AU2017250509B2 - Selenium disulfide compositions for use in treating meibomian gland dysfunction - Google Patents

Selenium disulfide compositions for use in treating meibomian gland dysfunction Download PDF

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Publication number
AU2017250509B2
AU2017250509B2 AU2017250509A AU2017250509A AU2017250509B2 AU 2017250509 B2 AU2017250509 B2 AU 2017250509B2 AU 2017250509 A AU2017250509 A AU 2017250509A AU 2017250509 A AU2017250509 A AU 2017250509A AU 2017250509 B2 AU2017250509 B2 AU 2017250509B2
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AU
Australia
Prior art keywords
composition
selenium disulfide
anhydrous
meibomian gland
oil
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AU2017250509A
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AU2017250509A1 (en
Inventor
Yair Alster
Shimon Amselem
Doron Friedman
Zakhar Nudelman
Omer Rafaeli
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Azura Ophthalmics Ltd
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Azura Ophthalmics Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AU2017250509A 2016-04-14 2017-04-13 Selenium disulfide compositions for use in treating meibomian gland dysfunction Active AU2017250509B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662322627P 2016-04-14 2016-04-14
US62/322,627 2016-04-14
PCT/IB2017/000542 WO2017178892A2 (en) 2016-04-14 2017-04-13 Selenium disulfide compositions for use in treating meibomian gland dysfunction

Publications (2)

Publication Number Publication Date
AU2017250509A1 AU2017250509A1 (en) 2018-10-18
AU2017250509B2 true AU2017250509B2 (en) 2023-03-02

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AU2017250509A Active AU2017250509B2 (en) 2016-04-14 2017-04-13 Selenium disulfide compositions for use in treating meibomian gland dysfunction

Country Status (12)

Country Link
US (4) US11040062B2 (https=)
EP (1) EP3442519A4 (https=)
JP (4) JP6919970B2 (https=)
KR (1) KR102414557B1 (https=)
CN (2) CN109310665A (https=)
AU (1) AU2017250509B2 (https=)
BR (1) BR112018070852B1 (https=)
CA (1) CA3019349A1 (https=)
IL (1) IL262212B (https=)
MA (1) MA44676A (https=)
MX (1) MX385752B (https=)
WO (1) WO2017178892A2 (https=)

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US10688122B2 (en) * 2015-09-28 2020-06-23 Azura Ophthalmics Ltd. Thiol and disulfide-containing agents for increasing meibomian gland lipid secretion
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WO2021090070A2 (en) * 2019-11-04 2021-05-14 Azura Ophthalmics Ltd. Metered dose for disorders in or around the eye
WO2021090058A2 (en) * 2019-11-04 2021-05-14 Azura Ophthalmics Ltd. Metered dose for demodex and disorders related thereto
JP2023513415A (ja) * 2020-01-02 2023-03-31 アズーラ オフサルミックス エルティーディー． 二硫化セレン組成物の製造
EP4087655A4 (en) 2020-01-10 2024-02-21 Azura Ophthalmics Ltd INSTRUCTIONS FOR COMPOSITION AND SENSITIVITY
AU2022296017A1 (en) * 2021-06-24 2024-01-18 Azura Ophthalmics Ltd. Compositions and methods for vision improvement
CN114159322B (zh) * 2021-12-09 2023-04-18 江苏知原药业股份有限公司 一种二硫化硒洗发水及提高二硫化硒洗发水稳定性的方法
CN116672273A (zh) * 2023-05-29 2023-09-01 无锡知妍生物科技有限公司 一种多孔SiO2复合物及其制备方法
WO2025012701A2 (en) * 2023-07-07 2025-01-16 Azura Ophthalmics Ltd. Administration of keratolytics to ocular and periocular surfaces

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WO2017178892A3 (en) 2017-11-23
US12011457B2 (en) 2024-06-18
MA44676A (fr) 2019-02-20
IL262212A (en) 2018-11-29
MX385752B (es) 2025-03-18
EP3442519A2 (en) 2019-02-20
JP2019513705A (ja) 2019-05-30
US20240299445A1 (en) 2024-09-12
US20210330703A1 (en) 2021-10-28
JP2024164200A (ja) 2024-11-26
JP2023134452A (ja) 2023-09-27
WO2017178892A2 (en) 2017-10-19
CN109310665A (zh) 2019-02-05
CN114469991A (zh) 2022-05-13
MX2018012390A (es) 2019-07-04
BR112018070852B1 (pt) 2024-01-16
EP3442519A4 (en) 2019-12-04
IL262212B (en) 2021-07-29
BR112018070852A2 (pt) 2019-02-05
US20260021135A1 (en) 2026-01-22
AU2017250509A1 (en) 2018-10-18
JP2021181449A (ja) 2021-11-25
US20200281966A1 (en) 2020-09-10
CA3019349A1 (en) 2017-10-19
KR102414557B1 (ko) 2022-06-28
US11040062B2 (en) 2021-06-22
US12458661B2 (en) 2025-11-04
KR20180129920A (ko) 2018-12-05
JP6919970B2 (ja) 2021-08-18

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