CN113382985A - 用作lxr激动剂的双八氢菲羧酰胺类衍生物及其蛋白质偶联物 - Google Patents

用作lxr激动剂的双八氢菲羧酰胺类衍生物及其蛋白质偶联物 Download PDF

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Publication number
CN113382985A
CN113382985A CN201980089547.4A CN201980089547A CN113382985A CN 113382985 A CN113382985 A CN 113382985A CN 201980089547 A CN201980089547 A CN 201980089547A CN 113382985 A CN113382985 A CN 113382985A
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compound
group
amino acid
acid
antibody
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Chinese (zh)
Inventor
J·格罗玛达
V·古萨罗娃
A·韩
S·哈西纳斯托
A·J·墨菲
W·奥尔松
M·思利曼
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the nitrogen atom of at least one of the carboxamide groups further acylated
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CN201980089547.4A 2018-11-20 2019-11-19 用作lxr激动剂的双八氢菲羧酰胺类衍生物及其蛋白质偶联物 Pending CN113382985A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862769946P 2018-11-20 2018-11-20
US62/769946 2018-11-20
PCT/US2019/062302 WO2020106780A1 (en) 2018-11-20 2019-11-19 Bis-octahydrophenanthrene carboxamide derivatives and protein conjugates thereof for use as lxr agonists

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CN113382985A true CN113382985A (zh) 2021-09-10

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US (2) US12209180B2 (https=)
EP (2) EP4428142A3 (https=)
JP (2) JP7702866B2 (https=)
KR (1) KR20210094568A (https=)
CN (1) CN113382985A (https=)
AU (1) AU2019384136B2 (https=)
BR (1) BR112021009673A2 (https=)
CA (1) CA3120528A1 (https=)
CL (1) CL2021001308A1 (https=)
CO (1) CO2021007581A2 (https=)
EA (1) EA202191430A1 (https=)
ES (1) ES2984190T3 (https=)
IL (1) IL283313B2 (https=)
MA (1) MA53455B1 (https=)
MX (1) MX2021005822A (https=)
MY (1) MY206542A (https=)
PH (1) PH12021551153A1 (https=)
SG (1) SG11202105175WA (https=)
WO (1) WO2020106780A1 (https=)
ZA (1) ZA202103431B (https=)

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CN115505028A (zh) * 2022-09-16 2022-12-23 辽宁键凯科技有限公司 一种分支型聚乙二醇连接子及其用途
CN115594766A (zh) * 2021-12-30 2023-01-13 辽宁键凯科技有限公司（Cn） 一种缀合物及用其制备的抗体偶联药物

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KR20250114431A (ko) 2016-11-08 2025-07-29 리제너론 파마슈티칼스 인코포레이티드 스테로이드 및 이의 단백질-접합체
KR20250008984A (ko) 2017-05-18 2025-01-16 리제너론 파마슈티칼스 인코포레이티드 사이클로덱스트린 단백질 약물 접합체
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MA53455B1 (fr) * 2018-11-20 2022-11-30 Regeneron Pharma Dérivés de bis-octahydrophénanthrène carboxamide et leurs conjugués protéiques destinés à être utilisés en tant qu'agonistes de lxr
KR20240038138A (ko) * 2020-07-13 2024-03-22 리제너론 파마슈티칼스 인코포레이티드 단백질에서 글루타민 잔기에 접합된 캄토테신 유사체 및 그의 용도
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