AU6675881A (en) 1981-08-13
AU535320B2 true AU535320B2 (en) 1984-03-15

Family

ID=10511105

Family Applications (1)

Application Number Title Priority Date Filing Date
AU66758/81A Ceased AU535320B2 (en) 1980-02-04 1981-01-30 2-(2-(1,4-benzodioxanyl))-2-imidazoling derivatives

Country Status (26)

Country Link
US (1) US4818764A (esLanguage)
EP (1) EP0033655B1 (esLanguage)
JP (1) JPS56122378A (esLanguage)
AR (1) AR225794A1 (esLanguage)
AT (1) ATE7228T1 (esLanguage)
AU (1) AU535320B2 (esLanguage)
CA (1) CA1156241A (esLanguage)
CS (1) CS254956B2 (esLanguage)
DD (1) DD155991A5 (esLanguage)
DE (1) DE3163256D1 (esLanguage)
DK (1) DK160092C (esLanguage)
ES (1) ES499034A0 (esLanguage)
FI (1) FI67543C (esLanguage)
GB (1) GB2068376B (esLanguage)
GR (1) GR73853B (esLanguage)
HU (1) HU187295B (esLanguage)
IE (1) IE51736B1 (esLanguage)
IL (1) IL62039A (esLanguage)
NO (1) NO154882C (esLanguage)
NZ (1) NZ196162A (esLanguage)
PH (1) PH16249A (esLanguage)
PL (1) PL128368B1 (esLanguage)
PT (1) PT72435B (esLanguage)
SU (1) SU1128837A3 (esLanguage)
ZA (1) ZA81666B (esLanguage)
ZW (1) ZW2381A1 (esLanguage)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199469A (en) * 1981-01-30 1984-03-16 Reckitt & Colmann Prod Ltd Benzodioxanyl-2-imidazoline derivatives and pharmaceutical compositions
US4436914A (en) * 1981-08-03 1984-03-13 Kluge Arthur F Benzodioxane-imidazoline compounds as antihypertensives
NZ203680A (en) * 1982-04-17 1985-08-16 Reckitt & Colmann Prod Ltd Imidazolines and pharmaceutical compositions
FR2527208B1 (fr) * 1982-05-19 1985-07-19 Inst Nat Sante Rech Med Isomeres optiques de la (benzodioxanne-1,4 yl-2)-2d-2 imidazoline, leur preparation et leur application en therapeutique
DE3367391D1 (en) * 1982-12-23 1986-12-11 Ici America Inc Chroman compounds
US4634714A (en) * 1983-12-01 1987-01-06 American Home Products Corporation Inhibition of prolactin release by a benzodioxinylimidazoline derivative
US4882343A (en) * 1987-08-28 1989-11-21 G. D. Searle & Co. Biarylalkylimidazole derivatives as anti-depressants
US5240930A (en) * 1987-09-02 1993-08-31 National Research Development Corporation Pharmaceutical compositions for treatment of depression and low blood pressure
GB8720600D0 (en) * 1987-09-02 1987-10-07 Saad Al Damluji Pharmaceutical compositions
FR2698789B1 (fr) * 1992-12-07 1995-03-03 Pf Medicament Utilisation de l'idazoxan et ses dérivés pour la préparation d'un médicament destiné au traitement de la maladie de Parkinson et de son évolution.
FR2700113B1 (fr) * 1993-01-07 1995-03-24 Pf Medicament Utilisation de l'Idazoxan et ses dérivés pour la fabrication de médicaments destinés au traitement des maladies neurodégénératives et en particulier l'évolution de la maladie d'Alzheimer.
US5574059A (en) * 1995-10-27 1996-11-12 Cornell Research Foundation, Inc. Treating disorders mediated by vascular smooth muscle cell proliferation
FR2795727B1 (fr) * 1999-06-29 2001-09-21 Pf Medicament Nouveaux derives benzodioxanne imidazolines fluores, leur preparation et leurs applications en therapeutique
FR2801786B1 (fr) * 1999-12-01 2002-03-01 Fabre Pierre Cosmetique Nouvelles compositions topiques a base d'idazoxan et de cafeine ou de ses derives solubles et leur utilisation comme amincissant et/ou dans le traitement de la cellulite
AU2001243297A1 (en) * 2000-02-29 2001-09-12 Merck Frosst Canada And Co. Method for treating or preventing depression
FR2861299B1 (fr) * 2003-10-28 2006-01-27 Pf Medicament Compositions pharmaceutiques a base de derives d'idasoxan sous formes polymorphes
US7595335B2 (en) * 2003-10-28 2009-09-29 Pierre Fabre Medicament Pharmaceutical composition based on idazoxan, salts, hydrates or polymorphs thereof
US8476307B2 (en) * 2003-10-28 2013-07-02 Pierre Fabre Medicament Pharmaceutical composition based on idazoxan, salts, hydrates or polymorphs thereof
EP4479365A4 (en) * 2022-02-16 2026-03-11 Terran Biosciences Inc IDAZOXAN DEUTERE AND ITS METHODS OF USE

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2641601A (en) * 1950-11-24 1953-06-09 Hoffmann La Roche Furans and method of preparation
US2979511A (en) * 1959-03-25 1961-04-11 Olin Mathieson Certain 1, 4-benzodioxanyl imidazolines and corresponding pyrimidines and process
EP0003732B1 (en) * 1978-02-01 1983-10-19 The Wellcome Foundation Limited Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof
US4302469A (en) * 1980-09-10 1981-11-24 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
US4315021A (en) * 1980-12-03 1982-02-09 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles
US4301171A (en) * 1980-12-03 1981-11-17 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)benzimidazoles useful as anti-depressants
US4436914A (en) * 1981-08-03 1984-03-13 Kluge Arthur F Benzodioxane-imidazoline compounds as antihypertensives
US4352809A (en) * 1981-09-04 1982-10-05 Smithkline Corporation Method of producing alpha2 antagonism

Also Published As

Publication number Publication date
ES8202553A1 (es) 1982-02-01
EP0033655A3 (en) 1981-11-25
US4818764A (en) 1989-04-04
ES499034A0 (es) 1982-02-01
CS254956B2 (en) 1988-02-15
PH16249A (en) 1983-08-16
JPS56122378A (en) 1981-09-25
NZ196162A (en) 1983-06-17
PT72435B (pt) 1982-01-29
DK45081A (da) 1981-08-05
PL128368B1 (en) 1984-01-31
HU187295B (en) 1985-12-28
NO154882B (no) 1986-09-29
FI67543C (fi) 1985-04-10
IE810199L (en) 1981-08-04
IL62039A0 (en) 1981-03-31
EP0033655A2 (en) 1981-08-12
DE3163256D1 (en) 1984-05-30
PL229488A1 (esLanguage) 1981-10-16
PT72435A (en) 1981-03-01
CA1156241A (en) 1983-11-01
ZA81666B (en) 1982-04-28
GB2068376B (en) 1983-06-22
IE51736B1 (en) 1987-03-18
CS73881A2 (en) 1987-07-16
ATE7228T1 (de) 1984-05-15
DK160092C (da) 1991-06-24
DD155991A5 (de) 1982-07-21
GB2068376A (en) 1981-08-12
AU6675881A (en) 1981-08-13
DK160092B (da) 1991-01-28
NO810351L (no) 1981-08-05
AR225794A1 (es) 1982-04-30
FI810288L (fi) 1981-08-05
SU1128837A3 (ru) 1984-12-07
NO154882C (no) 1987-01-07
ZW2381A1 (en) 1981-06-24
GR73853B (esLanguage) 1984-05-07
EP0033655B1 (en) 1984-04-25
IL62039A (en) 1985-01-31
FI67543B (fi) 1984-12-31
JPH0231077B2 (esLanguage) 1990-07-11

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired