AU2019261329B2 - Inhalable liposomal sustained release composition for use in treating pulmonary diseases - Google Patents

Inhalable liposomal sustained release composition for use in treating pulmonary diseases Download PDF

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Publication number
AU2019261329B2
AU2019261329B2 AU2019261329A AU2019261329A AU2019261329B2 AU 2019261329 B2 AU2019261329 B2 AU 2019261329B2 AU 2019261329 A AU2019261329 A AU 2019261329A AU 2019261329 A AU2019261329 A AU 2019261329A AU 2019261329 B2 AU2019261329 B2 AU 2019261329B2
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Prior art keywords
anilino
liposomal
indolinone
mol
methylene
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AU2019261329A
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AU2019261329A1 (en
Inventor
Ting-yu CHENG
Jonathan FANG
Keelung Hong
Jo-Hsin TANG
Yu-Cheng Tseng
Wan-ni YU
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Inspirmed Corp
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Inspirmed Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2019261329A 2018-04-23 2019-04-23 Inhalable liposomal sustained release composition for use in treating pulmonary diseases Active AU2019261329B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862661217P 2018-04-23 2018-04-23
US62/661,217 2018-04-23
PCT/US2019/028647 WO2019209787A1 (en) 2018-04-23 2019-04-23 Inhalable liposomal sustained release composition for use in treating pulmonary diseases

Publications (2)

Publication Number Publication Date
AU2019261329A1 AU2019261329A1 (en) 2020-11-12
AU2019261329B2 true AU2019261329B2 (en) 2024-09-05

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AU2019261329A Active AU2019261329B2 (en) 2018-04-23 2019-04-23 Inhalable liposomal sustained release composition for use in treating pulmonary diseases

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US (2) US11534399B2 (enExample)
EP (1) EP3784213B1 (enExample)
JP (1) JP7391039B2 (enExample)
KR (1) KR20210003197A (enExample)
CN (1) CN112004527B (enExample)
AU (1) AU2019261329B2 (enExample)
BR (1) BR112020021412A8 (enExample)
CA (1) CA3101102A1 (enExample)
ES (1) ES2964413T3 (enExample)
IL (1) IL278079B2 (enExample)
TW (1) TWI866908B (enExample)
WO (1) WO2019209787A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3784213B1 (en) 2018-04-23 2023-09-06 InspirMed Corp. Inhalable liposomal sustained release composition for use in treating pulmonary diseases
TWI786328B (zh) * 2018-09-10 2022-12-11 台灣微脂體股份有限公司 緩釋眼用藥物組合物及其用途
US12599557B2 (en) 2019-04-25 2026-04-14 Tlc Biopharmaceuticals, Inc. Liposomal sustained-release compositions containing a therapeutic drug and use thereof
TWI853932B (zh) * 2019-05-14 2024-09-01 盈擘生技股份有限公司 用於治療肺部疾病之可吸入的支氣管擴張劑緩釋組成物
WO2021194927A1 (en) * 2020-03-22 2021-09-30 Tlc Biopharmaceuticals, Inc. Composition of antiviral agent for use in prophylactic or post-exposure treatment of infectious or respiratory diseases
CN112472791A (zh) * 2020-11-16 2021-03-12 复旦大学 CsA脂质体在制备抗SARS-CoV-2药物中的应用
EP4259101A4 (en) * 2020-12-14 2024-11-27 Nanotech Pharma Inc. COMPOSITIONS AND METHODS FOR DELIVERY OF ANTICANCER AGENTS WITH IMPROVED THERAPEUTIC INDEX
CN114642656B8 (zh) * 2020-12-18 2025-12-12 盈科瑞（天津）创新医药研究有限公司 一种吸入用尼达尼布溶液及其制备方法
US20250325549A1 (en) * 2021-08-18 2025-10-23 Samyang Holdings Corporation Oral tablet composition of ruxolitinib and method for preparing same
KR102348901B1 (ko) 2021-08-26 2022-01-07 충북대학교 산학협력단 레고라페닙을 유효성분으로 포함하는 만성폐쇄성 폐질환의 예방 또는 치료용 조성물
CN116064394A (zh) * 2021-11-01 2023-05-05 中国医学科学院医药生物技术研究所 肿瘤细胞外泌体与脂质体的杂化外泌体、其制备方法及其抗肿瘤用途
JP2025069482A (ja) * 2022-03-25 2025-05-01 国立研究開発法人医薬基盤・健康・栄養研究所 特発性肺線維症の治療または予防剤
CN120076792A (zh) * 2022-09-30 2025-05-30 上海济昀生物科技有限公司 一种脂质体药物组合物及其制备方法和应用
BE1031669B1 (fr) * 2023-06-02 2025-01-14 Inhatarget Therapeutics Composition pharmaceutique pour inhalation
EP4637764A1 (en) * 2023-12-22 2025-10-29 Zedira GmbH Oxo-pyridine derivatives as inhibitors of transglutaminases for use in the treatment of pulmonary fibrosis
WO2025138298A1 (zh) * 2023-12-30 2025-07-03 北京睿创康泰医药研究院有限公司 一种尼达尼布超分子复合体的药物组合物
CN117899020A (zh) * 2024-01-16 2024-04-19 中山大学 一种载抗生素黏液渗透型脂质体粉雾剂的制备方法及其应用
CN118948812A (zh) * 2024-08-06 2024-11-15 北京悦康科创医药科技股份有限公司 一种多肽脂质体吸入剂及其制备方法和应用
KR102859152B1 (ko) * 2024-10-24 2025-09-12 주식회사 한국리포좀 합성 지질 리포좀 기반의 일본 뇌염 바이러스 백신 및 그의 제조방법

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150044288A1 (en) * 2013-07-31 2015-02-12 Windward Pharma, Inc. Aerosol tyrosine kinase inhibitor compounds and uses thereof
US20150064114A1 (en) * 2013-09-03 2015-03-05 Samsung Electronics Co., Ltd. Liposome including hydrophobic material and imaging agent and use of the liposome

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63500175A (ja) 1985-05-22 1988-01-21 リポソ−ム　テクノロジ−，インコ−ポレイテツド リポソ−ム吸入法および吸入システム
IE63869B1 (en) 1986-11-06 1995-06-14 Res Dev Foundation Aerosols containing liposomes and method for their preparation
US5958378A (en) 1996-07-03 1999-09-28 Research Development Foundation High dose liposomal aerosol formulations containing cyclosporin A or budesonide
GB9912639D0 (en) 1999-05-28 1999-07-28 Britannia Pharmaceuticals Ltd Improvements in and relating to treatment of respiratory conditions
DE10214983A1 (de) 2002-04-04 2004-04-08 TransMIT Gesellschaft für Technologietransfer mbH Vernebelbare Liposomen und ihre Verwendung zur pulmonalen Applikation von Wirkstoffen
DE10237423A1 (de) 2002-08-16 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen
PT1581236E (pt) 2002-10-29 2013-12-24 Insmed Inc Libertação prolongada de anti-infecciosos
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
EP1628637A2 (en) 2003-05-30 2006-03-01 Alza Corporation Method of pulmonary administration of an agent
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
EP3067047B1 (en) 2005-12-08 2022-04-20 Insmed Incorporated Lipid-based compositions of antiinfectives for treating pulmonary infections
US8268347B1 (en) 2006-10-24 2012-09-18 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US8119156B2 (en) 2006-10-24 2012-02-21 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US8071127B2 (en) 2006-10-24 2011-12-06 Aradigm Corporation Dual action, inhaled formulations providing both an immediate and sustained release profile
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
CN101878229A (zh) * 2007-09-28 2010-11-03 巴塞尔大学医院 用于治疗癌症的免疫脂质体
US9233971B2 (en) * 2010-08-26 2016-01-12 Kunyuan Cui Lipomacrocycles and uses thereof
JP2013537172A (ja) 2010-09-09 2013-09-30 トリフォイリウム エーピーエス 血管新生阻害剤の気道投与
MX2011007675A (es) 2011-07-19 2012-07-11 Cell Therapy And Technology S A De C V Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas.
WO2014121211A2 (en) * 2013-02-01 2014-08-07 Zoneone Pharma, Inc. Remote loading of sparingly water-soluble drugs into liposomes
AU2015204558B2 (en) 2014-01-10 2020-04-30 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
WO2016090111A1 (en) 2014-12-05 2016-06-09 Vindico NanoBio Technology Inc. Compositions and methods for inducing nanoparticle-mediated microvascular embolization of tumors
WO2016178064A1 (en) 2015-05-06 2016-11-10 Suven Life Sciences Limited Polymorph of nintedanib ethanesulphonate, processes and intermediates thereof
US20180344644A1 (en) * 2015-09-21 2018-12-06 Mallinckrodt Llc Improved stability of liposome formulations and uses thereof
EP4218739A3 (en) * 2016-01-08 2023-08-09 The Regents of The University of California Mesoporous silica nanoparticles with lipid bilayer coating for cargo delivery
WO2017136774A1 (en) * 2016-02-04 2017-08-10 Stem Cell Theranostics, Inc. Pharmaceutical compositions and methods for countering chemotherapy induced cardiotoxicity
EP3784213B1 (en) 2018-04-23 2023-09-06 InspirMed Corp. Inhalable liposomal sustained release composition for use in treating pulmonary diseases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150044288A1 (en) * 2013-07-31 2015-02-12 Windward Pharma, Inc. Aerosol tyrosine kinase inhibitor compounds and uses thereof
US20150064114A1 (en) * 2013-09-03 2015-03-05 Samsung Electronics Co., Ltd. Liposome including hydrophobic material and imaging agent and use of the liposome

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PERES-FILHO, M. et al., "Antiproliferative Activity and VEGF Expression Reduction in MCF7 and PC-3 Cancer Cells by Paclitaxel and Imatinib Co-encapsulation in Folate-Targeted Liposomes" AAPS PharmSciTech, 2018 vol.19, pages 201-212 *
Shi, Ji-Feng, et al. "A combination of targeted sunitinib liposomes and targeted vinorelbine liposomes for treating invasive breast cancer." J biomed nanotech 2015 Vol.11, Number 9, pages 1568-1582 *

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JP7391039B2 (ja) 2023-12-04
US20230088661A1 (en) 2023-03-23
CN112004527A (zh) 2020-11-27
US11534399B2 (en) 2022-12-27
EP3784213B1 (en) 2023-09-06
EP3784213C0 (en) 2023-09-06
JP2021522163A (ja) 2021-08-30
TW202011941A (zh) 2020-04-01
IL278079A (en) 2020-11-30
ES2964413T3 (es) 2024-04-05
CN112004527B (zh) 2024-09-24
KR20210003197A (ko) 2021-01-11
IL278079B2 (en) 2025-08-01
CA3101102A1 (en) 2019-10-31
EP3784213A1 (en) 2021-03-03
US20210145740A1 (en) 2021-05-20
US12533313B2 (en) 2026-01-27
BR112020021412A8 (pt) 2022-07-05
BR112020021412A2 (pt) 2021-01-19
TWI866908B (zh) 2024-12-21
WO2019209787A1 (en) 2019-10-31
AU2019261329A1 (en) 2020-11-12
IL278079B1 (en) 2025-04-01

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