CN112888698A - 2’-卤代-4’-硫代-2’-脱氧-5-氮杂胞苷类似物及其使用方法 - Google Patents

2’-卤代-4’-硫代-2’-脱氧-5-氮杂胞苷类似物及其使用方法 Download PDF

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Publication number
CN112888698A
CN112888698A CN201980062607.3A CN201980062607A CN112888698A CN 112888698 A CN112888698 A CN 112888698A CN 201980062607 A CN201980062607 A CN 201980062607A CN 112888698 A CN112888698 A CN 112888698A
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compound
cancer
administration
effective amount
therapeutically effective
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Chinese (zh)
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J·莫里斯
D·G·维什卡
O·D·洛佩斯
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US Department of Health and Human Services
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US Department of Health and Human Services
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN201980062607.3A 2018-09-25 2019-09-23 2’-卤代-4’-硫代-2’-脱氧-5-氮杂胞苷类似物及其使用方法 Pending CN112888698A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862736246P 2018-09-25 2018-09-25
US62/736,246 2018-09-25
PCT/US2019/052410 WO2020068657A1 (en) 2018-09-25 2019-09-23 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof

Publications (1)

Publication Number Publication Date
CN112888698A true CN112888698A (zh) 2021-06-01

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ID=68136598

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CN201980062607.3A Pending CN112888698A (zh) 2018-09-25 2019-09-23 2’-卤代-4’-硫代-2’-脱氧-5-氮杂胞苷类似物及其使用方法

Country Status (7)

Country Link
US (2) US20220033387A1 (https=)
EP (1) EP3856754A1 (https=)
JP (1) JP7520822B2 (https=)
CN (1) CN112888698A (https=)
AU (1) AU2019349424B2 (https=)
CA (1) CA3110224A1 (https=)
WO (1) WO2020068657A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3856754A1 (en) * 2018-09-25 2021-08-04 The United States of America, as represented by the Secretary, Department of Health and Human Services 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof
EP4138843A4 (en) * 2020-04-23 2024-07-10 Southern Research Institute COMPOSITION FOR THE TREATMENT OF BLOOD CANCER USING 4'-THIO-5-AZA-2'-DEOXYCYTIDINE AND USES THEREOF
CN114644668B (zh) * 2020-12-18 2026-04-14 鲁南制药集团股份有限公司 一种合成地西他滨的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101282986A (zh) * 2005-09-29 2008-10-08 苏伯俭股份有限公司 其中结合5-氮杂-胞嘧啶的寡核苷酸类似物
CN103172662A (zh) * 2004-10-25 2013-06-26 德克技术公司 作为抗肿瘤剂的异磷酰胺氮芥及其类似物的盐
CN103626765A (zh) * 2012-08-27 2014-03-12 广东东阳光药业有限公司 取代的氮杂吲哚化合物及其盐、组合物和用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675189A (en) 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
CA1256638A (en) 1984-07-06 1989-06-27 Motoaki Tanaka Polymer and its production
JP2551756B2 (ja) 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
WO1997038001A1 (en) * 1996-04-09 1997-10-16 Yamasa Corporation 1-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINES
US20060128654A1 (en) 2004-12-10 2006-06-15 Chunlin Tang Pharmaceutical formulation of cytidine analogs and derivatives
RU2559364C2 (ru) 2009-12-18 2015-08-10 Либрамедисина, Инк. СПОСОБ ПОЛУЧЕНИЯ ЗАМЕЩЕННЫХ 1-О-АЦИЛ-2-ДЕЗОКСИ-2-ФТОР-4-ТИО-β-D-АРАБИНОФУРАНОЗ
SG10201603288XA (en) 2012-03-28 2016-05-30 Fujifilm Corp Salt Of 1-(2-Deoxy-2-Fluoro-4-Thio-beta-D-Arabinofuranosyl)Cytosine
KR20170001722A (ko) 2012-08-13 2017-01-04 후지필름 가부시키가이샤 1-(2-데옥시-2-플루오로-4-티오-β-D-아라비노푸라노실)시토신의 합성 중간체, 티오뉴클레오시드의 합성 중간체, 및 그들의 제조법
EP3109245B1 (en) 2014-02-18 2018-01-03 FUJIFILM Corporation Method for producting thiolane skeleton-type glycoconjugate, and thiolane skeleton-type glycoconjugate
JP6450356B2 (ja) 2016-02-29 2019-01-09 富士フイルム株式会社 液状医薬製剤
EP3746452B1 (en) 2018-02-01 2023-09-13 The United States of America, as represented by the Secretary, Department of Health and Human Services Stereoselective synthesis and process for the manufacturing of 2'-deoxynucleosides
EP3856754A1 (en) * 2018-09-25 2021-08-04 The United States of America, as represented by the Secretary, Department of Health and Human Services 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103172662A (zh) * 2004-10-25 2013-06-26 德克技术公司 作为抗肿瘤剂的异磷酰胺氮芥及其类似物的盐
CN101282986A (zh) * 2005-09-29 2008-10-08 苏伯俭股份有限公司 其中结合5-氮杂-胞嘧啶的寡核苷酸类似物
CN103626765A (zh) * 2012-08-27 2014-03-12 广东东阳光药业有限公司 取代的氮杂吲哚化合物及其盐、组合物和用途

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BOZHOK, T. S.: "Synthesis, Hydrolytic Stability, and Antileukemic Activity of Azacytidine Nucleoside Analogs", PHARMACEUTICAL CHEMISTRY JOURNAL, 31 December 2016 (2016-12-31), pages 804 - 809 *
DAIFUKU, RICHARD: "5-aza-2\'2\'-difluroro deoxycytidine (NUC013): a novel nucleoside DNA methyl transferase inhibitor and ribonucleotide reductase inhibitor for the treatment of cancer", PHARMACEUTICALS, 31 December 2017 (2017-12-31), pages 1 - 65 *
THOTTASSERY, JAIDEEP V: "Novel DNA methyltransferase-1 (DNMT1) depleting anticancer nucleosides, 4\'-thio-2\'-deoxycytidine and 5-aza-4\'-thio-2\'-deoxycytidine", CANCER CHEMOTHERAPY AND PHARMACOLOGY, 31 December 2014 (2014-12-31), pages 291 - 302 *
TIWARI, KAMAL N.: "Synthesis and Anti-cancer Activity of Some Novel 5-Azacytosine Nucleosides", NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, 31 December 2003 (2003-12-31), pages 2161 - 2170, XP055221323, DOI: 10.1081/NCN-120026872 *

Also Published As

Publication number Publication date
US11254662B2 (en) 2022-02-22
WO2020068657A8 (en) 2021-03-18
JP7520822B2 (ja) 2024-07-23
CA3110224A1 (en) 2020-04-02
AU2019349424A1 (en) 2021-03-18
AU2019349424B2 (en) 2024-04-04
US20220033387A1 (en) 2022-02-03
US20210292310A1 (en) 2021-09-23
EP3856754A1 (en) 2021-08-04
JP2022502378A (ja) 2022-01-11
WO2020068657A1 (en) 2020-04-02

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