AU2015364245B2 - Chimeric antigen receptors and methods of use thereof - Google Patents

Chimeric antigen receptors and methods of use thereof Download PDF

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Publication number
AU2015364245B2
AU2015364245B2 AU2015364245A AU2015364245A AU2015364245B2 AU 2015364245 B2 AU2015364245 B2 AU 2015364245B2 AU 2015364245 A AU2015364245 A AU 2015364245A AU 2015364245 A AU2015364245 A AU 2015364245A AU 2015364245 B2 AU2015364245 B2 AU 2015364245B2
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amino acid
cells
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cell
caix
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AU2015364245A1 (en
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Wayne A. Marasco
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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Priority to AU2022200257A priority patent/AU2022200257B2/en
Priority to AU2024200592A priority patent/AU2024200592A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2015364245A 2014-12-19 2015-12-21 Chimeric antigen receptors and methods of use thereof Active AU2015364245B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2020204373A AU2020204373B2 (en) 2014-12-19 2020-06-30 Chimeric antigen receptors and methods of use thereof
AU2022200257A AU2022200257B2 (en) 2014-12-19 2022-01-17 Chimeric antigen receptors and methods of use thereof
AU2024200592A AU2024200592A1 (en) 2014-12-19 2024-01-31 Chimeric antigen receptors and methods of use thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462094625P 2014-12-19 2014-12-19
US62/094,625 2014-12-19
US201562252083P 2015-11-06 2015-11-06
US62/252,083 2015-11-06
PCT/US2015/067225 WO2016100985A2 (en) 2014-12-19 2015-12-21 Chimeric antigen receptors and methods of use thereof

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AU2015364245A1 AU2015364245A1 (en) 2017-06-08
AU2015364245B2 true AU2015364245B2 (en) 2020-04-02

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AU2020204373A Active AU2020204373B2 (en) 2014-12-19 2020-06-30 Chimeric antigen receptors and methods of use thereof
AU2022200257A Active AU2022200257B2 (en) 2014-12-19 2022-01-17 Chimeric antigen receptors and methods of use thereof
AU2024200592A Pending AU2024200592A1 (en) 2014-12-19 2024-01-31 Chimeric antigen receptors and methods of use thereof

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AU2022200257A Active AU2022200257B2 (en) 2014-12-19 2022-01-17 Chimeric antigen receptors and methods of use thereof
AU2024200592A Pending AU2024200592A1 (en) 2014-12-19 2024-01-31 Chimeric antigen receptors and methods of use thereof

Country Status (11)

Country Link
US (3) US20170362297A1 (cg-RX-API-DMAC7.html)
EP (1) EP3233900A2 (cg-RX-API-DMAC7.html)
JP (3) JP2018504894A (cg-RX-API-DMAC7.html)
KR (1) KR20170090506A (cg-RX-API-DMAC7.html)
CN (1) CN108064252A (cg-RX-API-DMAC7.html)
AU (4) AU2015364245B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017013176A2 (cg-RX-API-DMAC7.html)
CA (1) CA2968412A1 (cg-RX-API-DMAC7.html)
IL (3) IL252295B2 (cg-RX-API-DMAC7.html)
RU (1) RU2017125531A (cg-RX-API-DMAC7.html)
WO (1) WO2016100985A2 (cg-RX-API-DMAC7.html)

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