AU2015350108B2 - Method for treating cancer - Google Patents

Method for treating cancer Download PDF

Info

Publication number
AU2015350108B2
AU2015350108B2 AU2015350108A AU2015350108A AU2015350108B2 AU 2015350108 B2 AU2015350108 B2 AU 2015350108B2 AU 2015350108 A AU2015350108 A AU 2015350108A AU 2015350108 A AU2015350108 A AU 2015350108A AU 2015350108 B2 AU2015350108 B2 AU 2015350108B2
Authority
AU
Australia
Prior art keywords
amount
compound
salt
hydroxypropyl cellulose
epz
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2015350108A
Other languages
English (en)
Other versions
AU2015350108A1 (en
Inventor
Heike KEILHACK
Tsukasa Murase
Futoshi SHIKATA
Yuta Suzuki
Brett TRUITT
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Epizyme Inc
Original Assignee
Eisai R&D Management Co Ltd
Epizyme Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Management Co Ltd, Epizyme Inc filed Critical Eisai R&D Management Co Ltd
Publication of AU2015350108A1 publication Critical patent/AU2015350108A1/en
Application granted granted Critical
Publication of AU2015350108B2 publication Critical patent/AU2015350108B2/en
Priority to AU2021204706A priority Critical patent/AU2021204706B2/en
Priority to AU2024201171A priority patent/AU2024201171B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2015350108A 2014-11-17 2015-11-17 Method for treating cancer Active AU2015350108B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2021204706A AU2021204706B2 (en) 2014-11-17 2021-07-06 Method for treating cancer
AU2024201171A AU2024201171B2 (en) 2014-11-17 2024-02-22 Method for treating cancer

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462080985P 2014-11-17 2014-11-17
US62/080,985 2014-11-17
US201562166572P 2015-05-26 2015-05-26
US62/166,572 2015-05-26
US201562251903P 2015-11-06 2015-11-06
US62/251,903 2015-11-06
PCT/US2015/061194 WO2016081523A1 (en) 2014-11-17 2015-11-17 Method for treating cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021204706A Division AU2021204706B2 (en) 2014-11-17 2021-07-06 Method for treating cancer

Publications (2)

Publication Number Publication Date
AU2015350108A1 AU2015350108A1 (en) 2017-05-25
AU2015350108B2 true AU2015350108B2 (en) 2021-04-08

Family

ID=56014476

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2015350108A Active AU2015350108B2 (en) 2014-11-17 2015-11-17 Method for treating cancer
AU2021204706A Active AU2021204706B2 (en) 2014-11-17 2021-07-06 Method for treating cancer
AU2024201171A Active AU2024201171B2 (en) 2014-11-17 2024-02-22 Method for treating cancer

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2021204706A Active AU2021204706B2 (en) 2014-11-17 2021-07-06 Method for treating cancer
AU2024201171A Active AU2024201171B2 (en) 2014-11-17 2024-02-22 Method for treating cancer

Country Status (20)

Country Link
US (3) US10786511B2 (enExample)
EP (2) EP4272742A1 (enExample)
JP (3) JP6829684B2 (enExample)
KR (3) KR20240035908A (enExample)
CN (2) CN107249591B (enExample)
AU (3) AU2015350108B2 (enExample)
BR (1) BR112017010166A2 (enExample)
DK (1) DK3220916T3 (enExample)
EA (1) EA201791095A1 (enExample)
ES (1) ES2947819T3 (enExample)
FI (1) FI3220916T3 (enExample)
HU (1) HUE062159T2 (enExample)
IL (4) IL296080B2 (enExample)
LT (1) LT3220916T (enExample)
MX (2) MX383484B (enExample)
PL (1) PL3220916T3 (enExample)
PT (1) PT3220916T (enExample)
SG (1) SG11201703806XA (enExample)
SI (1) SI3220916T1 (enExample)
WO (1) WO2016081523A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3438B1 (ar) 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
RS59541B1 (sr) 2012-10-15 2019-12-31 Epizyme Inc Metodi lečenja kancera
EP3888659A1 (en) 2013-12-06 2021-10-06 Epizyme Inc Combination therapy for treating cancer
KR102497728B1 (ko) 2014-06-17 2023-02-09 에피자임, 인코포레이티드 림프종 치료를 위한 ｅｚｈ2 억제제
SI3220916T1 (sl) * 2014-11-17 2023-09-29 Epizyme, Inc. Postopek zdravljenja raka z n-((4,6-dimetil-2-okso-1,2-dihidropiridin-3 -il)metil)-5-(etil(tetrahidro-2h-piran-4-il) amino)-4-metil-4'- (morfolinometil)-(1,1'-bifenil)-3-karboksamidom
MX391720B (es) 2015-04-20 2025-03-21 Epizyme Inc Terapia combinada para tratar cáncer.
AU2016275051A1 (en) 2015-06-10 2017-12-07 Epizyme, Inc. EZH2 inhibitors for treating lymphoma
EP3341080A4 (en) 2015-08-24 2019-03-20 Epizyme Inc METHOD FOR THE TREATMENT OF CANCER
US11951108B2 (en) 2016-01-29 2024-04-09 Epizyme, Inc. Combination therapy for treating cancer
JP7121660B2 (ja) 2016-06-01 2022-08-18 エピザイム，インコーポレイティド 癌を処置するためのｅｚｈ２阻害剤の使用
US11147819B2 (en) 2016-06-17 2021-10-19 Epizyme, Inc. EZH2 inhibitors for treating cancer
CA3050221C (en) 2017-01-19 2021-09-28 Daiichi Sankyo Company, Limited Pharmaceutical composition used for treatment of htlv-1-associated myelopathy
WO2018183885A1 (en) 2017-03-31 2018-10-04 Epizyme, Inc. Combination therapy for treating cancer
US11602529B2 (en) 2017-06-02 2023-03-14 Epizyme, Inc. Use of EZH2 inhibitors for treating cancer
JP7399079B2 (ja) 2017-09-05 2023-12-15 エピザイム，インコーポレイティド 癌を処置するための併用療法
BR112022012258A2 (pt) * 2019-12-20 2022-08-30 Epizyme Inc Sal cristalino de bromidreto de um inibidor de ezh2, sua preparação e composição farmacêutica útil para o tratamento de câncer
JP7628876B2 (ja) 2021-04-23 2025-02-12 日立Astemo株式会社 情報処理装置、情報処理方法、プログラムおよび記憶媒体
WO2023159124A2 (en) * 2022-02-17 2023-08-24 Memorial Sloan-Kettering Cancer Center Methods for overcoming tazemetostat-resistance in cancer patients
CA3249707A1 (en) 2022-04-27 2023-11-02 Daiichi Sankyo Company, Limited COMBINATION OF AN ANTIBODY-DRUG CONJUGATE WITH AN EZH1 AND/OR EZH2 INHIBITOR

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013138361A1 (en) * 2012-03-12 2013-09-19 Epizyme, Inc. Inhibitors of human ezh2, and methods of use thereof
WO2013155464A1 (en) * 2012-04-13 2013-10-17 Epizyme, Inc. Combination therapy for treating cancer
WO2014062720A2 (en) * 2012-10-15 2014-04-24 Epizyme, Inc. Methods of treating cancer
WO2014100080A1 (en) * 2012-12-19 2014-06-26 Glaxosmithkline Llc Combination
WO2015195848A1 (en) * 2014-06-17 2015-12-23 Epizyme, Inc. Ezh2 inhibitors for treating lymphoma

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9119052D0 (en) 1991-09-06 1991-10-23 Boots Co Plc Pharmaceutical compositions
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US7229774B2 (en) 2001-08-02 2007-06-12 Regents Of The University Of Michigan Expression profile of prostate cancer
US20070026064A1 (en) * 2005-07-29 2007-02-01 Yoder Steven L Pharmaceutical dosage forms having watermark-type identification and authentication inditia
WO2008121476A1 (en) * 2007-03-28 2008-10-09 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
US20100278921A1 (en) * 2009-04-30 2010-11-04 Fischer Cristina M Solid oral formulation of abt-263
AU2011298987B2 (en) * 2010-09-10 2017-09-28 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
US9175331B2 (en) 2010-09-10 2015-11-03 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
WO2012097222A1 (en) * 2011-01-14 2012-07-19 Bristol-Myers Squibb Company High drug load tablet formulation of brivanib alaninate
EP2681216B1 (en) 2011-02-28 2017-09-27 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
TW201733984A (zh) 2011-04-13 2017-10-01 雅酶股份有限公司 經取代之苯化合物
JO3438B1 (ar) * 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
RS59392B1 (sr) 2012-04-13 2019-11-29 Epizyme Inc N-((4,6-dimetil-2-okso-l,2-dihidropiridin-3-il)metil)-5-(etil(tetrahidro-2h-piran-4-il)amino)-4-metil-4’ (morfolinometil)-[l,1’-bifenil]-3-karboksamid hidrobromid za upotrebu u lečenju proliferativnih poremećaja ćelija hematološkog sistema
HK1213552A1 (zh) 2012-10-15 2016-07-08 Epizyme, Inc. 经取代的苯化合物
WO2014100665A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. 1,4-pyridone bicyclic heteroaryl compounds
US20150344427A1 (en) 2012-12-21 2015-12-03 Epizyme, Inc. 1,4-pyridone compounds
WO2014144747A1 (en) 2013-03-15 2014-09-18 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
EP2970281A4 (en) 2013-03-15 2016-08-03 Epizyme Inc SUBSTITUTED BENZOL COMPOUNDS
US10150764B2 (en) 2013-07-19 2018-12-11 Epizyme, Inc. Substituted benzene compounds
CN105829302B (zh) 2013-10-16 2020-09-08 Epizyme股份有限公司 用于ezh2抑制的盐酸盐形式
AU2014337121A1 (en) * 2013-10-18 2016-04-14 Epizyme, Inc. Method of treating cancer
EP3888659A1 (en) 2013-12-06 2021-10-06 Epizyme Inc Combination therapy for treating cancer
US20170217941A1 (en) 2014-06-25 2017-08-03 Epizyme, Inc. Substituted benzene and 6,5-fused bicyclic heteroaryl compounds
KR102397720B1 (ko) 2014-10-16 2022-05-13 에피자임, 인코포레이티드 암을 치료하기 위한 방법
SI3220916T1 (sl) * 2014-11-17 2023-09-29 Epizyme, Inc. Postopek zdravljenja raka z n-((4,6-dimetil-2-okso-1,2-dihidropiridin-3 -il)metil)-5-(etil(tetrahidro-2h-piran-4-il) amino)-4-metil-4'- (morfolinometil)-(1,1'-bifenil)-3-karboksamidom
AU2016275051A1 (en) * 2015-06-10 2017-12-07 Epizyme, Inc. EZH2 inhibitors for treating lymphoma
US11147819B2 (en) * 2016-06-17 2021-10-19 Epizyme, Inc. EZH2 inhibitors for treating cancer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013138361A1 (en) * 2012-03-12 2013-09-19 Epizyme, Inc. Inhibitors of human ezh2, and methods of use thereof
WO2013155464A1 (en) * 2012-04-13 2013-10-17 Epizyme, Inc. Combination therapy for treating cancer
WO2014062720A2 (en) * 2012-10-15 2014-04-24 Epizyme, Inc. Methods of treating cancer
WO2014100080A1 (en) * 2012-12-19 2014-06-26 Glaxosmithkline Llc Combination
WO2015195848A1 (en) * 2014-06-17 2015-12-23 Epizyme, Inc. Ezh2 inhibitors for treating lymphoma

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
COPELAND, R. A. et al., "EZH2 Inhibitor EPZ-6438 (E7438) in Non-Hodgkin Lymphoma: Pre-Clinical Models and Early Clinical Observations", (2014-08-12) *
KNUTSON, S. K. et al., "Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma", Molecular Cancer Therapeutics., (2014), vol. 13, no. 4, pages 842 - 854 *
SANDEEP, N. et al., "Immediate Drug Release Dosage Form: A Review", Journal of Drug Delivery & Therapeutics., (2013), vol. 3, no. 2, pages 155 - 161 *

Also Published As

Publication number Publication date
JP6829684B2 (ja) 2021-02-10
IL304252A (en) 2023-09-01
LT3220916T (lt) 2023-07-25
IL296080B2 (en) 2023-12-01
EP3220916B1 (en) 2023-04-19
US20170360797A1 (en) 2017-12-21
CN116650500A (zh) 2023-08-29
EP4272742A1 (en) 2023-11-08
KR102338802B1 (ko) 2021-12-14
JP7485810B2 (ja) 2024-05-16
US20210060030A1 (en) 2021-03-04
PL3220916T3 (pl) 2023-08-14
NZ768247A (en) 2024-05-31
US10786511B2 (en) 2020-09-29
US20250064822A1 (en) 2025-02-27
KR20210156840A (ko) 2021-12-27
EP3220916A4 (en) 2018-07-11
SG11201703806XA (en) 2017-06-29
ES2947819T3 (es) 2023-08-21
IL252182B (en) 2022-10-01
JP2017537899A (ja) 2017-12-21
IL304252B1 (en) 2025-11-01
EP3220916A1 (en) 2017-09-27
US12168014B2 (en) 2024-12-17
KR20240035908A (ko) 2024-03-18
KR102644844B1 (ko) 2024-03-07
IL296080B1 (en) 2023-08-01
AU2021204706A1 (en) 2021-07-29
JP2023062189A (ja) 2023-05-02
AU2015350108A1 (en) 2017-05-25
FI3220916T3 (fi) 2023-06-19
MX2021006734A (es) 2021-07-02
CN107249591B (zh) 2024-01-30
AU2024201171B2 (en) 2026-01-29
KR20170103768A (ko) 2017-09-13
DK3220916T3 (da) 2023-06-26
IL323396A (en) 2025-11-01
AU2024201171A1 (en) 2024-03-14
IL252182A0 (en) 2017-07-31
PT3220916T (pt) 2023-06-26
AU2021204706B2 (en) 2023-11-23
BR112017010166A2 (en) 2018-02-14
MX383484B (es) 2025-03-11
IL252182B2 (en) 2023-02-01
IL296080A (en) 2022-11-01
SI3220916T1 (sl) 2023-09-29
JP2021073241A (ja) 2021-05-13
WO2016081523A1 (en) 2016-05-26
CN107249591A (zh) 2017-10-13
HUE062159T2 (hu) 2023-10-28
EA201791095A1 (ru) 2017-10-31
CA2967664A1 (en) 2016-05-26
NZ731696A (en) 2024-03-22
MX2017006089A (es) 2017-12-11

Similar Documents

Publication Publication Date Title
AU2021204706B2 (en) Method for treating cancer
US11642349B2 (en) Method for treating cancer
CA2967664C (en) Pharmaceutical formulations comprising inhibitors of human histone methyltransferase ezh2
HK40103478A (en) Epz-6438 for use in a method for treating cancer
HK40098963A (zh) 治疗癌症的方法
EA048689B1 (ru) Твердый фармацевтический состав для лечения рака

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)