AU2017361253B2 - MAGL inhibitors - Google Patents

MAGL inhibitors Download PDF

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Publication number
AU2017361253B2
AU2017361253B2 AU2017361253A AU2017361253A AU2017361253B2 AU 2017361253 B2 AU2017361253 B2 AU 2017361253B2 AU 2017361253 A AU2017361253 A AU 2017361253A AU 2017361253 A AU2017361253 A AU 2017361253A AU 2017361253 B2 AU2017361253 B2 AU 2017361253B2
Authority
AU
Australia
Prior art keywords
compound
pharmaceutically acceptable
solvate
acceptable salt
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2017361253A
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English (en)
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AU2017361253A1 (en
Inventor
Daniel J. Buzard
Cheryl A. Grice
Michael B. SHAGHAFI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62145825&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2017361253(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of AU2017361253A1 publication Critical patent/AU2017361253A1/en
Assigned to LUNDBECK LA JOLLA RESEARCH CENTER, INC. reassignment LUNDBECK LA JOLLA RESEARCH CENTER, INC. Request for Assignment Assignors: ABIDE THERAPEUTICS, INC.
Assigned to H. LUNDBECK A/S. reassignment H. LUNDBECK A/S. Request for Assignment Assignors: LUNDBECK LA JOLLA RESEARCH CENTER, INC.
Application granted granted Critical
Publication of AU2017361253B2 publication Critical patent/AU2017361253B2/en
Ceased legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2017361253A 2016-11-16 2017-11-15 MAGL inhibitors Ceased AU2017361253B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662423102P 2016-11-16 2016-11-16
US62/423,102 2016-11-16
PCT/US2017/061870 WO2018093949A1 (en) 2016-11-16 2017-11-15 Magl inhibitors

Publications (2)

Publication Number Publication Date
AU2017361253A1 AU2017361253A1 (en) 2019-05-30
AU2017361253B2 true AU2017361253B2 (en) 2021-08-05

Family

ID=62145825

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017361253A Ceased AU2017361253B2 (en) 2016-11-16 2017-11-15 MAGL inhibitors

Country Status (27)

Country Link
US (2) US11059822B2 (OSRAM)
EP (1) EP3541820B1 (OSRAM)
JP (1) JP7042468B2 (OSRAM)
KR (1) KR20190080935A (OSRAM)
CN (1) CN110267962B (OSRAM)
AU (1) AU2017361253B2 (OSRAM)
BR (1) BR112019009880A2 (OSRAM)
CA (1) CA3043617A1 (OSRAM)
CL (1) CL2019001336A1 (OSRAM)
CO (1) CO2019004945A2 (OSRAM)
CR (1) CR20190239A (OSRAM)
DO (1) DOP2019000118A (OSRAM)
EA (1) EA038150B1 (OSRAM)
EC (1) ECSP19034535A (OSRAM)
ES (1) ES2952582T3 (OSRAM)
IL (1) IL266547B (OSRAM)
JO (1) JOP20190107A1 (OSRAM)
MA (1) MA46855A (OSRAM)
MX (1) MX389627B (OSRAM)
NI (1) NI201900049A (OSRAM)
PE (1) PE20191145A1 (OSRAM)
PH (1) PH12019501079A1 (OSRAM)
RU (1) RU2019115784A (OSRAM)
TN (1) TN2019000149A1 (OSRAM)
UA (1) UA125523C2 (OSRAM)
WO (1) WO2018093949A1 (OSRAM)
ZA (1) ZA201903099B (OSRAM)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109496213B (zh) * 2016-05-12 2022-03-04 H.隆德贝克有限公司 螺环化合物及其制备和使用方法
JOP20190108B1 (ar) 2016-11-16 2023-09-17 H Lundbeck As تركيبات صيدلانية
JOP20190105A1 (ar) * 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
HUE064559T2 (hu) 2016-11-16 2024-03-28 H Lundbeck As MAGL inhibitor kristályos formája
JOP20190107A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
US10927105B1 (en) 2017-05-23 2021-02-23 Lundbeck La Jolla Research Center, Inc. Pyrazole MAGL inhibitors
RS64006B1 (sr) 2017-05-23 2023-03-31 H Lundbeck As Pirazol magl inhibitori
BR112020003946A2 (pt) 2017-08-29 2020-09-08 Lundbeck La Jolla Research Center, Inc. compostos de espirociclo e métodos para produzir e usar os mesmos
ES2952332T3 (es) 2017-08-29 2023-10-30 H Lundbeck As Compuestos espirocíclicos y sus métodos de preparación y uso
KR20210033504A (ko) * 2018-07-19 2021-03-26 화이자 인코포레이티드 Magl 억제제로서 헤테로환형 스피로 화합물
HUE067912T2 (hu) 2018-08-13 2024-11-28 Hoffmann La Roche Új heterociklusos vegyületek, mint monoacil-glicerin-lipáz inhibitorok
KR20230004622A (ko) 2020-04-21 2023-01-06 하. 룬드벡 아크티에셀스카브 모노아실글리세롤 리파제 억제제의 합성
US11434222B2 (en) 2020-11-13 2022-09-06 H. Lundbeck A/S MAGL inhibitors
US20250084065A1 (en) 2021-12-29 2025-03-13 Psy Therapeutics, Inc. Inhibiting monoacylglycerol lipase (magl)
CN119137114A (zh) 2022-05-04 2024-12-13 H.隆德贝克有限公司 作为单酰基甘油脂肪酶抑制剂的(s)-1-(哒嗪-3-基氨基甲酰基)-6-氮杂螺[2.5]辛烷-6-甲酸1,1,1,3,3,3-六氟丙-2-酯的结晶形式
WO2024168426A1 (en) 2023-02-13 2024-08-22 Apogee Pharmaceuticals, Inc. Small molecules as monoacylglycerol lipase (magl) inhibitors, compositions and use thereof

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US20150148330A1 (en) * 2012-01-06 2015-05-28 Abide Therapeutics, Inc. Carbamate compounds and of making and using same
US20160137649A1 (en) * 2013-07-03 2016-05-19 Abide Therapeutics, Inc. Pyrrolo-pyrrole carbamate and related organic compounds, pharmaceutical compositions, and medical uses thereof
WO2016149401A2 (en) * 2015-03-18 2016-09-22 Abide Therapeutics, Inc. Piperazine carbamates and methods of making and using same
WO2018093946A1 (en) * 2016-11-16 2018-05-24 Abide Therapeutics, Inc. Magl inhibitors

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JP2014005245A (ja) * 2012-06-26 2014-01-16 Dainippon Sumitomo Pharma Co Ltd 二環性ピリミジン誘導体を含有する医薬組成物
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US10385057B2 (en) 2015-11-20 2019-08-20 Lundbeck La Jolla Research Center, Inc. Pyrazole compounds and methods of making and using same
TWI738753B (zh) 2016-03-31 2021-09-11 日商武田藥品工業股份有限公司 雜環化合物
CN109496213B (zh) 2016-05-12 2022-03-04 H.隆德贝克有限公司 螺环化合物及其制备和使用方法
JOP20190049A1 (ar) 2016-09-23 2019-03-20 Bial Portela & C? S A مثبطات دوبامين-b-هيدروكسيلاز
HUE064559T2 (hu) 2016-11-16 2024-03-28 H Lundbeck As MAGL inhibitor kristályos formája
JOP20190108B1 (ar) 2016-11-16 2023-09-17 H Lundbeck As تركيبات صيدلانية
JOP20190107A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
JOP20190106A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
CN117510468A (zh) 2017-03-13 2024-02-06 灵北拉荷亚研究中心公司 双重magl和faah抑制剂
RS64006B1 (sr) 2017-05-23 2023-03-31 H Lundbeck As Pirazol magl inhibitori
JOP20190267A1 (ar) 2017-05-23 2019-11-18 Lundbeck La Jolla Research Center Inc مثبطات بيرازول magl
BR112020003946A2 (pt) 2017-08-29 2020-09-08 Lundbeck La Jolla Research Center, Inc. compostos de espirociclo e métodos para produzir e usar os mesmos
ES2952332T3 (es) 2017-08-29 2023-10-30 H Lundbeck As Compuestos espirocíclicos y sus métodos de preparación y uso
US11434222B2 (en) 2020-11-13 2022-09-06 H. Lundbeck A/S MAGL inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150148330A1 (en) * 2012-01-06 2015-05-28 Abide Therapeutics, Inc. Carbamate compounds and of making and using same
US20160137649A1 (en) * 2013-07-03 2016-05-19 Abide Therapeutics, Inc. Pyrrolo-pyrrole carbamate and related organic compounds, pharmaceutical compositions, and medical uses thereof
WO2016149401A2 (en) * 2015-03-18 2016-09-22 Abide Therapeutics, Inc. Piperazine carbamates and methods of making and using same
WO2018093946A1 (en) * 2016-11-16 2018-05-24 Abide Therapeutics, Inc. Magl inhibitors

Also Published As

Publication number Publication date
US11059822B2 (en) 2021-07-13
BR112019009880A2 (pt) 2019-08-13
US20200291023A1 (en) 2020-09-17
ES2952582T3 (es) 2023-11-02
AU2017361253A1 (en) 2019-05-30
EA038150B1 (ru) 2021-07-14
MA46855A (fr) 2021-05-19
CL2019001336A1 (es) 2019-10-04
WO2018093949A1 (en) 2018-05-24
CO2019004945A2 (es) 2019-05-21
US20220135563A1 (en) 2022-05-05
KR20190080935A (ko) 2019-07-08
CN110267962A (zh) 2019-09-20
PH12019501079A1 (en) 2019-08-19
UA125523C2 (uk) 2022-04-13
CN110267962B (zh) 2022-04-01
CR20190239A (es) 2019-06-26
ZA201903099B (en) 2021-01-27
RU2019115784A3 (OSRAM) 2021-03-12
EP3541820A4 (en) 2020-06-10
TN2019000149A1 (en) 2020-10-05
NZ753471A (en) 2021-01-29
MX389627B (es) 2025-03-20
DOP2019000118A (es) 2019-09-30
RU2019115784A (ru) 2020-12-17
EP3541820C0 (en) 2023-07-05
NI201900049A (es) 2019-10-30
CA3043617A1 (en) 2018-05-24
MX2019005773A (es) 2019-12-05
PE20191145A1 (es) 2019-09-02
JP2020500178A (ja) 2020-01-09
EP3541820B1 (en) 2023-07-05
EP3541820A1 (en) 2019-09-25
IL266547A (en) 2019-07-31
JP7042468B2 (ja) 2022-03-28
IL266547B (en) 2022-06-01
EA201991029A1 (ru) 2019-12-30
US11691975B2 (en) 2023-07-04
JOP20190107A1 (ar) 2019-05-09
ECSP19034535A (es) 2019-05-31

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Legal Events

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PC1 Assignment before grant (sect. 113)

Owner name: H. LUNDBECK A/S.

Free format text: FORMER APPLICANT(S): LUNDBECK LA JOLLA RESEARCH CENTER, INC.

Owner name: LUNDBECK LA JOLLA RESEARCH CENTER, INC.

Free format text: FORMER APPLICANT(S): ABIDE THERAPEUTICS, INC.

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired