AU2018221722B2 - Calcium channel inhibitors - Google Patents

Calcium channel inhibitors Download PDF

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Publication number
AU2018221722B2
AU2018221722B2 AU2018221722A AU2018221722A AU2018221722B2 AU 2018221722 B2 AU2018221722 B2 AU 2018221722B2 AU 2018221722 A AU2018221722 A AU 2018221722A AU 2018221722 A AU2018221722 A AU 2018221722A AU 2018221722 B2 AU2018221722 B2 AU 2018221722B2
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AU
Australia
Prior art keywords
ethyl
amino
methyl
fluoro
optionally substituted
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AU2018221722A
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AU2018221722A1 (en
Inventor
Michelle HIGGIN
Timothy Macdonald
Thomas E. Richardson
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Cavion LLC
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Cavion LLC
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Publication of AU2018221722A1 publication Critical patent/AU2018221722A1/en
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Publication of AU2018221722B2 publication Critical patent/AU2018221722B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2018221722A 2017-02-15 2018-02-15 Calcium channel inhibitors Active AU2018221722B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762459355P 2017-02-15 2017-02-15
US62/459,355 2017-02-15
PCT/US2018/018356 WO2018152317A1 (en) 2017-02-15 2018-02-15 Calcium channel inhibitors

Publications (2)

Publication Number Publication Date
AU2018221722A1 AU2018221722A1 (en) 2019-10-03
AU2018221722B2 true AU2018221722B2 (en) 2022-02-03

Family

ID=63170001

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018221722A Active AU2018221722B2 (en) 2017-02-15 2018-02-15 Calcium channel inhibitors

Country Status (8)

Country Link
US (1) US11130750B2 (enExample)
EP (1) EP3585376A4 (enExample)
JP (1) JP7134178B2 (enExample)
KR (1) KR102642063B1 (enExample)
CN (1) CN110545806A (enExample)
AU (1) AU2018221722B2 (enExample)
CA (1) CA3053781A1 (enExample)
WO (1) WO2018152317A1 (enExample)

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* Cited by examiner, † Cited by third party
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US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US12478604B1 (en) 2016-07-22 2025-11-25 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US12186296B1 (en) 2016-07-22 2025-01-07 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
AU2020231916B2 (en) 2019-03-01 2025-08-28 Flamel Ireland Limited Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics

Citations (3)

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Publication number Priority date Publication date Assignee Title
EP0177960A2 (de) * 1984-10-11 1986-04-16 F. Hoffmann-La Roche Ag Tetrahydronaphtalinderivate, Verfahren und Zwischenprodukte zu deren Herstellung sowie diese enthaltende Arzneimittel
US4808605A (en) * 1986-11-14 1989-02-28 Hoffmann-La Roche Inc. Tetrahydronaphthalene derivatives as calcium antagonists
KR101679262B1 (ko) * 2015-06-08 2016-11-24 한국과학기술연구원 4-이소프로필크로만-3-올 화합물

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Also Published As

Publication number Publication date
CN110545806A (zh) 2019-12-06
EP3585376A4 (en) 2020-11-25
CA3053781A1 (en) 2018-08-23
US11130750B2 (en) 2021-09-28
AU2018221722A1 (en) 2019-10-03
JP2020507606A (ja) 2020-03-12
KR102642063B1 (ko) 2024-03-04
US20200385367A1 (en) 2020-12-10
KR20190130573A (ko) 2019-11-22
EP3585376A1 (en) 2020-01-01
WO2018152317A1 (en) 2018-08-23
JP7134178B2 (ja) 2022-09-09

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