AU2016263311A1 - Novel amidoheteroaryl aroyl hydrazide ethynes - Google Patents
Novel amidoheteroaryl aroyl hydrazide ethynes Download PDFInfo
- Publication number
- AU2016263311A1 AU2016263311A1 AU2016263311A AU2016263311A AU2016263311A1 AU 2016263311 A1 AU2016263311 A1 AU 2016263311A1 AU 2016263311 A AU2016263311 A AU 2016263311A AU 2016263311 A AU2016263311 A AU 2016263311A AU 2016263311 A1 AU2016263311 A1 AU 2016263311A1
- Authority
- AU
- Australia
- Prior art keywords
- pyridin
- alkyl
- phenylethynyl
- formula
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
- C07B43/06—Formation or introduction of functional groups containing nitrogen of amide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1953MU2015 | 2015-05-18 | ||
| IN1953/MUM/2015 | 2015-05-18 | ||
| PCT/IN2016/050142 WO2016185490A1 (en) | 2015-05-18 | 2016-05-18 | Novel amidoheteroaryl aroyl hydrazide ethynes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2016263311A1 true AU2016263311A1 (en) | 2017-11-30 |
Family
ID=57319598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2016263311A Abandoned AU2016263311A1 (en) | 2015-05-18 | 2016-05-18 | Novel amidoheteroaryl aroyl hydrazide ethynes |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10150733B2 (enExample) |
| EP (1) | EP3297991B1 (enExample) |
| JP (1) | JP6689887B2 (enExample) |
| KR (1) | KR20180011772A (enExample) |
| CN (1) | CN107709300A (enExample) |
| AU (1) | AU2016263311A1 (enExample) |
| BR (1) | BR112017024633A2 (enExample) |
| CA (1) | CA2985161A1 (enExample) |
| EA (1) | EA032697B1 (enExample) |
| ES (1) | ES2774501T3 (enExample) |
| MX (1) | MX2017014752A (enExample) |
| WO (1) | WO2016185490A1 (enExample) |
| ZA (1) | ZA201707664B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA037697B1 (ru) * | 2016-06-02 | 2021-05-12 | Сан Фарма Адвансед Ресёрч Компани Лимитед | Лечение болезни паркинсона |
| WO2017208267A1 (en) | 2016-06-02 | 2017-12-07 | Sun Pharma Advanced Research Company Limited | Treatment for parkinson's disease |
| MA47798A (fr) | 2017-03-15 | 2020-01-22 | Sun Pharma Advanced Res Co Ltd | Nouvelle dispersion amorphe d'acide cyclopropanecarboxylique (5-{5-[ n'-(2-chloro-6-méthylbenzoyl) hydrazinocarbonyl] -2-méthyl-phényléthynyl}-pyridin-2-yl) amide |
| CN120305263A (zh) | 2018-06-15 | 2025-07-15 | 汉达癌症医药责任有限公司 | 卡博替尼的盐类于制备治疗癌症的剂型的用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007133560A2 (en) | 2006-05-08 | 2007-11-22 | Ariad Pharmaceuticals, Inc. | Acetylenic heteroaryl compounds |
| CN103370324B (zh) * | 2010-12-27 | 2016-05-18 | 孙树萍 | 作为蛋白激酶抑制剂的芳炔类衍生物及其医疗用途 |
| AU2012208388C1 (en) * | 2011-01-21 | 2017-04-27 | Sun Pharma Advanced Research Company Ltd | Diarylacetylene hydrazide containing tyrosine kinase inhibitors |
| US8859541B2 (en) | 2012-02-27 | 2014-10-14 | Boehringer Ingelheim International Gmbh | 6-alkynylpyridines |
-
2016
- 2016-05-18 US US15/574,967 patent/US10150733B2/en active Active
- 2016-05-18 ES ES16796030T patent/ES2774501T3/es active Active
- 2016-05-18 CN CN201680028615.2A patent/CN107709300A/zh not_active Withdrawn
- 2016-05-18 BR BR112017024633A patent/BR112017024633A2/pt not_active Application Discontinuation
- 2016-05-18 EP EP16796030.1A patent/EP3297991B1/en active Active
- 2016-05-18 KR KR1020177033739A patent/KR20180011772A/ko not_active Withdrawn
- 2016-05-18 AU AU2016263311A patent/AU2016263311A1/en not_active Abandoned
- 2016-05-18 CA CA2985161A patent/CA2985161A1/en not_active Abandoned
- 2016-05-18 WO PCT/IN2016/050142 patent/WO2016185490A1/en not_active Ceased
- 2016-05-18 JP JP2017560135A patent/JP6689887B2/ja not_active Expired - Fee Related
- 2016-05-18 MX MX2017014752A patent/MX2017014752A/es unknown
- 2016-05-18 EA EA201792445A patent/EA032697B1/ru not_active IP Right Cessation
-
2017
- 2017-11-13 ZA ZA2017/07664A patent/ZA201707664B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN107709300A (zh) | 2018-02-16 |
| EA201792445A1 (ru) | 2018-04-30 |
| MX2017014752A (es) | 2018-03-23 |
| KR20180011772A (ko) | 2018-02-02 |
| ES2774501T3 (es) | 2020-07-21 |
| US20180127372A1 (en) | 2018-05-10 |
| CA2985161A1 (en) | 2016-11-24 |
| EP3297991A4 (en) | 2018-11-21 |
| EP3297991B1 (en) | 2020-01-29 |
| EA032697B1 (ru) | 2019-07-31 |
| JP2018515550A (ja) | 2018-06-14 |
| ZA201707664B (en) | 2019-08-28 |
| JP6689887B2 (ja) | 2020-04-28 |
| BR112017024633A2 (pt) | 2018-07-31 |
| US10150733B2 (en) | 2018-12-11 |
| EP3297991A1 (en) | 2018-03-28 |
| WO2016185490A1 (en) | 2016-11-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |