AU2019384136B2 - Bis-octahydrophenanthrene carboxamide derivatives and protein conjugates thereof for use as LXR agonists - Google Patents

Bis-octahydrophenanthrene carboxamide derivatives and protein conjugates thereof for use as LXR agonists Download PDF

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AU2019384136B2
AU2019384136B2 AU2019384136A AU2019384136A AU2019384136B2 AU 2019384136 B2 AU2019384136 B2 AU 2019384136B2 AU 2019384136 A AU2019384136 A AU 2019384136A AU 2019384136 A AU2019384136 A AU 2019384136A AU 2019384136 B2 AU2019384136 B2 AU 2019384136B2
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compound
alkyl
dmf
antibody
amino acid
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AU2019384136A1 (en
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Jesper Gromada
Viktoria Gusarova
Amy Han
Sokol Haxhinasto
Andrew J. Murphy
William Olson
Matthew Sleeman
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the nitrogen atom of at least one of the carboxamide groups further acylated
    • A—HUMAN NECESSITIES
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
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    • C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes

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  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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AU2019384136A 2018-11-20 2019-11-19 Bis-octahydrophenanthrene carboxamide derivatives and protein conjugates thereof for use as LXR agonists Active AU2019384136B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862769946P 2018-11-20 2018-11-20
US62/769,946 2018-11-20
PCT/US2019/062302 WO2020106780A1 (en) 2018-11-20 2019-11-19 Bis-octahydrophenanthrene carboxamide derivatives and protein conjugates thereof for use as lxr agonists

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AU2019384136A1 AU2019384136A1 (en) 2021-06-10
AU2019384136B2 true AU2019384136B2 (en) 2024-06-06

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US (2) US12209180B2 (https=)
EP (2) EP4428142A3 (https=)
JP (2) JP7702866B2 (https=)
KR (1) KR20210094568A (https=)
CN (1) CN113382985A (https=)
AU (1) AU2019384136B2 (https=)
BR (1) BR112021009673A2 (https=)
CA (1) CA3120528A1 (https=)
CL (1) CL2021001308A1 (https=)
CO (1) CO2021007581A2 (https=)
EA (1) EA202191430A1 (https=)
ES (1) ES2984190T3 (https=)
IL (1) IL283313B2 (https=)
MA (1) MA53455B1 (https=)
MX (1) MX2021005822A (https=)
MY (1) MY206542A (https=)
PH (1) PH12021551153A1 (https=)
SG (1) SG11202105175WA (https=)
WO (1) WO2020106780A1 (https=)
ZA (1) ZA202103431B (https=)

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KR20240038138A (ko) * 2020-07-13 2024-03-22 리제너론 파마슈티칼스 인코포레이티드 단백질에서 글루타민 잔기에 접합된 캄토테신 유사체 및 그의 용도
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