AU2020336017B2 - Methods for the administration of certain VMAT2 inhibitors to patients with severe renal impairment - Google Patents

Methods for the administration of certain VMAT2 inhibitors to patients with severe renal impairment

Info

Publication number
AU2020336017B2
AU2020336017B2 AU2020336017A AU2020336017A AU2020336017B2 AU 2020336017 B2 AU2020336017 B2 AU 2020336017B2 AU 2020336017 A AU2020336017 A AU 2020336017A AU 2020336017 A AU2020336017 A AU 2020336017A AU 2020336017 B2 AU2020336017 B2 AU 2020336017B2
Authority
AU
Australia
Prior art keywords
patient
vmat2
inhibitor
subject
hexahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2020336017A
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English (en)
Other versions
AU2020336017A1 (en
Inventor
Gordon Raphael LOEWEN
Sha Rosa Luo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurocrine Biosciences Inc
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=72292706&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2020336017(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Publication of AU2020336017A1 publication Critical patent/AU2020336017A1/en
Application granted granted Critical
Publication of AU2020336017B2 publication Critical patent/AU2020336017B2/en
Priority to AU2025279628A priority Critical patent/AU2025279628A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AU2020336017A 2019-08-23 2020-08-21 Methods for the administration of certain VMAT2 inhibitors to patients with severe renal impairment Active AU2020336017B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2025279628A AU2025279628A1 (en) 2019-08-23 2025-12-09 Methods for the administration of certain VMAT2 inhibitors to patients with severe renal impairment

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962890697P 2019-08-23 2019-08-23
US62/890,697 2019-08-23
US202063028754P 2020-05-22 2020-05-22
US63/028,754 2020-05-22
PCT/US2020/047392 WO2021041208A1 (en) 2019-08-23 2020-08-21 Methods for the administration of certain vmat2 inhibitors to patients with severe renal impairment

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2025279628A Division AU2025279628A1 (en) 2019-08-23 2025-12-09 Methods for the administration of certain VMAT2 inhibitors to patients with severe renal impairment

Publications (2)

Publication Number Publication Date
AU2020336017A1 AU2020336017A1 (en) 2022-04-07
AU2020336017B2 true AU2020336017B2 (en) 2025-09-18

Family

ID=72292706

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2020336017A Active AU2020336017B2 (en) 2019-08-23 2020-08-21 Methods for the administration of certain VMAT2 inhibitors to patients with severe renal impairment
AU2025279628A Pending AU2025279628A1 (en) 2019-08-23 2025-12-09 Methods for the administration of certain VMAT2 inhibitors to patients with severe renal impairment

Family Applications After (1)

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AU2025279628A Pending AU2025279628A1 (en) 2019-08-23 2025-12-09 Methods for the administration of certain VMAT2 inhibitors to patients with severe renal impairment

Country Status (26)

Country Link
US (1) US10940141B1 (cg-RX-API-DMAC10.html)
EP (2) EP4652986A3 (cg-RX-API-DMAC10.html)
JP (2) JP7603662B2 (cg-RX-API-DMAC10.html)
KR (1) KR20220051239A (cg-RX-API-DMAC10.html)
CN (1) CN114679906A (cg-RX-API-DMAC10.html)
AU (2) AU2020336017B2 (cg-RX-API-DMAC10.html)
BR (1) BR112022002834A2 (cg-RX-API-DMAC10.html)
CA (1) CA3149033A1 (cg-RX-API-DMAC10.html)
DK (1) DK4017494T3 (cg-RX-API-DMAC10.html)
ES (1) ES3040583T3 (cg-RX-API-DMAC10.html)
FI (1) FI4017494T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20251281T1 (cg-RX-API-DMAC10.html)
HU (1) HUE073484T2 (cg-RX-API-DMAC10.html)
IL (1) IL290686B2 (cg-RX-API-DMAC10.html)
JO (1) JOP20220040A1 (cg-RX-API-DMAC10.html)
LT (1) LT4017494T (cg-RX-API-DMAC10.html)
MA (1) MA56930B1 (cg-RX-API-DMAC10.html)
MD (1) MD4017494T2 (cg-RX-API-DMAC10.html)
MX (1) MX2022000559A (cg-RX-API-DMAC10.html)
PH (1) PH12022550385A1 (cg-RX-API-DMAC10.html)
PT (1) PT4017494T (cg-RX-API-DMAC10.html)
RS (1) RS67194B1 (cg-RX-API-DMAC10.html)
SI (1) SI4017494T1 (cg-RX-API-DMAC10.html)
SM (1) SMT202500480T1 (cg-RX-API-DMAC10.html)
TW (1) TWI894161B (cg-RX-API-DMAC10.html)
WO (1) WO2021041208A1 (cg-RX-API-DMAC10.html)

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KR20230170136A (ko) 2017-01-27 2023-12-18 뉴로크린 바이오사이언시즈 인코퍼레이티드 특정 vmat2 억제제의 투여 방법
CA3076000A1 (en) 2017-09-21 2019-03-28 Neurocrine Biosciences, Inc. High dosage valbenazine formulation and compositions, methods, and kits related thereto
US20200230127A1 (en) 2017-10-10 2020-07-23 Neurocrine Biosciences, Inc. Methods for the Administration of Certain VMAT2 Inhibitors
SG11202100303QA (en) 2018-08-15 2021-02-25 Neurocrine Biosciences Inc Methods for the administration of certain vmat2 inhibitors
US20240197714A1 (en) * 2021-04-15 2024-06-20 Neurocrine Biosciences, Inc. Methods for the administration of certain vmat2 inhibitors
JP2024514873A (ja) * 2021-04-15 2024-04-03 ニューロクライン バイオサイエンシーズ，インコーポレイテッド デューテトラベナジンおよびｃｙｐ２ｄ６阻害剤の併用投与のための方法
IL309172A (en) 2021-06-30 2024-02-01 Neurocrine Biosciences Inc Vulbanazine for use in the additional treatment of schizophrenia
CA3221728A1 (en) * 2021-06-30 2023-01-05 Grace S. LIANG Valbenazine for use in the treatment of dyskinesia due to cerebral palsy
CA3245030A1 (en) 2022-03-07 2023-09-14 Neurocrine Biosciences, Inc. VALBENAZINE, A VMAT2 INHIBITOR, AS A FREE BASE OF A TOSYLATE OR DITOSYLATE SALT, INTENDED FOR USE IN THE TREATMENT OF CHOREA ASSOCIATED WITH HUNTINGTON'S DISEASE
WO2025038959A1 (en) 2023-08-17 2025-02-20 Neurocrine Biosciences, Inc. Methods for the administration of certain vmat2 inhibitors
TW202521119A (zh) 2023-08-17 2025-06-01 美商紐羅克里生物科學有限公司 用於投與特定vmat2抑制劑之方法
WO2025096823A1 (en) 2023-11-01 2025-05-08 Neurocrine Biosciences, Inc. Improvement, maintenance or reduction of decline of motor function associated with huntington disease using valbenazine
WO2025188830A1 (en) 2024-03-06 2025-09-12 Neurocrine Biosciences, Inc. Methods for the administration of certain vmat2 inhibitors

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WO2019060322A2 (en) * 2017-09-21 2019-03-28 Neurocrine Biosciences, Inc. HIGH DOSAGE VALBENAZINE FORMULATION AND COMPOSITIONS, METHODS AND KITS THEREOF

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