AU4774501A - Amidino compounds useful as nitric oxide synthase inhibitors - Google Patents
Amidino compounds useful as nitric oxide synthase inhibitorsInfo
- Publication number
- AU4774501A AU4774501A AU4774501A AU4774501A AU4774501A AU 4774501 A AU4774501 A AU 4774501A AU 4774501 A AU4774501 A AU 4774501A AU 4774501 A AU4774501 A AU 4774501A AU 4774501 A AU4774501 A AU 4774501A
- Authority
- AU
- Australia
- Prior art keywords
- nitric oxide
- compounds useful
- oxide synthase
- synthase inhibitors
- amidino compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 title 1
- 239000000236 nitric oxide synthase inhibitor Substances 0.000 title 1
- CSYSULGPHGCBQD-UHFFFAOYSA-N s-ethylisothiouronium diethylphosphate Chemical compound CCSC(N)=N.CCOP(O)(=O)OCC CSYSULGPHGCBQD-UHFFFAOYSA-N 0.000 title 1
Classifications
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- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19192300P | 2000-03-24 | 2000-03-24 | |
| PCT/US2001/009431 WO2001072702A2 (en) | 2000-03-24 | 2001-03-23 | Amidino compounds useful as nitric oxide synthase inhibitors |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6403830B2 (en) * | 2000-03-24 | 2002-06-11 | Pharmacia Corporation | Amidino compound and salts thereof useful as nitric oxide synthase inhibitors |
| US7393652B2 (en) | 2000-05-10 | 2008-07-01 | The Trustees Of Columbia University In The City Of New York | Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2) |
| US7718644B2 (en) | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
| US7879840B2 (en) | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US8022058B2 (en) | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US7012098B2 (en) * | 2001-03-23 | 2006-03-14 | Pharmacia Corporation | Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers |
| AU2002307217A1 (en) * | 2001-03-28 | 2002-10-15 | University Of South Florida | Materials and methods for treatment of cancer and identification of anti-cancer compounds |
| PE20021017A1 (es) * | 2001-04-03 | 2002-11-24 | Pharmacia Corp | Composicion parenteral reconstituible |
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| US20030119826A1 (en) * | 2001-09-24 | 2003-06-26 | Pharmacia Corporation | Neuroprotective treatment methods using selective iNOS inhibitors |
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| EP1505972A2 (en) * | 2002-05-16 | 2005-02-16 | Pharmacia Corporation | A selective inos inhibitor and a pde inhibitor in combination for the treatment of respiratory diseases |
| EP1506040A2 (en) * | 2002-05-16 | 2005-02-16 | Pharmacia Corporation | Selective inos inhibitors for the treatment of respiratory diseases and conditions |
| KR20050010826A (ko) * | 2002-06-05 | 2005-01-28 | 가부시키가이샤 가네카 | 광학 활성 α-메틸시스테인 유도체의 제조 방법 |
| EP1528921A2 (en) * | 2002-08-02 | 2005-05-11 | Pharmacia Corporation | Methods for treatment and prevention of gastrointestinal conditions |
| AU2003269406A1 (en) * | 2002-11-01 | 2004-05-25 | Pharmacia & Upjohn Company Llc | Process for preparing s-(2-aminoethyl)-2-methyl-l-cysteine |
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| WO2004064767A2 (en) * | 2003-01-23 | 2004-08-05 | Kahn Nighat N | Nitric oxide inducing agents |
| DE10308580B3 (de) * | 2003-02-27 | 2004-09-09 | Consortium für elektrochemische Industrie GmbH | Verfahren zur elektrophilen Substitution von Thiazolidinen oder Oxazolidinen |
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| US20070219223A1 (en) * | 2006-03-07 | 2007-09-20 | Endacea, Inc. | Compositions and methods for treating respiratory disorders |
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| CN101758337B (zh) | 2009-12-03 | 2012-02-15 | 湖南阿斯达生化科技有限公司 | 一种助焊剂用非卤素活性剂 |
| US10745467B2 (en) | 2010-03-26 | 2020-08-18 | The Trustees Of Dartmouth College | VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders |
| US20150231215A1 (en) | 2012-06-22 | 2015-08-20 | Randolph J. Noelle | VISTA Antagonist and Methods of Use |
| EP2552947A4 (en) | 2010-03-26 | 2013-11-13 | Dartmouth College | VISTA REGULATORY T CELL MEDIATOR PROTEIN, VISTA BINDING ACTIVE SUBSTANCES AND USE THEREOF |
| US9293197B2 (en) | 2011-08-15 | 2016-03-22 | Lockheed Martin Corporation | Reconfigurable phase change material masks for electro-optical compressive sensing |
| US9890215B2 (en) | 2012-06-22 | 2018-02-13 | King's College London | Vista modulators for diagnosis and treatment of cancer |
| DK3421486T5 (da) | 2012-06-22 | 2024-09-16 | The Trustees Of Darthmouth College | Nye Vista-IG-konstruktioner og anvendelse af Vista-IG til behandling af autoimmune, allergiske og inflammatoriske lidelser |
| CA2884704C (en) | 2012-09-07 | 2023-04-04 | Randolph J. Noelle | Vista modulators for diagnosis and treatment of cancer |
| US9340446B1 (en) | 2013-02-04 | 2016-05-17 | Lockheed Martin Corporation | Optical apparatus and method of forming a gradient index device |
| WO2014178433A1 (ja) | 2013-05-02 | 2014-11-06 | 株式会社エーピーアイ コーポレーション | α-置換システインもしくはその塩又はα-置換システイン合成中間体の製造方法 |
| EP4147693A1 (en) | 2013-09-13 | 2023-03-15 | Replicon Health OY | Method for enhancing energy production and metabolism in cells |
| IL301714A (en) | 2013-12-24 | 2023-05-01 | Janssen Pharmaceutica Nv | Antibodies and anti-VISTA fragments |
| US11014987B2 (en) | 2013-12-24 | 2021-05-25 | Janssen Pharmaceutics Nv | Anti-vista antibodies and fragments, uses thereof, and methods of identifying same |
| MX389695B (es) | 2014-06-11 | 2025-03-20 | Kathy A Green | Uso de agonistas y antagonistas vista para suprimir o aumentar la inmunidad humoral. |
| US10437083B1 (en) | 2014-10-20 | 2019-10-08 | Lockheed Martin Corporation | Individually addressable infrared mask array |
| CA2969730A1 (en) | 2014-12-05 | 2016-06-09 | Immunext, Inc. | Identification of vsig8 as the putative vista receptor and its use thereof to produce vista/vsig8 modulators |
| CN114805576A (zh) | 2015-06-24 | 2022-07-29 | 詹森药业有限公司 | 抗vista抗体和片段 |
| GB201512635D0 (en) | 2015-07-17 | 2015-08-26 | Ucl Business Plc | Uses of therapeutic compounds |
| BR112018016461A2 (pt) | 2016-02-12 | 2019-10-01 | Janssen Pharmaceutica Nv | anticorpos e fragmentos anti-vista, usos dos mesmos e métodos de identificação dos mesmos |
| CA3020848A1 (en) | 2016-04-15 | 2017-10-19 | Janssen Pharmaceuticals, Inc. | Anti-human vista antibodies and use thereof |
| US9969647B2 (en) | 2016-05-17 | 2018-05-15 | Lockheed Martin Energy, Llc | Glass composites having a gradient index of refraction and methods for production thereof |
| US9908808B1 (en) | 2016-08-18 | 2018-03-06 | Lockheed Martin Corporation | Ternary glass materials with low refractive index variability |
| EP3398941A1 (en) * | 2017-05-03 | 2018-11-07 | AXXAM S.p.A. | Heterocyclic p2x7 antagonists |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2036770C (en) | 1990-02-26 | 2003-09-09 | Jeffrey P. Whitten | Inhibitors of nitric oxide biosynthesis |
| US5132453A (en) | 1991-03-22 | 1992-07-21 | Cornell Research Foundation, Inc. | N6 -(hydrazinoiminomethyl)lysine and method of inhibiting nitric oxide formation in body |
| JP2648897B2 (ja) | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
| GB9127376D0 (en) | 1991-12-24 | 1992-02-19 | Wellcome Found | Amidino derivatives |
| GB9203347D0 (en) | 1992-02-17 | 1992-04-01 | Wellcome Found | Hypolipidaemic compounds |
| DE4234867A1 (de) * | 1992-10-16 | 1994-04-21 | Degussa | Verfahren zur Herstellung von Aminoalkylhydantoin und Aminoalkyl-alpha-aminosäuren |
| JPH08503940A (ja) | 1992-11-27 | 1996-04-30 | ザ ウエルカム ファウンデーション リミテッド | 酵素阻害薬 |
| JPH08504798A (ja) | 1992-12-18 | 1996-05-21 | ザ ウエルカム ファウンデーション リミテッド | 酵素阻害薬としての,ピリミジン,ピリジン,プテリジノンおよびインダゾール誘導体 |
| DE4324088A1 (de) * | 1993-07-17 | 1995-01-19 | Hoechst Ag | Hochtemperatursupraleitende Massivkörper und Verfahren zu ihrer Herstellung |
| CA2170735A1 (en) | 1993-10-21 | 1995-04-27 | Foe S. Tjoeng | Amidino derivatives useful as nitric oxide synthase inhibitors |
| US5854234A (en) | 1993-10-21 | 1998-12-29 | G. D. Searle & Co. | Amidino dervatives useful as nitric oxide synthase inhibitors |
| GB9405211D0 (en) | 1994-03-17 | 1994-04-27 | Deas Alexander R | Noise cancellation apparatus |
| AU2190895A (en) | 1994-03-24 | 1995-10-09 | G.D. Searle & Co. | Amidino derivatives useful as nitric oxide synthase inhibitors |
| ATE191470T1 (de) * | 1994-06-15 | 2000-04-15 | Wellcome Found | Enzymhemmer |
| US5994391A (en) | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US5684008A (en) | 1994-11-09 | 1997-11-04 | G. D. Searle & Co. | Aminotetrazole derivatives useful as nitric oxide synthase inhibitors |
| NZ305799A (en) | 1995-04-20 | 1999-01-28 | Searle & Co | Cyclic amidino agents useful as nitric oxide synthase inhibitors |
| AU712995B2 (en) | 1995-05-10 | 1999-11-18 | G.D. Searle & Co. | Nitric oxide synthase inhibitors derived from cyclic amidines |
| GB9516709D0 (en) | 1995-08-15 | 1995-10-18 | Zeneca Ltd | Medicament |
| US5830917A (en) | 1995-09-11 | 1998-11-03 | G. D. Searle & Co. | L-N6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors |
| US5945408A (en) | 1996-03-06 | 1999-08-31 | G.D. Searle & Co. | Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors |
| US5981511A (en) | 1996-03-06 | 1999-11-09 | G.D. Searle & Co. | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors |
| MY117948A (en) * | 1997-01-13 | 2004-08-30 | Glaxo Group Ltd | Nitride oxide synthase inhibitors. |
| WO1999029865A2 (en) | 1997-12-12 | 1999-06-17 | The Rockefeller University | A protein belonging to the tnf superfamily, nucleic acids encoding same, and methods of use thereof |
| EP1415982A1 (en) | 1998-03-11 | 2004-05-06 | G.D. SEARLE & CO. | Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors |
| GB9811599D0 (en) * | 1998-05-30 | 1998-07-29 | Glaxo Group Ltd | Nitric oxide synthase inhibitors |
| US6403830B2 (en) * | 2000-03-24 | 2002-06-11 | Pharmacia Corporation | Amidino compound and salts thereof useful as nitric oxide synthase inhibitors |
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2001
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- 2001-03-23 DK DK01920718T patent/DK1265859T3/da active
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