EA202190915A1 - Композиции и способы в отношении сконструированных и несконструированных t-клеток для лечения солидных опухолей - Google Patents

Композиции и способы в отношении сконструированных и несконструированных t-клеток для лечения солидных опухолей

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Publication number
EA202190915A1
EA202190915A1 EA202190915A EA202190915A EA202190915A1 EA 202190915 A1 EA202190915 A1 EA 202190915A1 EA 202190915 A EA202190915 A EA 202190915A EA 202190915 A EA202190915 A EA 202190915A EA 202190915 A1 EA202190915 A1 EA 202190915A1
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EA
Eurasian Patent Office
Prior art keywords
domain
cells
methods
solid tumors
compositions
Prior art date
Application number
EA202190915A
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English (en)
Russian (ru)
Inventor
Даулет Кадил Сатпаев
Марисса Энн Херрман
Джейсон Майкл Ромеро
Ифэн Фрэнк Цзин
Цили Ан
Айя Якобовиц
Original Assignee
Эдисет Био, Инк.
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Application filed by Эдисет Био, Инк. filed Critical Эдисет Био, Инк.
Publication of EA202190915A1 publication Critical patent/EA202190915A1/ru

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    • C07K16/30Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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EA202190915A 2018-10-01 2019-10-01 Композиции и способы в отношении сконструированных и несконструированных t-клеток для лечения солидных опухолей EA202190915A1 (ru)

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Application Number Priority Date Filing Date Title
US201862739826P 2018-10-01 2018-10-01
PCT/US2019/054144 WO2020072546A2 (en) 2018-10-01 2019-10-01 COMPOSITIONS AND METHODS REGARDING ENGINEERED AND NON-ENGINEERED γδ -T CELLS FOR TREATMENT OF SOLID TUMORS

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EA202190915A1 true EA202190915A1 (ru) 2021-08-17

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US (1) US20210388109A1 (https=)
EP (1) EP3860716A2 (https=)
JP (2) JP7679298B2 (https=)
KR (1) KR20210087458A (https=)
CN (1) CN113272016A (https=)
AU (1) AU2019354395A1 (https=)
BR (1) BR112021006254A2 (https=)
CA (1) CA3115059A1 (https=)
EA (1) EA202190915A1 (https=)
IL (1) IL281943A (https=)
MX (1) MX2021003744A (https=)
SG (1) SG11202103234RA (https=)
WO (1) WO2020072546A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
WO2021050789A1 (en) 2019-09-10 2021-03-18 Obsidian Therapeutics, Inc. Ca2-il15 fusion proteins for tunable regulation
WO2022197949A2 (en) * 2021-03-17 2022-09-22 Myeloid Therapeutics, Inc. Engineered chimeric fusion protein compositions and methods of use thereof
CN121419997A (zh) * 2023-06-14 2026-01-27 上海北恒生物科技有限公司 包含新型共刺激结构域的嵌合抗原受体及其用途

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100953520B1 (ko) 2001-06-22 2010-04-21 츄가이 세이야꾸 가부시키가이샤 항글리피칸 3항체를 포함하는 항암제
CA2569509C (en) * 2004-06-03 2014-08-12 Novimmune S.A. Anti-cd3 antibodies and methods of use thereof
SI1674111T1 (sl) 2004-07-09 2011-02-28 Chugai Pharmaceutical Co Ltd Protitelo proti glipikanu 3
AU2005336093B2 (en) 2004-10-08 2011-02-24 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Adoptive immunotherapy with enhanced T lymphocyte survival
AU2005297772B2 (en) 2004-10-26 2011-06-23 Chugai Seiyaku Kabushiki Kaisha Anti-glypican 3 antibody having modified sugar chain
US20070087005A1 (en) 2005-10-14 2007-04-19 Lazar Gregory A Anti-glypican-3 antibody
EP2144935A2 (en) 2007-03-29 2010-01-20 Technion Research & Development Foundation Ltd. Antibodies, methods and kits for diagnosing and treating melanoma
WO2010042490A1 (en) 2008-10-06 2010-04-15 Boston Medical Center Corporation A single lentiviral vector system for induced pluripotent (ips) stem cells derivation
WO2010088160A1 (en) 2009-01-28 2010-08-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors and related materials and methods of use
PT2710123T (pt) 2011-05-19 2017-10-13 Inst De Medicina Molecular Linha celular de linfócitos compreendendo células t gama-delta, método de composição e produção resultante dos mesmos
WO2013070468A1 (en) * 2011-11-08 2013-05-16 The Trustees Of The University Of Pennsylvania Glypican-3-specific antibody and uses thereof
CN103833852A (zh) * 2012-11-23 2014-06-04 上海市肿瘤研究所 针对磷脂酰肌醇蛋白多糖-3和t细胞抗原的双特异性抗体
CN104140974B (zh) 2013-05-08 2017-09-29 科济生物医药(上海)有限公司 编码gpc‑3嵌合抗原受体蛋白的核酸及表达gpc‑3嵌合抗原受体蛋白的t淋巴细胞
EP3060059A4 (en) 2013-10-25 2017-11-01 Board of Regents, The University of Texas System Polyclonal gamma delta t cells for immunotherapy
CN107075480A (zh) 2014-07-09 2017-08-18 Tc生物制药有限公司 γδT细胞及其用途
GB201506423D0 (en) * 2015-04-15 2015-05-27 Tc Biopharm Ltd Gamma delta T cells and uses thereof
US10093746B2 (en) 2014-09-04 2018-10-09 The Trustees Of The University Of Pennsylvania Glypican-3 antibody and uses thereof
MA40764A (fr) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd Agent thérapeutique induisant une cytotoxicité
JP2017529851A (ja) 2014-09-26 2017-10-12 ベイラー カレッジ オブ メディスンBaylor College Of Medicine 養子免疫療法のためのグリピカン−3特異的キメラ抗原レセプター
IL297773B2 (en) 2014-11-17 2024-07-01 Adicet Bio Inc Engineered gamma delta t-cells
CN105713881B (zh) 2014-12-04 2019-12-06 科济生物医药(上海)有限公司 双靶向gpc3和asgpr1的转基因免疫效应细胞及其应用
GB201507368D0 (en) * 2015-04-30 2015-06-17 Ucl Business Plc Cell
NL2014935B1 (en) 2015-06-08 2017-02-03 Applied Immune Tech Ltd T cell receptor like antibodies having fine specificity.
AU2016274633B2 (en) 2015-06-09 2022-04-21 Gammadelta Therapeutics Ltd Methods for the production of TCR gamma delta+ T cells
ES2883240T3 (es) * 2015-08-03 2021-12-07 Cafa Therapeutics Ltd Anticuerpo contra glipicano-3 y aplicación del mismo
AU2016323985B2 (en) * 2015-09-17 2022-12-15 Novartis Ag CAR T cell therapies with enhanced efficacy
SG11201803934YA (en) 2015-11-11 2018-06-28 Intrexon Corp Compositions and methods for expression of multiple biologically active polypeptides from a single vector for treatment of cardiac conditions and other pathologies
US20190048085A1 (en) * 2016-02-25 2019-02-14 Cell Medica Switzerland Ag Modified cells for immunotherapy
US11299708B2 (en) 2016-05-12 2022-04-12 Adicet Bio, Inc. Methods for selective expansion of γδ T-cell populations and compositions thereof
CN107523545A (zh) * 2016-06-20 2017-12-29 上海细胞治疗研究院 一种高效稳定表达抗体的杀伤性细胞及其用途
JP2019530431A (ja) 2016-07-26 2019-10-24 テッサ・セラピューティクス・プライベート・リミテッド キメラ抗原受容体
MX2019008221A (es) * 2017-01-10 2019-12-09 Univ Yamaguchi Anticuerpo anti-gpc3.
GB201701332D0 (en) * 2017-01-26 2017-03-15 Tc Biopharm Ltd Immune cells with modified metabolism and their use thereof
SG10202107136XA (en) * 2017-02-08 2021-07-29 Agency Science Tech & Res Gamma delta t cells and a method of augmenting the tumoricidal activity of the same
EP3615574A4 (en) * 2017-04-26 2021-02-24 Eureka Therapeutics, Inc. SPECIFIC GLYPICAN 3 RECOGNIZING CONSTRUCTS AND THEIR USE
GB2562774A (en) 2017-05-25 2018-11-28 Mcdonald Michael Genetic construct
CN111032076A (zh) * 2017-06-14 2020-04-17 阿迪塞特生物公司 能够以hla限制性方式结合hla-a2/tyrd的抗体及其用途
EP3561053A1 (en) * 2018-04-26 2019-10-30 Baylor College of Medicine Immune effector cells and molecular adaptors with an antigen cytokine complex for effective cancer immunotherapy
EP3784256A4 (en) * 2018-04-27 2022-06-29 Baylor College of Medicine Car t cells with one or more interleukins
CN108588023B (zh) * 2018-05-09 2020-02-14 河北森朗生物科技有限公司 一种生产嵌合抗原受体修饰的γδT细胞的方法
WO2020017479A1 (ja) * 2018-07-17 2020-01-23 ノイルイミューン・バイオテック株式会社 抗gpc3一本鎖抗体を含むcar

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