AU2016355268B2 - Combination therapy of tetracyclic quinolone analogs for treating cancer - Google Patents

Combination therapy of tetracyclic quinolone analogs for treating cancer Download PDF

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AU2016355268B2
AU2016355268B2 AU2016355268A AU2016355268A AU2016355268B2 AU 2016355268 B2 AU2016355268 B2 AU 2016355268B2 AU 2016355268 A AU2016355268 A AU 2016355268A AU 2016355268 A AU2016355268 A AU 2016355268A AU 2016355268 B2 AU2016355268 B2 AU 2016355268B2
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cancer
compound
optionally substituted
alkyl
pharmaceutically acceptable
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AU2016355268A1 (en
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John Soong
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Senhwa Biosciences Inc
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Senhwa Biosciences Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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AU2016355268A 2015-11-20 2016-11-09 Combination therapy of tetracyclic quinolone analogs for treating cancer Active AU2016355268B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2021225157A AU2021225157B2 (en) 2015-11-20 2021-08-31 Combination therapy of tetracyclic quinolone analogs for treating cancer
AU2023229524A AU2023229524B2 (en) 2015-11-20 2023-09-13 Combination therapy of tetracyclic quinolone analogs for treating cancer

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562258211P 2015-11-20 2015-11-20
US62/258,211 2015-11-20
PCT/US2016/061176 WO2017087235A1 (en) 2015-11-20 2016-11-09 Combination therapy of tetracyclic quinolone analogs for treating cancer

Related Child Applications (1)

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AU2021225157A Division AU2021225157B2 (en) 2015-11-20 2021-08-31 Combination therapy of tetracyclic quinolone analogs for treating cancer

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AU2016355268A1 AU2016355268A1 (en) 2018-06-14
AU2016355268B2 true AU2016355268B2 (en) 2021-08-19

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AU2016355268A Active AU2016355268B2 (en) 2015-11-20 2016-11-09 Combination therapy of tetracyclic quinolone analogs for treating cancer
AU2021225157A Active AU2021225157B2 (en) 2015-11-20 2021-08-31 Combination therapy of tetracyclic quinolone analogs for treating cancer
AU2023229524A Active AU2023229524B2 (en) 2015-11-20 2023-09-13 Combination therapy of tetracyclic quinolone analogs for treating cancer

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AU2021225157A Active AU2021225157B2 (en) 2015-11-20 2021-08-31 Combination therapy of tetracyclic quinolone analogs for treating cancer
AU2023229524A Active AU2023229524B2 (en) 2015-11-20 2023-09-13 Combination therapy of tetracyclic quinolone analogs for treating cancer

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Country Link
US (4) US10857156B2 (enExample)
EP (1) EP3377068B1 (enExample)
JP (2) JP7017509B2 (enExample)
KR (2) KR20250065935A (enExample)
CN (2) CN119185322A (enExample)
AU (3) AU2016355268B2 (enExample)
CA (1) CA3005730A1 (enExample)
IL (1) IL259423A (enExample)
RU (1) RU2752506C2 (enExample)
TW (1) TWI730013B (enExample)
WO (1) WO2017087235A1 (enExample)

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TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
CA3037928A1 (en) * 2016-09-23 2018-03-29 The Johns Hopkins University Combinatory treatment strategies of cancer based on rna polymerase i inhibition
EP3601286A4 (en) 2017-03-28 2020-09-23 Pimera, Inc. NEW CRYSTALLINE FORMS OF A POL1 INHIBITOR
WO2018200571A1 (en) 2017-04-25 2018-11-01 Arbutus Biopharma Corporation Substituted 2,3-dihydro-1h-indene analogs and methods using same
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CN112334133A (zh) * 2018-02-15 2021-02-05 生华生物科技股份有限公司 喹诺酮类似物及其盐、组合物及其使用方法
EP3766499A4 (en) * 2018-03-13 2021-04-21 Osaka University TUMOR IMMUNE STIMULATOR
WO2019191624A1 (en) 2018-03-29 2019-10-03 Arbutus Biopharma, Inc. Substituted 1,1'-biphenyl compounds, analogues thereof, and methods using same
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JP2022517301A (ja) * 2018-12-07 2022-03-08 カファ セラピューティクス リミテッド 腫瘍併用免疫療法
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CN110075061A (zh) * 2019-03-13 2019-08-02 安庆瑄宇医药科技有限公司 一种尼拉帕尼口服液及其制备方法
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IL294399A (en) * 2020-01-09 2022-08-01 Astrazeneca Ab Combination therapy for treating cancer
CN113491768A (zh) * 2020-04-01 2021-10-12 深圳市罗湖区人民医院 Cd137抗体在制备促进nk细胞表达cd16分子的药物中的应用
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CN114409681A (zh) * 2022-03-18 2022-04-29 信义核新(北京)生物科技有限公司 用于治疗dna损伤修复缺陷肿瘤的喹诺酮类似物及其应用
CN115160341B (zh) * 2022-07-18 2023-07-18 中国医学科学院医学实验动物研究所 苯并噁嗪类化合物及其药物用途
KR20250054778A (ko) * 2022-08-30 2025-04-23 도레이 카부시키가이샤 암의 치료 및/또는 예방을 위한 의약품
CN116063328B (zh) * 2023-03-29 2023-06-20 信义核新(北京)生物科技有限公司 一种四环喹诺酮化合物、药学上可接受的盐及其应用
CN121399139A (zh) * 2023-04-23 2026-01-23 信义核新(北京)生物科技有限公司 喹诺酮衍生物及其在抗肿瘤中的应用
WO2024242545A1 (ko) * 2023-05-23 2024-11-28 (주) 메티메디제약 칼슘 락테이트를 활성 성분으로 포함하는 암 백신 조성물 및 그 용도
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