ZA201707664B - Novel amidoheteroaryl aroyl hydrazide ethynes - Google Patents

Novel amidoheteroaryl aroyl hydrazide ethynes

Info

Publication number
ZA201707664B
ZA201707664B ZA2017/07664A ZA201707664A ZA201707664B ZA 201707664 B ZA201707664 B ZA 201707664B ZA 2017/07664 A ZA2017/07664 A ZA 2017/07664A ZA 201707664 A ZA201707664 A ZA 201707664A ZA 201707664 B ZA201707664 B ZA 201707664B
Authority
ZA
South Africa
Prior art keywords
amidoheteroaryl
ethynes
novel
aroyl
hydrazide
Prior art date
Application number
ZA2017/07664A
Other languages
English (en)
Inventor
Hemant Ashvinbhai Chokshi
Sabbirhusen Yusufbhai Chimanwala
Varun Anilkumar Mehta
Prabal Sengupta
Chitturi Trinadha Rao
Original Assignee
Sun Pharma Advanced Res Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharma Advanced Res Co Ltd filed Critical Sun Pharma Advanced Res Co Ltd
Publication of ZA201707664B publication Critical patent/ZA201707664B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C07B43/06—Formation or introduction of functional groups containing nitrogen of amide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
ZA2017/07664A 2015-05-18 2017-11-13 Novel amidoheteroaryl aroyl hydrazide ethynes ZA201707664B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1953MU2015 2015-05-18
PCT/IN2016/050142 WO2016185490A1 (en) 2015-05-18 2016-05-18 Novel amidoheteroaryl aroyl hydrazide ethynes

Publications (1)

Publication Number Publication Date
ZA201707664B true ZA201707664B (en) 2019-08-28

Family

ID=57319598

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2017/07664A ZA201707664B (en) 2015-05-18 2017-11-13 Novel amidoheteroaryl aroyl hydrazide ethynes

Country Status (13)

Country Link
US (1) US10150733B2 (enExample)
EP (1) EP3297991B1 (enExample)
JP (1) JP6689887B2 (enExample)
KR (1) KR20180011772A (enExample)
CN (1) CN107709300A (enExample)
AU (1) AU2016263311A1 (enExample)
BR (1) BR112017024633A2 (enExample)
CA (1) CA2985161A1 (enExample)
EA (1) EA032697B1 (enExample)
ES (1) ES2774501T3 (enExample)
MX (1) MX2017014752A (enExample)
WO (1) WO2016185490A1 (enExample)
ZA (1) ZA201707664B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA037697B1 (ru) * 2016-06-02 2021-05-12 Сан Фарма Адвансед Ресёрч Компани Лимитед Лечение болезни паркинсона
LT3463351T (lt) 2016-06-02 2022-06-10 Sun Pharma Advanced Research Company Limited Parkinsono ligos gydymas
EP3596049A4 (en) * 2017-03-15 2021-01-13 Sun Pharma Advanced Research Company Limited NEW AMORPHIC DISPERSION OF CYCLOPROPANECARBOXYLIC ACID (5- {5- [N '- (2-CHLORO-6-METHYLBENZOYL) HYDRAZINOCARBONYL] -2-METHYL-PHENYLETHYNYL} -PYRIDIN-2-AMIDE
TWI787523B (zh) 2018-06-15 2022-12-21 漢達生技醫藥股份有限公司 達沙替尼十二烷基硫酸鹽之結晶
JP2024063350A (ja) * 2022-10-26 2024-05-13 Toppanホールディングス株式会社 電極触媒層及び膜電極接合体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0710328A2 (pt) 2006-05-08 2011-08-09 Ariad Pharma Inc composto da fórmula i, um tautomer da mesma, ou um sal farmaceuticamente aceitável, hidrato ou outro solvato do mesmo e método para o tratamento de cáncer em um mamìfero necessitado do mesmo e composição
CN103370324B (zh) * 2010-12-27 2016-05-18 孙树萍 作为蛋白激酶抑制剂的芳炔类衍生物及其医疗用途
EP2665709B1 (en) * 2011-01-21 2016-12-07 Sun Pharma Advanced Research Company Limited Diarylacetylene hydrazide containing tyrosine kinase inhibitors
US8859541B2 (en) 2012-02-27 2014-10-14 Boehringer Ingelheim International Gmbh 6-alkynylpyridines

Also Published As

Publication number Publication date
EP3297991A4 (en) 2018-11-21
EP3297991B1 (en) 2020-01-29
US20180127372A1 (en) 2018-05-10
BR112017024633A2 (pt) 2018-07-31
EA032697B1 (ru) 2019-07-31
JP2018515550A (ja) 2018-06-14
KR20180011772A (ko) 2018-02-02
CA2985161A1 (en) 2016-11-24
CN107709300A (zh) 2018-02-16
EA201792445A1 (ru) 2018-04-30
US10150733B2 (en) 2018-12-11
MX2017014752A (es) 2018-03-23
JP6689887B2 (ja) 2020-04-28
ES2774501T3 (es) 2020-07-21
EP3297991A1 (en) 2018-03-28
WO2016185490A1 (en) 2016-11-24
AU2016263311A1 (en) 2017-11-30

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