AU472777B2 - Process forthe manufacture of benzodiazepine derivatives - Google Patents

Process forthe manufacture of benzodiazepine derivatives

Info

Publication number
AU472777B2
AU472777B2 AU59180/73A AU5918073A AU472777B2 AU 472777 B2 AU472777 B2 AU 472777B2 AU 59180/73 A AU59180/73 A AU 59180/73A AU 5918073 A AU5918073 A AU 5918073A AU 472777 B2 AU472777 B2 AU 472777B2
Authority
AU
Australia
Prior art keywords
benzodiazepine derivatives
process forthe
forthe manufacture
manufacture
benzodiazepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU59180/73A
Other languages
English (en)
Other versions
AU5918073A (en
Inventor
Oswald Chase George
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU5918073A publication Critical patent/AU5918073A/en
Application granted granted Critical
Publication of AU472777B2 publication Critical patent/AU472777B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/30—Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU59180/73A 1972-08-21 1973-08-13 Process forthe manufacture of benzodiazepine derivatives Expired AU472777B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28221772A 1972-08-21 1972-08-21
USUS282,217 1972-08-21
US35981473A 1973-05-14 1973-05-14

Publications (2)

Publication Number Publication Date
AU5918073A AU5918073A (en) 1975-02-13
AU472777B2 true AU472777B2 (en) 1976-06-03

Family

ID=26961312

Family Applications (1)

Application Number Title Priority Date Filing Date
AU59180/73A Expired AU472777B2 (en) 1972-08-21 1973-08-13 Process forthe manufacture of benzodiazepine derivatives

Country Status (24)

Country Link
JP (1) JPS5911589B2 (ja)
AR (1) AR198108A1 (ja)
AT (1) AT341527B (ja)
AU (1) AU472777B2 (ja)
CA (1) CA1012535A (ja)
CH (1) CH578544A5 (ja)
DD (1) DD107040A5 (ja)
DE (1) DE2340159A1 (ja)
DK (1) DK155326C (ja)
ES (1) ES418014A1 (ja)
FI (1) FI57939C (ja)
FR (1) FR2197003B1 (ja)
GB (1) GB1392681A (ja)
HU (1) HU170153B (ja)
IE (1) IE38091B1 (ja)
IL (1) IL42947A (ja)
LU (1) LU68269A1 (ja)
NL (1) NL179582C (ja)
NO (1) NO139481C (ja)
PH (1) PH13640A (ja)
PL (1) PL99162B1 (ja)
SE (1) SE408302B (ja)
SU (1) SU550980A3 (ja)
YU (1) YU219873A (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5334792A (en) * 1976-09-13 1978-03-31 Scherico Ltd Production of 1*44 benzodiazepines and 1*44 benzodiazepinee22ones
CN113149915B (zh) * 2021-03-01 2024-03-15 中国科学院成都有机化学有限公司 一种合成氯硝西泮化合物的方法
CN116023342B (zh) * 2021-10-26 2024-06-25 江苏昱林生物科技有限公司 一种高纯度氯硝西泮的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1136709B (de) * 1959-12-10 1962-09-20 Hoffmann La Roche Verfahren zur Herstellung von 2-Oxo-1, 2-dihydro-1, 4-benzodiazepinen
CH537393A (de) * 1969-10-16 1973-05-31 Hoffmann La Roche Verfahren zur Herstellung von 1,4-Benzodiazepin-derivaten
BE785962A (fr) * 1971-07-08 1973-01-08 Hoffmann La Roche Procede pour la preparation de derives de benzodiazepine

Also Published As

Publication number Publication date
GB1392681A (en) 1975-04-30
AT341527B (de) 1978-02-10
SE408302B (sv) 1979-06-05
JPS4956992A (ja) 1974-06-03
SU550980A3 (ru) 1977-03-15
FI57939C (fi) 1980-11-10
NL179582C (nl) 1986-10-01
ES418014A1 (es) 1976-03-16
LU68269A1 (ja) 1975-05-21
PL99162B1 (pl) 1978-06-30
FR2197003A1 (ja) 1974-03-22
ATA720773A (de) 1977-06-15
CA1012535A (en) 1977-06-21
FI57939B (fi) 1980-07-31
NL7311507A (ja) 1974-02-25
PH13640A (en) 1980-08-18
DE2340159C2 (ja) 1989-01-19
NO139481B (no) 1978-12-11
IE38091B1 (en) 1977-12-21
FR2197003B1 (ja) 1978-01-13
AU5918073A (en) 1975-02-13
JPS5911589B2 (ja) 1984-03-16
YU219873A (en) 1982-06-30
DE2340159A1 (de) 1974-03-07
NL179582B (nl) 1986-05-01
IL42947A0 (en) 1973-11-28
DK155326B (da) 1989-03-28
DD107040A5 (ja) 1974-07-12
CH578544A5 (ja) 1976-08-13
IE38091L (en) 1974-02-21
DK155326C (da) 1989-08-14
IL42947A (en) 1977-01-31
NO139481C (no) 1979-03-21
HU170153B (ja) 1977-04-28
AR198108A1 (es) 1974-05-31

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