AU2019349424B2 - 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof - Google Patents

2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof Download PDF

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Publication number
AU2019349424B2
AU2019349424B2 AU2019349424A AU2019349424A AU2019349424B2 AU 2019349424 B2 AU2019349424 B2 AU 2019349424B2 AU 2019349424 A AU2019349424 A AU 2019349424A AU 2019349424 A AU2019349424 A AU 2019349424A AU 2019349424 B2 AU2019349424 B2 AU 2019349424B2
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AU2019349424A1 (en
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Omar Diego LOPEZ
Joel Morris
Donn G. Wishka
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US Department of Health and Human Services
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Government of the United States of America
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AU2019349424A 2018-09-25 2019-09-23 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof Ceased AU2019349424B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862736246P 2018-09-25 2018-09-25
US62/736,246 2018-09-25
PCT/US2019/052410 WO2020068657A1 (en) 2018-09-25 2019-09-23 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof

Publications (2)

Publication Number Publication Date
AU2019349424A1 AU2019349424A1 (en) 2021-03-18
AU2019349424B2 true AU2019349424B2 (en) 2024-04-04

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ID=68136598

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AU2019349424A Ceased AU2019349424B2 (en) 2018-09-25 2019-09-23 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof

Country Status (7)

Country Link
US (2) US20220033387A1 (https=)
EP (1) EP3856754A1 (https=)
JP (1) JP7520822B2 (https=)
CN (1) CN112888698A (https=)
AU (1) AU2019349424B2 (https=)
CA (1) CA3110224A1 (https=)
WO (1) WO2020068657A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3856754A1 (en) * 2018-09-25 2021-08-04 The United States of America, as represented by the Secretary, Department of Health and Human Services 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof
EP4138843A4 (en) * 2020-04-23 2024-07-10 Southern Research Institute COMPOSITION FOR THE TREATMENT OF BLOOD CANCER USING 4'-THIO-5-AZA-2'-DEOXYCYTIDINE AND USES THEREOF
CN114644668B (zh) * 2020-12-18 2026-04-14 鲁南制药集团股份有限公司 一种合成地西他滨的方法

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SG10201603288XA (en) 2012-03-28 2016-05-30 Fujifilm Corp Salt Of 1-(2-Deoxy-2-Fluoro-4-Thio-beta-D-Arabinofuranosyl)Cytosine
KR20170001722A (ko) 2012-08-13 2017-01-04 후지필름 가부시키가이샤 1-(2-데옥시-2-플루오로-4-티오-β-D-아라비노푸라노실)시토신의 합성 중간체, 티오뉴클레오시드의 합성 중간체, 및 그들의 제조법
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EP3856754A1 (en) * 2018-09-25 2021-08-04 The United States of America, as represented by the Secretary, Department of Health and Human Services 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof

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Title
BOZHOK T S ET AL: "Synthesis, Hydrolytic Stability, and Antileukemic Activity of Azacytidine Nucleoside Analogs", PHARMACEUTICAL CHEMISTRY JOURNAL, vol. 49, no. 12, 4 April 2016, pages 804 - 809, DOI: 10.1007/S11094-016-1375-4 *
JAIDEEP V. THOTTASSERY ET AL: "Novel DNA methyltransferase-1...5-aza-4'-thio-2'-deoxycytidine", CANCER CHEMOTHERAPY AND PHARMACOLOGY., vol. 74, no. 2, 8 June 2014, pages 291 - 302, DOI: 10.1007/s00280-014-2503-z *
KAMAL N. TIWARI ET AL: "Synthesis and Anti-cancer Activity of Some Novel 5-Azacytosine Nucleosides", NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS., vol. 22, no. 12, 31 December 2003 (2003-12-31), pages 2161 - 2170, DOI: 10.1081/NCN-120026872 *
RICHARD DAIFUKU ET AL: "5-aza-2',2'-Difluoro Deoxycytidine (NUC013): A Novel Nucleoside...for the Treatment of Cancer", PHARMACEUTICALS, vol. 10, no. 3, 20 July 2017, pages 65, DOI: 10.3390/ph10030065 *

Also Published As

Publication number Publication date
US11254662B2 (en) 2022-02-22
CN112888698A (zh) 2021-06-01
WO2020068657A8 (en) 2021-03-18
JP7520822B2 (ja) 2024-07-23
CA3110224A1 (en) 2020-04-02
AU2019349424A1 (en) 2021-03-18
US20220033387A1 (en) 2022-02-03
US20210292310A1 (en) 2021-09-23
EP3856754A1 (en) 2021-08-04
JP2022502378A (ja) 2022-01-11
WO2020068657A1 (en) 2020-04-02

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