JP6599354B2 - 改変されたcpmvエンハンサーエレメント - Google Patents
改変されたcpmvエンハンサーエレメント Download PDFInfo
- Publication number
- JP6599354B2 JP6599354B2 JP2016558734A JP2016558734A JP6599354B2 JP 6599354 B2 JP6599354 B2 JP 6599354B2 JP 2016558734 A JP2016558734 A JP 2016558734A JP 2016558734 A JP2016558734 A JP 2016558734A JP 6599354 B2 JP6599354 B2 JP 6599354B2
- Authority
- JP
- Japan
- Prior art keywords
- plant
- sequence
- cpmv
- protein
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/11—Orthomyxoviridae, e.g. influenza virus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Pulmonology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Physiology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461971274P | 2014-03-27 | 2014-03-27 | |
| US61/971,274 | 2014-03-27 | ||
| PCT/CA2014/050326 WO2014153674A1 (en) | 2013-03-28 | 2014-03-28 | Influenza virus-like particle production in plants |
| CAPCT/CA2014/050326 | 2014-03-28 | ||
| PCT/CA2015/050240 WO2015143567A1 (en) | 2014-03-27 | 2015-03-27 | Modified cpmv enhancer elements |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017513467A JP2017513467A (ja) | 2017-06-01 |
| JP2017513467A5 JP2017513467A5 (cg-RX-API-DMAC7.html) | 2018-05-10 |
| JP6599354B2 true JP6599354B2 (ja) | 2019-10-30 |
Family
ID=54193828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016558734A Expired - Fee Related JP6599354B2 (ja) | 2014-03-27 | 2015-03-27 | 改変されたcpmvエンハンサーエレメント |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10563213B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3122883B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6599354B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN106460005B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015234595B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2943796C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2912291T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015143567A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0800272D0 (en) | 2008-01-08 | 2008-02-13 | Plant Bioscience Ltd | Protein expression systems |
| DK3092309T3 (da) * | 2014-01-10 | 2021-04-12 | Medicago Inc | Cpmv-forstærkerelementer |
| CN106460005B (zh) | 2014-03-27 | 2020-01-03 | 莫迪卡戈公司 | 修饰的cpmv增强子元件 |
| EP3765618A4 (en) * | 2018-03-14 | 2022-01-05 | Medicago Inc. | PLANT EXPRESSION ACTIVATOR |
| CN112654707B (zh) * | 2018-06-27 | 2025-02-28 | 阿拉米斯生物技术公司 | 流感病毒血凝素突变体 |
| BR112021017899A2 (pt) * | 2019-03-14 | 2021-12-21 | Medicago Inc | Intensificador de expressão vegetal endógeno |
| EP4323382A4 (en) * | 2021-04-15 | 2025-06-18 | Biorchestra Co., Ltd. | POLYNUCLEOTIDES FOR ENHANCED PROTEIN EXPRESSION AND USES THEREOF |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5428147A (en) | 1983-04-15 | 1995-06-27 | Mycogen Plant Science, Inc. | Octopine T-DNA promoters |
| CA1280081C (en) | 1984-09-24 | 1991-02-12 | Calgene, Inc. | Plant cell microinjection technique |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5036006A (en) | 1984-11-13 | 1991-07-30 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5100792A (en) | 1984-11-13 | 1992-03-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues |
| AU7360087A (en) | 1986-04-30 | 1987-11-24 | Boyce Thompson Institute For Plant Research Inc. | Electric field mediated dna transformation of plant cells and organelles |
| US4962028A (en) | 1986-07-09 | 1990-10-09 | Dna Plant Technology Corporation | Plant promotors |
| US4692028A (en) | 1986-08-19 | 1987-09-08 | Crafco, Inc. | Sealant melter/applicator with automatic load switching system |
| NZ224470A (en) | 1987-05-05 | 1991-06-25 | Sandoz Ltd | Method of transforming plant cell material; plant cell material and plants |
| EP0331083A3 (de) | 1988-03-02 | 1990-11-28 | Schweizerische Eidgenossenschaft Eidgenössische Technische Hochschule (Eth) | Verfahren zur Herstellung transgener Pflanzen |
| US6403865B1 (en) | 1990-08-24 | 2002-06-11 | Syngenta Investment Corp. | Method of producing transgenic maize using direct transformation of commercially important genotypes |
| EP0558676B1 (en) | 1990-11-23 | 2000-04-19 | Plant Genetic Systems, N.V. | Process for transforming monocotyledonous plants |
| UA48104C2 (uk) | 1991-10-04 | 2002-08-15 | Новартіс Аг | Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника |
| WO1994000583A1 (en) | 1992-06-23 | 1994-01-06 | South Dakota State University | Transformation of plants by direct injection of dna |
| AU2594300A (en) | 1998-12-23 | 2000-07-12 | Samuel Roberts Noble Foundation, Inc., The | Plant transformation process |
| CA2370638A1 (en) | 1999-04-21 | 2000-10-26 | Igor Kardailsky | Plant transformation process |
| US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
| MXPA02005559A (es) * | 1999-12-06 | 2004-09-10 | Univ Illinois | Proteinas de tcr de alta afinidad y metodos. |
| DE10109354A1 (de) | 2001-02-27 | 2002-09-05 | Icon Genetics Ag | Rekombinante virale Schaltersysteme |
| US8080255B2 (en) | 2003-07-11 | 2011-12-20 | Novavax Inc. | Functional influenza virus like particles (VLPs) |
| AU2006304640B2 (en) | 2005-10-18 | 2012-10-11 | Novavax, Inc. | Functional influenza virus like particles (VLPs) |
| EP2476432B1 (en) | 2006-03-07 | 2015-08-19 | Vaxinnate Corporation | Compositions that include hemagglutinin, methods of making and methods of use thereof |
| US7618815B2 (en) | 2006-03-08 | 2009-11-17 | University Of Kentucky Research Foundation | Viral vectors useful in soybean and methods of use |
| WO2007135480A1 (en) | 2006-05-22 | 2007-11-29 | Plant Bioscience Limited | Bipartite system, method and composition for the constitutive and inducible expression of high levels of foreign proteins in plants |
| US8697088B2 (en) | 2007-05-25 | 2014-04-15 | Novavax, Inc. | VLPs derived from cells that do not express a viral matrix or core protein |
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| NZ587108A (en) | 2007-11-27 | 2013-04-26 | Medicago Inc | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
| GB0800272D0 (en) * | 2008-01-08 | 2008-02-13 | Plant Bioscience Ltd | Protein expression systems |
| KR101956910B1 (ko) | 2008-01-21 | 2019-03-12 | 메디카고 인코포레이티드 | 헤마글루티닌을 발현하는 트랜스제닉 식물에서 생산된 재조합 인플루엔자 바이러스-유사 입자(VLPs) |
| EP2454229B1 (en) | 2009-05-06 | 2017-09-13 | Risen (Shanghai) Pharma Tech Co, Ltd. | Amino acid derivatives for the treatment of neuropathic pain |
| JP5871796B2 (ja) | 2009-06-24 | 2016-03-01 | メディカゴ インコーポレイテッド | ヘマグルチニンを含むキメラインフルエンザウイルス様粒子 |
| JP2013503640A (ja) * | 2009-09-04 | 2013-02-04 | シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト | 植物におけるポリペプチドの発現を増加させるための翻訳エンハンサー要素のスタッキング |
| CA2815887C (en) * | 2010-11-04 | 2013-12-10 | Medicago Inc. | Plant expression system |
| TWI526539B (zh) | 2010-12-22 | 2016-03-21 | 苜蓿股份有限公司 | 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| AU2012269684B2 (en) * | 2011-06-13 | 2017-06-22 | Medicago Inc. | Rabies virus like particle production in plants |
| PL220281B1 (pl) | 2011-09-23 | 2015-09-30 | Inst Biochemii I Biofizyki Polskiej Akademii Nauk | Szczepionka DNA, sposób indukowania odpowiedzi immunologicznej, przeciwciała specyficznie rozpoznające białko hemaglutyniny H5 wirusa grypy i zastosowanie szczepionki DNA |
| IN2014CN03077A (cg-RX-API-DMAC7.html) * | 2011-09-30 | 2015-07-03 | Medicago Inc | |
| JP6390846B2 (ja) | 2011-11-11 | 2018-09-19 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | ニコチアナタバカムにおいて生成される血球凝集素を含むインフルエンザウイルス様粒子(vlp) |
| AU2014245779B2 (en) | 2013-03-28 | 2020-02-06 | Aramis Biotechnologies Inc. | Influenza virus-like particle production in plants |
| CN106460005B (zh) | 2014-03-27 | 2020-01-03 | 莫迪卡戈公司 | 修饰的cpmv增强子元件 |
-
2015
- 2015-03-27 CN CN201580024026.2A patent/CN106460005B/zh not_active Expired - Fee Related
- 2015-03-27 AU AU2015234595A patent/AU2015234595B2/en not_active Ceased
- 2015-03-27 US US15/129,269 patent/US10563213B2/en active Active
- 2015-03-27 WO PCT/CA2015/050240 patent/WO2015143567A1/en not_active Ceased
- 2015-03-27 CA CA2943796A patent/CA2943796C/en active Active
- 2015-03-27 EP EP15769248.4A patent/EP3122883B1/en not_active Not-in-force
- 2015-03-27 JP JP2016558734A patent/JP6599354B2/ja not_active Expired - Fee Related
- 2015-03-27 ES ES15769248T patent/ES2912291T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10563213B2 (en) | 2020-02-18 |
| CA2943796A1 (en) | 2015-10-01 |
| AU2015234595A1 (en) | 2016-10-13 |
| ES2912291T3 (es) | 2022-05-25 |
| EP3122883A1 (en) | 2017-02-01 |
| EP3122883B1 (en) | 2022-03-02 |
| EP3122883A4 (en) | 2017-11-29 |
| CN106460005A (zh) | 2017-02-22 |
| AU2015234595B2 (en) | 2021-03-25 |
| US20180119158A1 (en) | 2018-05-03 |
| JP2017513467A (ja) | 2017-06-01 |
| CN106460005B (zh) | 2020-01-03 |
| CA2943796C (en) | 2023-02-14 |
| WO2015143567A1 (en) | 2015-10-01 |
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| US11884929B2 (en) | CPMV enhancer elements | |
| US20250207144A1 (en) | Endogenous plant expression enhancer |
Legal Events
| Date | Code | Title | Description |
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| LAPS | Cancellation because of no payment of annual fees |