MX2023010424A - Degradadores bifuncionales de inmunoglobulina deficientes en galactosa. - Google Patents
Degradadores bifuncionales de inmunoglobulina deficientes en galactosa.Info
- Publication number
- MX2023010424A MX2023010424A MX2023010424A MX2023010424A MX2023010424A MX 2023010424 A MX2023010424 A MX 2023010424A MX 2023010424 A MX2023010424 A MX 2023010424A MX 2023010424 A MX2023010424 A MX 2023010424A MX 2023010424 A MX2023010424 A MX 2023010424A
- Authority
- MX
- Mexico
- Prior art keywords
- immunoglobulins
- galactose
- deficient
- moiety
- glycan
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163159383P | 2021-03-10 | 2021-03-10 | |
| PCT/US2022/019658 WO2022192478A1 (en) | 2021-03-10 | 2022-03-10 | Bifunctional degraders of galactose-deficient immunoglobulins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023010424A true MX2023010424A (es) | 2023-09-18 |
Family
ID=83227063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023010424A MX2023010424A (es) | 2021-03-10 | 2022-03-10 | Degradadores bifuncionales de inmunoglobulina deficientes en galactosa. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20240309114A1 (https=) |
| EP (1) | EP4304579A1 (https=) |
| JP (1) | JP2024509282A (https=) |
| KR (1) | KR20230154900A (https=) |
| CN (1) | CN116997337A (https=) |
| AU (1) | AU2022232620A1 (https=) |
| BR (1) | BR112023017702A2 (https=) |
| CA (1) | CA3211335A1 (https=) |
| IL (1) | IL305665A (https=) |
| MX (1) | MX2023010424A (https=) |
| WO (1) | WO2022192478A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2023013274A (es) * | 2021-05-17 | 2023-11-30 | Biohaven Therapeutics Ltd | Composiciones que incluyen potenciadores de tratamientos conjugados. |
| EP4370157A1 (en) | 2021-07-14 | 2024-05-22 | Lycia Therapeutics, Inc. | Asgpr cell surface receptor binding compounds and conjugates |
| WO2024228935A1 (en) * | 2023-04-29 | 2024-11-07 | Biohaven Therapeutics Ltd. | Bifunctional degraders of galactose-deficient immunoglobulins |
| WO2026083257A1 (en) | 2024-10-14 | 2026-04-23 | Biohaven Therapeutics Ltd. | Antigen-specific degraders of immunoglobulin a and their uses |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8440191B2 (en) * | 2005-11-18 | 2013-05-14 | Tufts Medical Center | Clearance of abnormal IGA1 in IGA1 deposition diseases |
| PL2991683T3 (pl) * | 2013-05-02 | 2020-03-31 | Glykos Finland Oy | Koniugaty glikoproteiny lub glikanu z toksycznym ładunkiem |
| SG11201606761RA (en) * | 2014-02-21 | 2016-09-29 | Ecole Polytecnique Federale De Lausanne Epfl Epfl Tto | Glycotargeting therapeutics |
| PL3145934T3 (pl) * | 2014-05-19 | 2021-08-16 | Pfizer Inc. | Podstawione związki 6,8-dioksabicyklo[3.2.1]oktano-2,3-diolu jako środki kierujące do ASGPR |
| EP3773727A4 (en) * | 2018-04-09 | 2022-05-04 | Yale University | BIFUNCTIONAL SMALL MOLECULES TO TARGETING THE SELECTIVE DEGRADATION OF CIRCULATING PROTEINS |
-
2022
- 2022-03-10 WO PCT/US2022/019658 patent/WO2022192478A1/en not_active Ceased
- 2022-03-10 BR BR112023017702A patent/BR112023017702A2/pt unknown
- 2022-03-10 EP EP22767951.1A patent/EP4304579A1/en active Pending
- 2022-03-10 CA CA3211335A patent/CA3211335A1/en active Pending
- 2022-03-10 JP JP2023555333A patent/JP2024509282A/ja active Pending
- 2022-03-10 MX MX2023010424A patent/MX2023010424A/es unknown
- 2022-03-10 KR KR1020237033102A patent/KR20230154900A/ko active Pending
- 2022-03-10 AU AU2022232620A patent/AU2022232620A1/en active Pending
- 2022-03-10 CN CN202280020292.8A patent/CN116997337A/zh active Pending
- 2022-03-10 US US18/548,113 patent/US20240309114A1/en active Pending
- 2022-03-10 IL IL305665A patent/IL305665A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20240309114A1 (en) | 2024-09-19 |
| WO2022192478A1 (en) | 2022-09-15 |
| EP4304579A1 (en) | 2024-01-17 |
| KR20230154900A (ko) | 2023-11-09 |
| CA3211335A1 (en) | 2022-09-15 |
| IL305665A (en) | 2023-11-01 |
| JP2024509282A (ja) | 2024-02-29 |
| BR112023017702A2 (pt) | 2023-12-12 |
| AU2022232620A1 (en) | 2023-09-21 |
| CN116997337A (zh) | 2023-11-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2023010424A (es) | Degradadores bifuncionales de inmunoglobulina deficientes en galactosa. | |
| MX2025012882A (es) | Degradadores bifuncionales de inmunoglobulinas deficientes en galactosa | |
| MX2023008000A (es) | Conjugados de anticuerpo dirigido a b7-h4 y farmaco, y metodos de uso de los mismos. | |
| EP3941945A4 (en) | ANTITROPHOBLAST CELL SURFACE ANTIGEN 2 (TROP2) ANTIBODIES AND ANTIBODY-DRUG CONJUGATES THEREOF | |
| WO2002064634A3 (en) | Human monoclonal antibodies to fc alpha receptor (cd89) | |
| MX2022016180A (es) | Conjugados anticuerpo-fármaco que comprenden anticuerpos anti-b7-h3. | |
| SG10201810743WA (en) | Conjugation methods | |
| WO2018151817A8 (en) | Co-use of anti-bcma antibody and antibody-coupled t celll receptor (actr) in cancer therapy and b cell disorders | |
| WO2020172528A8 (en) | Albumin binding antibodies and use thereof | |
| EP2570137A3 (en) | Antibodies that bind human dendritic and epithelial cell 205 (DEC-205) | |
| RU2016111137A (ru) | Сконструированные конъюгаты против dll3 и способы применения | |
| MX2023004434A (es) | Anticuerpos anti-fgfr2 y metodos para usarlos. | |
| JP2018537410A5 (https=) | ||
| NO20072670L (no) | PLAD domene peptider med okt halveringstid i serum pa grunn av konjugering til domene antistoffer | |
| WO2019215510A3 (en) | Compositions and methods related to anti-cd19 antibody drug conjugates | |
| TW200616662A (en) | Humanized anti-5t4 antibodies and anti-5t4 antibody/calicheamicin conjugates | |
| TW200607523A (en) | Drug compositions, fusions and conjugates | |
| MX2022010599A (es) | Moleculas biespecificas de union al antigeno que se unen a her2, y metodos de uso de los mismos. | |
| MX2023010099A (es) | Enlazadores ramificados para conjugados de anticuerpo-fármaco y métodos de uso de estos. | |
| PH12022551000A1 (en) | Directed conjugation technologies | |
| WO1998023646A3 (en) | Binding agents specific for IGA receptor | |
| MY199140A (en) | Bifunctional proteins combining checkpoint blockade for targeted therapy | |
| WO2006073493A3 (en) | Vaccine conjugates comprising a monoclonal antibody binding to human dentritic cells and beta human chronic gonadotropin | |
| DE69726674D1 (de) | Zellmodulierende konjugate aus elementen aus spezifischen bindungspaaren | |
| WO2009132081A3 (en) | Monoclonal antibody-based targeting of folate receptors |