AU2087388A - Capillary device for immunoassay of multiple analytes - Google Patents
Capillary device for immunoassay of multiple analytesInfo
- Publication number
- AU2087388A AU2087388A AU20873/88A AU2087388A AU2087388A AU 2087388 A AU2087388 A AU 2087388A AU 20873/88 A AU20873/88 A AU 20873/88A AU 2087388 A AU2087388 A AU 2087388A AU 2087388 A AU2087388 A AU 2087388A
- Authority
- AU
- Australia
- Prior art keywords
- segments
- capillary tubing
- reactive
- tubing
- ige
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000003018 immunoassay Methods 0.000 title description 8
- 239000013566 allergen Substances 0.000 claims description 71
- 239000003153 chemical reaction reagent Substances 0.000 claims description 41
- 238000000034 method Methods 0.000 claims description 38
- 239000000427 antigen Substances 0.000 claims description 30
- 102000036639 antigens Human genes 0.000 claims description 30
- 108091007433 antigens Proteins 0.000 claims description 30
- 238000006243 chemical reaction Methods 0.000 claims description 22
- 239000000758 substrate Substances 0.000 claims description 19
- 102000004190 Enzymes Human genes 0.000 claims description 16
- 108090000790 Enzymes Proteins 0.000 claims description 16
- 239000012530 fluid Substances 0.000 claims description 15
- 230000000984 immunochemical effect Effects 0.000 claims description 10
- 238000011049 filling Methods 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 9
- 238000001514 detection method Methods 0.000 claims description 8
- 238000005406 washing Methods 0.000 claims description 6
- 108060003951 Immunoglobulin Proteins 0.000 claims description 5
- 102000018358 immunoglobulin Human genes 0.000 claims description 5
- 239000012491 analyte Substances 0.000 claims description 4
- 239000013060 biological fluid Substances 0.000 claims description 4
- 229920003023 plastic Polymers 0.000 claims description 4
- 239000004033 plastic Substances 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 3
- 230000002285 radioactive effect Effects 0.000 claims description 3
- 210000001736 capillary Anatomy 0.000 claims 31
- 230000000694 effects Effects 0.000 claims 1
- 229940072221 immunoglobulins Drugs 0.000 claims 1
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- 238000012360 testing method Methods 0.000 description 39
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 230000008859 change Effects 0.000 description 6
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- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 5
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 4
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- JWDFQMWEFLOOED-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCSSC1=CC=CC=N1 JWDFQMWEFLOOED-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- 240000006122 Chenopodium album Species 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 244000239204 Plantago lanceolata Species 0.000 description 2
- 235000010503 Plantago lanceolata Nutrition 0.000 description 2
- 241000209504 Poaceae Species 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229940074608 allergen extract Drugs 0.000 description 2
- 230000000890 antigenic effect Effects 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
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- 239000000428 dust Substances 0.000 description 2
- -1 e.g. Substances 0.000 description 2
- XJRPTMORGOIMMI-UHFFFAOYSA-N ethyl 2-amino-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate Chemical compound CCOC(=O)C=1SC(N)=NC=1C(F)(F)F XJRPTMORGOIMMI-UHFFFAOYSA-N 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 230000009610 hypersensitivity Effects 0.000 description 2
- 229940127121 immunoconjugate Drugs 0.000 description 2
- KRTSDMXIXPKRQR-AATRIKPKSA-N monocrotophos Chemical compound CNC(=O)\C=C(/C)OP(=O)(OC)OC KRTSDMXIXPKRQR-AATRIKPKSA-N 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 238000012207 quantitative assay Methods 0.000 description 2
- 239000000700 radioactive tracer Substances 0.000 description 2
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- 239000005720 sucrose Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- LEELWLKZRKDMAS-UHFFFAOYSA-N 2-(2,4-dimethoxy-3-methylsulfanylphenyl)ethanamine Chemical compound COC1=CC=C(CCN)C(OC)=C1SC LEELWLKZRKDMAS-UHFFFAOYSA-N 0.000 description 1
- YRNWIFYIFSBPAU-UHFFFAOYSA-N 4-[4-(dimethylamino)phenyl]-n,n-dimethylaniline Chemical compound C1=CC(N(C)C)=CC=C1C1=CC=C(N(C)C)C=C1 YRNWIFYIFSBPAU-UHFFFAOYSA-N 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 241000223600 Alternaria Species 0.000 description 1
- 241000223602 Alternaria alternata Species 0.000 description 1
- 244000036975 Ambrosia artemisiifolia Species 0.000 description 1
- 235000003129 Ambrosia artemisiifolia var elatior Nutrition 0.000 description 1
- 241000532370 Atla Species 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
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- 238000006873 Coates reaction Methods 0.000 description 1
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- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- 241000721668 Juniperus ashei Species 0.000 description 1
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- 240000004658 Medicago sativa Species 0.000 description 1
- 206010028164 Multiple allergies Diseases 0.000 description 1
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- 241000282320 Panthera leo Species 0.000 description 1
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- 229920002684 Sepharose Polymers 0.000 description 1
- 244000204900 Talipariti tiliaceum Species 0.000 description 1
- 229920004890 Triton X-100 Polymers 0.000 description 1
- 239000013504 Triton X-100 Substances 0.000 description 1
- 241000261594 Tyrophagus longior Species 0.000 description 1
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- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000002009 allergenic effect Effects 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 208000010216 atopic IgE responsiveness Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
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- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000006957 competitive inhibition Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
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- 239000008367 deionised water Substances 0.000 description 1
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- 239000003599 detergent Substances 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
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- 238000005516 engineering process Methods 0.000 description 1
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- 238000001704 evaporation Methods 0.000 description 1
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- 238000001914 filtration Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
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- 239000008273 gelatin Substances 0.000 description 1
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- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 208000005252 hepatitis A Diseases 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 239000003547 immunosorbent Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000012948 isocyanate Substances 0.000 description 1
- 150000002513 isocyanates Chemical class 0.000 description 1
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- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
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- 102000013415 peroxidase activity proteins Human genes 0.000 description 1
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- 239000012071 phase Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 229940124272 protein stabilizer Drugs 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000012113 quantitative test Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000003998 snake venom Substances 0.000 description 1
- ACXGJHCPFCFILV-UHFFFAOYSA-M sodium;2-(4-chloro-2-methylphenoxy)acetate;3,6-dichloro-2-methoxybenzoic acid Chemical compound [Na+].COC1=C(Cl)C=CC(Cl)=C1C(O)=O.CC1=CC(Cl)=CC=C1OCC([O-])=O ACXGJHCPFCFILV-UHFFFAOYSA-M 0.000 description 1
- 239000002594 sorbent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- SRVJKTDHMYAMHA-WUXMJOGZSA-N thioacetazone Chemical compound CC(=O)NC1=CC=C(\C=N\NC(N)=S)C=C1 SRVJKTDHMYAMHA-WUXMJOGZSA-N 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000006226 wash reagent Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6949387A | 1987-07-02 | 1987-07-02 | |
| US069493 | 1987-07-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2087388A true AU2087388A (en) | 1989-01-30 |
Family
ID=22089359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU20873/88A Abandoned AU2087388A (en) | 1987-07-02 | 1988-06-23 | Capillary device for immunoassay of multiple analytes |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0367794A4 (enrdf_load_stackoverflow) |
| JP (1) | JPH02504188A (enrdf_load_stackoverflow) |
| AU (1) | AU2087388A (enrdf_load_stackoverflow) |
| ES (1) | ES2009312A6 (enrdf_load_stackoverflow) |
| IN (1) | IN171202B (enrdf_load_stackoverflow) |
| WO (1) | WO1989000290A1 (enrdf_load_stackoverflow) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989010974A1 (en) * | 1988-05-11 | 1989-11-16 | Trustees Of The Sisters Of Charity Of Australia | Enzyme immunoassay system |
| DE4124778A1 (de) * | 1991-07-26 | 1993-01-28 | Univ Schiller Jena | Verfahren und anordnung zur analyse von agglutinationsreaktionen |
| US5342790A (en) * | 1992-10-30 | 1994-08-30 | Becton Dickinson And Company | Apparatus for indirect fluorescent assay of blood samples |
| EP0781997A1 (en) * | 1995-12-27 | 1997-07-02 | FUJIREBIO Inc. | Instrument for simplified immunoassay and simplified immunoassay method using the instrument |
| IL124275A (en) | 1997-05-02 | 2002-03-10 | Bio Merieux Vitek Inc | A method to produce sequences of nucleic acids |
| US6558901B1 (en) | 1997-05-02 | 2003-05-06 | Biomerieux Vitek | Nucleic acid assays |
| DE19721151C2 (de) * | 1997-05-21 | 2002-10-31 | Merck Patent Gmbh | Streifentest zur in-vitro-Allergiediagnostik |
| DE10260733B4 (de) * | 2002-12-23 | 2010-08-12 | Outokumpu Oyj | Verfahren und Anlage zur Wärmebehandlung von eisenoxidhaltigen Feststoffen |
| FR2932890B1 (fr) * | 2008-06-20 | 2010-07-30 | Applistick | Dispositif et procede de test pour la detection d'une substance. |
| TWI711819B (zh) * | 2012-07-16 | 2020-12-01 | 大陸商昌和生物醫學科技（揚州）有限公司 | 增強疾病檢測與鑒定的器件與方法 |
| GB201400115D0 (en) * | 2014-01-05 | 2014-02-19 | Gerardos Georgios | Multiple ligands detection using an immunoassay device |
| CN109444408A (zh) * | 2018-10-26 | 2019-03-08 | 成都普利泰生物科技有限公司 | 一种检测动物血液皮质醇的试剂盒 |
| CN109444409A (zh) * | 2018-10-26 | 2019-03-08 | 成都普利泰生物科技有限公司 | 一种犬瘟热病毒抗体的化学发光免疫检测试剂盒 |
| CN109444420A (zh) * | 2018-10-26 | 2019-03-08 | 成都普利泰生物科技有限公司 | 一种定量测定猫血清淀粉样蛋白a的化学发光免疫分析试剂盒 |
| CN109444412A (zh) * | 2018-10-26 | 2019-03-08 | 成都普利泰生物科技有限公司 | 一种用于微型化学发光免疫分析系统的宠物d-二聚体检测试剂盒 |
| CN109444410A (zh) * | 2018-10-26 | 2019-03-08 | 成都普利泰生物科技有限公司 | 一种兽用狂犬病毒中和抗体化学发光检测试剂盒 |
| CN109444419A (zh) * | 2018-10-26 | 2019-03-08 | 成都普利泰生物科技有限公司 | 一种检测犬促甲状腺激素的化学发光免疫分析试剂盒 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3941876A (en) * | 1973-04-25 | 1976-03-02 | Gte New Ventures Corporation | In vitro method for determining allergic hypersensitivity |
| US4301139A (en) * | 1979-06-21 | 1981-11-17 | Ames-Yissum Ltd. | Multilayer column chromatography specific binding assay method, test device and test kit |
| NZ199286A (en) * | 1980-12-22 | 1986-05-09 | Commw Serum Lab Commission | A method of detecting antibodies or an antigenic or haptenic substance in a sample |
| US4425438A (en) * | 1981-03-13 | 1984-01-10 | Bauman David S | Assay method and device |
| DE3214287A1 (de) * | 1981-04-23 | 1982-12-02 | Günther Prof. Dipl.-Ing. Dr. 8047 Graz Knapp | Roehrchen zur durchfuehrung eines radioimmunoassays |
| US5073484A (en) * | 1982-03-09 | 1991-12-17 | Bio-Metric Systems, Inc. | Quantitative analysis apparatus and method |
| US4673657A (en) * | 1983-08-26 | 1987-06-16 | The Regents Of The University Of California | Multiple assay card and system |
| EP0149168B1 (en) * | 1983-12-19 | 1991-04-24 | Daiichi Pure Chemicals Co. Ltd. | Immunoassay |
| SE458643B (sv) * | 1984-12-07 | 1989-04-17 | Pharmacia Ab | Anordning med kolonnelement uppdelat i provparti och referenspatri |
-
1988
- 1988-06-23 EP EP19880906563 patent/EP0367794A4/en not_active Withdrawn
- 1988-06-23 WO PCT/US1988/002132 patent/WO1989000290A1/en not_active Application Discontinuation
- 1988-06-23 AU AU20873/88A patent/AU2087388A/en not_active Abandoned
- 1988-06-23 JP JP63506265A patent/JPH02504188A/ja active Pending
- 1988-07-01 IN IN541/CAL/88A patent/IN171202B/en unknown
- 1988-07-01 ES ES8802071A patent/ES2009312A6/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0367794A4 (en) | 1991-03-13 |
| IN171202B (enrdf_load_stackoverflow) | 1992-08-15 |
| JPH02504188A (ja) | 1990-11-29 |
| WO1989000290A1 (en) | 1989-01-12 |
| ES2009312A6 (es) | 1989-09-16 |
| EP0367794A1 (en) | 1990-05-16 |
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