AU464107B2 - 3-heterocyclic thiomethylcephalosporins - Google Patents

3-heterocyclic thiomethylcephalosporins

Info

Publication number
AU464107B2
AU464107B2 AU52345/73A AU5234573A AU464107B2 AU 464107 B2 AU464107 B2 AU 464107B2 AU 52345/73 A AU52345/73 A AU 52345/73A AU 5234573 A AU5234573 A AU 5234573A AU 464107 B2 AU464107 B2 AU 464107B2
Authority
AU
Australia
Prior art keywords
compound
formula
group
amino
cephem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU52345/73A
Other languages
English (en)
Other versions
AU5234573A (en
Inventor
LAWRENCE DUNN and JOHN RUSSEL EUGENE HOOVER GEORGE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US262903A external-priority patent/US3867380A/en
Priority claimed from US00289499A external-priority patent/US3855213A/en
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of AU5234573A publication Critical patent/AU5234573A/en
Application granted granted Critical
Publication of AU464107B2 publication Critical patent/AU464107B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU52345/73A 1972-06-14 1973-02-19 3-heterocyclic thiomethylcephalosporins Expired AU464107B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
USUS262903 1972-06-14
US262903A US3867380A (en) 1971-02-18 1972-06-14 3-Heterocyclic thiomethylcephalosporins
USUS289499 1972-09-15
US00289499A US3855213A (en) 1971-02-18 1972-09-15 3-heterocyclic thiomethyl-cephalosporins

Publications (2)

Publication Number Publication Date
AU5234573A AU5234573A (en) 1974-08-22
AU464107B2 true AU464107B2 (en) 1975-08-14

Family

ID=26949532

Family Applications (1)

Application Number Title Priority Date Filing Date
AU52345/73A Expired AU464107B2 (en) 1972-06-14 1973-02-19 3-heterocyclic thiomethylcephalosporins

Country Status (20)

Country Link
JP (2) JPS5518716B2 (enExample)
AR (1) AR197237A1 (enExample)
AT (1) AT324560B (enExample)
AU (1) AU464107B2 (enExample)
CA (2) CA1076560A (enExample)
CH (2) CH586709A5 (enExample)
DD (1) DD105238A5 (enExample)
DE (1) DE2316867C2 (enExample)
DK (1) DK142913B (enExample)
ES (2) ES412207A1 (enExample)
FI (1) FI56843C (enExample)
FR (2) FR2187298B1 (enExample)
GB (2) GB1363833A (enExample)
HU (1) HU168689B (enExample)
IE (2) IE37409B1 (enExample)
IL (1) IL42126A (enExample)
NL (2) NL7302817A (enExample)
PH (1) PH9941A (enExample)
PL (1) PL91074B1 (enExample)
SE (2) SE416472B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR780000197B1 (en) * 1972-12-26 1978-05-26 Bristol Myers Co Method for preparing antibacterial agent
PH16419A (en) * 1973-01-31 1983-09-29 Bristol Myers Co 7-(d-alpha-amino-alpha-(3'-methyl-4'-hydroxyphenyl)-acetamido)-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid,pharmaceutically acceptable esters and salts thereof
GB1476981A (en) * 1974-06-05 1977-06-16 Bristol Myers Co Substituted penicillanic acids
CA1074784A (en) * 1974-09-06 1980-04-01 Sumitomo Chemical Company N-ACYLAMINO-.alpha.-ARYLACETAMIDO CEPHALOSPORINS
JPS5346995A (en) * 1976-10-12 1978-04-27 Sangyo Kagaku Kenkyu Kyokai Antibacterial agents
NL162387C (nl) * 1977-09-06 1980-05-16 Gist Brocades Nv Werkwijze voor het bereiden van 6-(d-alpha-amino-p- -hydroxyfenylacetamido)penicillanzuur.
JPS6182606A (ja) * 1984-09-29 1986-04-26 東芝ライテック株式会社 昇降装置

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA698494B (en) * 1969-02-26 1971-07-28 Lilly Co Eli Sulfur-containing cephalosporing antibiotics
US3641021A (en) * 1969-04-18 1972-02-08 Lilly Co Eli 3 7-(ring-substituted) cephalosporin compounds

Also Published As

Publication number Publication date
SE416472B (sv) 1981-01-05
DE2316867C2 (de) 1982-05-19
IL42126A0 (en) 1973-06-29
PL91074B1 (en) 1977-02-28
IE37409B1 (en) 1977-07-20
CA1076560A (en) 1980-04-29
IL42126A (en) 1975-12-31
GB1358027A (en) 1974-06-26
FR2187299A1 (enExample) 1974-01-18
AR197237A1 (es) 1974-03-22
CH589093A5 (enExample) 1977-06-30
ES412207A1 (es) 1976-01-01
FR2187298A1 (enExample) 1974-01-18
GB1363833A (en) 1974-08-21
SE404190B (sv) 1978-09-25
JPS5953274B2 (ja) 1984-12-24
DE2316867A1 (de) 1974-01-03
FI56843B (fi) 1979-12-31
AU5234573A (en) 1974-08-22
IE37499L (en) 1973-12-14
DE2316866A1 (de) 1974-01-03
DD105238A5 (enExample) 1974-04-12
FI56843C (fi) 1980-04-10
CA999293A (en) 1976-11-02
NL7305206A (enExample) 1973-12-18
DE2316866B2 (de) 1976-10-07
FR2187299B1 (enExample) 1976-12-03
IE37499B1 (en) 1977-08-03
JPS4954393A (enExample) 1974-05-27
DK142913B (da) 1981-02-23
NL7302817A (enExample) 1973-12-18
FR2187298B1 (enExample) 1976-12-03
IE37409L (en) 1973-12-14
AT324560B (de) 1975-09-10
CH586709A5 (enExample) 1977-04-15
PH9941A (en) 1976-06-14
JPS4931689A (enExample) 1974-03-22
ES413501A1 (es) 1976-07-16
HU168689B (enExample) 1976-06-28
JPS5518716B2 (enExample) 1980-05-21
DK142913C (enExample) 1981-09-28

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