AU2019335199A1 - Process for preparing jak inhibitors and intermediates thereof - Google Patents
Process for preparing jak inhibitors and intermediates thereof Download PDFInfo
- Publication number
- AU2019335199A1 AU2019335199A1 AU2019335199A AU2019335199A AU2019335199A1 AU 2019335199 A1 AU2019335199 A1 AU 2019335199A1 AU 2019335199 A AU2019335199 A AU 2019335199A AU 2019335199 A AU2019335199 A AU 2019335199A AU 2019335199 A1 AU2019335199 A1 AU 2019335199A1
- Authority
- AU
- Australia
- Prior art keywords
- group
- compound
- salt
- formula
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862726600P | 2018-09-04 | 2018-09-04 | |
US62/726,600 | 2018-09-04 | ||
PCT/US2019/049338 WO2020051135A1 (fr) | 2018-09-04 | 2019-09-03 | Procédé de préparation d'inhibiteurs de jak et intermédiaires de ceux-ci |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2019335199A1 true AU2019335199A1 (en) | 2021-03-11 |
Family
ID=67957449
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2019335199A Abandoned AU2019335199A1 (en) | 2018-09-04 | 2019-09-03 | Process for preparing jak inhibitors and intermediates thereof |
Country Status (15)
Country | Link |
---|---|
US (1) | US10844057B2 (fr) |
EP (1) | EP3837253B1 (fr) |
JP (1) | JP2021535176A (fr) |
KR (1) | KR20210056382A (fr) |
CN (1) | CN112638902A (fr) |
AR (1) | AR116116A1 (fr) |
AU (1) | AU2019335199A1 (fr) |
BR (1) | BR112021004087A2 (fr) |
CA (1) | CA3108848A1 (fr) |
IL (1) | IL281152B2 (fr) |
MX (1) | MX2021002273A (fr) |
PH (1) | PH12021550388A1 (fr) |
SG (1) | SG11202101785UA (fr) |
TW (1) | TWI808250B (fr) |
WO (1) | WO2020051135A1 (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3001542C (fr) | 2015-11-03 | 2021-02-16 | Theravance Biopharma R&D Ip, Llc | Composes inhibiteurs de kinase jak pour le traitement de maladies respiratoires |
SG11201907840RA (en) | 2017-03-09 | 2019-09-27 | Theravance Biopharma R&D Ip Llc | Fused imidazo-piperidine jak inhibitors |
AU2019335200A1 (en) * | 2018-09-04 | 2021-03-11 | Theravance Biopharma R&D Ip, Llc | 5 to 7 membered heterocyclic amides as JAK inhibitors |
IL281146B2 (en) | 2018-09-04 | 2023-12-01 | Theravance Biopharma R& D Ip Llc | Dimethyl amino aztidine amides as JAK inhibitors |
TW202144343A (zh) | 2020-03-02 | 2021-12-01 | 美商施萬生物製藥研發 Ip有限責任公司 | Jak抑制劑化合物之結晶水合物 |
EP4146202A1 (fr) * | 2020-05-08 | 2023-03-15 | Theravance Biopharma R&D IP, LLC | Procédé de traitement d'un patient infecté par un coronavirus avec du nézulcitinib |
WO2022081872A1 (fr) * | 2020-10-16 | 2022-04-21 | Gb008, Inc. | Inhibiteurs de janus kinase |
WO2022271604A1 (fr) * | 2021-06-21 | 2022-12-29 | Theravance Biopharma R&D Ip, Llc | Méthode de traitement d'un patient infecté par un coronavirus et ayant un niveau de base de crp inférieur à 150 mg/l |
WO2023215478A1 (fr) | 2022-05-05 | 2023-11-09 | Theravance Biopharma R&D Ip, Llc | Nézulcitinib pour administration par inhalation par voie orale sous forme nébulisée |
WO2023230236A1 (fr) * | 2022-05-26 | 2023-11-30 | Theravance Biopharma R&D Ip, Llc | Procédé de préparation d'inhibiteurs de jak et d'intermédiaires de ceux-ci |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4812462A (en) * | 1986-04-01 | 1989-03-14 | Warner-Lambert Company | 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity |
TWI262914B (en) | 1999-07-02 | 2006-10-01 | Agouron Pharma | Compounds and pharmaceutical compositions for inhibiting protein kinases |
JP4836788B2 (ja) | 2003-07-23 | 2011-12-14 | エグゼリクシス, インコーポレイテッド | 未分化リンパ腫キナーゼ変調因子及びその使用法 |
US20050090529A1 (en) | 2003-07-31 | 2005-04-28 | Pfizer Inc | 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation |
US7884109B2 (en) | 2005-04-05 | 2011-02-08 | Wyeth Llc | Purine and imidazopyridine derivatives for immunosuppression |
US8648069B2 (en) | 2007-06-08 | 2014-02-11 | Abbvie Inc. | 5-substituted indazoles as kinase inhibitors |
JP2010111624A (ja) | 2008-11-06 | 2010-05-20 | Shionogi & Co Ltd | Ttk阻害作用を有するインダゾール誘導体 |
JOP20190231A1 (ar) * | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
WO2010114971A1 (fr) | 2009-04-03 | 2010-10-07 | Sepracor Inc. | Composés utilisables pour le traitement de troubles à médiation par le récepteur métabotropique 5 au glutamate et leurs procédés d'utilisation |
CN102595899A (zh) * | 2009-08-10 | 2012-07-18 | 埃皮瑟瑞克斯有限公司 | 作为wnt/b-联蛋白信号传导途径抑制剂的吲唑及其治疗用途 |
EP3305073B1 (fr) | 2009-12-21 | 2019-05-15 | Samumed, LLC | 1h-pyrazolo [3,4-b] pyridines et leurs utilisations thérapeutiques |
US8575336B2 (en) * | 2011-07-27 | 2013-11-05 | Pfizer Limited | Indazoles |
UA111854C2 (uk) * | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
HUE057262T2 (hu) * | 2013-03-06 | 2022-04-28 | Incyte Holdings Corp | Eljárás és köztitermékek JAK inhibitor elõállítására |
UA117040C2 (uk) | 2013-12-05 | 2018-06-11 | Пфайзер Інк. | ПІРОЛО[2,3-d]ПІРИМІДИНІЛ-, ПІРОЛО[2,3-b]ПІРАЗИНІЛ- ТА ПІРОЛО[2,3-d]ПІРИДИНІЛАКРИЛАМІДИ |
KR20170002623A (ko) | 2014-05-14 | 2017-01-06 | 화이자 인코포레이티드 | 피라졸로피리딘 및 피라졸로피리미딘 |
WO2016026078A1 (fr) | 2014-08-19 | 2016-02-25 | Changzhou Jiekai Pharmatech Co., Ltd. | Composés hétérocycliques utilisés comme inhibiteurs de erk |
KR101663277B1 (ko) | 2015-03-30 | 2016-10-06 | 주식회사 녹십자 | TNIK, IKKε 및 TBK1 억제제로서의 피라졸계 유도체 및 이를 포함하는 약학적 조성물 |
PT3371185T (pt) | 2015-11-03 | 2020-12-28 | Topivert Pharma Ltd | Derivados de 4,5,6,7-tetrahidro-1h-imidazo[4,5-c]piridina e 1,4,5,6,7,8-hexahidroimidazo[4,5-d]azepina como inibidores de janus quinase |
WO2017077283A1 (fr) * | 2015-11-03 | 2017-05-11 | Topivert Pharma Limited | Dérivés 4,5,6,7-tétrahydro-1h-imidazo[4,5-c]pyridine et 1,4,5,6,7,8-héxahydroimidazo[4,5-d]azépine en tant qu'inhibiteurs de janus kinase |
CA3001542C (fr) | 2015-11-03 | 2021-02-16 | Theravance Biopharma R&D Ip, Llc | Composes inhibiteurs de kinase jak pour le traitement de maladies respiratoires |
SG11201907840RA (en) | 2017-03-09 | 2019-09-27 | Theravance Biopharma R&D Ip Llc | Fused imidazo-piperidine jak inhibitors |
AR111495A1 (es) | 2017-05-01 | 2019-07-17 | Theravance Biopharma R&D Ip Llc | Compuestos de imidazo-piperidina fusionada como inhibidores de jak |
SG11201909376TA (en) | 2017-05-01 | 2019-11-28 | Theravance Biopharma R&D Ip Llc | Crystalline forms of a jak inhibitor compound |
AU2018261588A1 (en) | 2017-05-01 | 2019-10-31 | Theravance Biopharma R&D Ip, Llc | Methods of treatment using a JAK inhibitor compound |
AU2019335200A1 (en) | 2018-09-04 | 2021-03-11 | Theravance Biopharma R&D Ip, Llc | 5 to 7 membered heterocyclic amides as JAK inhibitors |
IL281146B2 (en) | 2018-09-04 | 2023-12-01 | Theravance Biopharma R& D Ip Llc | Dimethyl amino aztidine amides as JAK inhibitors |
EP3853229A1 (fr) | 2018-10-29 | 2021-07-28 | Theravance Biopharma R&D IP, LLC | Composé de 2-azabicyclo hexane utilisé en tant qu'inhibiteur de jak |
KR20210132666A (ko) | 2019-02-25 | 2021-11-04 | 허난 메디노 파마슈티컬 테크놀로지 컴퍼니 리미티드 | Jak 억제제 화합물 및 그 사용 |
-
2019
- 2019-09-03 CA CA3108848A patent/CA3108848A1/fr active Pending
- 2019-09-03 SG SG11202101785UA patent/SG11202101785UA/en unknown
- 2019-09-03 AU AU2019335199A patent/AU2019335199A1/en not_active Abandoned
- 2019-09-03 CN CN201980057683.5A patent/CN112638902A/zh active Pending
- 2019-09-03 TW TW108131709A patent/TWI808250B/zh active
- 2019-09-03 WO PCT/US2019/049338 patent/WO2020051135A1/fr active Application Filing
- 2019-09-03 US US16/559,091 patent/US10844057B2/en active Active
- 2019-09-03 IL IL281152A patent/IL281152B2/en unknown
- 2019-09-03 MX MX2021002273A patent/MX2021002273A/es unknown
- 2019-09-03 KR KR1020217009940A patent/KR20210056382A/ko active Search and Examination
- 2019-09-03 JP JP2021512248A patent/JP2021535176A/ja not_active Ceased
- 2019-09-03 AR ARP190102521A patent/AR116116A1/es unknown
- 2019-09-03 BR BR112021004087-0A patent/BR112021004087A2/pt unknown
- 2019-09-03 EP EP19769346.8A patent/EP3837253B1/fr active Active
-
2021
- 2021-02-24 PH PH12021550388A patent/PH12021550388A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
SG11202101785UA (en) | 2021-03-30 |
IL281152B2 (en) | 2023-12-01 |
IL281152B1 (en) | 2023-08-01 |
EP3837253A1 (fr) | 2021-06-23 |
IL281152A (en) | 2021-04-29 |
US20200071324A1 (en) | 2020-03-05 |
CN112638902A (zh) | 2021-04-09 |
EP3837253C0 (fr) | 2023-06-07 |
US10844057B2 (en) | 2020-11-24 |
PH12021550388A1 (en) | 2021-11-08 |
BR112021004087A2 (pt) | 2021-05-25 |
KR20210056382A (ko) | 2021-05-18 |
AR116116A1 (es) | 2021-03-31 |
WO2020051135A1 (fr) | 2020-03-12 |
EP3837253B1 (fr) | 2023-06-07 |
CA3108848A1 (fr) | 2020-03-12 |
JP2021535176A (ja) | 2021-12-16 |
TW202024074A (zh) | 2020-07-01 |
MX2021002273A (es) | 2021-05-27 |
TWI808250B (zh) | 2023-07-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |