AU2021235304A1 - Treatment of coronavirus infection - Google Patents

Treatment of coronavirus infection Download PDF

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Publication number
AU2021235304A1
AU2021235304A1 AU2021235304A AU2021235304A AU2021235304A1 AU 2021235304 A1 AU2021235304 A1 AU 2021235304A1 AU 2021235304 A AU2021235304 A AU 2021235304A AU 2021235304 A AU2021235304 A AU 2021235304A AU 2021235304 A1 AU2021235304 A1 AU 2021235304A1
Authority
AU
Australia
Prior art keywords
dosage form
sars
cov
virus
coronavirus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2021235304A
Other languages
English (en)
Inventor
Dror BEN-ASHER
Reza Fathi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Redhill Biopharma Ltd
Original Assignee
Redhill Biopharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Redhill Biopharma Ltd filed Critical Redhill Biopharma Ltd
Publication of AU2021235304A1 publication Critical patent/AU2021235304A1/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/485Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AU2021235304A 2020-03-10 2021-03-08 Treatment of coronavirus infection Pending AU2021235304A1 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US202062987429P 2020-03-10 2020-03-10
US62/987,429 2020-03-10
US202063003601P 2020-04-01 2020-04-01
US63/003,601 2020-04-01
US202063034817P 2020-06-04 2020-06-04
US63/034,817 2020-06-04
US202063074799P 2020-09-04 2020-09-04
US63/074,799 2020-09-04
US202063125427P 2020-12-15 2020-12-15
US63/125,427 2020-12-15
PCT/IB2021/000131 WO2021181157A1 (en) 2020-03-10 2021-03-08 Treatment of coronavirus infection

Publications (1)

Publication Number Publication Date
AU2021235304A1 true AU2021235304A1 (en) 2022-10-06

Family

ID=76548186

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2021235304A Pending AU2021235304A1 (en) 2020-03-10 2021-03-08 Treatment of coronavirus infection

Country Status (11)

Country Link
US (6) US11052073B1 (https=)
EP (1) EP4117630A4 (https=)
JP (1) JP7822946B2 (https=)
KR (1) KR20220151613A (https=)
CN (2) CN117695284B (https=)
AU (1) AU2021235304A1 (https=)
BR (1) BR112022017923A2 (https=)
CA (1) CA3174438A1 (https=)
IL (1) IL295658A (https=)
MX (1) MX2022011173A (https=)
WO (1) WO2021181157A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210244705A1 (en) * 2020-02-07 2021-08-12 Centre For Digestive Diseases Therapeutic compositions, products of manufacture and methods for ameliorating or preventing coronavirus infection
CN117695284B (zh) 2020-03-10 2025-06-17 红山生物医药有限公司 冠状病毒感染的治疗
US11471448B2 (en) * 2020-12-15 2022-10-18 Redhill Biopharma Ltd. Sphingosine kinase 2 inhibitor for treating coronavirus infection in moderately severe patients with pneumonia
CN113398219A (zh) * 2021-06-30 2021-09-17 广州白云山星群(药业)股份有限公司 橘红痰咳浸膏在制备抑制人冠状病毒感染的药物中的用途
EP4286851A1 (en) 2022-06-01 2023-12-06 Universität Wien Methods and means for molecular characterization of post-viral fatigue syndrome
WO2025133697A2 (en) * 2023-12-20 2025-06-26 Redhill Biopharma Ltd. Combination therapy for inhibition of ebolavirus

Family Cites Families (26)

* Cited by examiner, † Cited by third party
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US7342018B2 (en) 1998-07-20 2008-03-11 Wilex Ag Urokinase inhibitors and uses thereof
US6624169B1 (en) 1998-07-20 2003-09-23 Wilex Biotechnology Gmbh Urokinase inhibitors
AU9059798A (en) 1998-09-18 2000-04-10 Pentapharm Ag Urokinase inhibitors
DE50211672D1 (de) 2001-03-21 2008-03-27 Wilex Ag Urokinase-inhibitoren
CH695999A5 (de) 2002-02-28 2006-11-15 Wilex Ag Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten.
WO2004011449A2 (de) 2002-07-25 2004-02-05 Wilex Ag Verfahren zur herstellung von phenylalanin-derivaten
DE10238048A1 (de) 2002-07-25 2004-02-05 Wilex Ag Verfahren zur Herstellung von Phenylalanin-Derivaten
US9770349B2 (en) * 2002-11-13 2017-09-26 University Of Virginia Patent Foundation Nanoporous stents with enhanced cellular adhesion and reduced neointimal formation
DE10323898A1 (de) 2003-05-26 2004-12-23 Wilex Ag Hydroxyamidin- und Hydroxyguanidin-Verbindungen als Urokinase-Hemmstoffe
RU2234313C1 (ru) 2003-06-04 2004-08-20 Кривошеин Юрий Семенович Средство инактивации коронавирусов
GB0420874D0 (en) 2004-09-20 2004-10-20 Swetree Technologies Ab Modulation of flowering time and growth cessation in perennial plants
DE102004045720A1 (de) 2004-09-21 2006-03-23 Wilex Ag Stabile Dosierungsform von Phenylalanin-Derivaten
BRPI0516106B1 (pt) 2004-10-14 2021-08-24 Wilex Ag Métodos para purificação e preparação de derivados de 3-hidroxiamidinofenilalanina, e para produção de derivados de 3-amidinofenilalanina
DE102004057195A1 (de) 2004-11-26 2006-06-01 Wilex Ag Kristalline Modifikationen von N-Alpha-(2,4,6-Triisopropylphenylsulfonyl)-3-hydroxyamidino-(L)-phenylalanin-4-ethoxycarbonylpiperazid und/oder Salzen davon
US8324237B2 (en) 2005-05-20 2012-12-04 Smith Charles D Methods for the treatment and prevention of inflammatory diseases
ES2528451T3 (es) 2005-06-17 2015-02-10 Apogee Biothechnology Corporation Inhibidores de esfingosina cinasa
WO2012166859A2 (en) * 2011-06-01 2012-12-06 The Curators Of The University Of Missouri Modulation of sphingosine 1-phosphate metabolizing enzymes for the treatment of negative-strand rna virus infections
WO2015161908A1 (en) * 2014-03-11 2015-10-29 Ludwig-Maximilians-Universität München Non-immunosuppressive cyclophilin inhibitors for the treatment of coronavirus infections
CA2965258C (en) * 2014-10-24 2023-09-19 Redhill Biopharma Ltd. Therapy for inhibition of single-stranded rna virus replication
DK3297438T3 (da) * 2015-05-21 2022-01-17 Chemocentryx Inc Ccr2-modulatorer
WO2017060771A2 (en) * 2015-10-06 2017-04-13 Redhill Biopharma Ltd. Combination therapies for treating cancer
US10195188B2 (en) * 2016-06-13 2019-02-05 Chemocentryx, Inc. Method of treating pancreatic cancer
US10251888B2 (en) * 2016-06-13 2019-04-09 Chemocentryx, Inc. Method of treating pancreatic cancer
DE102018217334A1 (de) * 2018-10-10 2020-04-16 Harbins Ruhr Bioscience, Inc. Sphingoid-Base und/oder Wirkstoff zur Verwendung bei der Prophylaxe und/oder Therapie einer viralen Infektion und/oder viralen Infektionskrankheit oder der Desinfektion, Nahrungsmittel/Nahrungsergänzungsmittel, Futtermittel/Futterergänzungsmittel und Pflanzenschutzmittel
CN117695284B (zh) * 2020-03-10 2025-06-17 红山生物医药有限公司 冠状病毒感染的治疗
EP4126234A1 (en) 2020-04-02 2023-02-08 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Compositions for coronavirus infection treatment and/or prevention

Also Published As

Publication number Publication date
US11918560B2 (en) 2024-03-05
CN117695284A (zh) 2024-03-15
IL295658A (en) 2022-10-01
US11052073B1 (en) 2021-07-06
US12551469B2 (en) 2026-02-17
CN115515560A (zh) 2022-12-23
US11045453B1 (en) 2021-06-29
KR20220151613A (ko) 2022-11-15
JP2023517920A (ja) 2023-04-27
CN115515560B (zh) 2023-12-15
CN117695284B (zh) 2025-06-17
MX2022011173A (es) 2022-10-18
CA3174438A1 (en) 2021-09-16
US20240350461A1 (en) 2024-10-24
US20210299108A1 (en) 2021-09-30
US12502381B2 (en) 2025-12-23
EP4117630A1 (en) 2023-01-18
US11364227B2 (en) 2022-06-21
BR112022017923A2 (pt) 2022-10-18
EP4117630A4 (en) 2024-07-03
JP7822946B2 (ja) 2026-03-03
WO2021181157A1 (en) 2021-09-16
US20220031682A1 (en) 2022-02-03
US20210322390A1 (en) 2021-10-21

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