AU2022232620A1 - Bifunctional degraders of galactose-deficient immunoglobulins - Google Patents

Bifunctional degraders of galactose-deficient immunoglobulins Download PDF

Info

Publication number
AU2022232620A1
AU2022232620A1 AU2022232620A AU2022232620A AU2022232620A1 AU 2022232620 A1 AU2022232620 A1 AU 2022232620A1 AU 2022232620 A AU2022232620 A AU 2022232620A AU 2022232620 A AU2022232620 A AU 2022232620A AU 2022232620 A1 AU2022232620 A1 AU 2022232620A1
Authority
AU
Australia
Prior art keywords
group
optionally substituted
groups
moiety
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2022232620A
Other languages
English (en)
Inventor
Reese M. CALDWELL
Gene M. Dubowchik
David Spiegel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biohaven Therapeutics Ltd
Original Assignee
Biohaven Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biohaven Therapeutics Ltd filed Critical Biohaven Therapeutics Ltd
Publication of AU2022232620A1 publication Critical patent/AU2022232620A1/en
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549Sugars, nucleosides, nucleotides or nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AU2022232620A 2021-03-10 2022-03-10 Bifunctional degraders of galactose-deficient immunoglobulins Pending AU2022232620A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163159383P 2021-03-10 2021-03-10
US63/159,383 2021-03-10
PCT/US2022/019658 WO2022192478A1 (en) 2021-03-10 2022-03-10 Bifunctional degraders of galactose-deficient immunoglobulins

Publications (1)

Publication Number Publication Date
AU2022232620A1 true AU2022232620A1 (en) 2023-09-21

Family

ID=83227063

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2022232620A Pending AU2022232620A1 (en) 2021-03-10 2022-03-10 Bifunctional degraders of galactose-deficient immunoglobulins

Country Status (11)

Country Link
US (1) US20240309114A1 (https=)
EP (1) EP4304579A1 (https=)
JP (1) JP2024509282A (https=)
KR (1) KR20230154900A (https=)
CN (1) CN116997337A (https=)
AU (1) AU2022232620A1 (https=)
BR (1) BR112023017702A2 (https=)
CA (1) CA3211335A1 (https=)
IL (1) IL305665A (https=)
MX (1) MX2023010424A (https=)
WO (1) WO2022192478A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2023013274A (es) * 2021-05-17 2023-11-30 Biohaven Therapeutics Ltd Composiciones que incluyen potenciadores de tratamientos conjugados.
EP4370157A1 (en) 2021-07-14 2024-05-22 Lycia Therapeutics, Inc. Asgpr cell surface receptor binding compounds and conjugates
WO2024228935A1 (en) * 2023-04-29 2024-11-07 Biohaven Therapeutics Ltd. Bifunctional degraders of galactose-deficient immunoglobulins
WO2026083257A1 (en) 2024-10-14 2026-04-23 Biohaven Therapeutics Ltd. Antigen-specific degraders of immunoglobulin a and their uses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8440191B2 (en) * 2005-11-18 2013-05-14 Tufts Medical Center Clearance of abnormal IGA1 in IGA1 deposition diseases
PL2991683T3 (pl) * 2013-05-02 2020-03-31 Glykos Finland Oy Koniugaty glikoproteiny lub glikanu z toksycznym ładunkiem
SG11201606761RA (en) * 2014-02-21 2016-09-29 Ecole Polytecnique Federale De Lausanne Epfl Epfl Tto Glycotargeting therapeutics
PL3145934T3 (pl) * 2014-05-19 2021-08-16 Pfizer Inc. Podstawione związki 6,8-dioksabicyklo[3.2.1]oktano-2,3-diolu jako środki kierujące do ASGPR
EP3773727A4 (en) * 2018-04-09 2022-05-04 Yale University BIFUNCTIONAL SMALL MOLECULES TO TARGETING THE SELECTIVE DEGRADATION OF CIRCULATING PROTEINS

Also Published As

Publication number Publication date
US20240309114A1 (en) 2024-09-19
MX2023010424A (es) 2023-09-18
WO2022192478A1 (en) 2022-09-15
EP4304579A1 (en) 2024-01-17
KR20230154900A (ko) 2023-11-09
CA3211335A1 (en) 2022-09-15
IL305665A (en) 2023-11-01
JP2024509282A (ja) 2024-02-29
BR112023017702A2 (pt) 2023-12-12
CN116997337A (zh) 2023-11-03

Similar Documents

Publication Publication Date Title
EP4304579A1 (en) Bifunctional degraders of galactose-deficient immunoglobulins
JP7754361B2 (ja) 可溶性タンパク質に対する親和性物質、切断性部分および反応性基を有する化合物またはその塩
CN113227124B (zh) 具有针对抗体的亲和性物质、切割性部分及反应性基团的化合物或其盐
US20240173427A1 (en) Glypican 3 antibodies and conjugates thereof
KR20210020015A (ko) 항체에 대한 친화성 물질 및 생체 직교성 관능기를 갖는 화합물 또는 이의 염
EP4277629A1 (en) Camptothecine antibody-drug conjugates and methods of use thereof
JP7846624B2 (ja) ペプチド含有リンカーとの部位特異的抗体-薬物コンジュゲート
EP4110405A1 (fr) Conjugués anticorps-médicament anti-cd56 et leur utilisation en thérapie
JP2021528431A (ja) Il−17に結合するためのペプチドリガンド
CN121038815A (zh) 半乳糖缺陷型免疫球蛋白的双功能降解剂
JP2018502045A (ja) タンパク薬物複合体で使用するためのリンカーに関連する材料および方法
WO2012093733A1 (ja) 抗シグナルペプチド抗体の製造方法
AU2023241225A1 (en) Antibody-conjugates for targeting of tumours expressing trop-2
US20240383961A1 (en) Conjugated antibodies for treating diseases
KR101536037B1 (ko) 아포리포단백질을 포함하는 항체-약물 결합체
JP2025531032A (ja) 抗体薬物複合体の医薬組成物
WO2022097500A1 (ja) ペプチド架橋剤及び当該架橋剤で架橋された架橋ペプチド
RU2857183C2 (ru) Производное полиэтиленгликоля, композиция, содержащая такое производное, и способ получения конъюгата биоактивного полипептида с использованием такого производного
JP7714024B2 (ja) ポリエチレングリコール誘導体、それを含む組成物、及びそれを利用した生理活性ポリペプチド結合体の製造方法
US20240400644A1 (en) Fusion proteins comprising 071 core peptide and use thereof
WO2013125769A1 (ko) 아포리포단백질을 포함하는 항체-약물 결합체
WO2025137580A1 (en) Class ii hla with inter-chain disulfide bond
CN121175323A (zh) 复合物、药物组合物、疫苗及其应用
KR20250051793A (ko) 항-her2 항체-면역 작용제 접합체의 약학적 조성물 및 이의 응용