AU2015354360B2 - Methods of using bispecific antigen-binding constructs targeting HER2 - Google Patents

Methods of using bispecific antigen-binding constructs targeting HER2 Download PDF

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AU2015354360B2
AU2015354360B2 AU2015354360A AU2015354360A AU2015354360B2 AU 2015354360 B2 AU2015354360 B2 AU 2015354360B2 AU 2015354360 A AU2015354360 A AU 2015354360A AU 2015354360 A AU2015354360 A AU 2015354360A AU 2015354360 B2 AU2015354360 B2 AU 2015354360B2
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her2
antigen
seq
set forth
binding
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AU2015354360A1 (en
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Gordon Yiu Kon Ng
Nina E. Weisser
Grant Raymond Wickman
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Zymeworks BC Inc
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Zymeworks BC Inc
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    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6879—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin the immunoglobulin having two or more different antigen-binding sites, e.g. bispecific or multispecific immunoglobulin
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AU2015354360A 2014-11-27 2015-11-26 Methods of using bispecific antigen-binding constructs targeting HER2 Active AU2015354360B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AUPCT/CA2014/051140 2014-11-27
PCT/CA2014/051140 WO2015077891A1 (en) 2013-11-27 2014-11-27 Bispecific antigen-binding constructs targeting her2
US201562166844P 2015-05-27 2015-05-27
US62/166,844 2015-05-27
PCT/CA2015/051238 WO2016082044A1 (en) 2014-11-27 2015-11-26 Methods of using bispecific antigen-binding constructs targeting her2

Publications (2)

Publication Number Publication Date
AU2015354360A1 AU2015354360A1 (en) 2017-06-29
AU2015354360B2 true AU2015354360B2 (en) 2021-09-09

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AU2015354360A Active AU2015354360B2 (en) 2014-11-27 2015-11-26 Methods of using bispecific antigen-binding constructs targeting HER2

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US (3) US20170355779A1 (enExample)
EP (2) EP3223848B1 (enExample)
JP (1) JP6872482B2 (enExample)
AU (1) AU2015354360B2 (enExample)
CA (1) CA2968258A1 (enExample)
DK (1) DK3223848T3 (enExample)
ES (1) ES3014819T3 (enExample)
FI (1) FI3223848T3 (enExample)
WO (1) WO2016082044A1 (enExample)

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FI3223848T3 (fi) 2014-11-27 2025-02-28 Zymeworks Bc Inc Menetelmiä käyttää bispesifisiä antigeenia sitovia rakenteita, jotka kohdistuvat her2:een
CA2984458A1 (en) 2015-05-13 2016-11-17 Zymeworks Inc. Antigen-binding constructs targeting her2
JP7556687B2 (ja) 2017-02-24 2024-09-26 中外製薬株式会社 薬学的組成物、抗原結合分子、治療方法、およびスクリーニング方法
JP6988158B2 (ja) * 2017-05-11 2022-01-05 株式会社島津製作所 液体クロマトグラフ質量分析方法及び液体クロマトグラフ質量分析装置
AU2019235634A1 (en) * 2018-03-13 2020-10-22 Zymeworks Bc Inc. Anti-HER2 biparatopic antibody-drug conjugates and methods of use
JP7523349B2 (ja) * 2018-08-29 2024-07-26 中外製薬株式会社 抗体半分子、および抗体半分子のホモ二量体形成を抑制する方法
US20220143178A1 (en) * 2019-02-03 2022-05-12 Shanghai Bao Pharmaceuticals Co., Ltd. Anti-her2 bispecific antibody and application thereof
CN113646622B (zh) 2019-03-29 2024-11-12 豪夫迈·罗氏有限公司 用于多价分子的功能分析的基于spr的结合测定
EP3976098A4 (en) * 2019-05-31 2023-01-18 Zymeworks Inc. METHOD OF USING A BISPECIFIC ANTIGEN-BINDING CONSTRUCT THAT TARGETS HER2 FOR THE TREATMENT OF BILAGE DUCT CANCER
KR102889153B1 (ko) 2019-07-22 2025-11-24 리제너론 파아마슈티컬스, 인크. 항체 분석을 위한 친화력 크로마토그래피-결합된 네이티브 질량 분석법
EP4058150A2 (en) * 2019-11-15 2022-09-21 Genzyme Corporation Biparatopic cd73 antibodies
IL311003A (en) 2021-08-25 2024-04-01 Denali Therapeutics Inc Anti-2HER antibodies and methods of using them
IL311380A (en) * 2021-09-15 2024-05-01 Zymeworks Bc Inc Methods for treating cancer with anti-HER2 biphasic antibodies

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