JOP20200298A1 - مركبات مثبطة لـ vmat2 وتركيبات وطرق تتعلق بها - Google Patents

مركبات مثبطة لـ vmat2 وتركيبات وطرق تتعلق بها

Info

Publication number
JOP20200298A1
JOP20200298A1 JOP/2020/0298A JOP20200298A JOP20200298A1 JO P20200298 A1 JOP20200298 A1 JO P20200298A1 JO P20200298 A JOP20200298 A JO P20200298A JO P20200298 A1 JOP20200298 A1 JO P20200298A1
Authority
JO
Jordan
Prior art keywords
vmat2 inhibitor
compositions
inhibitor compounds
methods relating
methods
Prior art date
Application number
JOP/2020/0298A
Other languages
English (en)
Inventor
Nicole Harriott
Christopher F O'brien
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Publication of JOP20200298A1 publication Critical patent/JOP20200298A1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

غير متوفر
JOP/2020/0298A 2018-06-14 2019-06-13 مركبات مثبطة لـ vmat2 وتركيبات وطرق تتعلق بها JOP20200298A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862684935P 2018-06-14 2018-06-14
PCT/US2019/037046 WO2019241555A1 (en) 2018-06-14 2019-06-13 Vmat2 inhibitor compounds, compositions, and methods relating thereto

Publications (1)

Publication Number Publication Date
JOP20200298A1 true JOP20200298A1 (ar) 2020-11-22

Family

ID=67263041

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2020/0298A JOP20200298A1 (ar) 2018-06-14 2019-06-13 مركبات مثبطة لـ vmat2 وتركيبات وطرق تتعلق بها

Country Status (16)

Country Link
EP (1) EP3806856A1 (ar)
JP (1) JP2021528386A (ar)
KR (1) KR20210021006A (ar)
CN (1) CN112638387A (ar)
AU (1) AU2019287524A1 (ar)
BR (1) BR112020024018A2 (ar)
CA (1) CA3100694A1 (ar)
EA (1) EA202092750A1 (ar)
IL (1) IL278758A (ar)
JO (1) JOP20200298A1 (ar)
MA (1) MA52896A (ar)
MX (1) MX2020013004A (ar)
PH (1) PH12020552088A1 (ar)
SG (1) SG11202011544UA (ar)
TW (1) TW202011963A (ar)
WO (1) WO2019241555A1 (ar)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3002074A1 (en) 2015-10-30 2017-05-04 Neurocrine Biosciences, Inc. Valbenazine salts and polymorphs thereof
JP6869988B2 (ja) 2015-12-23 2021-05-12 ニューロクライン バイオサイエンシーズ，インコーポレイテッド （Ｓ）−（２Ｒ，３Ｒ，１１ｂＲ）−３−イソブチル−９，１０−ジメトキシ−２，３，４，６，７，１１ｂ−ヘキサヒドロ−１Ｈ−ピリド［２，１−ａ］イソキノリン−２−イル２−アミノ−３−メチルブタノエートジ（４−メチルベンゼンスルホネート）の調製のための合成方法
CN110769826A (zh) 2017-01-27 2020-02-07 纽罗克里生物科学有限公司 施用某些vmat2抑制剂的方法
EP3684333A2 (en) 2017-09-21 2020-07-29 Neurocrine Biosciences, Inc. High dosage valbenazine formulation and compositions, methods, and kits related thereto
US10993941B2 (en) 2017-10-10 2021-05-04 Neurocrine Biosciences, Inc. Methods for the administration of certain VMAT2 inhibitors
AU2017435893B2 (en) 2017-10-10 2023-06-29 Neurocrine Biosciences, Inc Methods for the administration of certain VMAT2 inhibitors
BR112021000019A2 (pt) 2018-08-15 2021-04-06 Neurocrine Biosciences Inc. Métodos para administração de certos inibidores de vmat2
US10940141B1 (en) 2019-08-23 2021-03-09 Neurocrine Biosciences, Inc. Methods for the administration of certain VMAT2 inhibitors
WO2023076568A1 (en) * 2021-10-29 2023-05-04 Neurocrine Biosciences, Inc. Valbenazine compositions

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JOP20190239A1 (ar) * 2017-04-19 2019-10-09 Neurocrine Biosciences Inc مركبات مثبطة لـ vmat2 وتركيبات منها
EP3684333A2 (en) 2017-09-21 2020-07-29 Neurocrine Biosciences, Inc. High dosage valbenazine formulation and compositions, methods, and kits related thereto

Also Published As

Publication number Publication date
CA3100694A1 (en) 2019-12-19
WO2019241555A1 (en) 2019-12-19
BR112020024018A2 (pt) 2021-02-23
EA202092750A1 (ru) 2021-05-13
EP3806856A1 (en) 2021-04-21
CN112638387A (zh) 2021-04-09
IL278758A (en) 2021-01-31
MX2020013004A (es) 2021-02-17
AU2019287524A1 (en) 2020-12-24
TW202011963A (zh) 2020-04-01
JP2021528386A (ja) 2021-10-21
SG11202011544UA (en) 2020-12-30
MA52896A (fr) 2021-04-21
KR20210021006A (ko) 2021-02-24
PH12020552088A1 (en) 2021-08-02

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