AU2015354360B2 - Methods of using bispecific antigen-binding constructs targeting HER2 - Google Patents

Methods of using bispecific antigen-binding constructs targeting HER2 Download PDF

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AU2015354360B2
AU2015354360B2 AU2015354360A AU2015354360A AU2015354360B2 AU 2015354360 B2 AU2015354360 B2 AU 2015354360B2 AU 2015354360 A AU2015354360 A AU 2015354360A AU 2015354360 A AU2015354360 A AU 2015354360A AU 2015354360 B2 AU2015354360 B2 AU 2015354360B2
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her2
antigen
seq
set forth
binding
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AU2015354360A1 (en
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Gordon Yiu Kon Ng
Nina E. Weisser
Grant Raymond Wickman
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Zymeworks BC Inc
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Zymeworks BC Inc
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    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6875—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin
    • A61K47/6879—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin the immunoglobulin having two or more different antigen-binding sites, e.g. bispecific or multispecific immunoglobulin
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
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AU2015354360A 2014-11-27 2015-11-26 Methods of using bispecific antigen-binding constructs targeting HER2 Active AU2015354360B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AUPCT/CA2014/051140 2014-11-27
PCT/CA2014/051140 WO2015077891A1 (en) 2013-11-27 2014-11-27 Bispecific antigen-binding constructs targeting her2
US201562166844P 2015-05-27 2015-05-27
US62/166,844 2015-05-27
PCT/CA2015/051238 WO2016082044A1 (en) 2014-11-27 2015-11-26 Methods of using bispecific antigen-binding constructs targeting her2

Publications (2)

Publication Number Publication Date
AU2015354360A1 AU2015354360A1 (en) 2017-06-29
AU2015354360B2 true AU2015354360B2 (en) 2021-09-09

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AU2015354360A Active AU2015354360B2 (en) 2014-11-27 2015-11-26 Methods of using bispecific antigen-binding constructs targeting HER2

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US (3) US20170355779A1 (enExample)
EP (2) EP3223848B1 (enExample)
JP (1) JP6872482B2 (enExample)
AU (1) AU2015354360B2 (enExample)
CA (1) CA2968258A1 (enExample)
DK (1) DK3223848T3 (enExample)
ES (1) ES3014819T3 (enExample)
FI (1) FI3223848T3 (enExample)
WO (1) WO2016082044A1 (enExample)

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MX376384B (es) 2013-11-27 2025-03-07 Zymeworks Bc Inc Construcciones de union a antigenos biespecificas dirigidas a her2.
CA2968258A1 (en) 2014-11-27 2016-06-02 Zymeworks Inc. Methods of using bispecific antigen-binding constructs targeting her2
EP3294772B1 (en) 2015-05-13 2025-11-05 Zymeworks BC Inc. Antigen-binding constructs targeting her2
TW201834688A (zh) 2017-02-24 2018-10-01 日商中外製藥股份有限公司 藥學組成物、抗原結合分子、治療方法以及篩選方法
JP6988158B2 (ja) 2017-05-11 2022-01-05 株式会社島津製作所 液体クロマトグラフ質量分析方法及び液体クロマトグラフ質量分析装置
IL277049B2 (en) * 2018-03-13 2024-02-01 Zymeworks Bc Inc Conjugates of biparatopic anti-HER2 antibody and drug and methods of use
JP7523349B2 (ja) * 2018-08-29 2024-07-26 中外製薬株式会社 抗体半分子、および抗体半分子のホモ二量体形成を抑制する方法
JP7644978B2 (ja) * 2019-02-03 2025-03-13 上海宝済薬業股▲ふん▼有限公司 Ｈｅｒ２に対する二重特異性抗体及びその応用
CN113646622B (zh) 2019-03-29 2024-11-12 豪夫迈·罗氏有限公司 用于多价分子的功能分析的基于spr的结合测定
JP7436520B2 (ja) * 2019-05-31 2024-02-21 ザイムワークス ビーシー インコーポレイテッド 胆道癌の治療のための、ｈｅｒ２を標的とする二重特異性抗原結合構築物の使用方法
CN114430804A (zh) * 2019-07-22 2022-05-03 瑞泽恩制药公司 用于抗体分析的亲和色谱-非变性质谱联用法
WO2023039672A1 (en) * 2021-09-15 2023-03-23 Zymeworks Bc Inc. Methods of treating cancer with anti-her2 biparatopic antibodies

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