AU2016219204B2 - Use of Plinabulin in combination with immune checkpoint inhibitors - Google Patents

Use of Plinabulin in combination with immune checkpoint inhibitors Download PDF

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Publication number
AU2016219204B2
AU2016219204B2 AU2016219204A AU2016219204A AU2016219204B2 AU 2016219204 B2 AU2016219204 B2 AU 2016219204B2 AU 2016219204 A AU2016219204 A AU 2016219204A AU 2016219204 A AU2016219204 A AU 2016219204A AU 2016219204 B2 AU2016219204 B2 AU 2016219204B2
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Prior art keywords
immune checkpoint
cancer
inhibitor
checkpoint inhibitor
plinabulin
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AU2016219204A
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AU2016219204A1 (en
Inventor
Lan Huang
Gloria Tsi-Yie Lee
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BeyondSpring Pharmaceuticals Inc
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BeyondSpring Pharmaceuticals Inc
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Priority to AU2021202416A priority Critical patent/AU2021202416B2/en
Priority to AU2024200672A priority patent/AU2024200672B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2016219204A 2015-02-12 2016-02-11 Use of Plinabulin in combination with immune checkpoint inhibitors Active AU2016219204B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2021202416A AU2021202416B2 (en) 2015-02-12 2021-04-21 Use of plinabulin in combination with immune checkpoint inhibitors
AU2024200672A AU2024200672B2 (en) 2015-02-12 2024-02-02 Use of plinabulin in combination with immune checkpoint inhibitors

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562115468P 2015-02-12 2015-02-12
US62/115,468 2015-02-12
US201562255259P 2015-11-13 2015-11-13
US62/255,259 2015-11-13
PCT/US2016/017602 WO2016130839A1 (en) 2015-02-12 2016-02-11 Use of plinabulin in combination with immune checkpoint inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021202416A Division AU2021202416B2 (en) 2015-02-12 2021-04-21 Use of plinabulin in combination with immune checkpoint inhibitors

Publications (2)

Publication Number Publication Date
AU2016219204A1 AU2016219204A1 (en) 2017-08-24
AU2016219204B2 true AU2016219204B2 (en) 2021-01-21

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AU2016219204A Active AU2016219204B2 (en) 2015-02-12 2016-02-11 Use of Plinabulin in combination with immune checkpoint inhibitors
AU2021202416A Active AU2021202416B2 (en) 2015-02-12 2021-04-21 Use of plinabulin in combination with immune checkpoint inhibitors
AU2024200672A Active AU2024200672B2 (en) 2015-02-12 2024-02-02 Use of plinabulin in combination with immune checkpoint inhibitors

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AU2024200672A Active AU2024200672B2 (en) 2015-02-12 2024-02-02 Use of plinabulin in combination with immune checkpoint inhibitors

Country Status (16)

Country Link
US (1) US20180028531A1 (https=)
EP (1) EP3256130A4 (https=)
JP (4) JP7243021B2 (https=)
KR (2) KR20170117113A (https=)
CN (2) CN107427510A (https=)
AU (3) AU2016219204B2 (https=)
CA (1) CA2975729A1 (https=)
CL (1) CL2017002050A1 (https=)
HK (1) HK1247816A1 (https=)
IL (2) IL286282B2 (https=)
MX (2) MX394865B (https=)
MY (1) MY193968A (https=)
NZ (1) NZ734256A (https=)
RU (1) RU2723021C2 (https=)
SG (1) SG11201706281YA (https=)
WO (1) WO2016130839A1 (https=)

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CN109498627B (zh) * 2017-09-15 2021-06-04 深圳华大海洋科技有限公司 一种治疗肿瘤的药物组合物及其应用
KR20200112881A (ko) * 2018-01-24 2020-10-05 비욘드스프링 파마수티컬스, 인코포레이티드. 플리나불린의 투여를 통해 혈소판감소증을 감소시키는 조성물 및 방법
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Also Published As

Publication number Publication date
KR20170117113A (ko) 2017-10-20
MX2022007472A (es) 2022-06-29
JP7157181B2 (ja) 2022-10-19
AU2016219204A1 (en) 2017-08-24
RU2017127966A3 (https=) 2019-06-20
IL253784B (en) 2021-09-30
JP7564172B2 (ja) 2024-10-08
MX2017010338A (es) 2017-12-20
CL2017002050A1 (es) 2018-04-13
AU2024200672A1 (en) 2024-02-22
JP7243021B2 (ja) 2023-03-22
IL253784A0 (en) 2017-09-28
SG11201706281YA (en) 2017-09-28
KR20240110996A (ko) 2024-07-16
JP2018508572A (ja) 2018-03-29
NZ750444A (en) 2021-03-26
RU2017127966A (ru) 2019-03-12
EP3256130A1 (en) 2017-12-20
EP3256130A4 (en) 2018-08-01
JP2021050247A (ja) 2021-04-01
IL286282B2 (en) 2023-10-01
CN107427510A (zh) 2017-12-01
BR112017016902A2 (pt) 2018-03-27
AU2021202416B2 (en) 2024-02-15
AU2021202416A1 (en) 2021-05-20
US20180028531A1 (en) 2018-02-01
WO2016130839A1 (en) 2016-08-18
IL286282A (en) 2021-10-31
NZ734256A (en) 2019-02-22
HK1247816A1 (zh) 2018-10-05
IL286282B1 (en) 2023-06-01
MY193968A (en) 2022-11-03
RU2723021C2 (ru) 2020-06-08
AU2024200672B2 (en) 2026-03-05
CA2975729A1 (en) 2016-08-18
MX394865B (es) 2025-03-24
JP2024174070A (ja) 2024-12-13
JP2022190005A (ja) 2022-12-22
CN117100753A (zh) 2023-11-24

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