AU511358B2 - Heterocyclic derivatives of 1-(1, 3-dioxolan-2-ylmethy) 1h-imidazoles and 1H-1, 2, 4-triazoles - Google Patents
Heterocyclic derivatives of 1-(1, 3-dioxolan-2-ylmethy) 1h-imidazoles and 1H-1, 2, 4-triazolesInfo
- Publication number
- AU511358B2 AU511358B2 AU32852/78A AU3285278A AU511358B2 AU 511358 B2 AU511358 B2 AU 511358B2 AU 32852/78 A AU32852/78 A AU 32852/78A AU 3285278 A AU3285278 A AU 3285278A AU 511358 B2 AU511358 B2 AU 511358B2
- Authority
- AU
- Australia
- Prior art keywords
- ylmethy
- dioxolan
- triazoles
- imidazoles
- heterocyclic derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical class C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76426577A | 1977-01-31 | 1977-01-31 | |
| USUS764265 | 1977-01-31 | ||
| US05/853,726 US4160841A (en) | 1977-01-31 | 1977-11-21 | Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles |
| USUS853726 | 1977-11-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU3285278A AU3285278A (en) | 1979-08-09 |
| AU511358B2 true AU511358B2 (en) | 1980-08-14 |
Family
ID=27117425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU32852/78A Expired AU511358B2 (en) | 1977-01-31 | 1978-01-31 | Heterocyclic derivatives of 1-(1, 3-dioxolan-2-ylmethy) 1h-imidazoles and 1H-1, 2, 4-triazoles |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4160841A (en, 2012) |
| JP (1) | JPS53101377A (en, 2012) |
| AT (1) | AT367419B (en, 2012) |
| AU (1) | AU511358B2 (en, 2012) |
| BE (1) | BE863437A (en, 2012) |
| CA (1) | CA1117534A (en, 2012) |
| CH (1) | CH644117A5 (en, 2012) |
| DE (1) | DE2803870A1 (en, 2012) |
| DK (1) | DK42778A (en, 2012) |
| ES (1) | ES466483A1 (en, 2012) |
| FI (1) | FI62836C (en, 2012) |
| FR (1) | FR2378780A1 (en, 2012) |
| GB (1) | GB1594860A (en, 2012) |
| GR (1) | GR66115B (en, 2012) |
| HU (1) | HU177458B (en, 2012) |
| IE (1) | IE46055B1 (en, 2012) |
| IL (1) | IL53924A (en, 2012) |
| IT (1) | IT1105153B (en, 2012) |
| LU (1) | LU78969A1 (en, 2012) |
| NL (1) | NL7801088A (en, 2012) |
| PH (1) | PH13955A (en, 2012) |
| PT (1) | PT67599B (en, 2012) |
| SE (1) | SE439633B (en, 2012) |
| SU (1) | SU703020A3 (en, 2012) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4144346A (en) * | 1977-01-31 | 1979-03-13 | Janssen Pharmaceutica N.V. | Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles |
| US4218458A (en) * | 1978-06-23 | 1980-08-19 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles |
| EP0006722B1 (en) * | 1978-07-03 | 1984-09-05 | Janssen Pharmaceutica N.V. | Derivatives of (4-(piperazin-1-yl-phenyloxymethyl)-1.3-dioxolan-2-ylmethyl)-1h-imidazoles and -1h-1.2.4-triazoles, their preparation and use as fungicides and bactericides |
| US4287195A (en) * | 1978-07-14 | 1981-09-01 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of [4-(piperazin-1-yl-phenyloxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazoles and 1H-1,2,4-triazoles |
| US4338327A (en) * | 1978-10-06 | 1982-07-06 | Janssen Pharmaceutica, N.V. | Substituted 1-(2-aryl-1,3-dioxolan-2-ylmethyl)-1H-1,2,4-triazoles |
| US4402957A (en) * | 1979-04-04 | 1983-09-06 | Janssen Pharmaceutica N.V. | Heterocyclic derivatives of [4-(piperazin-1-ylphenyloxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazoles and 1H-1,2,4-triazoles |
| DE3039087A1 (de) * | 1980-10-16 | 1982-05-19 | Hoechst Ag, 6000 Frankfurt | 1-(1,3-dioxolan-2-ylmethyl)-azole, ihre salze, verfahren zu ihrer herstellung und ihre verwendung |
| DE3104311A1 (de) * | 1981-02-07 | 1982-08-19 | Bayer Ag, 5090 Leverkusen | 2-azolylmethyl-1,3-dioxolan- und -dioxan-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide |
| DE3104380A1 (de) * | 1981-02-07 | 1982-08-19 | Bayer Ag, 5090 Leverkusen | Antimikrobielle mittel |
| US4456605A (en) * | 1981-05-07 | 1984-06-26 | Janssen Pharmaceutica N.V. | Heterocyclic derivatives of [4-(piperazin-1-yl-phenyloxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazoles and 1H-1,2,4-triazoles |
| JPS59139380A (ja) * | 1983-01-28 | 1984-08-10 | Yoshiki Hamada | １，３―ジオキソランアシラート誘導体及びその製造法 |
| US4619931A (en) * | 1983-02-28 | 1986-10-28 | Janssen Pharmaceutica, N.V. | [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles |
| EP0121081B1 (de) * | 1983-03-03 | 1991-01-30 | BASF Aktiengesellschaft | Azolylmethylcycloalkane, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE3308554A1 (de) * | 1983-03-10 | 1984-09-13 | Hoechst Ag, 6230 Frankfurt | 1-/1,3-dioxolan-2-ylmethyl)-azole, ihre salze, verfahren zu ihrer herstellung und ihre verwendung |
| JPS59205366A (ja) * | 1983-04-12 | 1984-11-20 | スミスクライン・ベツクマン・コ−ポレイシヨン | ド−パミン−β−ヒドロキシラ−ゼ抑制物質 |
| WO2002032877A2 (en) * | 2000-10-16 | 2002-04-25 | Chugai Seiyaku Kabushiki Kaisha | Process for preparation of n-substituted 2-sulfanylimidazoles |
| US20050074494A1 (en) * | 2003-10-06 | 2005-04-07 | Xiu-Xiu Cheng | Itraconazole immediate release formulation |
| WO2007021877A1 (en) * | 2005-08-18 | 2007-02-22 | Synta Pharmaceuticals Corp. | Imidazole compounds that modulate hsp90 activity |
| KR100793693B1 (ko) | 2006-05-09 | 2008-01-10 | (주)유케이케미팜 | 이트라코나졸의 개선된 제조 방법 |
| PL2938609T3 (pl) * | 2012-12-25 | 2017-08-31 | Hua Medicine | Sposób wytwarzania 1-([1,3]dioksolan-4-ylometylo)-1h-pirazol-3- iloaminy |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3575999A (en) * | 1968-08-19 | 1971-04-20 | Janssen Pharmaceutica Nv | Ketal derivatives of imidazole |
| CA1065873A (en) * | 1975-01-27 | 1979-11-06 | Janssen Pharmaceutica Naamloze Vennootschap | Imidazole derivatives |
| US3936470A (en) * | 1975-01-27 | 1976-02-03 | Janssen Pharmaceutica N.V. | 1,3-Dioxolan-2-ylmethylimidazoles |
| US4101666A (en) * | 1975-10-06 | 1978-07-18 | Janssen Pharmaceutica N.V. | 1-(2-Ar-4-R-1,3-dioxolan-2-ylmethyl)imidazoles |
-
1977
- 1977-11-21 US US05/853,726 patent/US4160841A/en not_active Expired - Lifetime
-
1978
- 1978-01-14 PH PH20761A patent/PH13955A/en unknown
- 1978-01-20 GB GB2468/78A patent/GB1594860A/en not_active Expired
- 1978-01-25 GR GR55266A patent/GR66115B/el unknown
- 1978-01-26 CA CA000295742A patent/CA1117534A/en not_active Expired
- 1978-01-30 AT AT0063778A patent/AT367419B/de not_active IP Right Cessation
- 1978-01-30 JP JP841678A patent/JPS53101377A/ja active Granted
- 1978-01-30 HU HU78JA809A patent/HU177458B/hu not_active IP Right Cessation
- 1978-01-30 ES ES466483A patent/ES466483A1/es not_active Expired
- 1978-01-30 DK DK42778A patent/DK42778A/da not_active Application Discontinuation
- 1978-01-30 DE DE19782803870 patent/DE2803870A1/de not_active Ceased
- 1978-01-30 IL IL53924A patent/IL53924A/xx unknown
- 1978-01-30 IT IT47838/78A patent/IT1105153B/it active
- 1978-01-30 PT PT67599A patent/PT67599B/pt unknown
- 1978-01-30 BE BE184722A patent/BE863437A/xx unknown
- 1978-01-30 IE IE196/78A patent/IE46055B1/en unknown
- 1978-01-30 SE SE7801089A patent/SE439633B/sv not_active IP Right Cessation
- 1978-01-30 FR FR7802565A patent/FR2378780A1/fr active Granted
- 1978-01-30 FI FI780293A patent/FI62836C/fi not_active IP Right Cessation
- 1978-01-31 NL NL7801088A patent/NL7801088A/xx not_active Application Discontinuation
- 1978-01-31 AU AU32852/78A patent/AU511358B2/en not_active Expired
- 1978-01-31 CH CH105778A patent/CH644117A5/de not_active IP Right Cessation
- 1978-01-31 LU LU78969A patent/LU78969A1/xx unknown
- 1978-01-31 SU SU782571951A patent/SU703020A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| LU78969A1 (fr) | 1978-06-21 |
| IE780196L (en) | 1978-07-31 |
| IT1105153B (it) | 1985-10-28 |
| FI62836B (fi) | 1982-11-30 |
| DE2803870A1 (de) | 1978-08-03 |
| US4160841A (en) | 1979-07-10 |
| CH644117A5 (de) | 1984-07-13 |
| IE46055B1 (en) | 1983-02-09 |
| IT7847838A0 (it) | 1978-01-30 |
| PH13955A (en) | 1980-11-12 |
| DK42778A (da) | 1978-08-01 |
| IL53924A (en) | 1981-12-31 |
| GB1594860A (en) | 1981-08-05 |
| FI780293A7 (fi) | 1978-08-01 |
| AU3285278A (en) | 1979-08-09 |
| NL7801088A (nl) | 1978-08-02 |
| ATA63778A (de) | 1981-11-15 |
| BE863437A (nl) | 1978-07-31 |
| SE439633B (sv) | 1985-06-24 |
| JPS6339595B2 (en, 2012) | 1988-08-05 |
| JPS53101377A (en) | 1978-09-04 |
| HU177458B (en) | 1981-10-28 |
| IL53924A0 (en) | 1978-04-30 |
| FI62836C (fi) | 1983-03-10 |
| SU703020A3 (ru) | 1979-12-05 |
| PT67599A (en) | 1978-02-01 |
| SE7801089L (sv) | 1978-08-01 |
| ES466483A1 (es) | 1979-06-01 |
| CA1117534A (en) | 1982-02-02 |
| AT367419B (de) | 1982-07-12 |
| PT67599B (en) | 1980-01-14 |
| GR66115B (en, 2012) | 1981-01-16 |
| FR2378780B1 (en, 2012) | 1984-11-30 |
| FR2378780A1 (fr) | 1978-08-25 |
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