AU2016243034A1 - Devices and methods for sample analysis - Google Patents

Devices and methods for sample analysis Download PDF

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Publication number
AU2016243034A1
AU2016243034A1 AU2016243034A AU2016243034A AU2016243034A1 AU 2016243034 A1 AU2016243034 A1 AU 2016243034A1 AU 2016243034 A AU2016243034 A AU 2016243034A AU 2016243034 A AU2016243034 A AU 2016243034A AU 2016243034 A1 AU2016243034 A1 AU 2016243034A1
Authority
AU
Australia
Prior art keywords
wells
array
substrate
mixture
analyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2016243034A
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English (en)
Inventor
Andrew FISCHER (Andy)
Mark A. Hayden
Shelley R. Holets-Mccormack
Jeffrey B. Huff
Peter J. KARABATSOS
Sophie Laurenson
John M. Robinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of AU2016243034A1 publication Critical patent/AU2016243034A1/en
Priority to AU2021209235A priority Critical patent/AU2021209235B2/en
Priority to AU2023204113A priority patent/AU2023204113B2/en
Abandoned legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/142—Preventing evaporation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0858—Side walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427—Electrowetting

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Fluid Mechanics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Micromachines (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
AU2016243034A 2015-04-03 2016-04-02 Devices and methods for sample analysis Abandoned AU2016243034A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2021209235A AU2021209235B2 (en) 2015-04-03 2021-07-28 Devices and methods for sample analysis
AU2023204113A AU2023204113B2 (en) 2015-04-03 2023-06-28 Devices and methods for sample analysis

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562142858P 2015-04-03 2015-04-03
US62/142,858 2015-04-03
PCT/US2016/025785 WO2016161400A1 (en) 2015-04-03 2016-04-02 Devices and methods for sample analysis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021209235A Division AU2021209235B2 (en) 2015-04-03 2021-07-28 Devices and methods for sample analysis

Publications (1)

Publication Number Publication Date
AU2016243034A1 true AU2016243034A1 (en) 2017-10-19

Family

ID=55808860

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2016243034A Abandoned AU2016243034A1 (en) 2015-04-03 2016-04-02 Devices and methods for sample analysis
AU2021209235A Active AU2021209235B2 (en) 2015-04-03 2021-07-28 Devices and methods for sample analysis
AU2023204113A Active AU2023204113B2 (en) 2015-04-03 2023-06-28 Devices and methods for sample analysis

Family Applications After (2)

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AU2021209235A Active AU2021209235B2 (en) 2015-04-03 2021-07-28 Devices and methods for sample analysis
AU2023204113A Active AU2023204113B2 (en) 2015-04-03 2023-06-28 Devices and methods for sample analysis

Country Status (10)

Country Link
US (2) US11633738B2 (https=)
EP (1) EP3277427A1 (https=)
JP (3) JP2018518655A (https=)
CN (2) CN107666962B (https=)
AU (3) AU2016243034A1 (https=)
BR (1) BR112017021256A2 (https=)
MX (1) MX2017012742A (https=)
RU (2) RU2020100511A (https=)
WO (1) WO2016161400A1 (https=)
ZA (1) ZA201706572B (https=)

Families Citing this family (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2916662C (en) 2013-06-25 2022-03-08 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
EP3901282B1 (en) 2015-04-10 2023-06-28 Spatial Transcriptomics AB Spatially distinguished, multiplex nucleic acid analysis of biological specimens
CN110383068A (zh) 2016-10-03 2019-10-25 雅培实验室 评估患者样品中uch-l1状态的改进方法
EP3523640B1 (en) 2016-10-05 2023-01-18 Abbott Laboratories Devices for sample analysis
CN109863396B (zh) 2016-10-05 2021-11-05 雅培实验室 用于样品分析的装置和方法
CN106769359B (zh) * 2016-12-30 2023-07-07 中国农业科学院草原研究所 一种植物根部观测仪以及检测植物根部的方法
WO2018136509A1 (en) 2017-01-18 2018-07-26 Abbott Laboratories Methods and devices for sample analysis
CA3261113A1 (en) 2017-03-23 2025-10-27 Abbott Laboratories Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase l1
JP7212940B2 (ja) * 2017-03-29 2023-01-26 国立研究開発法人科学技術振興機構 微小物質検出方法及び微小物質検出用デバイス
WO2018191531A1 (en) 2017-04-15 2018-10-18 Abbott Laboratories Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury in a human subject using early biomarkers
ES3053676T3 (en) 2017-04-28 2026-01-23 Abbott Lab Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury using early biomarkers on at least two samples from the same human subject
US10866251B2 (en) 2017-05-25 2020-12-15 Abbott Laboratories Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers
JP7269182B2 (ja) 2017-05-30 2023-05-08 アボット・ラボラトリーズ 心臓トロポニンｉ及び早期バイオマーカーを使用する、ヒト対象における軽度外傷性脳損傷を診断及び査定する一助となるための方法
US10942110B2 (en) * 2017-06-15 2021-03-09 United Arab Emirates University System and method for detecting abnormalities in cells
US11169159B2 (en) 2017-07-03 2021-11-09 Abbott Laboratories Methods for measuring ubiquitin carboxy-terminal hydrolase L1 levels in blood
US10408788B2 (en) * 2017-07-12 2019-09-10 Sharp Life Science (Eu) Limited Spacer for side loaded EWOD device
WO2019023646A2 (en) * 2017-07-27 2019-01-31 Maxim Integrated Products, Inc. ANALYTE SENSOR HOUSING AND METHOD FOR ANALYZING FLUID SAMPLES
US10391492B2 (en) * 2017-08-29 2019-08-27 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
EP3721233A2 (en) 2017-12-09 2020-10-14 Abbott Laboratories Methods for aiding in the diagnosis and evaluation of a subject who has sustained an orthopedic injury and that has or may have sustained an injury to the head, such as mild traumatic brain injury (tbi), using glial fibrillary acidic protein (gfap) and/or ubiquitin carboxy-terminal hydrolase l1 (uch-l1)
JP7379165B2 (ja) 2017-12-09 2023-11-14 アボット・ラボラトリーズ Ｇｆａｐとｕｃｈ－ｌ１との組合せを使用する、ヒト対象における外傷性脳損傷を診断及び査定する一助となるための方法
CN111699391A (zh) 2017-12-29 2020-09-22 雅培实验室 用于诊断和评估创伤性脑损伤的新型生物标志物和方法
EP3735315B1 (en) * 2018-01-05 2026-03-04 SiMPore Inc. Sample preparation and flow-through sensors using functionalized silicon nanomembranes
MX2020007284A (es) * 2018-01-08 2020-09-10 Quantum Si Inc Sistema y metodos para la carga electrocinetica de camaras de reaccion a escala submicrometrica.
CN108254549A (zh) * 2018-02-07 2018-07-06 上海澜澈生物科技有限公司 一种待测标志物的分子数量的检测方法及系统、芯片
CN108169480B (zh) * 2018-02-07 2024-03-08 上海澜澈生物科技有限公司 一种生物标志物的分子数量的检测方法及系统、芯片
US10871430B2 (en) 2018-03-03 2020-12-22 Labcyte Inc. System and method for extracting a target moiety from a sample using acoustic droplet ejection
WO2019213619A1 (en) 2018-05-04 2019-11-07 Abbott Laboratories Hbv diagnostic, prognostic, and therapeutic methods and products
US20190376963A1 (en) 2018-05-04 2019-12-12 Abbott Laboratories Sequential sampling method for improving immunoassay sensitivity and kinetics of small volume samples
AU2019269615B2 (en) * 2018-05-17 2023-04-06 Recognition AnalytiX, Inc. Device, system and method for direct electrical measurement of enzyme activity
DE102018112258B4 (de) * 2018-05-22 2023-01-05 Leibniz-Institut Für Festkörper- Und Werkstoffforschung Dresden E.V. Akustofluidische bauelemente und verfahren zu ihrer herstellung
US11198130B2 (en) * 2018-06-21 2021-12-14 Sharp Life Science (Eu) Limited EWOD system and methods to increase dynamic range for digital nucleic acid amplification
EP3845907A4 (en) * 2018-08-29 2022-06-08 Hitachi High-Tech Corporation AUTOMATIC ANALYZER
US11733195B2 (en) 2018-09-29 2023-08-22 Boe Technology Group Co., Ltd. Electrochemical sensor for humoral detection and detection device
KR102577837B1 (ko) * 2018-10-15 2023-09-12 이 잉크 코포레이션 디지털 미세유체 전달 디바이스
JP6899588B2 (ja) * 2018-11-20 2021-07-07 国立研究開発法人産業技術総合研究所 液体操作装置
US12529094B2 (en) 2018-12-10 2026-01-20 10X Genomics, Inc. Imaging system hardware
WO2020123316A2 (en) 2018-12-10 2020-06-18 10X Genomics, Inc. Methods for determining a location of a biological analyte in a biological sample
US12061200B2 (en) 2018-12-28 2024-08-13 Abbott Laboratories Direct detection of single molecules on microparticles
CN109731621B (zh) * 2019-01-02 2020-07-24 京东方科技集团股份有限公司 微流控基板及其制备方法、微流控面板
TWI873119B (zh) * 2019-01-29 2025-02-21 美商伊路米納有限公司 流通槽及製備其之方法
US12351855B2 (en) 2019-01-30 2025-07-08 Arizona Board Of Regents On Behalf Of Arizona State University Bioelectronic circuits, systems and methods for preparing and using them
EP3931573A1 (en) 2019-03-01 2022-01-05 Abbott Laboratories Methods for predicting major adverse cardiovascular events in subjects with coronary artery disease
KR102369629B1 (ko) * 2019-03-20 2022-03-03 주식회사 토바 롤투롤을 활용한 바이오칩 제작 시스템
US11567068B2 (en) * 2019-03-28 2023-01-31 Autonomous Medical Devices Inc. Detection of cardiac troponin or biological markers via shear horizontal surface acoustic wave biosensor using a wet-dry bioanalytical technique
WO2020247533A1 (en) * 2019-06-03 2020-12-10 Abbott Laboratories Devices and methods for sample analysis
EP3976255A1 (en) * 2019-06-03 2022-04-06 Abbott Laboratories Devices and methods for fluid actuation
EP3956061A1 (en) * 2019-06-26 2022-02-23 TECAN Trading AG Cartridge, electrowetting sample processing system and droplet formation
WO2020261512A1 (ja) * 2019-06-27 2020-12-30 昭和電工マテリアルズ株式会社 被覆膜付き基体及びその製造方法、並びに、検査センサ
US11292715B2 (en) 2019-06-27 2022-04-05 Taiwan Semiconductor Manufacturing Company, Ltd. Conductive bond structure to increase membrane sensitivity in MEMS device
CN110562954B (zh) * 2019-08-02 2022-09-30 安徽师范大学 一种荧光碳点探针的制备方法及在检测Fe2+的应用
CN114503066A (zh) 2019-08-06 2022-05-13 徕卡生物系统成像股份有限公司 用于载玻片扫描仪控制的图形用户界面
US20220291223A1 (en) 2019-08-07 2022-09-15 Abbott Laboratories Chemiluminescent compounds for multiplexing
AU2020336448A1 (en) * 2019-08-27 2022-03-24 Volta Labs, Inc. Methods and systems for droplet manipulation
US20220291235A1 (en) * 2019-08-30 2022-09-15 The Regents Of The University Of Colorado - A Body Corporate Acousto-thermal shift assay for label-free protein analysis
CN113993623B (zh) * 2019-09-02 2023-12-15 陈笃生医院私人有限公司 进行化验的磁性数字微流体系统和方法
US12157124B2 (en) 2019-11-06 2024-12-03 10X Genomics, Inc. Imaging system hardware
US11130994B2 (en) * 2019-12-13 2021-09-28 Autonomous Medical Devices Inc. Automated, cloud-based, point-of-care (POC) pathogen and antibody array detection system and method
DE102019220017A1 (de) * 2019-12-18 2021-06-24 Robert Bosch Gesellschaft mit beschränkter Haftung Aufnahmeeinheit zum Aufnehmen eines Fluids, Verfahren und Vorrichtung zum Herstellen einer Aufnahmeeinheit, Verfahren und Vorrichtung zum Betreiben einer Aufnahmeeinheit und Aufnahmeeinrichtung
CN114556110B (zh) * 2019-12-26 2025-07-08 深圳华大智造科技股份有限公司 液体转移装置与方法、生化物质反应装置及生化物质分析装置与方法
US12405264B2 (en) 2020-01-17 2025-09-02 10X Genomics, Inc. Electrophoretic system and method for analyte capture
RU200329U1 (ru) * 2020-02-03 2020-10-16 Акционерное общество "ПРОТОН-ЭЛЕКТРОТЕКС", АО "ПРОТОН-ЭЛЕКТРОТЕКС" Устройство контроля качества очистки поверхности кремниевых пластин
US20230096203A1 (en) 2020-02-27 2023-03-30 The Regents Of The University Of Michigan Methods for detecting food allergies
IL273038B (en) 2020-03-03 2022-02-01 Ben Zion Karmon bone graft
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
EP4118432A1 (en) * 2020-03-10 2023-01-18 Abbott Laboratories Method for droplet loading into nanowells
EP4136459A1 (en) 2020-04-13 2023-02-22 Abbott Laboratories Methods, complexes and kits for detecting or determining an amount of a ss-coronavirus antibody in a sample
EP4142940A1 (en) 2020-04-29 2023-03-08 Abbott Laboratories Systems and methods for sample analysis
IL297732A (en) 2020-04-30 2022-12-01 Univ Arizona State Methods for sequencing biopolymers
US12416603B2 (en) 2020-05-19 2025-09-16 10X Genomics, Inc. Electrophoresis cassettes and instrumentation
EP4414459B1 (en) 2020-05-22 2025-09-03 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
EP4421186B1 (en) 2020-06-08 2025-08-13 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
WO2021252747A1 (en) 2020-06-10 2021-12-16 1Ox Genomics, Inc. Fluid delivery methods
EP3922991A1 (en) * 2020-06-10 2021-12-15 PreOmics GmbH Dispersion using a moving magnet
US11988671B2 (en) 2020-08-04 2024-05-21 Abbott Rapid Diagnostics International Unlimited Company Assays for detecting SARS-CoV-2
CA3188349A1 (en) 2020-08-04 2022-02-10 A. Scott Muerhoff Improved methods and kits for detecting sars-cov-2 protein in a sample
JP7567276B2 (ja) * 2020-08-20 2024-10-16 大日本印刷株式会社 試薬担持基材、試薬入りマイクロ流路構造体、及び試薬入りマイクロ流路デバイス
WO2022061150A2 (en) 2020-09-18 2022-03-24 10X Geonomics, Inc. Sample handling apparatus and image registration methods
US20220170948A1 (en) 2020-12-01 2022-06-02 Abbott Laboratories Use of one or more biomarkers to determine traumatic brain injury (tbi) in a human subject having received a head computerized tomography scan that is negative for a tbi
WO2023102384A1 (en) 2021-11-30 2023-06-08 Abbott Laboratories Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi
EP4729631A2 (en) 2020-12-21 2026-04-22 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
RU203940U1 (ru) * 2020-12-29 2021-04-28 Федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации Электрофоретический чип для экспресс-анализа
WO2022147178A1 (en) 2020-12-30 2022-07-07 Abbott Laboratories Improved methods, reagents and kits for detergent-based inactivation of betacoronavirus prior to and/or while assessing a biological sample for sars-cov-2 antigen or antibody
EP4271998A1 (en) 2020-12-30 2023-11-08 Abbott Laboratories Methods for determining sars-cov-2 antigen and anti-sars-cov-2 antibody in a sample
US20240230638A9 (en) * 2021-01-27 2024-07-11 Nicoya Lifesciences, Inc. Small molecule screening assay for digital microfluidic platform
EP4421491A3 (en) 2021-02-19 2024-11-27 10X Genomics, Inc. Method of using a modular assay support device
KR20230175195A (ko) 2021-03-12 2023-12-29 유니버시티 오브 유타 리써치 파운데이션 생물분석 감도 향상을 위한 마이크로유체 마이크로입자-표지 임피던스 센서 배열
US20220381796A1 (en) 2021-05-18 2022-12-01 Abbott Laboratories Methods of evaluating brain injury in a pediatric subject
WO2022256503A1 (en) 2021-06-03 2022-12-08 10X Genomics, Inc. Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis
KR102671385B1 (ko) * 2021-06-04 2024-05-31 국립창원대학교 산학협력단 유전영동을 이용한 미세입자 포집장치
WO2022266034A1 (en) 2021-06-14 2022-12-22 Abbott Laboratories Methods of diagnosing or aiding in diagnosis of brain injury caused by acoustic energy, electromagnetic energy, an over pressurization wave, and/or blast wind
WO2023287404A1 (en) * 2021-07-14 2023-01-19 Hewlett-Packard Development Company, L.P. Mechanical cell lysis in digital microfluidic devices
US12553805B2 (en) 2021-08-02 2026-02-17 10X Genomics, Inc. Methods of preserving a biological sample
EP4392783A1 (en) 2021-08-27 2024-07-03 Abbott Laboratories Methods for detecting immunoglobulin g, subclass 4 (igg4) in a biological sample
CN118715440A (zh) 2021-08-31 2024-09-27 雅培实验室 诊断脑损伤的方法和系统
JP2024534849A (ja) 2021-08-31 2024-09-26 アボット・ラボラトリーズ 脳の損傷を診断する方法及びシステム
USD1064308S1 (en) 2021-09-17 2025-02-25 10X Genomics, Inc. Sample handling device
JP2024538608A (ja) 2021-09-30 2024-10-23 アボット・ラボラトリーズ 脳の損傷を診断する方法及びシステム
JP2024541917A (ja) 2021-11-03 2024-11-13 アボット・ラボラトリーズ サンプル分析のためのシステム及び方法
LU500832B1 (en) * 2021-11-06 2023-05-15 Dispendix Gmbh Carrier Device for a Dispensing Device
WO2023102118A2 (en) 2021-12-01 2023-06-08 10X Genomics, Inc. Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis
EP4448179A1 (en) 2021-12-17 2024-10-23 Abbott Laboratories Systems and methods for determining uch-l1, gfap, and other biomarkers in blood samples
WO2023122033A1 (en) 2021-12-20 2023-06-29 10X Genomics, Inc. Self-test for pathology/histology slide imaging device
WO2023150652A1 (en) 2022-02-04 2023-08-10 Abbott Laboratories Lateral flow methods, assays, and devices for detecting the presence or measuring the amount of ubiquitin carboxy-terminal hydrolase l1 and/or glial fibrillary acidic protein in a sample
JP7826113B2 (ja) * 2022-05-19 2026-03-09 日東電工株式会社 位相差観察用導電層付フィルム
CN120167040A (zh) 2022-06-29 2025-06-17 雅培实验室 用于确定生物样本中的gfap的磁性定点照护型系统和测定
JP2025530730A (ja) 2022-08-26 2025-09-17 アボット・ラボラトリーズ Ｉ型及びｉｉ型の心筋梗塞を識別するための心トロポニン及びガレクチン－３の使用
EP4587840A1 (en) 2022-09-15 2025-07-23 Abbott Laboratories Hbv diagnostic, prognostic, and therapeutic methods and products
JP2025532597A (ja) 2022-09-15 2025-10-01 アボット・ラボラトリーズ 軽度及び超軽度の外傷性脳損傷を区別するためのバイオマーカー及び方法
WO2024102383A1 (en) 2022-11-10 2024-05-16 Abbott Laboratories Methods of identifying macrotroponin in biological samples
WO2024150241A1 (en) * 2023-01-12 2024-07-18 Sigtuple Technologies Private Limited A cartridge for analysis of a biological fluid
WO2024176713A1 (ja) 2023-02-24 2024-08-29 Ａｇｃ株式会社 マイクロ流体デバイス及びその製造方法
WO2024211475A1 (en) 2023-04-04 2024-10-10 Abbott Laboratories Use of biomarkers to determine whether a subject has sustained, may have sustained or is suspected of sustaining a subacute acquired brain injury (abi)
WO2024227045A1 (en) * 2023-04-27 2024-10-31 Siemens Healthcare Diagnostics Inc. High-sensitivity assay for serum neurofilament light chain cross reference to related applications
EP4713682A1 (en) 2023-04-28 2026-03-25 Abbott Point of Care Inc. Improved assays, cartridges, and kits for detection of biomarkers, including brain injury biomarkers
CN121511407A (zh) 2023-04-28 2026-02-10 雅培实验室 晚期肝细胞癌的诊断
CN116273234B (zh) * 2023-05-12 2025-11-28 苏州矽劼微电子有限公司 一种微球制备装置及应用
WO2025111147A1 (en) 2023-11-21 2025-05-30 Abbott Laboratories Two-dimensional matrix droplet array
WO2025145020A2 (en) 2023-12-28 2025-07-03 Abbott Laboratories Methods, systems, compounds, and kits for determining an analyte of interest in a test sample
WO2025184193A1 (en) * 2024-02-27 2025-09-04 Aridica Corporation Pbmc separation systems and methods of use
KR20250132642A (ko) * 2024-02-29 2025-09-05 인제대학교 산학협력단 전기 습윤 현상을 이용한 액적 생성 장치
WO2025193825A1 (en) 2024-03-13 2025-09-18 Abbott Laboratories Diagnosis and monitoring of liver disease
WO2025245634A1 (en) * 2024-05-29 2025-12-04 1866402 Ontario Limited Method and device for volume partitioning in a digital microfluidic system
WO2026024677A1 (en) 2024-07-22 2026-01-29 Abbott Laboratories Method for determining the plasma volume of a blood sample and method for determining the dilution of plasma
WO2026024668A1 (en) 2024-07-22 2026-01-29 Abbott Laboratories Method of determining a volume of a liquid in a sample
WO2026024666A1 (en) 2024-07-22 2026-01-29 Abbott Laboratories Systems and methods for digital detection assays
GB202410743D0 (en) * 2024-07-23 2024-09-04 Acu Flow Ltd Acoustofluidic device, system and method of operation

Family Cites Families (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3750503T2 (de) 1986-10-22 1995-02-09 Abbott Lab Chemilumineszierende Acridinium- und Phenantridiniumsalze.
US5241070A (en) 1988-09-26 1993-08-31 Ciba Corning Diagnostics Corp. Nucleophilic polysubstituted aryl acridinium esters and uses thereof
US5683867A (en) 1990-06-11 1997-11-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: blended SELEX
US5567588A (en) 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US5496938A (en) 1990-06-11 1996-03-05 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to HIV-RT and HIV-1 rev
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
ES2259800T3 (es) 1990-06-11 2006-10-16 Gilead Sciences, Inc. Procedimientos de uso de ligandos de acido nucleico.
US5637459A (en) 1990-06-11 1997-06-10 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chimeric selex
US5705337A (en) 1990-06-11 1998-01-06 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
US5187096A (en) * 1991-08-08 1993-02-16 Rensselaer Polytechnic Institute Cell substrate electrical impedance sensor with multiple electrode array
JP3327551B2 (ja) 1992-03-30 2002-09-24 アボツト・ラボラトリーズ 流体試料中のチロキシンを検出・定量するための試薬および方法
US5352803A (en) 1992-03-30 1994-10-04 Abbott Laboratories 5(6)-methyl substituted fluorescein derivatives
US5696253A (en) 1994-06-30 1997-12-09 The Regents Of The University Of California Polynucleoside chain with 3'→5' guanidyl linkages
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5795782A (en) 1995-03-17 1998-08-18 President & Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US6027496A (en) 1997-03-25 2000-02-22 Abbott Laboratories Removal of stratum corneum by means of light
US7070921B2 (en) 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
US7632651B2 (en) 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
EP1056396B1 (en) 1998-02-17 2005-11-09 Abbott Laboratories Interstitial fluid collection and monitoring device
WO2000034527A2 (en) 1998-12-11 2000-06-15 The Regents Of The University Of California Targeted molecular bar codes
US6565727B1 (en) 1999-01-25 2003-05-20 Nanolytics, Inc. Actuators for microfluidics without moving parts
US6294063B1 (en) 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
US7118657B2 (en) 1999-06-22 2006-10-10 President And Fellows Of Harvard College Pulsed ion beam control of solid state features
EP2383776B1 (en) 1999-06-22 2015-02-25 President and Fellows of Harvard College Solid state nanopore device for evaluating biopolymers
US6783643B2 (en) 1999-06-22 2004-08-31 President And Fellows Of Harvard College Control of solid state dimensional features
US20050126905A1 (en) 1999-06-22 2005-06-16 President And Fellows Of Harvard College High-precision feedback control for ion sculpting of solid state features
US6464842B1 (en) 1999-06-22 2002-10-15 President And Fellows Of Harvard College Control of solid state dimensional features
WO2001018524A2 (en) * 1999-08-30 2001-03-15 Illumina, Inc. Methods for improving signal detection from an array
EP1212462B1 (en) 1999-09-07 2006-01-25 The Regents of the University of California Methods of determining the presence of double stranded nucleic acids in a sample
ATE403145T1 (de) * 2000-01-31 2008-08-15 Univ Texas Tragbare vorrichtung mit einer sensor-array- anordnung
US20020028457A1 (en) 2000-02-16 2002-03-07 Quantum Dot Corporation Single target counting assays using semiconductor nanocrystals
DE10011022A1 (de) * 2000-03-07 2001-09-27 Meinhard Knoll Vorrichtung und Verfahren zur Durchführung von Synthesen, Analysen oder Transportvorgängen
US7001792B2 (en) 2000-04-24 2006-02-21 Eagle Research & Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
US6413792B1 (en) 2000-04-24 2002-07-02 Eagle Research Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
US6531283B1 (en) * 2000-06-20 2003-03-11 Molecular Staging, Inc. Protein expression profiling
US6773566B2 (en) * 2000-08-31 2004-08-10 Nanolytics, Inc. Electrostatic actuators for microfluidics and methods for using same
US7348182B2 (en) 2000-10-03 2008-03-25 Mirari Biosciences, Inc. Directed microwave chemistry
WO2002029076A1 (en) 2000-10-03 2002-04-11 Mirari Biosciences, Inc. Methods and compositions for directed microwave chemistry
WO2002066992A1 (en) * 2001-02-23 2002-08-29 Japan Science And Technology Corporation Small liquid particle handling method, and device therefor
US6905586B2 (en) 2002-01-28 2005-06-14 Ut-Battelle, Llc DNA and RNA sequencing by nanoscale reading through programmable electrophoresis and nanoelectrode-gated tunneling and dielectric detection
US6911132B2 (en) 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
FR2848125B1 (fr) * 2002-12-04 2006-06-09 Commissariat Energie Atomique Dispositif microfluidique dans lequel l'interface liquide/fluide est stabilisee
US7282130B2 (en) 2003-01-31 2007-10-16 Agilent Technologies, Inc. Apparatus and method for control of biopolymer translocation through a nanopore
WO2004085609A2 (en) 2003-02-28 2004-10-07 Brown University Nanopores, methods for using same, methods for making same and methods for characterizing biomolecules using same
JP2005030987A (ja) * 2003-07-09 2005-02-03 Olympus Corp 液体搬送処理システム
FR2871076A1 (fr) * 2004-06-04 2005-12-09 Univ Lille Sciences Tech Dispositif pour desorption par rayonnement laser incorporant une manipulation de l'echantillon liquide sous forme de gouttes individuelles permettant leur traitement chimique et biochimique
FR2872809B1 (fr) 2004-07-09 2006-09-15 Commissariat Energie Atomique Methode d'adressage d'electrodes
CN101287845B (zh) * 2005-05-11 2012-07-18 先进液体逻辑公司 用于在多个温度下进行生化或化学反应的方法和设备
JP2006329904A (ja) * 2005-05-30 2006-12-07 Hitachi High-Technologies Corp 液体搬送デバイス及び分析システム
WO2007136386A2 (en) 2005-06-06 2007-11-29 The Regents Of The University Of California Droplet-based on-chip sample preparation for mass spectrometry
JP4431724B2 (ja) * 2005-07-05 2010-03-17 独立行政法人産業技術総合研究所 マイクロ流路ビーズアレイデバイス及びその作製方法
US8287808B2 (en) 2005-09-15 2012-10-16 Alcatel Lucent Surface for reversible wetting-dewetting
WO2009140671A2 (en) * 2008-05-16 2009-11-19 Advanced Liquid Logic, Inc. Droplet actuator devices and methods for manipulating beads
ATE542921T1 (de) * 2006-04-18 2012-02-15 Advanced Liquid Logic Inc Pyrosequenzierung auf tröpfchenbasis
US8980198B2 (en) 2006-04-18 2015-03-17 Advanced Liquid Logic, Inc. Filler fluids for droplet operations
US8114599B2 (en) 2006-12-19 2012-02-14 Northwestern University Compositions and methods for free-solution conjugate nucleic acid analysis
WO2008091031A1 (en) * 2007-01-25 2008-07-31 Seoul National University Industry Foundation Method of arraying cells at single-cell level inside microfluidic channel and method of analysing cells using the same, and cell analysis chip used for carrying out the same
US8003319B2 (en) 2007-02-02 2011-08-23 International Business Machines Corporation Systems and methods for controlling position of charged polymer inside nanopore
US7906293B2 (en) 2007-04-09 2011-03-15 Abbott Laboratories Acridinium phenyl esters useful in the analysis of biological
CN101679078B (zh) 2007-05-24 2013-04-03 数字化生物系统 基于电湿润的数字微流体
WO2009004533A1 (en) * 2007-07-03 2009-01-08 Nxp B.V. A microfluidic chip for and a method of handling fluidic droplets
JP5503540B2 (ja) * 2007-08-30 2014-05-28 トラスティーズ・オブ・タフツ・カレッジ 溶液中の分析物濃度を決定する方法
WO2009052095A1 (en) 2007-10-17 2009-04-23 Advanced Liquid Logic, Inc. Reagent storage and reconstitution for a droplet actuator
EP2250483A4 (en) 2008-03-04 2011-09-28 Waters Technologies Corp Interfacing with a digital microfluidic device
CN108088824B (zh) * 2008-03-14 2021-06-04 雅培快速诊断耶拿有限公司 一种用于检测分析物的系统
FI20085299A0 (fi) * 2008-04-10 2008-04-10 Valtion Teknillinen Mikrofluidistisia siruvälineitä ja niiden käyttö
WO2009137415A2 (en) * 2008-05-03 2009-11-12 Advanced Liquid Logic, Inc. Reagent and sample preparation, loading, and storage
GB0808856D0 (en) 2008-05-15 2008-06-25 Univ Warwick Fabricated nanopores and micropores for chemical and biochemical analysis
EP2346777A4 (en) 2008-10-10 2014-10-01 Univ Toronto HYBRID DIGITAL MICROFLUIDIC CHANNEL DEVICES AND MANUFACTURING METHOD THEREFOR
JP5372570B2 (ja) 2009-03-30 2013-12-18 株式会社日立ハイテクノロジーズ ナノポアを用いたバイオポリマー決定方法、システム、及びキット
US9017937B1 (en) 2009-04-10 2015-04-28 Pacific Biosciences Of California, Inc. Nanopore sequencing using ratiometric impedance
US8986928B2 (en) 2009-04-10 2015-03-24 Pacific Biosciences Of California, Inc. Nanopore sequencing devices and methods
US8926904B2 (en) 2009-05-12 2015-01-06 Daniel Wai-Cheong So Method and apparatus for the analysis and identification of molecules
GB0914762D0 (en) 2009-08-24 2009-09-30 Univ Glasgow Fluidics apparatus and fluidics substrate
US9091649B2 (en) 2009-11-06 2015-07-28 Advanced Liquid Logic, Inc. Integrated droplet actuator for gel; electrophoresis and molecular analysis
JP2011128019A (ja) * 2009-12-17 2011-06-30 Hitachi Maxell Ltd マイクロプレートデバイスおよびその利用方法
US8236574B2 (en) * 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
EP2553473A4 (en) * 2010-03-30 2016-08-10 Advanced Liquid Logic Inc DROPLET OPERATION PLATFORM
WO2011137533A1 (en) 2010-05-05 2011-11-10 The Governing Council Of The University Of Toronto Method of processing dried samples using digital microfluidic device
CN101947124B (zh) * 2010-06-25 2012-07-04 博奥生物有限公司 一种集成式微流控芯片装置及其使用方法
CN103118785B (zh) * 2010-08-05 2015-11-25 雅培医护站股份有限公司 使用易感磁微珠捕获的免疫测定方法和装置
WO2012045016A2 (en) 2010-09-30 2012-04-05 California Institute Of Technology Particulate nanosorting stack
JP2012157267A (ja) * 2011-01-31 2012-08-23 Hitachi Maxell Ltd 微細パターンを有するプレート部材
GB201103211D0 (en) 2011-02-24 2011-04-13 Univ Glasgow Fluidics apparatus, use of fluidics apparatus and process for the manufacture of fluidics apparatus
EP2685266A1 (en) * 2011-03-08 2014-01-15 Japan Science And Technology Agency Bead sealing method, method for detecting target molecule, array, kit, and target molecule detection device
US8339711B2 (en) 2011-04-22 2012-12-25 Sharp Kabushiki Kaisha Active matrix device and method of driving the same
US8940147B1 (en) 2011-04-25 2015-01-27 Sandia Corporation Microfluidic hubs, systems, and methods for interface fluidic modules
CA2840949A1 (en) * 2011-07-06 2013-01-10 Advanced Liquid Logic Inc Reagent storage on a droplet actuator
GB2497317A (en) 2011-12-06 2013-06-12 Univ Dublin System and method for the detection of analytes using rod-shaped nanoparticles
US9857332B2 (en) * 2011-07-22 2018-01-02 Tecan Trading Ag System for manipulating samples in liquid droplets
KR102023754B1 (ko) 2011-07-27 2019-09-20 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 생체분자 특성규명용 나노포어 센서
US8980075B2 (en) 2011-07-29 2015-03-17 The Texas A & M University System Digital microfluidic platform for actuating and heating individual liquid droplets
EP4230288A3 (en) * 2011-10-25 2023-11-15 Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University Programmable arrays
US8637242B2 (en) * 2011-11-07 2014-01-28 Illumina, Inc. Integrated sequencing apparatuses and methods of use
IN2014DN08308A (https=) * 2012-03-13 2015-05-15 Piramal Entpr Ltd
MX357200B (es) 2012-05-07 2018-06-29 Univ Ottawa Fabricacion de nanoporos utilizando campos electricos elevados.
US9914968B2 (en) * 2012-09-26 2018-03-13 Cepheid Honeycomb tube
WO2014062551A1 (en) 2012-10-15 2014-04-24 Advanced Liquid Logic, Inc. Digital microfluidics cartridge and system for operating a flow cell
AU2013334189B2 (en) 2012-10-24 2018-08-02 Genmark Diagnostics, Inc. Integrated multiplex target analysis
CA2841692C (en) * 2013-02-12 2023-08-22 Zhong Ding Reagent zone deposition pattern
JP2014169920A (ja) 2013-03-04 2014-09-18 Ngk Insulators Ltd 血液凝固検出装置及び血液凝固検出方法
US10732183B2 (en) 2013-03-15 2020-08-04 The Trustees Of Columbia University In The City Of New York Method for detecting multiple predetermined compounds in a sample
EP2979083B1 (en) * 2013-03-29 2017-12-13 Life Technologies Corporation Method for treating a semiconductor device
ITTO20130264A1 (it) * 2013-03-29 2014-09-30 St Microelectronics Srl Microreattore e metodo per caricare un liquido nel microreattore
KR20160081896A (ko) * 2013-08-30 2016-07-08 일루미나, 인코포레이티드 친수성 또는 다양한-친수성 표면 상에서의 액적의 조작
KR102144995B1 (ko) 2013-09-12 2020-08-14 삼성전자주식회사 그래핀 나노포어를 포함하는 나노포어 소자 및 그 제조 방법
US9714933B2 (en) 2014-01-28 2017-07-25 International Business Machines Corporation Micro-droplet fluidic cell for fast ionic current detection using nanopores
EP3248018B1 (en) * 2015-01-22 2020-01-08 Becton, Dickinson and Company Devices and systems for molecular barcoding of nucleic acid targets in single cells
US10488321B2 (en) * 2015-03-19 2019-11-26 The Board Of Trustees Of The Leland Stanford Junior University Devices and methods for high-throughput single cell and biomolecule analysis and retrieval in a microfluidic chip
US10576471B2 (en) 2015-03-20 2020-03-03 Illumina, Inc. Fluidics cartridge for use in the vertical or substantially vertical position

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