AU2019354395A1 - Compositions and methods regarding engineered and non-engineered γδ -T cells for treatment of solid tumors - Google Patents

Compositions and methods regarding engineered and non-engineered γδ -T cells for treatment of solid tumors Download PDF

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Publication number
AU2019354395A1
AU2019354395A1 AU2019354395A AU2019354395A AU2019354395A1 AU 2019354395 A1 AU2019354395 A1 AU 2019354395A1 AU 2019354395 A AU2019354395 A AU 2019354395A AU 2019354395 A AU2019354395 A AU 2019354395A AU 2019354395 A1 AU2019354395 A1 AU 2019354395A1
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cell
seq
cells
sequence
nucleic acid
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Inventor
Zili An
Marissa Ann HERRMAN
Aya Jakobovits
Yifeng Frank JING
Jason Michael ROMERO
Daulet Kadyl SATPAYEV
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Adicet Therapeutics Inc
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Adicet Therapeutics Inc
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Publication of AU2019354395A1 publication Critical patent/AU2019354395A1/en
Assigned to ADICET THERAPEUTICS, INC. reassignment ADICET THERAPEUTICS, INC. Amend patent request/document other than specification (104) Assignors: ADICET BIO, INC.
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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AU2019354395A 2018-10-01 2019-10-01 Compositions and methods regarding engineered and non-engineered γδ -T cells for treatment of solid tumors Pending AU2019354395A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862739826P 2018-10-01 2018-10-01
US62/739,826 2018-10-01
PCT/US2019/054144 WO2020072546A2 (en) 2018-10-01 2019-10-01 COMPOSITIONS AND METHODS REGARDING ENGINEERED AND NON-ENGINEERED γδ -T CELLS FOR TREATMENT OF SOLID TUMORS

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US (1) US20210388109A1 (https=)
EP (1) EP3860716A2 (https=)
JP (2) JP7679298B2 (https=)
KR (1) KR20210087458A (https=)
CN (1) CN113272016A (https=)
AU (1) AU2019354395A1 (https=)
BR (1) BR112021006254A2 (https=)
CA (1) CA3115059A1 (https=)
EA (1) EA202190915A1 (https=)
IL (1) IL281943A (https=)
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WO2021050789A1 (en) 2019-09-10 2021-03-18 Obsidian Therapeutics, Inc. Ca2-il15 fusion proteins for tunable regulation
WO2022197949A2 (en) * 2021-03-17 2022-09-22 Myeloid Therapeutics, Inc. Engineered chimeric fusion protein compositions and methods of use thereof
CN121419997A (zh) * 2023-06-14 2026-01-27 上海北恒生物科技有限公司 包含新型共刺激结构域的嵌合抗原受体及其用途

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