AU2017375958A1 - Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases - Google Patents

Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases Download PDF

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Publication number
AU2017375958A1
AU2017375958A1 AU2017375958A AU2017375958A AU2017375958A1 AU 2017375958 A1 AU2017375958 A1 AU 2017375958A1 AU 2017375958 A AU2017375958 A AU 2017375958A AU 2017375958 A AU2017375958 A AU 2017375958A AU 2017375958 A1 AU2017375958 A1 AU 2017375958A1
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Prior art keywords
virus
gene
inhibitor
viruses
protein
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Abandoned
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AU2017375958A
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English (en)
Inventor
Sunil Chada
Kerstin B. Menander
Robert E. Sobol
Dora WIEDERHOLD
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Multivir Inc
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Multivir Inc
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Publication of AU2017375958A1 publication Critical patent/AU2017375958A1/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • A61K35/761Adenovirus
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • A61K35/768Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • AHUMAN NECESSITIES
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • A61K38/162Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
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    • A61K38/19Cytokines; Lymphokines; Interferons
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    • A61K38/19Cytokines; Lymphokines; Interferons
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    • A61K39/001186MAGE
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/39541Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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    • C12N2710/10011Adenoviridae
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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AU2017375958A 2016-12-12 2017-12-12 Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases Abandoned AU2017375958A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662433075P 2016-12-12 2016-12-12
US62/433,075 2016-12-12
US201662438273P 2016-12-22 2016-12-22
US62/438,273 2016-12-22
US201762444160P 2017-01-09 2017-01-09
US62/444,160 2017-01-09
PCT/US2017/065861 WO2018111902A1 (en) 2016-12-12 2017-12-12 Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases

Publications (1)

Publication Number Publication Date
AU2017375958A1 true AU2017375958A1 (en) 2019-07-04

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AU2017375958A Abandoned AU2017375958A1 (en) 2016-12-12 2017-12-12 Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases

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US (1) US20200009203A1 (enExample)
EP (1) EP3551226A1 (enExample)
JP (1) JP2020510624A (enExample)
KR (1) KR20190112263A (enExample)
CN (1) CN110381997A (enExample)
AU (1) AU2017375958A1 (enExample)
CA (1) CA3046961A1 (enExample)
WO (1) WO2018111902A1 (enExample)

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CA3004530A1 (en) * 2015-11-07 2017-05-11 Multivir Inc. Methods and compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer
WO2017173498A1 (en) 2016-04-06 2017-10-12 Noxopharm Limited Isoflavonoid composition with improved pharmacokinetics
US20190336552A1 (en) 2016-05-30 2019-11-07 Astellas Pharma Inc. Genetically engineered vaccinia viruses
JP7300394B2 (ja) 2017-01-17 2023-06-29 ヘパリジェニックス ゲーエムベーハー 肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害
EA201991804A1 (ru) 2017-02-01 2020-02-07 МОДЕРНАТиЭкс, ИНК. ИММУНОМОДУЛИРУЮЩИЕ ТЕРАПЕВТИЧЕСКИЕ КОМПОЗИЦИИ мРНК, КОДИРУЮЩЕЙ ПЕПТИДЫ С АКТИВИРУЮЩЕЙ ОНКОГЕННОЙ МУТАЦИЕЙ
CN119236118A (zh) 2017-02-28 2025-01-03 基因药物株式会社 含肿瘤特异性溶瘤腺病毒和免疫检查点抑制剂的抗癌组合物
CN111278448A (zh) * 2017-10-27 2020-06-12 美国默沙东药厂 用于治疗肝癌的组合物和方法
CA3081436A1 (en) 2017-10-31 2019-05-09 Western Oncolytics Ltd. Platform oncolytic vector for systemic delivery
MY206167A (en) * 2018-09-26 2024-12-03 Astellas Pharma Inc Cancer therapy by combination use of oncolytic vaccinia virus and immune checkpoint inhibitor, and pharmaceutical composition and combination medicine for use in the cancer therapy
JP2022547234A (ja) * 2019-08-29 2022-11-10 アステラス製薬株式会社 遺伝子操作された腫瘍溶解性ワクシニアウイルスおよびその使用方法
KR20220080141A (ko) * 2019-10-11 2022-06-14 인스티튜트 구스타브 루시 암의 치료를 위한 옥사자포스포린의 유도체를 포함하는 신규 치료 병용물
CA3157334A1 (en) * 2019-11-07 2021-05-14 Miguel Angel MOLINA-VILLA Methods and compositions for use of growth factor antibodies in combination with non-tyrosine targeting kinase inhibitors
CN115989034A (zh) * 2019-11-27 2023-04-18 得克萨斯大学体系董事会 Nk细胞的大规模组合car转导和crispr基因编辑
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