AU533641B2 - Imidazodiaze pine derivaties - Google Patents

Imidazodiaze pine derivaties

Info

Publication number
AU533641B2
AU533641B2 AU62782/80A AU6278280A AU533641B2 AU 533641 B2 AU533641 B2 AU 533641B2 AU 62782/80 A AU62782/80 A AU 62782/80A AU 6278280 A AU6278280 A AU 6278280A AU 533641 B2 AU533641 B2 AU 533641B2
Authority
AU
Australia
Prior art keywords
ethyl
methyl
oxo
formula
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired, expires
Application number
AU62782/80A
Other languages
English (en)
Other versions
AU6278280A (en
Inventor
Max Gerecke
Willy Haefely
Walter Hunkeler
Emilio Kyburz
Hanns Mohler
Lorenzo Pieri
Petar Polc
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27509256&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU533641(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU6278280A publication Critical patent/AU6278280A/en
Application granted granted Critical
Publication of AU533641B2 publication Critical patent/AU533641B2/en
Assigned to F. HOFFMANN-LA ROCHE AG reassignment F. HOFFMANN-LA ROCHE AG Alteration of Name(s) in Register under S187 Assignors: F. HOFFMANN-LA ROCHE & CO.
Adjusted expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU62782/80A 1979-10-04 1980-09-29 Imidazodiaze pine derivaties Expired AU533641B2 (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
CH897279 1979-10-04
CH897179 1979-10-04
CH897179 1979-10-04
CH897279 1979-10-04
CH1066579 1979-11-30
CH1066579 1979-11-30
CH1066479 1979-11-30
CH1066479 1979-11-30
CH571680 1980-07-25
CH571680 1980-07-25

Publications (2)

Publication Number Publication Date
AU6278280A AU6278280A (en) 1981-04-09
AU533641B2 true AU533641B2 (en) 1983-12-01

Family

ID=27509256

Family Applications (1)

Application Number Title Priority Date Filing Date
AU62782/80A Expired AU533641B2 (en) 1979-10-04 1980-09-29 Imidazodiaze pine derivaties

Country Status (23)

Country Link
US (10) US4316839A (enExample)
EP (1) EP0027214B1 (enExample)
JP (1) JPH01156968A (enExample)
AR (1) AR227293A1 (enExample)
AU (1) AU533641B2 (enExample)
BR (1) BR8006404A (enExample)
CA (1) CA1143728A (enExample)
DE (1) DE3067868D1 (enExample)
DK (1) DK168094B1 (enExample)
FI (1) FI73683C (enExample)
GB (1) GB2060632B (enExample)
GR (1) GR70772B (enExample)
HU (1) HU182675B (enExample)
IE (1) IE50318B1 (enExample)
IL (1) IL61160A (enExample)
LU (1) LU88298I2 (enExample)
MC (1) MC1355A1 (enExample)
NL (1) NL930056I2 (enExample)
NO (1) NO155774C (enExample)
NZ (1) NZ195071A (enExample)
PH (1) PH16607A (enExample)
PT (1) PT71874B (enExample)
ZW (1) ZW21580A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU622206B2 (en) * 1988-08-05 1992-04-02 Nihon Medi-Physics Co., Ltd. Radioiodine benzodiazepine derivatives

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1143728A (en) * 1979-10-04 1983-03-29 Max Gerecke Imidazodiazepine derivatives
CA1174673A (en) * 1981-02-27 1984-09-18 Walter Hunkeler Imidazodiazepines
CA1184175A (en) * 1981-02-27 1985-03-19 Walter Hunkeler Imidazodiazepines
US4352817A (en) * 1981-02-27 1982-10-05 Hoffmann-La Roche Inc. Imidazo-diazepines and their use
CA1173441A (en) * 1981-02-27 1984-08-28 Hoffmann-La Roche Limited Imidazodiazepines
CA1185602A (en) * 1981-02-27 1985-04-16 Emilio Kyburz Imidazodiazepines
MC1528A1 (fr) * 1982-07-21 1984-04-13 Hoffmann La Roche Imidazobenzodiazepines
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
US4723003A (en) * 1983-05-18 1988-02-02 Hoechst-Roussel Pharmaceuticals Inc. Benzopyrrolobenzodiazepines and quinobenzodiazepines
CS249146B2 (en) * 1984-01-19 1987-03-12 Hoffmann La Roche Method of new imidazodiazepine's derivatives production
AU587802B2 (en) * 1985-03-08 1989-08-31 Ferrosan A/S Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
US4622321A (en) * 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method
US4745112A (en) * 1985-05-17 1988-05-17 A/S Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method III
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
FI880814A7 (fi) * 1987-03-10 1988-09-11 Hoffmann La Roche Imidazodiazepin-derivat.
GB8720414D0 (en) * 1987-08-28 1987-10-07 Roussel Lab Ltd Chemical compounds
US5096695A (en) * 1988-08-05 1992-03-17 Hoffmann-Laroche Inc. Radioiodine benzodiazepines as brain imaging agents
CA1327572C (en) * 1988-08-31 1994-03-08 F. Hoffmann-La Roche Ag Imidazodiazepine derivatives
GB8909700D0 (en) * 1989-04-27 1989-06-14 Roussel Lab Ltd Chemical compounds
CA2015336A1 (en) * 1989-05-19 1990-11-19 F. Hoffmann-La Roche Ag Imidazodiazepines for the treatment of neurological symptoms
FR2660310B1 (fr) * 1990-03-27 1992-06-05 Adir Nouveaux derives de la 4h-pyrrolo[1,2a] thieno[2,3-f] diazepine[1,4], leur procede de preparation et les compositions pharmaceutiques les renfermant.
US5276028A (en) * 1990-06-22 1994-01-04 Nordisk A/S Imidazoquinoxaline compounds
US5371080A (en) * 1990-06-22 1994-12-06 Novo Nordisk A/S Imidazoquinazoline compounds and their use
TW201311B (enExample) * 1991-06-17 1993-03-01 Hoffmann La Roche
US5565449A (en) * 1991-10-18 1996-10-15 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5438035A (en) * 1994-06-24 1995-08-01 American Cyanamid Company Methods for controlling undesirable plant species with benzodiazepine compounds
TW349100B (en) * 1994-11-11 1999-01-01 Hoffmann La Roche Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines
US5670640A (en) 1996-02-02 1997-09-23 Hoffmann-La Roche Inc. Process for the manufacture of imidazodiazepine derivatives
GB2328940B (en) * 1997-09-05 1999-12-08 Dong Kook Pharm Co Ltd A process for preparing benzodiazepine derivatives
PT1691811E (pt) 2003-12-11 2014-10-30 Sunovion Pharmaceuticals Inc Combinação de um sedativo e de um modulador de neurotransmissores e métodos para melhorar a qualidade do sono e tratamento da depressão
ATE402707T1 (de) 2004-10-12 2008-08-15 Hoffmann La Roche Imidazoä1,5aütriazoloä1,5dübenzodiazepin- derivative zur behandlung kognitiver störungen
RU2007114763A (ru) 2004-10-20 2008-11-27 Ф.Хоффманн-Ля Рош Аг (Ch) Галогенозамещенные производные бензодиазепинов
NZ554439A (en) 2004-10-20 2009-09-25 Hoffmann La Roche Imidazo-benzodiazepine derivatives
WO2006063708A1 (en) 2004-12-14 2006-06-22 F.Hoffmann-La Roche Ag Tetracyclic imidazo-benzodiazepines as gaba receptors modulators
US7595395B2 (en) * 2005-05-16 2009-09-29 Wisys Technology Foundation Gabaergic agents to treat memory deficits
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP2275096A3 (en) 2005-08-26 2011-07-13 Braincells, Inc. Neurogenesis via modulation of the muscarinic receptors
WO2007047978A2 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
CA2643199A1 (en) * 2006-03-08 2007-09-13 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2008030651A1 (en) * 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
EP2066355A2 (en) * 2006-09-19 2009-06-10 Braincells, Inc. Combination comprising a peroxisome proliferator activated receptor agent and a second neurogenic agent for treating a nervous system disorder, increasing neurodifferentiation and increasing neurogenesis
CN101827597B (zh) * 2007-08-20 2013-03-13 伊沃泰克国际有限责任公司 睡眠障碍的治疗
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
US20090270373A1 (en) * 2008-04-11 2009-10-29 Cypress Biosciences, Inc. Treatment of down syndrom with benzodiazepine receptor antagonists
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
GB0917612D0 (en) * 2009-10-08 2009-11-25 Ge Healthcare Ltd In vivo imaging agents
AU2012221704B2 (en) 2011-02-23 2013-12-05 Coeruleus Ltd. Flumazenil complexes, compositions comprising same and uses thereof
CN102267999B (zh) * 2011-07-15 2013-05-29 海南美兰史克制药有限公司 一种氟马西尼化合物及其制法

Family Cites Families (7)

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US3933794A (en) * 1971-08-04 1976-01-20 The Upjohn Company 2-(2-Alkynylamino)-3H-1,4-benzodiazepines
US4002610A (en) * 1975-09-22 1977-01-11 Mcneil Laboratories, Incorporated 2-Aminobenzodiazepine-5-ones
US4031079A (en) * 1975-09-22 1977-06-21 Mcneil Laboratories, Incorporated Intermediates for 2-aminobenzodiazepine-5-ones
US4118386A (en) * 1977-04-04 1978-10-03 Hoffmann-La Roche Inc. Synthesis of imidazo[1,5-a]diazepine-3-carboxylates
ZA806016B (en) * 1979-10-04 1981-09-30 Hoffmann La Roche Imidazodiazepine derivatives
CA1143728A (en) * 1979-10-04 1983-03-29 Max Gerecke Imidazodiazepine derivatives
JPH089074B2 (ja) * 1987-07-02 1996-01-31 株式会社アマダ タレツトパンチプレス

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU622206B2 (en) * 1988-08-05 1992-04-02 Nihon Medi-Physics Co., Ltd. Radioiodine benzodiazepine derivatives

Also Published As

Publication number Publication date
CA1143728A (en) 1983-03-29
AU6278280A (en) 1981-04-09
US4346032A (en) 1982-08-24
EP0027214A1 (de) 1981-04-22
NO155774B (no) 1987-02-16
DE3067868D1 (en) 1984-06-20
IE50318B1 (en) 1986-04-02
US4346036A (en) 1982-08-24
MC1355A1 (fr) 1981-08-10
GB2060632A (en) 1981-05-07
US4346034A (en) 1982-08-24
NL930056I1 (nl) 1993-09-01
NL930056I2 (nl) 1993-11-16
DK391280A (da) 1981-04-05
IL61160A (en) 1983-07-31
NO155774C (no) 1987-05-27
ZW21580A1 (en) 1981-04-29
US4346033A (en) 1982-08-24
JPH01156968A (ja) 1989-06-20
DK168094B1 (da) 1994-02-07
FI73683C (fi) 1987-11-09
GR70772B (enExample) 1983-03-22
FI73683B (fi) 1987-07-31
PH16607A (en) 1983-11-24
US4346030A (en) 1982-08-24
JPH0369913B2 (enExample) 1991-11-05
US4316839A (en) 1982-02-23
GB2060632B (en) 1983-11-02
PT71874A (en) 1980-11-01
BR8006404A (pt) 1981-04-14
IE802056L (en) 1981-04-04
EP0027214B1 (de) 1984-05-16
NO802946L (no) 1981-04-06
HU182675B (en) 1984-02-28
US4346031A (en) 1982-08-24
US4363762A (en) 1982-12-14
FI803135L (fi) 1981-04-05
LU88298I2 (fr) 1994-05-04
PT71874B (en) 1982-03-31
AR227293A1 (es) 1982-10-15
US4346035A (en) 1982-08-24
US4359420A (en) 1982-11-16
NZ195071A (en) 1984-08-24
IL61160A0 (en) 1980-11-30

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Legal Events

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NDB Extension of term for standard patent granted (sect.76)