AU2020222881C1 - Thioeno(3,2-b) pyridin-7-amine compounds for treating familial dysautonomia - Google Patents

Thioeno(3,2-b) pyridin-7-amine compounds for treating familial dysautonomia

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Publication number
AU2020222881C1
AU2020222881C1 AU2020222881A AU2020222881A AU2020222881C1 AU 2020222881 C1 AU2020222881 C1 AU 2020222881C1 AU 2020222881 A AU2020222881 A AU 2020222881A AU 2020222881 A AU2020222881 A AU 2020222881A AU 2020222881 C1 AU2020222881 C1 AU 2020222881C1
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AU
Australia
Prior art keywords
methyl
pyridin
amino
chloro
thieno
Prior art date
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AU2020222881A
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English (en)
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AU2020222881B2 (en
AU2020222881A1 (en
Inventor
Michael A. Arnold
Amal DAKKA
Gary Mitchell Karp
Tom Tuan LUONG
Jana Narasimhan
Nikolai A. Naryshkin
Jiashi WANG
Nanjing Zhang
Xiaoyan Zhang
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PTC Therapeutics Inc
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PTC Therapeutics Inc
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Publication of AU2020222881B2 publication Critical patent/AU2020222881B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2020222881A 2019-02-13 2020-02-10 Thioeno(3,2-b) pyridin-7-amine compounds for treating familial dysautonomia Active AU2020222881C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962805283P 2019-02-13 2019-02-13
US62/805,283 2019-02-13
PCT/US2020/017430 WO2020167628A1 (en) 2019-02-13 2020-02-10 Thioeno[3,2-b] pyridin-7-amine compounds for treating familial dysautonomia

Publications (3)

Publication Number Publication Date
AU2020222881A1 AU2020222881A1 (en) 2021-09-09
AU2020222881B2 AU2020222881B2 (en) 2025-07-10
AU2020222881C1 true AU2020222881C1 (en) 2026-01-22

Family

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Family Applications (1)

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AU2020222881A Active AU2020222881C1 (en) 2019-02-13 2020-02-10 Thioeno(3,2-b) pyridin-7-amine compounds for treating familial dysautonomia

Country Status (17)

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US (1) US12384797B2 (enExample)
EP (1) EP3924049B1 (enExample)
JP (1) JP7587511B2 (enExample)
KR (1) KR102907028B1 (enExample)
CN (1) CN113795304A (enExample)
AU (1) AU2020222881C1 (enExample)
BR (1) BR112021015853A2 (enExample)
CA (1) CA3129067A1 (enExample)
CL (1) CL2021002137A1 (enExample)
CO (1) CO2021010598A2 (enExample)
EA (1) EA202192170A1 (enExample)
IL (1) IL285399B2 (enExample)
MX (1) MX2021009667A (enExample)
PE (1) PE20220139A1 (enExample)
SG (1) SG11202108519TA (enExample)
UA (1) UA129890C2 (enExample)
WO (1) WO2020167628A1 (enExample)

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AU2022394333A1 (en) 2021-11-17 2024-06-27 Chdi Foundation, Inc. HTT modulators for treating Huntington’s disease
EP4514807B1 (en) 2022-04-27 2025-12-17 Skyhawk Therapeutics, Inc. Compositions useful for modulating splicing
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Also Published As

Publication number Publication date
US20220135586A1 (en) 2022-05-05
AU2020222881B2 (en) 2025-07-10
EA202192170A1 (ru) 2021-11-15
PE20220139A1 (es) 2022-01-27
EP3924049B1 (en) 2026-08-12
BR112021015853A2 (pt) 2021-10-05
CA3129067A1 (en) 2020-08-20
CN113795304A (zh) 2021-12-14
US12384797B2 (en) 2025-08-12
IL285399B2 (en) 2025-06-01
MX2021009667A (es) 2021-12-10
AU2020222881A1 (en) 2021-09-09
WO2020167628A1 (en) 2020-08-20
KR20210137040A (ko) 2021-11-17
JP2022520822A (ja) 2022-04-01
CL2021002137A1 (es) 2022-02-25
IL285399A (en) 2021-09-30
KR102907028B1 (ko) 2026-01-05
SG11202108519TA (en) 2021-09-29
CO2021010598A2 (es) 2021-08-30
JP7587511B2 (ja) 2024-11-20
IL285399B1 (en) 2025-02-01
EP3924049A1 (en) 2021-12-22
UA129890C2 (uk) 2025-09-03

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