AU2015234595B2 - Modified CPMV enhancer elements - Google Patents

Modified CPMV enhancer elements Download PDF

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Publication number
AU2015234595B2
AU2015234595B2 AU2015234595A AU2015234595A AU2015234595B2 AU 2015234595 B2 AU2015234595 B2 AU 2015234595B2 AU 2015234595 A AU2015234595 A AU 2015234595A AU 2015234595 A AU2015234595 A AU 2015234595A AU 2015234595 B2 AU2015234595 B2 AU 2015234595B2
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AU
Australia
Prior art keywords
leu
gly
ser
sequence
ile
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2015234595A
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English (en)
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AU2015234595A1 (en
Inventor
Marc-Andre D'aoust
Pierre-Olivier Lavoie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medicago Inc
Original Assignee
Medicago Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CA2014/050326 external-priority patent/WO2014153674A1/en
Application filed by Medicago Inc filed Critical Medicago Inc
Publication of AU2015234595A1 publication Critical patent/AU2015234595A1/en
Application granted granted Critical
Publication of AU2015234595B2 publication Critical patent/AU2015234595B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/11—Orthomyxoviridae, e.g. influenza virus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Physiology (AREA)
AU2015234595A 2014-03-27 2015-03-27 Modified CPMV enhancer elements Ceased AU2015234595B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461971274P 2014-03-27 2014-03-27
US61/971,274 2014-03-27
PCT/CA2014/050326 WO2014153674A1 (en) 2013-03-28 2014-03-28 Influenza virus-like particle production in plants
AUPCT/CA2014/050326 2014-03-28
PCT/CA2015/050240 WO2015143567A1 (en) 2014-03-27 2015-03-27 Modified cpmv enhancer elements

Publications (2)

Publication Number Publication Date
AU2015234595A1 AU2015234595A1 (en) 2016-10-13
AU2015234595B2 true AU2015234595B2 (en) 2021-03-25

Family

ID=54193828

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015234595A Ceased AU2015234595B2 (en) 2014-03-27 2015-03-27 Modified CPMV enhancer elements

Country Status (8)

Country Link
US (1) US10563213B2 (cg-RX-API-DMAC7.html)
EP (1) EP3122883B1 (cg-RX-API-DMAC7.html)
JP (1) JP6599354B2 (cg-RX-API-DMAC7.html)
CN (1) CN106460005B (cg-RX-API-DMAC7.html)
AU (1) AU2015234595B2 (cg-RX-API-DMAC7.html)
CA (1) CA2943796C (cg-RX-API-DMAC7.html)
ES (1) ES2912291T3 (cg-RX-API-DMAC7.html)
WO (1) WO2015143567A1 (cg-RX-API-DMAC7.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0800272D0 (en) 2008-01-08 2008-02-13 Plant Bioscience Ltd Protein expression systems
DK3092309T3 (da) * 2014-01-10 2021-04-12 Medicago Inc Cpmv-forstærkerelementer
CN106460005B (zh) 2014-03-27 2020-01-03 莫迪卡戈公司 修饰的cpmv增强子元件
EP3765618A4 (en) * 2018-03-14 2022-01-05 Medicago Inc. PLANT EXPRESSION ACTIVATOR
CN112654707B (zh) * 2018-06-27 2025-02-28 阿拉米斯生物技术公司 流感病毒血凝素突变体
BR112021017899A2 (pt) * 2019-03-14 2021-12-21 Medicago Inc Intensificador de expressão vegetal endógeno
EP4323382A4 (en) * 2021-04-15 2025-06-18 Biorchestra Co., Ltd. POLYNUCLEOTIDES FOR ENHANCED PROTEIN EXPRESSION AND USES THEREOF

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012058762A1 (en) * 2010-11-04 2012-05-10 Medicago Inc. Plant expression system
WO2013044390A1 (en) * 2011-09-30 2013-04-04 Medicago Inc. Increasing virus-like particle yield in plants

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428147A (en) 1983-04-15 1995-06-27 Mycogen Plant Science, Inc. Octopine T-DNA promoters
CA1280081C (en) 1984-09-24 1991-02-12 Calgene, Inc. Plant cell microinjection technique
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5036006A (en) 1984-11-13 1991-07-30 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5100792A (en) 1984-11-13 1992-03-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues
AU7360087A (en) 1986-04-30 1987-11-24 Boyce Thompson Institute For Plant Research Inc. Electric field mediated dna transformation of plant cells and organelles
US4962028A (en) 1986-07-09 1990-10-09 Dna Plant Technology Corporation Plant promotors
US4692028A (en) 1986-08-19 1987-09-08 Crafco, Inc. Sealant melter/applicator with automatic load switching system
NZ224470A (en) 1987-05-05 1991-06-25 Sandoz Ltd Method of transforming plant cell material; plant cell material and plants
EP0331083A3 (de) 1988-03-02 1990-11-28 Schweizerische Eidgenossenschaft Eidgenössische Technische Hochschule (Eth) Verfahren zur Herstellung transgener Pflanzen
US6403865B1 (en) 1990-08-24 2002-06-11 Syngenta Investment Corp. Method of producing transgenic maize using direct transformation of commercially important genotypes
EP0558676B1 (en) 1990-11-23 2000-04-19 Plant Genetic Systems, N.V. Process for transforming monocotyledonous plants
UA48104C2 (uk) 1991-10-04 2002-08-15 Новартіс Аг Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника
WO1994000583A1 (en) 1992-06-23 1994-01-06 South Dakota State University Transformation of plants by direct injection of dna
AU2594300A (en) 1998-12-23 2000-07-12 Samuel Roberts Noble Foundation, Inc., The Plant transformation process
CA2370638A1 (en) 1999-04-21 2000-10-26 Igor Kardailsky Plant transformation process
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
MXPA02005559A (es) * 1999-12-06 2004-09-10 Univ Illinois Proteinas de tcr de alta afinidad y metodos.
DE10109354A1 (de) 2001-02-27 2002-09-05 Icon Genetics Ag Rekombinante virale Schaltersysteme
US8080255B2 (en) 2003-07-11 2011-12-20 Novavax Inc. Functional influenza virus like particles (VLPs)
AU2006304640B2 (en) 2005-10-18 2012-10-11 Novavax, Inc. Functional influenza virus like particles (VLPs)
EP2476432B1 (en) 2006-03-07 2015-08-19 Vaxinnate Corporation Compositions that include hemagglutinin, methods of making and methods of use thereof
US7618815B2 (en) 2006-03-08 2009-11-17 University Of Kentucky Research Foundation Viral vectors useful in soybean and methods of use
WO2007135480A1 (en) 2006-05-22 2007-11-29 Plant Bioscience Limited Bipartite system, method and composition for the constitutive and inducible expression of high levels of foreign proteins in plants
US8697088B2 (en) 2007-05-25 2014-04-15 Novavax, Inc. VLPs derived from cells that do not express a viral matrix or core protein
CA2615372A1 (en) 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
NZ587108A (en) 2007-11-27 2013-04-26 Medicago Inc Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
GB0800272D0 (en) * 2008-01-08 2008-02-13 Plant Bioscience Ltd Protein expression systems
KR101956910B1 (ko) 2008-01-21 2019-03-12 메디카고 인코포레이티드 헤마글루티닌을 발현하는 트랜스제닉 식물에서 생산된 재조합 인플루엔자 바이러스-유사 입자(ＶＬＰｓ)
EP2454229B1 (en) 2009-05-06 2017-09-13 Risen (Shanghai) Pharma Tech Co, Ltd. Amino acid derivatives for the treatment of neuropathic pain
JP5871796B2 (ja) 2009-06-24 2016-03-01 メディカゴ インコーポレイテッド ヘマグルチニンを含むキメラインフルエンザウイルス様粒子
JP2013503640A (ja) * 2009-09-04 2013-02-04 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト 植物におけるポリペプチドの発現を増加させるための翻訳エンハンサー要素のスタッキング
TWI526539B (zh) 2010-12-22 2016-03-21 苜蓿股份有限公司 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp
TWI620816B (zh) 2011-03-23 2018-04-11 苜蓿股份有限公司 植物衍生蛋白回收方法
AU2012269684B2 (en) * 2011-06-13 2017-06-22 Medicago Inc. Rabies virus like particle production in plants
PL220281B1 (pl) 2011-09-23 2015-09-30 Inst Biochemii I Biofizyki Polskiej Akademii Nauk Szczepionka DNA, sposób indukowania odpowiedzi immunologicznej, przeciwciała specyficznie rozpoznające białko hemaglutyniny H5 wirusa grypy i zastosowanie szczepionki DNA
JP6390846B2 (ja) 2011-11-11 2018-09-19 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム ニコチアナタバカムにおいて生成される血球凝集素を含むインフルエンザウイルス様粒子（ｖｌｐ）
AU2014245779B2 (en) 2013-03-28 2020-02-06 Aramis Biotechnologies Inc. Influenza virus-like particle production in plants
CN106460005B (zh) 2014-03-27 2020-01-03 莫迪卡戈公司 修饰的cpmv增强子元件

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012058762A1 (en) * 2010-11-04 2012-05-10 Medicago Inc. Plant expression system
WO2013044390A1 (en) * 2011-09-30 2013-04-04 Medicago Inc. Increasing virus-like particle yield in plants

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Kanagarajan et al, 2012, PLoS One, 7: 1-10. *
Sainsbury et al, 2009, Plant Biotechnology Journal, 7:682-693. & Associated GenBank Accession No. GQ497234.1 08-SEP-2009 *

Also Published As

Publication number Publication date
US10563213B2 (en) 2020-02-18
CA2943796A1 (en) 2015-10-01
AU2015234595A1 (en) 2016-10-13
ES2912291T3 (es) 2022-05-25
EP3122883A1 (en) 2017-02-01
EP3122883B1 (en) 2022-03-02
EP3122883A4 (en) 2017-11-29
CN106460005A (zh) 2017-02-22
US20180119158A1 (en) 2018-05-03
JP2017513467A (ja) 2017-06-01
CN106460005B (zh) 2020-01-03
CA2943796C (en) 2023-02-14
WO2015143567A1 (en) 2015-10-01
JP6599354B2 (ja) 2019-10-30

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired